NO20025240L - Bis-(N,N'-bis-(2-halogenetyl)amino)-fosformidater som antitumormiddel - Google Patents

Bis-(N,N'-bis-(2-halogenetyl)amino)-fosformidater som antitumormiddel

Info

Publication number
NO20025240L
NO20025240L NO20025240A NO20025240A NO20025240L NO 20025240 L NO20025240 L NO 20025240L NO 20025240 A NO20025240 A NO 20025240A NO 20025240 A NO20025240 A NO 20025240A NO 20025240 L NO20025240 L NO 20025240L
Authority
NO
Norway
Prior art keywords
bis
phosphoridates
haloethyl
amino
antitumor agent
Prior art date
Application number
NO20025240A
Other languages
English (en)
Other versions
NO328854B1 (no
NO20025240D0 (no
Inventor
R Jason Herr
Robert T Lum
Steven R Schow
Fanying Meng
Michael R Kozlowski
Pavel Zhichkin
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of NO20025240D0 publication Critical patent/NO20025240D0/no
Publication of NO20025240L publication Critical patent/NO20025240L/no
Publication of NO328854B1 publication Critical patent/NO328854B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20025240A 2000-05-02 2002-11-01 Bis-(N',N'-bis-(2-halogenetyl)amino)-fosforamidat, farmasoytisk preparat omfattende forbindelsen, fremgangsmate for fremstilling og anvendelse av forbindelsen. NO328854B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (3)

Publication Number Publication Date
NO20025240D0 NO20025240D0 (no) 2002-11-01
NO20025240L true NO20025240L (no) 2002-12-04
NO328854B1 NO328854B1 (no) 2010-05-31

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20025240A NO328854B1 (no) 2000-05-02 2002-11-01 Bis-(N',N'-bis-(2-halogenetyl)amino)-fosforamidat, farmasoytisk preparat omfattende forbindelsen, fremgangsmate for fremstilling og anvendelse av forbindelsen.
NO20093371A NO331833B1 (no) 2000-05-02 2009-11-18 Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20093371A NO331833B1 (no) 2000-05-02 2009-11-18 Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene

Country Status (26)

Country Link
EP (2) EP1278759B1 (no)
JP (1) JP4249928B2 (no)
KR (1) KR100729980B1 (no)
CN (1) CN1182143C (no)
AR (1) AR029072A1 (no)
AT (2) ATE455779T1 (no)
AU (2) AU6115301A (no)
BR (1) BR0110553A (no)
CA (1) CA2407606C (no)
CZ (1) CZ20023615A3 (no)
DE (2) DE60141181D1 (no)
DK (2) DK1607399T3 (no)
EA (1) EA006852B1 (no)
ES (2) ES2337154T3 (no)
HK (2) HK1050368A1 (no)
HU (1) HUP0300688A3 (no)
IL (2) IL152325A0 (no)
MX (1) MXPA02010813A (no)
NO (2) NO328854B1 (no)
NZ (1) NZ522189A (no)
PL (1) PL207005B1 (no)
PT (1) PT1607399E (no)
TW (1) TWI308569B (no)
UA (1) UA74574C2 (no)
WO (1) WO2001083496A1 (no)
ZA (1) ZA200208591B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
EP2260111B2 (en) * 2008-03-14 2022-03-23 Genentech, Inc. Genetic variations associated with drug resistance

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
PL358155A1 (en) 2004-08-09
NZ522189A (en) 2004-04-30
KR100729980B1 (ko) 2007-06-20
ATE313549T1 (de) 2006-01-15
HUP0300688A2 (hu) 2003-07-28
NO328854B1 (no) 2010-05-31
EA200201154A1 (ru) 2003-04-24
DE60141181D1 (de) 2010-03-11
DK1607399T3 (da) 2010-05-10
DE60116081D1 (en) 2006-01-26
JP2003531913A (ja) 2003-10-28
EP1607399A2 (en) 2005-12-21
EP1278759A1 (en) 2003-01-29
HUP0300688A3 (en) 2005-02-28
EP1607399B1 (en) 2010-01-20
AU2001261153B2 (en) 2005-04-07
IL152325A (en) 2011-04-28
CZ20023615A3 (cs) 2003-04-16
PT1607399E (pt) 2010-02-02
EA006852B1 (ru) 2006-04-28
DE60116081T2 (de) 2006-08-03
ATE455779T1 (de) 2010-02-15
HK1050368A1 (en) 2003-06-20
AR029072A1 (es) 2003-06-04
PL207005B1 (pl) 2010-10-29
CA2407606A1 (en) 2001-11-08
WO2001083496A1 (en) 2001-11-08
ZA200208591B (en) 2004-03-04
EP1607399A3 (en) 2006-01-04
CA2407606C (en) 2008-07-15
NO20025240D0 (no) 2002-11-01
MXPA02010813A (es) 2004-02-26
ES2337154T3 (es) 2010-04-21
AU6115301A (en) 2001-11-12
NO20093371L (no) 2002-12-04
DK1278759T3 (da) 2006-02-13
TWI308569B (en) 2009-04-11
HK1084119A1 (en) 2006-07-21
IL152325A0 (en) 2003-05-29
JP4249928B2 (ja) 2009-04-08
CN1182143C (zh) 2004-12-29
CN1427844A (zh) 2003-07-02
EP1278759B1 (en) 2005-12-21
KR20020094000A (ko) 2002-12-16
UA74574C2 (en) 2006-01-16
ES2253380T3 (es) 2006-06-01
NO331833B1 (no) 2012-04-16
BR0110553A (pt) 2003-04-01

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