JP2007502263A5 - - Google Patents
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- Publication number
- JP2007502263A5 JP2007502263A5 JP2006523060A JP2006523060A JP2007502263A5 JP 2007502263 A5 JP2007502263 A5 JP 2007502263A5 JP 2006523060 A JP2006523060 A JP 2006523060A JP 2006523060 A JP2006523060 A JP 2006523060A JP 2007502263 A5 JP2007502263 A5 JP 2007502263A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- dyslipidemia
- nhc
- compound
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 208000032928 Dyslipidaemia Diseases 0.000 claims 9
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 6
- 208000027866 inflammatory disease Diseases 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 206010002383 Angina Pectoris Diseases 0.000 claims 3
- 206010003210 Arteriosclerosis Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 206010070901 Diabetic dyslipidaemia Diseases 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 3
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 3
- 208000006011 Stroke Diseases 0.000 claims 3
- 208000007536 Thrombosis Diseases 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 3
- 208000029078 coronary artery disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 230000037356 lipid metabolism Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 208000022531 anorexia Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- WIFSDCDETBPLOR-UHFFFAOYSA-N 2-aminobenzoic acid Chemical compound NC1=CC=CC=C1C(O)=O.NC1=CC=CC=C1C(O)=O WIFSDCDETBPLOR-UHFFFAOYSA-N 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 208000035762 Disorder of lipid metabolism Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- -1 aromatic alcohols Chemical class 0.000 claims 1
- 229920000080 bile acid sequestrant Polymers 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940125753 fibrate Drugs 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- JFZUABNDWZQLIJ-UHFFFAOYSA-N methyl 2-[(2-chloroacetyl)amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1NC(=O)CCl JFZUABNDWZQLIJ-UHFFFAOYSA-N 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0319126.9A GB0319126D0 (en) | 2003-08-14 | 2003-08-14 | Chemical compounds |
| PCT/GB2004/003516 WO2005016867A2 (en) | 2003-08-14 | 2004-08-13 | Anthranilic acid derivatives and their use as activators of the hm74a receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007502263A JP2007502263A (ja) | 2007-02-08 |
| JP2007502263A5 true JP2007502263A5 (https=) | 2007-09-13 |
Family
ID=28052523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523060A Withdrawn JP2007502263A (ja) | 2003-08-14 | 2004-08-13 | アントラニル酸誘導体およびｈｍ７４ａ受容体のアクチベーターとしてのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070191378A1 (https=) |
| EP (1) | EP1689699A2 (https=) |
| JP (1) | JP2007502263A (https=) |
| GB (1) | GB0319126D0 (https=) |
| WO (1) | WO2005016867A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004083388A2 (en) | 2003-03-14 | 2004-09-30 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| PE20050483A1 (es) | 2003-10-31 | 2005-08-25 | Arena Pharm Inc | Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas |
| CA2586156A1 (en) * | 2004-11-04 | 2006-05-18 | Merck & Co., Inc. | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
| CN101115726A (zh) | 2004-12-03 | 2008-01-30 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| PE20060949A1 (es) | 2004-12-23 | 2006-10-11 | Arena Pharm Inc | Derivados fusionados de pirazol como agonistas del receptor de niacina |
| JP2008530074A (ja) * | 2005-02-14 | 2008-08-07 | スミスクライン・ビーチャム・コーポレイション | Ｈｍ７４ａ受容体アゴニストとしてのアントラニル酸誘導体 |
| GB0503053D0 (en) * | 2005-02-14 | 2005-03-23 | Smithkline Beecham Corp | Chemical compounds |
| GB0503056D0 (en) * | 2005-02-14 | 2005-03-23 | Smithkline Beecham Corp | Chemical compounds |
