JP4249928B2 - 抗腫瘍剤としてのビス−（ｎ，ｎ’−ビス−（２−ハロエチル）アミノ）ホスホルアミデート - Google Patents

抗腫瘍剤としてのビス−（ｎ，ｎ’−ビス−（２−ハロエチル）アミノ）ホスホルアミデート Download PDF

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Publication number
JP4249928B2
JP4249928B2 JP2001580921A JP2001580921A JP4249928B2 JP 4249928 B2 JP4249928 B2 JP 4249928B2 JP 2001580921 A JP2001580921 A JP 2001580921A JP 2001580921 A JP2001580921 A JP 2001580921A JP 4249928 B2 JP4249928 B2 JP 4249928B2
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Japan
Prior art keywords
alkyl
substituted
aryl
heteroaryl
halo
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Expired - Fee Related
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JP2001580921A
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English (en)
Japanese (ja)
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JP2003531913A (ja
JP2003531913A5 (enExample
Inventor
アール・ジェイソン・ハー
ロバート・ティ・ラム
スティーブン・アール・ショウ
ファンイン・メン
マイケル・アール・コズロウスキー
ペイベル・ジチキン
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Terrapin Technologies Inc
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Terrapin Technologies Inc
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Publication of JP2003531913A publication Critical patent/JP2003531913A/ja
Publication of JP2003531913A5 publication Critical patent/JP2003531913A5/ja
Application granted granted Critical
Publication of JP4249928B2 publication Critical patent/JP4249928B2/ja
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001580921A 2000-05-02 2001-05-02 抗腫瘍剤としてのビス−（ｎ，ｎ’−ビス−（２−ハロエチル）アミノ）ホスホルアミデート Expired - Fee Related JP4249928B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
US09/563,181 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (3)

Publication Number Publication Date
JP2003531913A JP2003531913A (ja) 2003-10-28
JP2003531913A5 JP2003531913A5 (enExample) 2006-01-12
JP4249928B2 true JP4249928B2 (ja) 2009-04-08

Family

ID=24249433

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001580921A Expired - Fee Related JP4249928B2 (ja) 2000-05-02 2001-05-02 抗腫瘍剤としてのビス−（ｎ，ｎ’−ビス−（２−ハロエチル）アミノ）ホスホルアミデート

Country Status (25)

Country Link
EP (2) EP1278759B1 (enExample)
JP (1) JP4249928B2 (enExample)
KR (1) KR100729980B1 (enExample)
CN (1) CN1182143C (enExample)
AR (1) AR029072A1 (enExample)
AT (2) ATE455779T1 (enExample)
AU (2) AU6115301A (enExample)
BR (1) BR0110553A (enExample)
CA (1) CA2407606C (enExample)
CZ (1) CZ20023615A3 (enExample)
DE (2) DE60116081T2 (enExample)
DK (2) DK1607399T3 (enExample)
EA (1) EA006852B1 (enExample)
ES (2) ES2253380T3 (enExample)
HU (1) HUP0300688A3 (enExample)
IL (2) IL152325A0 (enExample)
MX (1) MXPA02010813A (enExample)
NO (2) NO328854B1 (enExample)
NZ (1) NZ522189A (enExample)
PL (1) PL207005B1 (enExample)
PT (1) PT1607399E (enExample)
TW (1) TWI308569B (enExample)
UA (1) UA74574C2 (enExample)
WO (1) WO2001083496A1 (enExample)
ZA (1) ZA200208591B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
PL2260111T3 (pl) 2008-03-14 2015-11-30 Genentech Inc Zróżnicowanie genetyczne powiązane z lekoopornością

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
CZ20023615A3 (cs) 2003-04-16
NZ522189A (en) 2004-04-30
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
PT1607399E (pt) 2010-02-02
ES2253380T3 (es) 2006-06-01
AR029072A1 (es) 2003-06-04
NO20025240L (no) 2002-12-04
PL358155A1 (en) 2004-08-09
ZA200208591B (en) 2004-03-04
AU2001261153B2 (en) 2005-04-07
UA74574C2 (en) 2006-01-16
KR20020094000A (ko) 2002-12-16
HK1050368A1 (en) 2003-06-20
HK1084119A1 (en) 2006-07-21
EP1607399A2 (en) 2005-12-21
ATE455779T1 (de) 2010-02-15
WO2001083496A1 (en) 2001-11-08
DE60116081D1 (en) 2006-01-26
EA200201154A1 (ru) 2003-04-24
CA2407606C (en) 2008-07-15
NO20093371L (no) 2002-12-04
DK1607399T3 (da) 2010-05-10
ATE313549T1 (de) 2006-01-15
NO328854B1 (no) 2010-05-31
KR100729980B1 (ko) 2007-06-20
BR0110553A (pt) 2003-04-01
HUP0300688A2 (hu) 2003-07-28
IL152325A (en) 2011-04-28
CN1182143C (zh) 2004-12-29
EP1278759A1 (en) 2003-01-29
IL152325A0 (en) 2003-05-29
NO331833B1 (no) 2012-04-16
TWI308569B (en) 2009-04-11
EP1278759B1 (en) 2005-12-21
EA006852B1 (ru) 2006-04-28
DE60141181D1 (de) 2010-03-11
EP1607399B1 (en) 2010-01-20
EP1607399A3 (en) 2006-01-04
CA2407606A1 (en) 2001-11-08
CN1427844A (zh) 2003-07-02
AU6115301A (en) 2001-11-12
PL207005B1 (pl) 2010-10-29
DE60116081T2 (de) 2006-08-03
DK1278759T3 (da) 2006-02-13
HUP0300688A3 (en) 2005-02-28
NO20025240D0 (no) 2002-11-01
MXPA02010813A (es) 2004-02-26

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