JP2003531913A5 - - Google Patents
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- Publication number
- JP2003531913A5 JP2003531913A5 JP2001580921A JP2001580921A JP2003531913A5 JP 2003531913 A5 JP2003531913 A5 JP 2003531913A5 JP 2001580921 A JP2001580921 A JP 2001580921A JP 2001580921 A JP2001580921 A JP 2001580921A JP 2003531913 A5 JP2003531913 A5 JP 2003531913A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- substituted
- heteroaryl
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 22
- 125000001072 heteroaryl group Chemical group 0.000 description 16
- 125000000217 alkyl group Chemical group 0.000 description 15
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 125000003107 substituted aryl group Chemical group 0.000 description 8
- 229910052801 chlorine Inorganic materials 0.000 description 7
- 239000000460 chlorine Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 4
- 150000002431 hydrogen Chemical group 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Chemical group 0.000 description 3
- 125000001309 chloro group Chemical group Cl* 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 0 *CCN(CC*)P(N(CC*)CC*)(OCC*)=O Chemical compound *CCN(CC*)P(N(CC*)CC*)(OCC*)=O 0.000 description 2
- -1 2-(Para-bromobenzenesulfonyl) ethyl Chemical group 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- VSNKRNNQPLVZNF-UHFFFAOYSA-N 1-chloro-2-diaminophosphoryloxyethane Chemical compound NP(N)(=O)OCCCl VSNKRNNQPLVZNF-UHFFFAOYSA-N 0.000 description 1
- SZPCVEAAUNRPLP-UHFFFAOYSA-N 2-[bis[bis(2-chloroethyl)amino]phosphoryloxy]ethanol Chemical compound OCCOP(=O)(N(CCCl)CCCl)N(CCCl)CCCl SZPCVEAAUNRPLP-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56318100A | 2000-05-02 | 2000-05-02 | |
| US09/563,181 | 2000-05-02 | ||
| PCT/US2001/014290 WO2001083496A1 (en) | 2000-05-02 | 2001-05-02 | Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003531913A JP2003531913A (ja) | 2003-10-28 |
| JP2003531913A5 true JP2003531913A5 (enExample) | 2006-01-12 |
| JP4249928B2 JP4249928B2 (ja) | 2009-04-08 |
Family
ID=24249433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001580921A Expired - Fee Related JP4249928B2 (ja) | 2000-05-02 | 2001-05-02 | 抗腫瘍剤としてのビス−（ｎ，ｎ’−ビス−（２−ハロエチル）アミノ）ホスホルアミデート |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP1278759B1 (enExample) |
| JP (1) | JP4249928B2 (enExample) |
| KR (1) | KR100729980B1 (enExample) |
| CN (1) | CN1182143C (enExample) |
| AR (1) | AR029072A1 (enExample) |
| AT (2) | ATE455779T1 (enExample) |
| AU (2) | AU6115301A (enExample) |
| BR (1) | BR0110553A (enExample) |
| CA (1) | CA2407606C (enExample) |
| CZ (1) | CZ20023615A3 (enExample) |
| DE (2) | DE60116081T2 (enExample) |
| DK (2) | DK1607399T3 (enExample) |
| EA (1) | EA006852B1 (enExample) |
| ES (2) | ES2253380T3 (enExample) |
| HU (1) | HUP0300688A3 (enExample) |
| IL (2) | IL152325A0 (enExample) |
| MX (1) | MXPA02010813A (enExample) |
| NO (2) | NO328854B1 (enExample) |
| NZ (1) | NZ522189A (enExample) |
| PL (1) | PL207005B1 (enExample) |
| PT (1) | PT1607399E (enExample) |
| TW (1) | TWI308569B (enExample) |
| UA (1) | UA74574C2 (enExample) |
| WO (1) | WO2001083496A1 (enExample) |
| ZA (1) | ZA200208591B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200600091A (en) * | 2004-05-21 | 2006-01-01 | Telik Inc | Sulfonylethyl phosphorodiamidates |
| US8198247B2 (en) | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
| US7655799B2 (en) | 2006-11-29 | 2010-02-02 | Telik, Inc. | 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates |
| US7872134B2 (en) | 2007-12-12 | 2011-01-18 | Telik, Inc. | 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates |
| PL2260111T3 (pl) | 2008-03-14 | 2015-11-30 | Genentech Inc | Zróżnicowanie genetyczne powiązane z lekoopornością |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
-
2001
- 2001-02-05 UA UA2002119554A patent/UA74574C2/uk unknown
- 2001-05-01 TW TW090110381A patent/TWI308569B/zh not_active IP Right Cessation
- 2001-05-02 DK DK05020467.6T patent/DK1607399T3/da active
- 2001-05-02 CA CA002407606A patent/CA2407606C/en not_active Expired - Fee Related
- 2001-05-02 IL IL15232501A patent/IL152325A0/xx unknown
- 2001-05-02 HU HU0300688A patent/HUP0300688A3/hu unknown
- 2001-05-02 EP EP01935025A patent/EP1278759B1/en not_active Expired - Lifetime
- 2001-05-02 AU AU6115301A patent/AU6115301A/xx active Pending
- 2001-05-02 CZ CZ20023615A patent/CZ20023615A3/cs unknown
- 2001-05-02 JP JP2001580921A patent/JP4249928B2/ja not_active Expired - Fee Related
- 2001-05-02 PL PL358155A patent/PL207005B1/pl not_active IP Right Cessation
- 2001-05-02 AR ARP010102067A patent/AR029072A1/es active IP Right Grant
- 2001-05-02 PT PT05020467T patent/PT1607399E/pt unknown
- 2001-05-02 WO PCT/US2001/014290 patent/WO2001083496A1/en not_active Ceased
- 2001-05-02 AT AT05020467T patent/ATE455779T1/de active
- 2001-05-02 ES ES01935025T patent/ES2253380T3/es not_active Expired - Lifetime
- 2001-05-02 AU AU2001261153A patent/AU2001261153B2/en not_active Ceased
- 2001-05-02 EP EP05020467A patent/EP1607399B1/en not_active Expired - Lifetime
- 2001-05-02 NZ NZ522189A patent/NZ522189A/en not_active IP Right Cessation
- 2001-05-02 DE DE60116081T patent/DE60116081T2/de not_active Expired - Lifetime
- 2001-05-02 ES ES05020467T patent/ES2337154T3/es not_active Expired - Lifetime
- 2001-05-02 EA EA200201154A patent/EA006852B1/ru not_active IP Right Cessation
- 2001-05-02 CN CNB018089623A patent/CN1182143C/zh not_active Expired - Fee Related
- 2001-05-02 KR KR1020027014577A patent/KR100729980B1/ko not_active Expired - Fee Related
- 2001-05-02 MX MXPA02010813A patent/MXPA02010813A/es active IP Right Grant
- 2001-05-02 BR BR0110553-1A patent/BR0110553A/pt active Search and Examination
- 2001-05-02 DE DE60141181T patent/DE60141181D1/de not_active Expired - Lifetime
- 2001-05-02 DK DK01935025T patent/DK1278759T3/da active
- 2001-05-02 AT AT01935025T patent/ATE313549T1/de active
-
2002
- 2002-10-16 IL IL152325A patent/IL152325A/en not_active IP Right Cessation
- 2002-10-23 ZA ZA200208591A patent/ZA200208591B/en unknown
- 2002-11-01 NO NO20025240A patent/NO328854B1/no not_active IP Right Cessation
-
2009
- 2009-11-18 NO NO20093371A patent/NO331833B1/no not_active IP Right Cessation
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