| GB0503054D0 (en) * | 2005-02-14 | 2005-03-23 | Smithkline Beecham Corp | Chemical compounds |
| MX2007015867A (es) * | 2005-06-14 | 2008-03-04 | Hoffmann La Roche | Derivados del acido antranilico. |
| SI1901731T1 (sl) | 2005-06-28 | 2011-07-29 | Merck Sharp & Dohme | Niacin receptorski antagonisti, sestavki vsebujoäśi take spojine in postopki zdravljenja |
| WO2007021744A1 (en) * | 2005-08-10 | 2007-02-22 | Arena Pharmaceuticals, Inc. | Methods for determining probability of an adverse or favorable reaction to a niacin receptor agonist |
| US20090258862A1 (en) * | 2005-08-29 | 2009-10-15 | Colletti Steven L | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
| DK2035369T3 (da) * | 2006-07-05 | 2014-10-06 | Fibrotech Therapeutics Pty Ltd | Terapeutiske |
| KR100832750B1 (ko) * | 2006-12-08 | 2008-05-27 | 한국화학연구원 | Ｎ-페닐아마이드 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물 |
| WO2008069611A1 (en) * | 2006-12-08 | 2008-06-12 | Korea Research Institute Of Chemical Technology | N-phenylamide derivative, process for the preparation thereof, and composition for preventing or treating ischemic diseases comprising same |
| CN101450912B (zh) * | 2007-11-24 | 2012-05-30 | 山东轩竹医药科技有限公司 | 四氢化萘取代的苯甲酸衍生物 |
| WO2009079692A1 (en) * | 2007-12-21 | 2009-07-02 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| WO2010144959A1 (en) * | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
| EP2491030B1 (en) | 2009-10-22 | 2015-07-15 | Fibrotech Therapeutics PTY LTD | Fused ring analogues of anti-fibrotic agents |
| US10092537B2 (en) | 2013-04-15 | 2018-10-09 | Renascience Co., Ltd. | Use for PAI-1 inhibitor |
| EP3349754B9 (en) * | 2015-09-17 | 2025-10-22 | City of Hope | Pcna inhibitors |
| CA3052036A1 (en) | 2017-02-03 | 2018-08-09 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| KR102242658B1 (ko) * | 2018-08-29 | 2021-04-21 | 숙명여자대학교산학협력단 | 치환된 인돌 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 PPARα, PPARγ 및 PPARδ 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN115197117B (zh) * | 2022-05-17 | 2023-09-15 | 沈阳化工大学 | 抑制金黄色葡萄球菌胱硫醚-γ-裂解酶的吲哚类衍生物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855285A (en) * | 1971-06-21 | 1974-12-17 | Pfizer | Acylmethylthio-trifluoromethyl-benzoic acids |
| JPS60139646A (ja) * | 1983-12-27 | 1985-07-24 | Otsuka Pharmaceut Factory Inc | ナフタレン誘導体 |
| JPS62132879A (ja) * | 1985-12-05 | 1987-06-16 | Kuraray Co Ltd | ３，４−ジヒドロ−２ｈ−ベンゾピラン誘導体類及びこれを有効成分とする抗アレルギ−剤 |
| JPH02215778A (ja) * | 1989-02-14 | 1990-08-28 | Kuraray Co Ltd | ３，４―ジヒドロ―２ｈ―ベンゾピラン誘導体及びその医薬用途 |
| JPH02255672A (ja) * | 1989-03-28 | 1990-10-16 | Tsumura & Co | 新規クロモン誘導体および該誘導体を有効成分とする抗アレルギー剤 |
| US5075313A (en) * | 1990-09-13 | 1991-12-24 | Eli Lilly And Company | 3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof |
| RU2051914C1 (ru) * | 1992-02-24 | 1996-01-10 | Пятигорский фармацевтический институт | Производные 6-метокси хромонил-3-акриланилида, обладающие антиаллергической активностью |
| FR2759368B1 (fr) * | 1997-02-10 | 2001-06-01 | Galderma Rech Dermatologique | Composes biaromatiques, compositions les contenant et utilisations |
| ES2230864T3 (es) * | 1998-07-24 | 2005-05-01 | Teijin Limited | Derivados del acido antranilico. |
| AU2002242910A1 (en) * | 2001-04-11 | 2002-10-28 | Glaxo Group Limited | Medicaments which are modulators of hm74 and/or hm74a activity |
| CN1506359A (zh) * | 2002-12-05 | 2004-06-23 | �й�ҽѧ��ѧԺҩ���о��� | 新的香豆素酰胺衍生物及其制法和其药物组合物与用途 |
-
2003
- 2003-08-14 GB GBGB0319126.9A patent/GB0319126D0/en not_active Ceased
-
2004
- 2004-08-13 JP JP2006523060A patent/JP2007502263A/ja not_active Withdrawn
- 2004-08-13 WO PCT/GB2004/003516 patent/WO2005016867A2/en not_active Ceased
- 2004-08-13 EP EP04768077A patent/EP1689699A2/en not_active Withdrawn
- 2004-08-13 US US10/568,029 patent/US20070191378A1/en not_active Abandoned
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