JP2003515623A5 - - Google Patents
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- Publication number
- JP2003515623A5 JP2003515623A5 JP2001541070A JP2001541070A JP2003515623A5 JP 2003515623 A5 JP2003515623 A5 JP 2003515623A5 JP 2001541070 A JP2001541070 A JP 2001541070A JP 2001541070 A JP2001541070 A JP 2001541070A JP 2003515623 A5 JP2003515623 A5 JP 2003515623A5
- Authority
- JP
- Japan
- Prior art keywords
- per
- cyclodextrin
- deoxy
- thio
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920000858 Cyclodextrin Polymers 0.000 description 14
- -1 carboxyphenyl Chemical group 0.000 description 14
- 239000001116 FEMA 4028 Substances 0.000 description 8
- 229960004853 betadex Drugs 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 description 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 1
- 229910000024 caesium carbonate Inorganic materials 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- YRIAPEVGKLRGHX-UHFFFAOYSA-N methyl 4-sulfanylbutanoate Chemical compound COC(=O)CCCS YRIAPEVGKLRGHX-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99309558 | 1999-11-29 | ||
| EP99309558.7 | 1999-11-29 | ||
| PCT/EP2000/011789 WO2001040316A1 (en) | 1999-11-29 | 2000-11-23 | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006195089A Division JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003515623A JP2003515623A (ja) | 2003-05-07 |
| JP2003515623A5 true JP2003515623A5 (enExample) | 2006-09-07 |
| JP3880041B2 JP3880041B2 (ja) | 2007-02-14 |
Family
ID=8241767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541070A Expired - Lifetime JP3880041B2 (ja) | 1999-11-29 | 2000-11-23 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
| JP2006195089A Expired - Lifetime JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006195089A Expired - Lifetime JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Country Status (33)
Families Citing this family (78)
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| US20040048830A1 (en) * | 2000-11-02 | 2004-03-11 | Mingqiang Zhang | Use of cortisol-sequestering agents for the treatment of hypercortisolaemia related disorders |
| CN101039682A (zh) | 2003-10-31 | 2007-09-19 | 堪萨斯大学 | 磺基烷基醚－烷基醚环糊精衍生物 |
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| HUE058227T2 (hu) | 2004-04-23 | 2022-07-28 | Cydex Pharmaceuticals Inc | DPI készítmény, amely szulfoalkil-éter-ciklodextrint tartalmaz |
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| MX348982B (es) | 2005-10-26 | 2017-07-06 | Cydex Pharmaceuticals Inc | Composiciones de eter sulfoalquilico-ciclodextrina y metodos de preparacion de las mismas. |
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| US7938283B2 (en) * | 2008-06-20 | 2011-05-10 | Grainpro, Inc. | System and method for hermetic storage of agricultural commodities during shipping |
| US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
| CN101591402B (zh) * | 2009-05-05 | 2011-11-30 | 杭州奥默医药技术有限公司 | 6-脱氧砜类环糊精衍生物及其制备方法 |
| US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
| DE102010012281A1 (de) * | 2010-03-22 | 2011-09-22 | Fresenius Medical Care Deutschland Gmbh | Pharmazeutische Zusammensetzungen enthaltend substituiertes 6-Deoxy-6-sulfanylcyclodextrin |
| CN101864003B (zh) * | 2010-06-11 | 2012-05-02 | 漆又毛 | 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法 |
| ES2551585T3 (es) * | 2010-08-25 | 2015-11-20 | Davuluri, Ramamohan Rao | Procedimiento mejorado para la preparación de Sugammadex |
| CN102060941B (zh) | 2010-11-26 | 2012-12-26 | 漆又毛 | 6-脱氧α-氨基酸衍生物环糊精及制备和应用 |
| WO2013123254A1 (en) | 2012-02-15 | 2013-08-22 | Cydex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
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| EP3270941B1 (en) | 2015-03-19 | 2021-05-26 | Cydex Pharmaceuticals, Inc. | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same |
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| EP3303413A4 (en) * | 2015-05-29 | 2019-02-06 | Alaparthi, Lakshmi Prasad | PROCESS FOR THE PREPARATION OF SUGAMMADEX AND INTERMEDIATE PRODUCTS THEREOF |
| CN104922693A (zh) * | 2015-06-19 | 2015-09-23 | 南开大学 | 一种阴离子型环糊精与抗癌药物包合物及制备方法 |
| WO2017059547A1 (en) * | 2015-10-07 | 2017-04-13 | Uti Limited Partnership | Multifunctional polyanionic cyclodextrin dendrimers |
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| CN108290964B (zh) * | 2015-11-25 | 2021-07-09 | 费森尤斯卡比依普莎姆有限责任公司 | 用于制备舒更葡糖及其中间体的改进的方法 |
