JP2004501904A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004501904A5 JP2004501904A5 JP2002505380A JP2002505380A JP2004501904A5 JP 2004501904 A5 JP2004501904 A5 JP 2004501904A5 JP 2002505380 A JP2002505380 A JP 2002505380A JP 2002505380 A JP2002505380 A JP 2002505380A JP 2004501904 A5 JP2004501904 A5 JP 2004501904A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- lower alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 9
- -1 heterocyclylamino Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 3
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 3
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000004949 alkyl amino carbonyl amino group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000006319 alkynyl amino group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 2
- 125000005162 aryl oxy carbonyl amino group Chemical group 0.000 claims 2
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005167 cycloalkylaminocarbonyl group Chemical group 0.000 claims 2
- 125000005169 cycloalkylcarbonylamino group Chemical group 0.000 claims 2
- 125000005170 cycloalkyloxycarbonyl group Chemical group 0.000 claims 2
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 2
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 2
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 125000006323 alkenyl amino group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0015904.6A GB0015904D0 (en) | 2000-06-28 | 2000-06-28 | Inhibitors of HPV E1 helicase enzyme |
| PCT/EP2001/006895 WO2002000632A1 (en) | 2000-06-28 | 2001-06-19 | Benzodiazepines as inhibitors of hpv e1 helicase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004501904A JP2004501904A (ja) | 2004-01-22 |
| JP2004501904A5 true JP2004501904A5 (https=) | 2005-02-03 |
Family
ID=9894630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002505380A Pending JP2004501904A (ja) | 2000-06-28 | 2001-06-19 | Ｈｐｖｅ１ヘリカーゼ阻害剤としてのベンゾジアゼピン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6703387B2 (https=) |
| EP (1) | EP1299364A1 (https=) |
| JP (1) | JP2004501904A (https=) |
| AU (1) | AU2001270580A1 (https=) |
| CA (1) | CA2411157A1 (https=) |
| GB (1) | GB0015904D0 (https=) |
| WO (1) | WO2002000632A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE552236T1 (de) | 2003-01-14 | 2012-04-15 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz |
| ES2314446T3 (es) * | 2003-06-10 | 2009-03-16 | Smithkline Beecham Corporation | Derivados de tetrahidrocarbazol y su uso farmaceutico. |
| RU2005138126A (ru) | 2003-06-12 | 2006-07-27 | СмитКлайн Бичем Корпорейшн (US) | Производные тетрагидрокарбазола и их фармацевтическое применение |
| ES2522579T3 (es) | 2004-06-17 | 2014-11-17 | Cytokinetics, Inc. | Compuestos, composiciones y métodos |
| US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| ES2419007T3 (es) | 2005-12-15 | 2013-08-19 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y procedimientos |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| WO2007078815A2 (en) | 2005-12-16 | 2007-07-12 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| WO2007078839A2 (en) | 2005-12-19 | 2007-07-12 | Cytokinetics, Inc. | Compounds, compositions and methods |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| AU2010307262A1 (en) | 2009-07-10 | 2012-03-01 | Microbiotix, Inc. | Inhibitors of filovirus entry into host cells |
| CN102902895B (zh) * | 2010-05-18 | 2017-04-05 | 小江生物技术有限公司 | 预防和治疗人乳头瘤病毒感染类疾病的化合物的筛选方法 |
| JP2013010740A (ja) * | 2011-06-03 | 2013-01-17 | Sumitomo Chemical Co Ltd | イソキサゾリン化合物を製造する方法 |
| US20180319753A1 (en) | 2015-10-28 | 2018-11-08 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1455048A (fr) * | 1965-01-09 | 1966-04-01 | Clin Byla Ets | Composés de la série des benzodiazépines et leur préparation |
| TW219896B (https=) * | 1988-07-07 | 1994-02-01 | Duphar Int Res | |
| US4847129A (en) * | 1988-09-16 | 1989-07-11 | Continental Pet Technologies, Inc. | Multilayer preform for hot fill containers |
| US5141735A (en) * | 1990-06-18 | 1992-08-25 | Hoffman-La Roche, Inc. | Substituted amino-benzodiazepines having anitviral activity |
| BR9913226A (pt) * | 1998-09-01 | 2001-05-22 | Innogenetics Nv | Benzodiazepinas e derivados de benzotiazepinas e peptìdios de hbsag ligados a anexinas, suas composições e uso |
| JP2002524442A (ja) * | 1998-09-04 | 2002-08-06 | インスティチュート オブ モレキュラー アンド セル バイオロジー | 治療用化合物と方法 |
-
2000
- 2000-06-28 GB GBGB0015904.6A patent/GB0015904D0/en not_active Ceased
-
2001
- 2001-06-19 EP EP01949420A patent/EP1299364A1/en not_active Withdrawn
- 2001-06-19 AU AU2001270580A patent/AU2001270580A1/en not_active Abandoned
- 2001-06-19 WO PCT/EP2001/006895 patent/WO2002000632A1/en not_active Ceased
- 2001-06-19 CA CA002411157A patent/CA2411157A1/en not_active Abandoned
- 2001-06-19 JP JP2002505380A patent/JP2004501904A/ja active Pending
- 2001-06-26 US US09/892,148 patent/US6703387B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004501904A5 (https=) | ||
| TW202446772A (zh) | Ｓｔｉｎｇ促效化合物 | |
| JP2002541259A5 (https=) | ||
| RU2350605C2 (ru) | Аналоги хиназолина в качестве ингибиторов рецепторных тирозинкиназ | |
| JP2016179996A5 (https=) | ||
| JP2016530259A5 (https=) | ||
| JP2020521741A5 (https=) | ||
| RU2005120780A (ru) | Соединения с конденсированным 1,3-дигидроимидазольным циклом | |
| JP2003503449A5 (https=) | ||
| JP2011518163A5 (https=) | ||
| JP2012532131A5 (https=) | ||
| JP2018517686A5 (https=) | ||
| JP2006524660A5 (https=) | ||
| JP2006507355A5 (https=) | ||
| JP2005523922A5 (https=) | ||
| JP2008526999A5 (https=) | ||
| JP2013502431A5 (https=) | ||
| JP2011509302A5 (https=) | ||
| JP2004517099A5 (https=) | ||
| JP2011509309A5 (https=) | ||
| JP2010510215A5 (https=) | ||
| JP2016525102A5 (https=) | ||
| JP2005530811A5 (https=) | ||
| JP2007522142A5 (https=) | ||
| EP1125936A3 (en) | Aryl substituted azabenzimidazoles and their use in the treatment of HIV and AIDS related diseases |