ES2570454T3 - Sistema de liberación controlada de morfina - Google Patents

Sistema de liberación controlada de morfina

Info

Publication number
ES2570454T3
ES2570454T3 ES10181692T ES10181692T ES2570454T3 ES 2570454 T3 ES2570454 T3 ES 2570454T3 ES 10181692 T ES10181692 T ES 10181692T ES 10181692 T ES10181692 T ES 10181692T ES 2570454 T3 ES2570454 T3 ES 2570454T3
Authority
ES
Spain
Prior art keywords
composition
opioid
styrene
matrix
polyethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10181692T
Other languages
English (en)
Inventor
Gina Fischer
Daniel Bar-Shalom
Lillian Slot
Christine Andersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egalet Ltd
Original Assignee
Egalet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egalet Ltd filed Critical Egalet Ltd
Application granted granted Critical
Publication of ES2570454T3 publication Critical patent/ES2570454T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

Composición farmacéutica para la liberación controlada de un opioide en un medio acuoso mediante erosión de una superficie de la composición, comprendiendo la composición una composición de matriz que comprende: a) un polímero o una mezcla de polímeros, en la que el polímero comprende un poli(óxido de etileno) y/o un copolímero de bloque de óxido de etileno y óxido de propileno, b) un opioide como principio activo y, opcionalmente, c) uno o más excipientes farmacéuticamente aceptables, y teniendo la composición la forma de una varilla cilíndrica que tiene uno o dos extremos de forma cónica que está dotada de un recubrimiento, que es sustancialmente insoluble en e impermeable a fluidos tales como fluidos corporales durante el periodo de liberación pretendido, teniendo el recubrimiento una abertura en uno o ambos extremos que expone la superficie de dicha matriz, comprendiendo el recubrimiento un polímero seleccionado de poliamida, polietileno, poli(tereftalato de etileno), polipropileno-poliuretano, poli(acetato de vinilo), poli(cloruro de vinilo), caucho de silicona, látex, polihidroxibutirato, polihidroxivalerato, teflón, poli(ácido láctico) o poli(ácido glicólico) y copolímeros de los mismos, copolímeros tales como etileno-acetato de vinilo (EVA), estireno-butadieno-estireno (SBS) y estireno-isopreno-estireno (SIS).
ES10181692T 2003-03-26 2004-03-26 Sistema de liberación controlada de morfina Expired - Lifetime ES2570454T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200300463 2003-03-26

Publications (1)

Publication Number Publication Date
ES2570454T3 true ES2570454T3 (es) 2016-05-18

Family

ID=33040855

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10181692T Expired - Lifetime ES2570454T3 (es) 2003-03-26 2004-03-26 Sistema de liberación controlada de morfina
ES04723522T Expired - Lifetime ES2360102T3 (es) 2003-03-26 2004-03-26 Sistema para la liberación controlada de morfina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04723522T Expired - Lifetime ES2360102T3 (es) 2003-03-26 2004-03-26 Sistema para la liberación controlada de morfina.

Country Status (6)

Country Link
US (3) US8877241B2 (es)
EP (2) EP1610767B1 (es)
AT (1) ATE495732T1 (es)
DE (1) DE602004031096D1 (es)
ES (2) ES2570454T3 (es)
WO (1) WO2004084868A1 (es)

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ATE495732T1 (de) 2011-02-15
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US9375428B2 (en) 2016-06-28
EP2301526A2 (en) 2011-03-30
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US20160361269A1 (en) 2016-12-15
US8877241B2 (en) 2014-11-04
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US9884029B2 (en) 2018-02-06
US20070003617A1 (en) 2007-01-04

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