DE60141181D1 - Bis-(N,N'-bis-(2-haloethyl)amino)-phosphoramidate als anti-Tumormittel - Google Patents

Bis-(N,N'-bis-(2-haloethyl)amino)-phosphoramidate als anti-Tumormittel

Info

Publication number
DE60141181D1
DE60141181D1 DE60141181T DE60141181T DE60141181D1 DE 60141181 D1 DE60141181 D1 DE 60141181D1 DE 60141181 T DE60141181 T DE 60141181T DE 60141181 T DE60141181 T DE 60141181T DE 60141181 D1 DE60141181 D1 DE 60141181D1
Authority
DE
Germany
Prior art keywords
bis
haloethyl
phosphoramidates
amino
tumor agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141181T
Other languages
English (en)
Inventor
Jason R Herr
Fanying Meng
Robert T Lum
Michael R Kozlowski
Steven R Schow
Pavel Zhichkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of DE60141181D1 publication Critical patent/DE60141181D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60141181T 2000-05-02 2001-05-02 Bis-(N,N'-bis-(2-haloethyl)amino)-phosphoramidate als anti-Tumormittel Expired - Lifetime DE60141181D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02

Publications (1)

Publication Number Publication Date
DE60141181D1 true DE60141181D1 (de) 2010-03-11

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60116081T Expired - Lifetime DE60116081T2 (de) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
DE60141181T Expired - Lifetime DE60141181D1 (de) 2000-05-02 2001-05-02 Bis-(N,N'-bis-(2-haloethyl)amino)-phosphoramidate als anti-Tumormittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60116081T Expired - Lifetime DE60116081T2 (de) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel

Country Status (26)

Country Link
EP (2) EP1278759B1 (de)
JP (1) JP4249928B2 (de)
KR (1) KR100729980B1 (de)
CN (1) CN1182143C (de)
AR (1) AR029072A1 (de)
AT (2) ATE455779T1 (de)
AU (2) AU2001261153B2 (de)
BR (1) BR0110553A (de)
CA (1) CA2407606C (de)
CZ (1) CZ20023615A3 (de)
DE (2) DE60116081T2 (de)
DK (2) DK1607399T3 (de)
EA (1) EA006852B1 (de)
ES (2) ES2337154T3 (de)
HK (2) HK1050368A1 (de)
HU (1) HUP0300688A3 (de)
IL (2) IL152325A0 (de)
MX (1) MXPA02010813A (de)
NO (2) NO328854B1 (de)
NZ (1) NZ522189A (de)
PL (1) PL207005B1 (de)
PT (1) PT1607399E (de)
TW (1) TWI308569B (de)
UA (1) UA74574C2 (de)
WO (1) WO2001083496A1 (de)
ZA (1) ZA200208591B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
BRPI0906049A8 (pt) 2008-03-14 2018-06-26 Genentech Inc método para determinar se um câncer em um paciente é resistente ao tratamento com um agente antimitótico, método para tratar um paciente com câncer que é resistente ao agente antimitótico e método de tratamento

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
JP4249928B2 (ja) 2009-04-08
ZA200208591B (en) 2004-03-04
DK1607399T3 (da) 2010-05-10
ES2253380T3 (es) 2006-06-01
KR20020094000A (ko) 2002-12-16
HUP0300688A2 (hu) 2003-07-28
NO20025240L (no) 2002-12-04
AU2001261153B2 (en) 2005-04-07
CA2407606C (en) 2008-07-15
HK1084119A1 (en) 2006-07-21
IL152325A0 (en) 2003-05-29
NO20093371L (no) 2002-12-04
ATE313549T1 (de) 2006-01-15
CN1427844A (zh) 2003-07-02
JP2003531913A (ja) 2003-10-28
ES2337154T3 (es) 2010-04-21
CA2407606A1 (en) 2001-11-08
NZ522189A (en) 2004-04-30
EP1607399A3 (de) 2006-01-04
EA006852B1 (ru) 2006-04-28
HK1050368A1 (en) 2003-06-20
PL207005B1 (pl) 2010-10-29
EP1607399B1 (de) 2010-01-20
IL152325A (en) 2011-04-28
ATE455779T1 (de) 2010-02-15
EA200201154A1 (ru) 2003-04-24
DE60116081T2 (de) 2006-08-03
TWI308569B (en) 2009-04-11
EP1278759B1 (de) 2005-12-21
HUP0300688A3 (en) 2005-02-28
AU6115301A (en) 2001-11-12
CN1182143C (zh) 2004-12-29
NO328854B1 (no) 2010-05-31
EP1607399A2 (de) 2005-12-21
PT1607399E (pt) 2010-02-02
BR0110553A (pt) 2003-04-01
KR100729980B1 (ko) 2007-06-20
EP1278759A1 (de) 2003-01-29
AR029072A1 (es) 2003-06-04
PL358155A1 (en) 2004-08-09
DE60116081D1 (en) 2006-01-26
UA74574C2 (en) 2006-01-16
MXPA02010813A (es) 2004-02-26
WO2001083496A1 (en) 2001-11-08
CZ20023615A3 (cs) 2003-04-16
NO20025240D0 (no) 2002-11-01
NO331833B1 (no) 2012-04-16
DK1278759T3 (da) 2006-02-13

Similar Documents

Publication Publication Date Title
ATE289640T1 (de) Amidofunktionelle aminopolydiorganosiloxane
BR0307924A (pt) N-aril-2-oxazolidinona-5-carboxamidas e seus derivados
ITTO20010108A0 (it) Maschera facciale per subacquei.
CY1110000T1 (el) Ενωσεις οκταϋδροβενζιμιδαζολονης ως αναλγητικα
DK1397366T3 (da) Hidtil ukendt ligander for nicotinacetylcholinreceptorer egnede i terapi
DK1322654T3 (da) Platinkomplekser som antitumormidler
HK1084119A1 (en) Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
CY1108791T1 (el) Φυτοενδυναμωτικο μεσον
NO20030868L (no) N-(3,5-diklor-2-metoksyfenyl)-4-metoksy-3-piperazin-1-yl- benzensulfonamid
BR0112600A (pt) Compostos calcilìticos
DE10295446D2 (de) Narkosegerät
DE60107240D1 (de) Bicyclyl oder heterobicyclyl methanesulfonylamino-substituierte n-hydroxyformamide
MXPA04003158A (es) Compuestos de carboniloxi-cianometilo cmo agentes.
PT102851A (pt) Mesa para maquina de costura
DE60229599D1 (de) Bis(diphenylvinyl)arenverbindung
ATE470655T1 (de) Substituierte 1,5-diaminopentan-3-ol-verbindungen
ITMI20010202V0 (it) Macchina per tendere nastri migliorata
ITVR20020090A1 (it) Capo d'abbigliamento componibile.
SE0103871D0 (sv) Appear Sweden överlevnadsmask
ITCE20000003U1 (it) "base dondolo".
DK1177185T3 (da) 4,5,6,7-tetrahydroindazolderivater som antitumormidler
UA5185S (uk) Газета «деревообробник»
UA6052S (uk) Штоф мірний «княжий град»
FI974550A0 (fi) Styrsystem foer en soekmaskin, som anvaends i samband med ett data- eller telekommunikationsnaet
ITTO20010065V0 (it) Indumento a cuscini d'aria anti-urto.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition