JP2002543065A5 - - Google Patents

Info

Publication number

JP2002543065A5

JP2002543065A5 JP2000613829A JP2000613829A JP2002543065A5 JP 2002543065 A5 JP2002543065 A5 JP 2002543065A5 JP 2000613829 A JP2000613829 A JP 2000613829A JP 2000613829 A JP2000613829 A JP 2000613829A JP 2002543065 A5 JP2002543065 A5 JP 2002543065A5

Authority

JP

Japan

Prior art keywords

compound according

medicament

manufacture

treatment

compound

Prior art date

2000-04-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 description 14
• 238000004519 manufacturing process Methods 0.000 description 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
• 235000021588 free fatty acids Nutrition 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
• 201000001320 Atherosclerosis Diseases 0.000 description 1
• 208000024172 Cardiovascular disease Diseases 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 208000031226 Hyperlipidaemia Diseases 0.000 description 1
• 206010020772 Hypertension Diseases 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 206010022489 Insulin Resistance Diseases 0.000 description 1
• 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 1
• 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 230000027455 binding Effects 0.000 description 1
• 230000036765 blood level Effects 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 201000001421 hyperglycemia Diseases 0.000 description 1
• 201000008980 hyperinsulinism Diseases 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1