JP2007522176A5 - - Google Patents

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Publication number
JP2007522176A5
JP2007522176A5 JP2006552565A JP2006552565A JP2007522176A5 JP 2007522176 A5 JP2007522176 A5 JP 2007522176A5 JP 2006552565 A JP2006552565 A JP 2006552565A JP 2006552565 A JP2006552565 A JP 2006552565A JP 2007522176 A5 JP2007522176 A5 JP 2007522176A5
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JP
Japan
Prior art keywords
alkyl
compound according
hydrogen
alkenyl
compound
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JP2006552565A
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English (en)
Japanese (ja)
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JP2007522176A (ja
JP5001012B2 (ja
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Priority claimed from GB0403282A external-priority patent/GB0403282D0/en
Priority claimed from GB0423562A external-priority patent/GB0423562D0/en
Priority claimed from GB0428375A external-priority patent/GB0428375D0/en
Application filed filed Critical
Priority claimed from PCT/EP2005/001449 external-priority patent/WO2005077950A2/en
Publication of JP2007522176A publication Critical patent/JP2007522176A/ja
Publication of JP2007522176A5 publication Critical patent/JP2007522176A5/ja
Application granted granted Critical
Publication of JP5001012B2 publication Critical patent/JP5001012B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2006552565A 2004-02-14 2005-02-10 Hm74a受容体活性を有する薬剤 Expired - Fee Related JP5001012B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0403282A GB0403282D0 (en) 2004-02-14 2004-02-14 Chemical compounds
GB0403282.7 2004-02-14
GB0423562.8 2004-10-22
GB0423562A GB0423562D0 (en) 2004-10-22 2004-10-22 Novel compounds
GB0428375A GB0428375D0 (en) 2004-12-24 2004-12-24 Novel compounds
GB0428375.0 2004-12-24
PCT/EP2005/001449 WO2005077950A2 (en) 2004-02-14 2005-02-10 Medicaments with hm74a receptor activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008030344A Division JP5020848B2 (ja) 2004-02-14 2008-02-12 Hm74a受容体活性を有する薬剤

Publications (3)

Publication Number Publication Date
JP2007522176A JP2007522176A (ja) 2007-08-09
JP2007522176A5 true JP2007522176A5 (https=) 2008-04-03
JP5001012B2 JP5001012B2 (ja) 2012-08-15

Family

ID=34864831

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006552565A Expired - Fee Related JP5001012B2 (ja) 2004-02-14 2005-02-10 Hm74a受容体活性を有する薬剤
JP2008030344A Expired - Fee Related JP5020848B2 (ja) 2004-02-14 2008-02-12 Hm74a受容体活性を有する薬剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008030344A Expired - Fee Related JP5020848B2 (ja) 2004-02-14 2008-02-12 Hm74a受容体活性を有する薬剤

Country Status (25)

