RU2006138495A - Использование агонистов рецепторов, активируемых пролифератором пероксисомы дельта для лечения рс и других демиелинизирующих заболеваний - Google Patents
Использование агонистов рецепторов, активируемых пролифератором пероксисомы дельта для лечения рс и других демиелинизирующих заболеваний Download PDFInfo
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- RU2006138495A RU2006138495A RU2006138495/14A RU2006138495A RU2006138495A RU 2006138495 A RU2006138495 A RU 2006138495A RU 2006138495/14 A RU2006138495/14 A RU 2006138495/14A RU 2006138495 A RU2006138495 A RU 2006138495A RU 2006138495 A RU2006138495 A RU 2006138495A
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- Prior art keywords
- compound
- disease
- formula
- multiple sclerosis
- delta
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (7)
1. Способ лечения демиелинизирующих заболеваний у пациента, предусматривающий введение терапевтически эффективного количества агониста hPPAR-дельта.
2. Способ по п.1, где агонист hPPAR-дельта является селективным агонистом.
3. Способ по п.1, где указанное демиелинизирующее заболевание выбрано из группы, состоящей из рассеянного склероза, болезни Шарко-Мари-Тута, болезни Пелицеуса-Мерцбахера, энцефаломиелита, миелоневрита зрительного нерва, адренолейкодистрофии, синдрома Гийена-Барре, и расстройств, при которых повреждаются производящие миелин глиальные клетки, в том числе травмы спинного мозга, невропатии и повреждения нервов.
4. Способ по п.3, где демиелинизирующим заболеванием является рассеянный склероз.
6. Фармацевтическая композиция, содержащая соединение, выбранное из группы, состоящей из соединения формулы (1) или соединения формулы (2) в количестве, эффективном для лечения рассеянного склероза, болезни Шарко-Мари-Тута, болезни Пелицеуса-Мерцбахера, энцефаломиелита, миелоневрита зрительного нерва, адренолейкодистрофии, синдрома Гийена-Барре, и расстройств, при которых повреждаются производящие миелин глиальные клетки, в том числе травмы спинного мозга, невропатии и повреждения нервов, в сочетании с по меньшей мере одним фармацевтически приемлемым носителем
(1)
(2).
7. Фармацевтическая композиция по п.6, содержащая эффективное количество для лечения рассеянного склероза.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55853304P | 2004-04-01 | 2004-04-01 | |
US60/558,533 | 2004-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2006138495A true RU2006138495A (ru) | 2008-05-10 |
Family
ID=34977094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006138495/14A RU2006138495A (ru) | 2004-04-01 | 2005-03-29 | Использование агонистов рецепторов, активируемых пролифератором пероксисомы дельта для лечения рс и других демиелинизирующих заболеваний |
Country Status (16)
Country | Link |
---|---|
US (1) | US20070149580A1 (ru) |
EP (1) | EP1737440A2 (ru) |
JP (1) | JP2007530703A (ru) |
KR (1) | KR20060134191A (ru) |
CN (1) | CN1950077A (ru) |
AU (1) | AU2005231358A1 (ru) |
BR (1) | BRPI0509540A (ru) |
CA (1) | CA2561159A1 (ru) |
IL (1) | IL178165A0 (ru) |
MA (1) | MA28561B1 (ru) |
MX (1) | MXPA06011218A (ru) |
NO (1) | NO20064985L (ru) |
RU (1) | RU2006138495A (ru) |
SG (1) | SG138623A1 (ru) |
WO (1) | WO2005097098A2 (ru) |
ZA (1) | ZA200607850B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1745003B1 (en) | 2004-05-05 | 2010-10-27 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
JP4981662B2 (ja) | 2004-05-05 | 2012-07-25 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規の化合物、その製法と使用 |
ES2449618T3 (es) | 2005-06-30 | 2014-03-20 | High Point Pharmaceuticals, Llc | Ácidos fenoxiacéticos como activadores de PPAR-delta |