| CN108779186B (zh) * | 2016-03-22 | 2021-07-13 | 费森尤斯卡比依普莎姆有限责任公司 | 一种改进的制备舒更葡萄糖的方法 |
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| CN109021148B (zh) * | 2017-06-08 | 2020-11-10 | 天津科伦药物研究有限公司 | 一种制备舒更葡糖钠的方法 |
| US10442871B2 (en) | 2017-06-22 | 2019-10-15 | Lawrence Livermore National Security, Llc | Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof |
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| TWI703163B (zh) * | 2017-08-23 | 2020-09-01 | 台耀化學股份有限公司 | 舒更葡糖鈉之製備方法及其晶型 |
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| JP6950966B2 (ja) * | 2018-11-01 | 2021-10-13 | 丸石製薬株式会社 | スガマデクス又はその薬理学的に許容される塩含有液剤及びその製造方法 |
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| CN111714459B (zh) * | 2020-06-18 | 2022-06-14 | 广州瑞尔医药科技有限公司 | 一种注射用舒更葡糖钠粉针剂及其制备方法 |
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| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| US20020111377A1 (en) | 2000-12-22 | 2002-08-15 | Albany College Of Pharmacy | Transdermal delivery of cannabinoids |
| WO2002064635A1 (en) | 2001-02-14 | 2002-08-22 | Akzo Nobel N.V. | 2-alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| TW200402417A (en) | 2002-06-21 | 2004-02-16 | Akzo Nobel Nv | 1-[(Indol-3-yl)carbonyl]piperazine derivatives |
-
2000
- 2000-11-08 TW TW089123585A patent/TWI242015B/zh not_active IP Right Cessation
- 2000-11-23 PL PL356097A patent/PL203012B1/pl unknown
- 2000-11-23 RU RU2002117302/04A patent/RU2260013C2/ru active Protection Beyond IP Right Term
- 2000-11-23 CN CNB00816360XA patent/CN1188428C/zh not_active Expired - Lifetime
- 2000-11-23 AT AT00993261T patent/ATE288450T1/de active
- 2000-11-23 DE DE60017947T patent/DE60017947T2/de not_active Expired - Lifetime
- 2000-11-23 NZ NZ518752A patent/NZ518752A/xx not_active IP Right Cessation
- 2000-11-23 DE DE122008000068C patent/DE122008000068I2/de active Active
- 2000-11-23 IL IL14942300A patent/IL149423A0/xx active Protection Beyond IP Right Term
- 2000-11-23 ES ES00993261T patent/ES2237496T3/es not_active Expired - Lifetime
- 2000-11-23 WO PCT/EP2000/011789 patent/WO2001040316A1/en not_active Ceased
- 2000-11-23 PT PT00993261T patent/PT1259550E/pt unknown
- 2000-11-23 BR BRPI0015947-6 patent/BRPI0015947B8/pt not_active IP Right Cessation
- 2000-11-23 KR KR1020027006871A patent/KR100716524B1/ko not_active Expired - Lifetime
- 2000-11-23 CZ CZ20021814A patent/CZ298206B6/cs not_active IP Right Cessation
- 2000-11-23 AU AU54380/01A patent/AU776536B2/en not_active Expired
- 2000-11-23 US US13/432,742 patent/USRE44733E1/en active Active
- 2000-11-23 JP JP2001541070A patent/JP3880041B2/ja not_active Expired - Lifetime
- 2000-11-23 DK DK00993261T patent/DK1259550T3/da active
- 2000-11-23 MX MXPA02004940A patent/MXPA02004940A/es active IP Right Grant
- 2000-11-23 SK SK726-2002A patent/SK286282B6/sk not_active IP Right Cessation
- 2000-11-23 HU HU0203755A patent/HU227451B1/hu active Protection Beyond IP Right Term
- 2000-11-23 EP EP00993261A patent/EP1259550B1/en not_active Expired - Lifetime
- 2000-11-23 CA CA002390463A patent/CA2390463C/en not_active Expired - Lifetime
- 2000-11-23 US US10/148,307 patent/US6670340B1/en not_active Ceased
- 2000-11-27 AR ARP000106216A patent/AR026605A1/es active IP Right Grant
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- 2000-11-28 PE PE2000001269A patent/PE20010902A1/es not_active IP Right Cessation
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2002
- 2002-05-03 ZA ZA200203538A patent/ZA200203538B/en unknown
- 2002-05-28 NO NO20022522A patent/NO328790B1/no not_active IP Right Cessation
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2003
- 2003-06-23 US US10/603,355 patent/US6949527B2/en not_active Expired - Lifetime
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2006
- 2006-07-18 JP JP2006195089A patent/JP4563972B2/ja not_active Expired - Lifetime
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2008
- 2008-08-06 NL NL300356C patent/NL300356I2/nl unknown
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- 2008-11-26 LU LU91501C patent/LU91501I2/xx unknown
- 2008-12-10 BE BE2008C047C patent/BE2008C047I2/fr unknown
- 2008-12-30 FR FR08C0052C patent/FR08C0052I2/fr active Active
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2010
- 2010-11-10 NO NO2010019C patent/NO2010019I2/no unknown
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