Country Link
US (5) US7713982B2 (https=)
EP (1) EP1781657B1 (https=)
JP (2) JP5001012B2 (https=)
KR (1) KR101100601B1 (https=)
CN (2) CN101103030B (https=)
AR (1) AR047669A1 (https=)
AU (1) AU2005212816C1 (https=)
BR (1) BRPI0507604A (https=)
CA (1) CA2556073C (https=)
CY (1) CY1114022T1 (https=)
DK (1) DK1781657T3 (https=)
ES (1) ES2406732T3 (https=)
HR (1) HRP20130406T1 (https=)
IL (1) IL177051A (https=)
MA (1) MA28357A1 (https=)
MY (1) MY148937A (https=)
NO (1) NO337281B1 (https=)
NZ (1) NZ548496A (https=)
PE (1) PE20060317A1 (https=)
PL (1) PL1781657T3 (https=)
PT (1) PT1781657E (https=)
SG (1) SG157242A1 (https=)
SI (1) SI1781657T1 (https=)
TW (1) TWI350289B (https=)
WO (1) WO2005077950A2 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100390178C (zh) * 1999-11-12 2008-05-28 拜奥根Idec马萨诸塞公司 作为腺苷受体拮抗剂的多环烷基嘌呤
AR039385A1 (es) 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
WO2004083388A2 (en) 2003-03-14 2004-09-30 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74
PE20050483A1 (es) 2003-10-31 2005-08-25 Arena Pharm Inc Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
CN101103030B (zh) * 2004-02-14 2010-10-13 史密丝克莱恩比彻姆公司 具有hm74a受体活性的药物
CN101115726A (zh) 2004-12-03 2008-01-30 先灵公司 作为cb1拮抗剂的取代哌嗪
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US7750015B2 (en) 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
BRPI0610133A2 (pt) 2005-05-17 2010-06-01 Schering Corp heterociclos como agonistas de receptor de ácido nicotìnico para o tratamento de dislipidemia
MX2007015867A (es) * 2005-06-14 2008-03-04 Hoffmann La Roche Derivados del acido antranilico.
SI1901731T1 (sl) 2005-06-28 2011-07-29 Merck Sharp & Dohme Niacin receptorski antagonisti, sestavki vsebujoäśi take spojine in postopki zdravljenja
BRPI0615145A2 (pt) * 2005-08-10 2009-11-03 Smithkline Beecham Corp derivados de xantina como agonistas hm74a seletivos
CN101400682A (zh) * 2006-01-20 2009-04-01 先灵公司 治疗异常脂血症的杂环烟酸受体激动剂
DE602007006947D1 (de) * 2006-05-23 2010-07-15 Hoffmann La Roche Pyridopyrimidinonderivate
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
KR20090025262A (ko) 2006-06-23 2009-03-10 인사이트 코포레이션 Hm74a 아고니스트로서 푸리논 유도체
WO2007150025A2 (en) 2006-06-23 2007-12-27 Incyte Corporation Purinone derivatives as hm74a agonists
EP2139895A1 (en) * 2007-03-23 2010-01-06 F. Hoffmann-Roche AG Aza-pyridopyrimidinone derivatives
US9163024B2 (en) * 2008-12-08 2015-10-20 Glaxosmithkline Llc Tris salts of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione
WO2010075069A1 (en) 2008-12-16 2010-07-01 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
CN102276610B (zh) * 2011-05-04 2013-01-09 北京工业大学 N7-鸟嘌呤烷化物的制备方法
CN103360394B (zh) * 2013-07-29 2015-07-22 上海万巷制药有限公司 8-氯茶碱的制备方法
CA2973746C (en) * 2015-01-30 2020-03-24 Shanton Pharma Co., Ltd. Prevention or treatment of uratic or gouty diseases
CN104892610B (zh) * 2015-05-27 2016-08-24 福建师范大学 一种8-酯基咖啡因衍生物的制备方法
CN105622610A (zh) * 2016-03-28 2016-06-01 浙江诚意药业股份有限公司 一种黄嘌呤化合物的制备方法
EP3490579B1 (en) 2016-07-27 2025-09-10 Hartis-Pharma SA Therapeutic combinations to treat red blood cell disorders
CN106632061B (zh) * 2016-11-23 2020-07-24 上海皓元医药股份有限公司 一种1-(4-苯基-1-烷基-1h-咪唑-2-基)乙酮及其衍生物的合成方法
AU2018208422B2 (en) 2017-01-10 2021-11-11 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
AU2020356570A1 (en) * 2019-09-25 2022-05-12 Goldfinch Bio, Inc. Xanthine CB1 inhibitors
CN112724141A (zh) * 2021-01-21 2021-04-30 南京艾美斐生物医药科技有限公司 一种gpr109a蛋白受体抑制剂及其制备和应用
CN113262882B (zh) * 2021-07-21 2021-09-17 北京矿冶研究总院 阳离子捕收剂、制备方法及在磷矿反浮选中的应用
US20260035370A1 (en) 2023-02-27 2026-02-05 Shanton Pharma Pte. Ltd. Crystal form of 8-chloro-3-pentyl-3,7-dihydro-1h-purin-2,6-dione compound and preparation method therefor