CA2630816C (en) * | 2005-11-28 | 2014-08-12 | Senju Pharmaceutical Co., Ltd. | Pharmaceutical comprising ppar agonist |
EP2386540A1 (en) | 2005-12-22 | 2011-11-16 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
WO2007101864A2 (en) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
US8716317B2 (en) | 2008-06-09 | 2014-05-06 | Sanofi | Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
JP2011523664A (ja) | 2008-06-09 | 2011-08-18 | サノフィ−アベンティス | オキサジアゾロン頭部基を有する、環付加された(annelated)N−複素環式スルホンアミド、それらの製造方法および医薬としてのそれらの使用 |
BR112012007137A2 (pt) | 2009-09-30 | 2015-09-15 | Harvard College | metodos para modulacao da autofagia por meio da modulacao de produtos genicos inibidores da autofagia |
SG10201408414RA (en) | 2009-12-17 | 2015-01-29 | Sanofi Sa | Animal model expressing luciferase under control of the myelin basic protein promoter (mbp-luci) and use of the model for bioluminescence in vivo imaging |
DK2675893T3 (en) * | 2011-02-18 | 2019-04-15 | Scripps Research Inst | Directed differentiation of oligodendrocyte precursor cells into a myelinating cell fate |
EP3043789B1 (en) | 2013-09-09 | 2020-07-08 | vTv Therapeutics LLC | Use of a ppar-delta agonists for treating muscle atrophy |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1856997A (en) * | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
WO2002013812A1 (en) * | 2000-08-17 | 2002-02-21 | Pershadsingh Harrihar A | Methods for treating inflammatory diseases |
GB0024362D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
GB0024361D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
US20050020654A1 (en) * | 2003-03-15 | 2005-01-27 | Pershadsingh Harrihar A. | Novel PPAR agonists, pharmaceutical compositions and uses thereof |
US20070037882A1 (en) * | 2003-04-22 | 2007-02-15 | Astellas Pharma Inc. | Remedy for cerebral neurodegenerative diseases using ppar agonist |
-
2005
- 2005-03-29 BR BRPI0509540-9A patent/BRPI0509540A/pt not_active IP Right Cessation
- 2005-03-29 AU AU2005231358A patent/AU2005231358A1/en not_active Abandoned
- 2005-03-29 JP JP2007506442A patent/JP2007530703A/ja not_active Abandoned
- 2005-03-29 CN CNA2005800148506A patent/CN1950077A/zh active Pending
- 2005-03-29 KR KR1020067022955A patent/KR20060134191A/ko not_active Application Discontinuation
- 2005-03-29 MX MXPA06011218A patent/MXPA06011218A/es not_active Application Discontinuation
- 2005-03-29 SG SG200800123-2A patent/SG138623A1/en unknown
- 2005-03-29 EP EP05729215A patent/EP1737440A2/en not_active Withdrawn
- 2005-03-29 WO PCT/US2005/010371 patent/WO2005097098A2/en active Application Filing
- 2005-03-29 RU RU2006138495/14A patent/RU2006138495A/ru not_active Application Discontinuation
- 2005-03-29 CA CA002561159A patent/CA2561159A1/en not_active Abandoned
-
2006
- 2006-09-18 IL IL178165A patent/IL178165A0/en unknown
- 2006-09-19 ZA ZA200607850A patent/ZA200607850B/xx unknown
- 2006-09-26 US US11/535,240 patent/US20070149580A1/en not_active Abandoned
- 2006-10-31 MA MA29427A patent/MA28561B1/fr unknown
- 2006-10-31 NO NO20064985A patent/NO20064985L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2005097098A2 (en) | 2005-10-20 |
EP1737440A2 (en) | 2007-01-03 |
JP2007530703A (ja) | 2007-11-01 |
SG138623A1 (en) | 2008-01-28 |
NO20064985L (no) | 2006-10-31 |
BRPI0509540A (pt) | 2007-09-18 |
AU2005231358A1 (en) | 2005-10-20 |
WO2005097098A3 (en) | 2005-12-22 |
CA2561159A1 (en) | 2005-10-20 |
CN1950077A (zh) | 2007-04-18 |
ZA200607850B (en) | 2008-10-29 |
KR20060134191A (ko) | 2006-12-27 |
US20070149580A1 (en) | 2007-06-28 |
MXPA06011218A (es) | 2007-01-16 |
MA28561B1 (fr) | 2007-04-03 |
IL178165A0 (en) | 2008-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20090709 |