JP2002510616A5 - - Google Patents
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- Publication number
- JP2002510616A5 JP2002510616A5 JP2000541979A JP2000541979A JP2002510616A5 JP 2002510616 A5 JP2002510616 A5 JP 2002510616A5 JP 2000541979 A JP2000541979 A JP 2000541979A JP 2000541979 A JP2000541979 A JP 2000541979A JP 2002510616 A5 JP2002510616 A5 JP 2002510616A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- matrix
- release
- active substance
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 35
- 239000011159 matrix material Substances 0.000 description 25
- 239000013543 active substance Substances 0.000 description 16
- 239000003607 modifier Substances 0.000 description 13
- 239000012736 aqueous medium Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 230000003628 erosive effect Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 238000011978 dissolution method Methods 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 239000002344 surface layer Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010102 injection blow moulding Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98610009 | 1998-04-03 | ||
| EP98610009.7 | 1998-04-03 | ||
| PCT/DK1999/000174 WO1999051208A1 (en) | 1998-04-03 | 1999-03-25 | Controlled release composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002510616A JP2002510616A (ja) | 2002-04-09 |
| JP2002510616A5 true JP2002510616A5 (enExample) | 2006-05-25 |
| JP4533531B2 JP4533531B2 (ja) | 2010-09-01 |
Family
ID=8235847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000541979A Expired - Fee Related JP4533531B2 (ja) | 1998-04-03 | 1999-03-25 | 制御放出組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7883722B2 (enExample) |
| EP (1) | EP1067910B1 (enExample) |
| JP (1) | JP4533531B2 (enExample) |
| AT (1) | ATE267589T1 (enExample) |
| AU (1) | AU3024399A (enExample) |
| CA (1) | CA2327685C (enExample) |
| DE (1) | DE69917618T2 (enExample) |
| DK (1) | DK1067910T3 (enExample) |
| ES (1) | ES2221370T3 (enExample) |
| WO (1) | WO1999051208A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69917618T2 (de) | 1998-04-03 | 2005-06-23 | Egalet A/S | Zusammensetzung mit kontrollierter wirkstoff-freisetzung |
| EP2957281A1 (en) | 2001-09-21 | 2015-12-23 | Egalet Ltd. | Polymer release system |
| WO2003024430A1 (en) * | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
| EP1429734B1 (en) | 2001-09-21 | 2007-12-26 | Egalet A/S | Controlled release solid dispersions of carvedilol |
| GB0203296D0 (en) | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
| GB0222612D0 (en) * | 2002-09-30 | 2002-11-06 | Univ Gent | Controlled delivery system for bioactive substances |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| WO2004041252A1 (en) * | 2002-11-08 | 2004-05-21 | Egalet A/S | Controlled release carvedilol compositions |
| EP2186510B1 (en) | 2003-03-26 | 2013-07-10 | Egalet Ltd. | Matrix compositions for controlled delivery of drug substances |
| US8877241B2 (en) | 2003-03-26 | 2014-11-04 | Egalet Ltd. | Morphine controlled release system |
| MXPA05011446A (es) | 2003-04-24 | 2006-05-31 | Jagotec Ag | Tableta con liberacion retardada con geometria de nucleo definida. |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| GB0318824D0 (en) * | 2003-08-11 | 2003-09-10 | Glaxo Group Ltd | Novel composition |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| JP2008509933A (ja) * | 2004-08-13 | 2008-04-03 | エミスフェアー・テクノロジーズ・インク | 送達剤のマイクロ粒子またはナノ粒子を含む医薬製剤 |
| DE102004043863A1 (de) | 2004-09-10 | 2006-03-16 | Nitec Pharma Ag | Tabletten mit orts- und zeitgesteuerter Wirkstofffreisetzung im Gastrointestinum |
| EP1799196B1 (en) * | 2004-10-08 | 2016-06-22 | Forward Pharma A/S | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| US20060246003A1 (en) * | 2004-12-27 | 2006-11-02 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
| US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
| US20060280789A1 (en) * | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
| AU2005320547B2 (en) * | 2004-12-27 | 2009-02-05 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| WO2006128471A2 (en) * | 2005-06-03 | 2006-12-07 | Egalet A/S | A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids |
| EA015304B1 (ru) | 2006-08-03 | 2011-06-30 | Нитек Фарма Аг | Лечение ревматоидного заболевания глюкокортикоидами с отсроченным высвобождением |
| EP1920767A1 (en) * | 2006-11-09 | 2008-05-14 | Abbott GmbH & Co. KG | Melt-processed imatinib dosage form |
| CA2674536C (en) * | 2007-01-16 | 2016-07-26 | Egalet A/S | Use of i) a polyglycol and ii) an active drug substance for the preparation of a pharmaceutical composition for i) mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse |
| NZ580972A (en) | 2007-06-04 | 2012-02-24 | Egalet Ltd | Controlled release pharmaceutical compositions for prolonged effect |
| JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
| EP2259803B2 (en) | 2008-02-29 | 2019-03-13 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| MX2010012039A (es) | 2008-05-09 | 2010-11-30 | Gruenenthal Gmbh | Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio. |
| EP2361082A1 (en) * | 2008-08-14 | 2011-08-31 | Bar-Shalom, Daniel | Coated tablets with a remaining degradation surface over the time |
| WO2010088911A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Pharmaceutical compositions resistant to abuse |
| WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
| EP2429492B1 (de) * | 2009-05-13 | 2014-06-25 | Basf Se | Feste pharmazeutische Zubereitungen enthaltend Copolymere auf Basis von Polyethern in Kombination mit wasserschwerlöslichen Polymeren |
| EP2445487A2 (en) | 2009-06-24 | 2012-05-02 | Egalet Ltd. | Controlled release formulations |
| ES2428938T3 (es) | 2009-07-22 | 2013-11-12 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación |
| BR112012001547A2 (pt) | 2009-07-22 | 2016-03-08 | Gruenenthal Gmbh | forma de dosagem farmacêutica extrusada por fusão a quente |
| EP2540317A4 (en) * | 2010-02-22 | 2014-04-16 | Daiichi Sankyo Co Ltd | SOLID PREPARATION WITH DELAYED RELEASE FOR ORAL ADMINISTRATION |
| RU2012143739A (ru) | 2010-03-15 | 2014-04-20 | Ферросан Медикал Дивайсиз А/С | Способ ускорения остановки кровотечения и/или заживления ран |
| KR101940207B1 (ko) | 2010-05-12 | 2019-01-18 | 스펙트럼 파마슈티컬즈 인크 | 란탄 카보네이트 하이드록사이드, 란탄 옥시카보네이트 및 이들의 제조 및 사용 방법 |
| CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
| CN103179954A (zh) | 2010-09-02 | 2013-06-26 | 格吕伦塔尔有限公司 | 包含阴离子聚合物的抗破碎剂型 |
| PL2736497T3 (pl) | 2011-07-29 | 2018-01-31 | Gruenenthal Gmbh | Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku |
| CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| RU2657955C2 (ru) | 2012-03-06 | 2018-06-18 | Ферросан Медикал Дивайсиз А/С | Контейнер под давлением, содержащий гемостатическую пасту |
| PL2838512T3 (pl) | 2012-04-18 | 2018-12-31 | Grünenthal GmbH | Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| RU2636240C2 (ru) | 2012-06-12 | 2017-11-21 | Ферросан Медикал Дивайсиз А/С | Сухая гемостатическая композиция |
| BR112015000150A2 (pt) | 2012-07-06 | 2017-06-27 | Egalet Ltd | composições farmacêuticas dissuasoras de abuso de liberação controlada |
| WO2014191396A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
| CN105358071B (zh) | 2013-06-21 | 2018-07-31 | 弗罗桑医疗设备公司 | 真空膨胀的干组合物和用于保留该干组合物的注射器 |
| US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| WO2015078891A1 (en) | 2013-11-26 | 2015-06-04 | Farmaceutici Formenti S.P.A. | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| WO2015086028A1 (en) | 2013-12-11 | 2015-06-18 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
| AU2014365038B2 (en) | 2013-12-16 | 2019-09-12 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion |
| WO2015122477A1 (ja) * | 2014-02-12 | 2015-08-20 | 沢井製薬株式会社 | フィルムコーティングされた口腔内崩壊錠 |
| US20150320690A1 (en) | 2014-05-12 | 2015-11-12 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| EP3148512A1 (en) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| US11046818B2 (en) | 2014-10-13 | 2021-06-29 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
| CN107206165B (zh) | 2014-12-24 | 2020-10-23 | 弗罗桑医疗设备公司 | 用于保持并混合第一和第二物质的注射器 |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| AU2016319203A1 (en) | 2015-09-10 | 2018-02-22 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| EP3790600B1 (en) | 2018-05-09 | 2023-12-27 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
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| EP1429734B1 (en) | 2001-09-21 | 2007-12-26 | Egalet A/S | Controlled release solid dispersions of carvedilol |
| WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
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-
1999
- 1999-03-25 DE DE69917618T patent/DE69917618T2/de not_active Expired - Lifetime
- 1999-03-25 ES ES99911627T patent/ES2221370T3/es not_active Expired - Lifetime
- 1999-03-25 EP EP99911627A patent/EP1067910B1/en not_active Expired - Lifetime
- 1999-03-25 DK DK99911627T patent/DK1067910T3/da active
- 1999-03-25 AU AU30243/99A patent/AU3024399A/en not_active Abandoned
- 1999-03-25 AT AT99911627T patent/ATE267589T1/de active
- 1999-03-25 WO PCT/DK1999/000174 patent/WO1999051208A1/en not_active Ceased
- 1999-03-25 JP JP2000541979A patent/JP4533531B2/ja not_active Expired - Fee Related
- 1999-03-25 CA CA002327685A patent/CA2327685C/en not_active Expired - Fee Related
-
2004
- 2004-05-14 US US10/845,522 patent/US7883722B2/en not_active Expired - Fee Related
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