JP2002541259A5 - - Google Patents
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- Publication number
- JP2002541259A5 JP2002541259A5 JP2000610857A JP2000610857A JP2002541259A5 JP 2002541259 A5 JP2002541259 A5 JP 2002541259A5 JP 2000610857 A JP2000610857 A JP 2000610857A JP 2000610857 A JP2000610857 A JP 2000610857A JP 2002541259 A5 JP2002541259 A5 JP 2002541259A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- alkenyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 40
- 125000003118 aryl group Chemical group 0.000 description 37
- 125000001072 heteroaryl group Chemical group 0.000 description 35
- 125000003342 alkenyl group Chemical group 0.000 description 17
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 16
- 125000000304 alkynyl group Chemical group 0.000 description 15
- 125000001424 substituent group Chemical group 0.000 description 15
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 13
- 125000000753 cycloalkyl group Chemical group 0.000 description 13
- 125000003545 alkoxy group Chemical group 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 11
- 125000003282 alkyl amino group Chemical group 0.000 description 10
- 125000005129 aryl carbonyl group Chemical group 0.000 description 10
- 150000001412 amines Chemical class 0.000 description 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
- 125000005199 aryl carbonyloxy group Chemical group 0.000 description 4
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 4
- -1 bicyclic heteroaromatic derivative compound Chemical class 0.000 description 4
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 description 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 3
- 125000004414 alkyl thio group Chemical group 0.000 description 3
- 125000005100 aryl amino carbonyl group Chemical group 0.000 description 3
- 125000001769 aryl amino group Chemical group 0.000 description 3
- 125000004658 aryl carbonyl amino group Chemical group 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- OEUOXBJHGMAALZ-UHFFFAOYSA-N 1-(6-acetyl-5-amino-4-phenylthieno[2,3-d]pyrimidin-2-yl)sulfanylpropan-2-one Chemical compound C=12C(N)=C(C(C)=O)SC2=NC(SCC(=O)C)=NC=1C1=CC=CC=C1 OEUOXBJHGMAALZ-UHFFFAOYSA-N 0.000 description 1
- CFOXWCSTGROSDJ-UHFFFAOYSA-N 2-(5-amino-6-benzoyl-4-phenylthieno[2,3-d]pyrimidin-2-yl)sulfanyl-1-phenylethanone Chemical compound N=1C(C=2C=CC=CC=2)=C2C(N)=C(C(=O)C=3C=CC=CC=3)SC2=NC=1SCC(=O)C1=CC=CC=C1 CFOXWCSTGROSDJ-UHFFFAOYSA-N 0.000 description 1
- KQEJRGGNDSECOH-UHFFFAOYSA-N 2-[5-amino-6-(4-chlorobenzoyl)-4-phenylthieno[2,3-d]pyrimidin-2-yl]sulfanyl-1-(4-chlorophenyl)ethanone Chemical compound N=1C(C=2C=CC=CC=2)=C2C(N)=C(C(=O)C=3C=CC(Cl)=CC=3)SC2=NC=1SCC(=O)C1=CC=C(Cl)C=C1 KQEJRGGNDSECOH-UHFFFAOYSA-N 0.000 description 1
- PPDHQXKWDDNEKZ-UHFFFAOYSA-N 2-[5-amino-6-(4-methylbenzoyl)-4-phenylthieno[2,3-d]pyrimidin-2-yl]sulfanyl-1-(4-methylphenyl)ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC1=NC(C=2C=CC=CC=2)=C(C(N)=C(S2)C(=O)C=3C=CC(C)=CC=3)C2=N1 PPDHQXKWDDNEKZ-UHFFFAOYSA-N 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- PXUOQUMRMYJMJB-UHFFFAOYSA-N ethyl 2-(5-amino-6-ethoxycarbothioyl-4-phenylthieno[2,3-d]pyrimidin-2-yl)acetate Chemical compound C=12C(N)=C(C(=S)OCC)SC2=NC(CC(=O)OCC)=NC=1C1=CC=CC=C1 PXUOQUMRMYJMJB-UHFFFAOYSA-N 0.000 description 1
