KR100729980B1 - 항종양제로서비스-(ｎ,ｎ'-비스-(2-할로에틸)아미노)포스포라미데이트 - Google Patents

항종양제로서비스-(ｎ,ｎ'-비스-(2-할로에틸)아미노)포스포라미데이트 Download PDF

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Publication number
KR100729980B1
KR100729980B1 KR1020027014577A KR20027014577A KR100729980B1 KR 100729980 B1 KR100729980 B1 KR 100729980B1 KR 1020027014577 A KR1020027014577 A KR 1020027014577A KR 20027014577 A KR20027014577 A KR 20027014577A KR 100729980 B1 KR100729980 B1 KR 100729980B1
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South Korea
Prior art keywords
alkyl
halo
compound
substituted
amino
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20020094000A (ko
Inventor
알 제이슨 헤어
로버트 티 럼
스티븐 알 스코우
판잉 멍
마이클 알 코즈로스키
파벨 지치킨
Original Assignee
텔리크 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020027014577A 2000-05-02 2001-05-02 항종양제로서비스-(ｎ,ｎ'-비스-(2-할로에틸)아미노)포스포라미데이트 Expired - Fee Related KR100729980B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
US09/563,181 2000-05-02

Publications (2)

Publication Number Publication Date
KR20020094000A KR20020094000A (ko) 2002-12-16
KR100729980B1 true KR100729980B1 (ko) 2007-06-20

Family

ID=24249433

Family Applications (1)

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KR1020027014577A Expired - Fee Related KR100729980B1 (ko) 2000-05-02 2001-05-02 항종양제로서비스-(ｎ,ｎ'-비스-(2-할로에틸)아미노)포스포라미데이트

Country Status (25)

Country Link
EP (2) EP1278759B1 (enExample)
JP (1) JP4249928B2 (enExample)
KR (1) KR100729980B1 (enExample)
CN (1) CN1182143C (enExample)
AR (1) AR029072A1 (enExample)
AT (2) ATE455779T1 (enExample)
AU (2) AU2001261153B2 (enExample)
BR (1) BR0110553A (enExample)
CA (1) CA2407606C (enExample)
CZ (1) CZ20023615A3 (enExample)
DE (2) DE60141181D1 (enExample)
DK (2) DK1607399T3 (enExample)
EA (1) EA006852B1 (enExample)
ES (2) ES2337154T3 (enExample)
HU (1) HUP0300688A3 (enExample)
IL (2) IL152325A0 (enExample)
MX (1) MXPA02010813A (enExample)
NO (2) NO328854B1 (enExample)
NZ (1) NZ522189A (enExample)
PL (1) PL207005B1 (enExample)
PT (1) PT1607399E (enExample)
TW (1) TWI308569B (enExample)
UA (1) UA74574C2 (enExample)
WO (1) WO2001083496A1 (enExample)
ZA (1) ZA200208591B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
MX2010009940A (es) 2008-03-14 2010-09-28 Genentech Inc Variaciones geneticas asociadas con resistencia a drogas.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009866A1 (en) * 1993-10-01 1995-04-13 Terrapin Technologies, Inc. Glutathione s-transferase-activated compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009866A1 (en) * 1993-10-01 1995-04-13 Terrapin Technologies, Inc. Glutathione s-transferase-activated compounds

Also Published As

Publication number Publication date
ATE455779T1 (de) 2010-02-15
HUP0300688A3 (en) 2005-02-28
NO20025240D0 (no) 2002-11-01
DE60116081T2 (de) 2006-08-03
PT1607399E (pt) 2010-02-02
BR0110553A (pt) 2003-04-01
NO331833B1 (no) 2012-04-16
DK1278759T3 (da) 2006-02-13
CZ20023615A3 (cs) 2003-04-16
EP1607399A3 (en) 2006-01-04
PL358155A1 (en) 2004-08-09
EP1607399B1 (en) 2010-01-20
AR029072A1 (es) 2003-06-04
NO20025240L (no) 2002-12-04
EP1278759A1 (en) 2003-01-29
IL152325A0 (en) 2003-05-29
NZ522189A (en) 2004-04-30
WO2001083496A1 (en) 2001-11-08
DE60141181D1 (de) 2010-03-11
EA200201154A1 (ru) 2003-04-24
EP1278759B1 (en) 2005-12-21
NO328854B1 (no) 2010-05-31
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
PL207005B1 (pl) 2010-10-29
HK1084119A1 (en) 2006-07-21
CN1182143C (zh) 2004-12-29
HUP0300688A2 (hu) 2003-07-28
AU2001261153B2 (en) 2005-04-07
HK1050368A1 (en) 2003-06-20
NO20093371L (no) 2002-12-04
EP1607399A2 (en) 2005-12-21
EA006852B1 (ru) 2006-04-28
KR20020094000A (ko) 2002-12-16
ZA200208591B (en) 2004-03-04
ATE313549T1 (de) 2006-01-15
CA2407606C (en) 2008-07-15
DK1607399T3 (da) 2010-05-10
UA74574C2 (en) 2006-01-16
MXPA02010813A (es) 2004-02-26
CN1427844A (zh) 2003-07-02
IL152325A (en) 2011-04-28
CA2407606A1 (en) 2001-11-08
TWI308569B (en) 2009-04-11
JP4249928B2 (ja) 2009-04-08
ES2253380T3 (es) 2006-06-01
DE60116081D1 (en) 2006-01-26
AU6115301A (en) 2001-11-12

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