ATE455779T1 - Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel - Google Patents

Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel

Info

Publication number
ATE455779T1
ATE455779T1 AT05020467T AT05020467T ATE455779T1 AT E455779 T1 ATE455779 T1 AT E455779T1 AT 05020467 T AT05020467 T AT 05020467T AT 05020467 T AT05020467 T AT 05020467T AT E455779 T1 ATE455779 T1 AT E455779T1
Authority
AT
Austria
Prior art keywords
bis
phosphoramida
haloethyl
amino
tumor agent
Prior art date
Application number
AT05020467T
Other languages
English (en)
Inventor
Jason R Herr
Fanying Meng
Robert T Lum
Michael R Kozlowski
Steven R Schow
Pavel Zhichkin
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of ATE455779T1 publication Critical patent/ATE455779T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05020467T 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel ATE455779T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02

Publications (1)

Publication Number Publication Date
ATE455779T1 true ATE455779T1 (de) 2010-02-15

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05020467T ATE455779T1 (de) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel
AT01935025T ATE313549T1 (de) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01935025T ATE313549T1 (de) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel

Country Status (26)

Country Link
EP (2) EP1278759B1 (de)
JP (1) JP4249928B2 (de)
KR (1) KR100729980B1 (de)
CN (1) CN1182143C (de)
AR (1) AR029072A1 (de)
AT (2) ATE455779T1 (de)
AU (2) AU6115301A (de)
BR (1) BR0110553A (de)
CA (1) CA2407606C (de)
CZ (1) CZ20023615A3 (de)
DE (2) DE60141181D1 (de)
DK (2) DK1607399T3 (de)
EA (1) EA006852B1 (de)
ES (2) ES2337154T3 (de)
HK (2) HK1050368A1 (de)
HU (1) HUP0300688A3 (de)
IL (2) IL152325A0 (de)
MX (1) MXPA02010813A (de)
NO (2) NO328854B1 (de)
NZ (1) NZ522189A (de)
PL (1) PL207005B1 (de)
PT (1) PT1607399E (de)
TW (1) TWI308569B (de)
UA (1) UA74574C2 (de)
WO (1) WO2001083496A1 (de)
ZA (1) ZA200208591B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
EP2260111B2 (de) * 2008-03-14 2022-03-23 Genentech, Inc. Mit resistenz gegen arzneistoffe assoziierte genetische variationen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
PL358155A1 (en) 2004-08-09
NZ522189A (en) 2004-04-30
KR100729980B1 (ko) 2007-06-20
ATE313549T1 (de) 2006-01-15
HUP0300688A2 (hu) 2003-07-28
NO328854B1 (no) 2010-05-31
EA200201154A1 (ru) 2003-04-24
DE60141181D1 (de) 2010-03-11
DK1607399T3 (da) 2010-05-10
DE60116081D1 (en) 2006-01-26
JP2003531913A (ja) 2003-10-28
EP1607399A2 (de) 2005-12-21
EP1278759A1 (de) 2003-01-29
HUP0300688A3 (en) 2005-02-28
EP1607399B1 (de) 2010-01-20
AU2001261153B2 (en) 2005-04-07
IL152325A (en) 2011-04-28
CZ20023615A3 (cs) 2003-04-16
PT1607399E (pt) 2010-02-02
EA006852B1 (ru) 2006-04-28
DE60116081T2 (de) 2006-08-03
HK1050368A1 (en) 2003-06-20
AR029072A1 (es) 2003-06-04
PL207005B1 (pl) 2010-10-29
CA2407606A1 (en) 2001-11-08
WO2001083496A1 (en) 2001-11-08
ZA200208591B (en) 2004-03-04
EP1607399A3 (de) 2006-01-04
CA2407606C (en) 2008-07-15
NO20025240D0 (no) 2002-11-01
MXPA02010813A (es) 2004-02-26
ES2337154T3 (es) 2010-04-21
AU6115301A (en) 2001-11-12
NO20093371L (no) 2002-12-04
DK1278759T3 (da) 2006-02-13
TWI308569B (en) 2009-04-11
NO20025240L (no) 2002-12-04
HK1084119A1 (en) 2006-07-21
IL152325A0 (en) 2003-05-29
JP4249928B2 (ja) 2009-04-08
CN1182143C (zh) 2004-12-29
CN1427844A (zh) 2003-07-02
EP1278759B1 (de) 2005-12-21
KR20020094000A (ko) 2002-12-16
UA74574C2 (en) 2006-01-16
ES2253380T3 (es) 2006-06-01
NO331833B1 (no) 2012-04-16
BR0110553A (pt) 2003-04-01

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