- PXCZIBJFJNWCJD-UHFFFAOYSA-N ethyl 5-amino-2-(2-ethoxy-2-oxoethyl)sulfanyl-4-pyridin-4-ylthieno[2,3-d]pyrimidine-6-carboxylate Chemical compound C=12C(N)=C(C(=O)OCC)SC2=NC(SCC(=O)OCC)=NC=1C1=CC=NC=C1 PXCZIBJFJNWCJD-UHFFFAOYSA-N 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- VXZTYHHYHXHGNN-UHFFFAOYSA-N o-ethyl 5-amino-2-methyl-4-phenylthieno[2,3-d]pyrimidine-6-carbothioate Chemical compound C=12C(N)=C(C(=S)OCC)SC2=NC(C)=NC=1C1=CC=CC=C1 VXZTYHHYHXHGNN-UHFFFAOYSA-N 0.000 description 1
- OYDUXFWQTZSKLB-UHFFFAOYSA-N o-ethyl 5-amino-4-(4-chlorophenyl)-2-methylthieno[2,3-d]pyrimidine-6-carbothioate Chemical compound C=12C(N)=C(C(=S)OCC)SC2=NC(C)=NC=1C1=CC=C(Cl)C=C1 OYDUXFWQTZSKLB-UHFFFAOYSA-N 0.000 description 1
- DZZZVDUQTNCWDN-UHFFFAOYSA-N o-methyl 5-amino-2-methyl-4-phenylthieno[2,3-d]pyrimidine-6-carbothioate Chemical compound C=12C(N)=C(C(=S)OC)SC2=NC(C)=NC=1C1=CC=CC=C1 DZZZVDUQTNCWDN-UHFFFAOYSA-N 0.000 description 1
- YXJVZXJVXAXLLD-UHFFFAOYSA-N o-methyl 5-amino-4-(4-chlorophenyl)-2-methylthieno[2,3-d]pyrimidine-6-carbothioate Chemical compound C=12C(N)=C(C(=S)OC)SC2=NC(C)=NC=1C1=CC=C(Cl)C=C1 YXJVZXJVXAXLLD-UHFFFAOYSA-N 0.000 description 1
- JVAYTXIFJIERGY-UHFFFAOYSA-N o-methyl 5-amino-4-(4-methoxyphenyl)-2-methylthieno[2,3-d]pyrimidine-6-carbothioate Chemical compound C=12C(N)=C(C(=S)OC)SC2=NC(C)=NC=1C1=CC=C(OC)C=C1 JVAYTXIFJIERGY-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201152 | 1999-04-08 | ||
| EP99201152.8 | 1999-04-08 | ||
| PCT/EP2000/002865 WO2000061586A1 (en) | 1999-04-08 | 2000-04-03 | Bicyclic heteroaromatic compounds useful as lh agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002541259A JP2002541259A (ja) | 2002-12-03 |
| JP2002541259A5 true JP2002541259A5 (https=) | 2011-03-24 |
| JP4854856B2 JP4854856B2 (ja) | 2012-01-18 |
Family
ID=8240094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000610857A Expired - Fee Related JP4854856B2 (ja) | 1999-04-08 | 2000-04-03 | 黄体化ホルモン作動薬として有用な二環式へテロ芳香族化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6569863B1 (https=) |
| EP (1) | EP1171443B1 (https=) |
| JP (1) | JP4854856B2 (https=) |
| KR (1) | KR100691546B1 (https=) |
| CN (1) | CN1177848C (https=) |
| AR (1) | AR028474A1 (https=) |
| AT (1) | ATE299507T1 (https=) |
| AU (1) | AU772258B2 (https=) |
| BR (1) | BRPI0009558B1 (https=) |
| CA (1) | CA2368834C (https=) |
| CO (1) | CO5160348A1 (https=) |
| CZ (1) | CZ300832B6 (https=) |
| DE (1) | DE60021262T2 (https=) |
| DK (1) | DK1171443T3 (https=) |
| ES (1) | ES2245304T3 (https=) |
| HK (1) | HK1041266B (https=) |
| HU (1) | HU229002B1 (https=) |
| ID (1) | ID30502A (https=) |
| IL (2) | IL145483A0 (https=) |
| MX (1) | MXPA01010144A (https=) |
| NO (1) | NO328826B1 (https=) |
| NZ (1) | NZ514445A (https=) |
| PE (1) | PE20010030A1 (https=) |
| PL (1) | PL219316B1 (https=) |
| PT (1) | PT1171443E (https=) |
| RU (1) | RU2248979C2 (https=) |
| TR (1) | TR200102839T2 (https=) |
| TW (1) | TW564247B (https=) |
| WO (1) | WO2000061586A1 (https=) |