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2797220A (en) * 1954-12-02 1957-06-25 Univ Michigan Substituted paraxanthines
US4847377A (en) * 1985-05-13 1989-07-11 Schering Corporation Substituted-2,3-dihydro-6-substituted-pyrimido[2,1-F]-purine-4,8(1H,9H)-diones
GB8906792D0 (en) * 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
NZ240644A (en) 1990-11-21 1994-08-26 Smithkline Beecham Corp Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf)
WO1993016699A1 (en) * 1992-02-21 1993-09-02 Smithkline Beecham Corporation Tnf inhibitors
DE69332634T2 (de) 1992-03-04 2003-05-08 Cell Therapeutics, Inc. Enantiomere hydroxylierte xanthinverbindungen
US6693105B1 (en) * 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US6469017B1 (en) * 1998-01-16 2002-10-22 Cell Therapeutics, Inc. Method of inhibiting interleukin-12 signaling
US5780476A (en) * 1992-11-16 1998-07-14 Cell Therapeutics, Inc. Hydroxyl-containing xanthine compounds
IL109161A0 (en) 1993-03-31 1994-06-24 Cell Therapeutics Inc Amino alcohol derivatives, methods for the preparation thereof, and pharmaceutical compositions containing the same
US5670506A (en) 1993-04-05 1997-09-23 Cell Therapeutics, Inc. Halogen, isothiocyanate or azide substituted xanthines
WO1994024133A1 (en) 1993-04-09 1994-10-27 Cell Therapeutics, Inc. Ring-substituted cell signaling inhibitors
WO1995020589A1 (en) 1994-01-28 1995-08-03 Cell Therapeutics, Inc. Cell signaling inhibitors
WO1995022546A1 (en) 1994-02-18 1995-08-24 Cell Therapeutics, Inc. Intracellular signalling mediators
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
US6878715B1 (en) * 1994-02-18 2005-04-12 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signals and method for using same
US6780865B1 (en) 1994-02-18 2004-08-24 Cell Therapeutics, Inc. Compounds having selective hydrolytic potentials
US5801182A (en) 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
US6323201B1 (en) 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
AR015966A1 (es) * 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
AU4205000A (en) 1999-04-09 2000-11-14 Cell Therapeutics, Inc. Xanthine derivatives and analogs as cell signaling inhibitors
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
EP1208100B1 (en) * 1999-08-31 2003-04-02 Vanderbilt University Selective antagonists of a2b adenosine receptors
AU2001276023A1 (en) * 2000-07-21 2002-02-05 Mark B Lyles Materials and methods for binding nucleic acids to surfaces
FR2812482B1 (fr) * 2000-07-28 2003-01-24 Inside Technologies Dispositif electronique portable comprenant plusieurs circuits integres sans contact
WO2002024194A2 (en) * 2000-09-19 2002-03-28 Novimmune S.A. Use of statins (hmg-coa reductase inhibitors) for the preparation of medicament as a novel type of immunomodulator, immunosuppressor and anti-inflammatory agent
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
KR100926247B1 (ko) * 2001-02-24 2009-11-12 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 크산틴 유도체를 포함하는 약제학적 조성물 및 이의제조방법
AU2002242910A1 (en) 2001-04-11 2002-10-28 Glaxo Group Limited Medicaments which are modulators of hm74 and/or hm74a activity
CN101103030B (zh) * 2004-02-14 2010-10-13 史密丝克莱恩比彻姆公司 具有hm74a受体活性的药物
WO2006045564A1 (en) 2004-10-22 2006-05-04 Smithkline Beecham Corporation Xanthine derivatives with hm74a receptor activity
US20090209561A1 (en) * 2004-10-22 2009-08-20 Richard Jonathan Daniel Hatley Xanthine Derivatives with HM74A Receptor Activity
BRPI0615145A2 (pt) 2005-08-10 2009-11-03 Smithkline Beecham Corp derivados de xantina como agonistas hm74a seletivos
EP1939197A1 (en) * 2006-12-22 2008-07-02 Schwarz Pharma Ag 8-ethinylxanthine derivatives as selective A2A receptor antagonists
US9163024B2 (en) * 2008-12-08 2015-10-20 Glaxosmithkline Llc Tris salts of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione
US20110065676A1 (en) * 2009-06-24 2011-03-17 Schering Corporation Combination therapies comprising par1 antagonists with nar agonists

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