ZA200208591B - Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents. - Google Patents

Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents. Download PDF

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Publication number
ZA200208591B
ZA200208591B ZA200208591A ZA200208591A ZA200208591B ZA 200208591 B ZA200208591 B ZA 200208591B ZA 200208591 A ZA200208591 A ZA 200208591A ZA 200208591 A ZA200208591 A ZA 200208591A ZA 200208591 B ZA200208591 B ZA 200208591B
Authority
ZA
South Africa
Prior art keywords
compound
substituted
lower alkyl
aryl
heteroaryl
Prior art date
Application number
ZA200208591A
Other languages
English (en)
Inventor
R Jason Herr
Steven R Schow
Michael R Kozlowski
Robert T Lum
Fanying Meng
Pavel Zhichkin
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of ZA200208591B publication Critical patent/ZA200208591B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200208591A 2000-05-02 2002-10-23 Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents. ZA200208591B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02

Publications (1)

Publication Number Publication Date
ZA200208591B true ZA200208591B (en) 2004-03-04

Family

ID=24249433

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200208591A ZA200208591B (en) 2000-05-02 2002-10-23 Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents.

Country Status (25)

Country Link
EP (2) EP1278759B1 (enExample)
JP (1) JP4249928B2 (enExample)
KR (1) KR100729980B1 (enExample)
CN (1) CN1182143C (enExample)
AR (1) AR029072A1 (enExample)
AT (2) ATE455779T1 (enExample)
AU (2) AU6115301A (enExample)
BR (1) BR0110553A (enExample)
CA (1) CA2407606C (enExample)
CZ (1) CZ20023615A3 (enExample)
DE (2) DE60116081T2 (enExample)
DK (2) DK1607399T3 (enExample)
EA (1) EA006852B1 (enExample)
ES (2) ES2253380T3 (enExample)
HU (1) HUP0300688A3 (enExample)
IL (2) IL152325A0 (enExample)
MX (1) MXPA02010813A (enExample)
NO (2) NO328854B1 (enExample)
NZ (1) NZ522189A (enExample)
PL (1) PL207005B1 (enExample)
PT (1) PT1607399E (enExample)
TW (1) TWI308569B (enExample)
UA (1) UA74574C2 (enExample)
WO (1) WO2001083496A1 (enExample)
ZA (1) ZA200208591B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
PL2260111T3 (pl) 2008-03-14 2015-11-30 Genentech Inc Zróżnicowanie genetyczne powiązane z lekoopornością

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
CZ20023615A3 (cs) 2003-04-16
NZ522189A (en) 2004-04-30
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
PT1607399E (pt) 2010-02-02
ES2253380T3 (es) 2006-06-01
AR029072A1 (es) 2003-06-04
NO20025240L (no) 2002-12-04
PL358155A1 (en) 2004-08-09
AU2001261153B2 (en) 2005-04-07
UA74574C2 (en) 2006-01-16
KR20020094000A (ko) 2002-12-16
HK1050368A1 (en) 2003-06-20
HK1084119A1 (en) 2006-07-21
EP1607399A2 (en) 2005-12-21
ATE455779T1 (de) 2010-02-15
WO2001083496A1 (en) 2001-11-08
DE60116081D1 (en) 2006-01-26
EA200201154A1 (ru) 2003-04-24
CA2407606C (en) 2008-07-15
NO20093371L (no) 2002-12-04
DK1607399T3 (da) 2010-05-10
ATE313549T1 (de) 2006-01-15
NO328854B1 (no) 2010-05-31
KR100729980B1 (ko) 2007-06-20
BR0110553A (pt) 2003-04-01
HUP0300688A2 (hu) 2003-07-28
IL152325A (en) 2011-04-28
JP4249928B2 (ja) 2009-04-08
CN1182143C (zh) 2004-12-29
EP1278759A1 (en) 2003-01-29
IL152325A0 (en) 2003-05-29
NO331833B1 (no) 2012-04-16
TWI308569B (en) 2009-04-11
EP1278759B1 (en) 2005-12-21
EA006852B1 (ru) 2006-04-28
DE60141181D1 (de) 2010-03-11
EP1607399B1 (en) 2010-01-20
EP1607399A3 (en) 2006-01-04
CA2407606A1 (en) 2001-11-08
CN1427844A (zh) 2003-07-02
AU6115301A (en) 2001-11-12
PL207005B1 (pl) 2010-10-29
DE60116081T2 (de) 2006-08-03
DK1278759T3 (da) 2006-02-13
HUP0300688A3 (en) 2005-02-28
NO20025240D0 (no) 2002-11-01
MXPA02010813A (es) 2004-02-26

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