| ZA (1) | ZA200107917B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287554B6 (sk) * | 2000-09-22 | 2011-01-04 | N.V. Organon | Bicyklické heteroaromatické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie |
| GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
| DE10108481A1 (de) * | 2001-02-22 | 2002-10-24 | Bayer Ag | Pyridylpyrimidine |
| TWI228508B (en) * | 2001-09-04 | 2005-03-01 | Akzo Nobel Nv | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity |
| HUP0401443A3 (en) * | 2001-09-04 | 2008-05-28 | Organon Nv | Glycine-substituted thieno[2,3-d]pyrimidines with lh and fsh agonistic activity, use of the compounds and pharmaceutical compositions containing same |
| DK1513516T3 (da) | 2002-06-06 | 2009-10-19 | Boehringer Ingelheim Pharma | Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser |
| US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
| WO2004092173A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| JPWO2005019225A1 (ja) * | 2003-08-21 | 2007-11-01 | 杏林製薬株式会社 | Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体 |
| US7550485B2 (en) * | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| JP4800216B2 (ja) * | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| JP2008507518A (ja) * | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するためのチエノピリジン |
| WO2007062222A2 (en) * | 2005-11-22 | 2007-05-31 | University Of South Florida | Inhibition of cell proliferation |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| EP2018384A2 (en) * | 2006-05-17 | 2009-01-28 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Pyrimidine low molecular weight ligands for modulating hormone receptors |
| JP2009539865A (ja) | 2006-06-06 | 2009-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換３−アミノ−チエノ［２，３−ｂ］ピリジン２−カルボン酸アミド化合物及び製造方法及びそれらの使用 |
| RU2444524C2 (ru) * | 2006-08-21 | 2012-03-10 | Дженентек, Инк. | Азабензотиофенильные соединения и способы применения |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| US8722894B2 (en) * | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| US8252937B2 (en) | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| US8653282B2 (en) * | 2007-10-18 | 2014-02-18 | Boehringer Ingelheim International Gmbh | Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein |
| RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153912A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| KR20140053991A (ko) | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물 |
| ES2575143T3 (es) | 2011-11-23 | 2016-06-24 | Cancer Research Technology Limited | Inhibidores de tienopiridina de la proteína quinasa C atípica |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR20220049612A (ko) | 2014-01-21 | 2022-04-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
| CN107602585A (zh) * | 2017-10-23 | 2018-01-19 | 遵义医学院 | 噻吩并吡啶双杂环化合物的制备工艺 |
| BR102019022529A2 (pt) * | 2019-10-25 | 2021-05-04 | Anhanguera Educacional Ltda. | Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993013664A2 (en) * | 1992-01-11 | 1993-07-22 | Schering Agrochemicals Limited | Biheterocyclic fungicidal compounds |
| TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| JP3854648B2 (ja) * | 1994-04-19 | 2006-12-06 | 武田薬品工業株式会社 | 縮合チオフェン誘導体、その製造法及び用途 |
| EP0791000B1 (en) | 1994-11-08 | 2002-10-02 | Takeda Chemical Industries, Ltd. | Thienopyridine or thienopyrimidine derivatives and their use |
| JPH09169766A (ja) * | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | チエノピリジン誘導体，その製造法および用途 |
| EP0862573A1 (en) | 1995-10-19 | 1998-09-09 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives as gonadotropin releasing hormone antagonists |
| JPH09169767A (ja) * | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および用途 |
| CA2250895A1 (en) * | 1996-04-26 | 1997-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their production and use |
-
2000
- 2000-03-23 TW TW089105361A patent/TW564247B/zh not_active IP Right Cessation
- 2000-04-03 BR BRPI0009558A patent/BRPI0009558B1/pt not_active IP Right Cessation
- 2000-04-03 HU HU0200653A patent/HU229002B1/hu not_active IP Right Cessation
- 2000-04-03 ES ES00917026T patent/ES2245304T3/es not_active Expired - Lifetime
- 2000-04-03 DE DE60021262T patent/DE60021262T2/de not_active Expired - Lifetime
- 2000-04-03 RU RU2001130051/04A patent/RU2248979C2/ru not_active IP Right Cessation
- 2000-04-03 AT AT00917026T patent/ATE299507T1/de active
- 2000-04-03 AU AU38166/00A patent/AU772258B2/en not_active Ceased
- 2000-04-03 EP EP00917026A patent/EP1171443B1/en not_active Expired - Lifetime
- 2000-04-03 MX MXPA01010144A patent/MXPA01010144A/es active IP Right Grant
- 2000-04-03 TR TR2001/02839T patent/TR200102839T2/xx unknown
- 2000-04-03 PT PT00917026T patent/PT1171443E/pt unknown
- 2000-04-03 IL IL14548300A patent/IL145483A0/xx active IP Right Grant
- 2000-04-03 KR KR1020017012792A patent/KR100691546B1/ko not_active Expired - Fee Related
- 2000-04-03 WO PCT/EP2000/002865 patent/WO2000061586A1/en not_active Ceased
- 2000-04-03 CA CA002368834A patent/CA2368834C/en not_active Expired - Fee Related
- 2000-04-03 CZ CZ20013605A patent/CZ300832B6/cs not_active IP Right Cessation
- 2000-04-03 JP JP2000610857A patent/JP4854856B2/ja not_active Expired - Fee Related
- 2000-04-03 NZ NZ514445A patent/NZ514445A/en not_active IP Right Cessation
- 2000-04-03 PL PL350964A patent/PL219316B1/pl unknown
- 2000-04-03 HK HK02103025.1A patent/HK1041266B/en not_active IP Right Cessation
- 2000-04-03 ID IDW00200102449A patent/ID30502A/id unknown
- 2000-04-03 US US09/937,416 patent/US6569863B1/en not_active Expired - Lifetime
- 2000-04-03 DK DK00917026T patent/DK1171443T3/da active
- 2000-04-03 CN CNB008069077A patent/CN1177848C/zh not_active Expired - Fee Related
- 2000-04-06 AR ARP000101578A patent/AR028474A1/es not_active Application Discontinuation
- 2000-04-06 PE PE2000000312A patent/PE20010030A1/es not_active Application Discontinuation
- 2000-04-07 CO CO00025852A patent/CO5160348A1/es unknown
-
2001
- 2001-09-16 IL IL145483A patent/IL145483A/en not_active IP Right Cessation
- 2001-09-26 ZA ZA200107917A patent/ZA200107917B/xx unknown
- 2001-10-04 NO NO20014824A patent/NO328826B1/no not_active IP Right Cessation
-
2003
- 2003-04-11 US US10/411,960 patent/US6841553B2/en not_active Expired - Lifetime
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