DE602004025159D1 - Matrixzubereitungen für die kontrollierte Darreichung von Arzneistoffen - Google Patents

Matrixzubereitungen für die kontrollierte Darreichung von Arzneistoffen

Info

Publication number
DE602004025159D1
DE602004025159D1 DE602004025159T DE602004025159T DE602004025159D1 DE 602004025159 D1 DE602004025159 D1 DE 602004025159D1 DE 602004025159 T DE602004025159 T DE 602004025159T DE 602004025159 T DE602004025159 T DE 602004025159T DE 602004025159 D1 DE602004025159 D1 DE 602004025159D1
Authority
DE
Germany
Prior art keywords
polymer
polyethylene
ethylene
matrix composition
styrene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004025159T
Other languages
English (en)
Inventor
Daniel Bar-Shalom
Gina Fischer
Lillian Slot
Anne-Marie Lademann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egalet AS
Original Assignee
Egalet AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2003/000765 external-priority patent/WO2004041252A1/en
Application filed by Egalet AS filed Critical Egalet AS
Publication of DE602004025159D1 publication Critical patent/DE602004025159D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004025159T 2003-03-26 2004-03-26 Matrixzubereitungen für die kontrollierte Darreichung von Arzneistoffen Expired - Lifetime DE602004025159D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300464 2003-03-26
PCT/DK2003/000765 WO2004041252A1 (en) 2002-11-08 2003-11-07 Controlled release carvedilol compositions

Publications (1)

Publication Number Publication Date
DE602004025159D1 true DE602004025159D1 (de) 2010-03-04

Family

ID=33099580

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602004025159T Expired - Lifetime DE602004025159D1 (de) 2003-03-26 2004-03-26 Matrixzubereitungen für die kontrollierte Darreichung von Arzneistoffen
DE602004014747T Expired - Lifetime DE602004014747D1 (de) 2003-03-26 2004-03-26 Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE602004014747T Expired - Lifetime DE602004014747D1 (de) 2003-03-26 2004-03-26 Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen

Country Status (9)

Country Link
US (2) US8298581B2 (de)
EP (3) EP2186510B1 (de)
JP (1) JP4989217B2 (de)
AT (2) ATE399538T1 (de)
CA (1) CA2520312C (de)
DE (2) DE602004025159D1 (de)
DK (1) DK1610768T3 (de)
ES (1) ES2307003T3 (de)
WO (1) WO2004084869A1 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69917618T2 (de) * 1998-04-03 2005-06-23 Egalet A/S Zusammensetzung mit kontrollierter wirkstoff-freisetzung
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
WO2003024429A1 (en) 2001-09-21 2003-03-27 Egalet A/S Polymer release system
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
WO2004041252A1 (en) * 2002-11-08 2004-05-21 Egalet A/S Controlled release carvedilol compositions
EP2301526B1 (de) 2003-03-26 2016-03-23 Egalet Ltd. System zur kontrollierten Freisetzung von Morphin
DK1610768T3 (da) * 2003-03-26 2008-09-22 Egalet As Matrikskompositioner til styret afgivelse af lægemiddelsubstanser
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
AU2006254554B2 (en) * 2005-06-03 2011-11-24 Egalet Ltd A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
DE602006019320D1 (de) * 2006-01-19 2011-02-10 Dow Global Technologies Inc Biologisch wirksame zusammensetzung mit ethylcellulose
CA2930487A1 (en) * 2007-01-16 2008-07-24 Egalet Ltd. Use of i) a polyglycol and ii) an active drug substance for the preparation of a pharmaceutical composition for i)mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
KR100932613B1 (ko) * 2007-04-27 2009-12-17 한남대학교 산학협력단 고분자 용융공정을 이용한 약물전달용 생체적합성 고분자나노 미립구의 제조방법 및 그 나노 미립구
NZ580972A (en) 2007-06-04 2012-02-24 Egalet Ltd Controlled release pharmaceutical compositions for prolonged effect
US7940978B2 (en) * 2007-06-05 2011-05-10 General Electric Company Automatic characterization of cellular motion
EP2219608B1 (de) * 2007-12-03 2014-03-19 Trilogic Pharma Llc Selbstverfestigendes bioerodierbares barriereimplantat
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
EP2259803B2 (de) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Vorrichtung zur förderung von hämostase und/oder wundheilung
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
AU2009258120B2 (en) * 2008-06-10 2014-11-27 Teva Pharmaceutical Industries, Ltd. Rasagiline soft gelatin capsules
ES2462090T5 (es) 2008-06-16 2017-07-12 Pfizer Inc. Nanopartículas poliméricas cargadas de fármaco y procedimientos de fabricación y uso de las mismas
WO2010005726A2 (en) * 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
EP2309991B1 (de) 2008-06-16 2019-03-06 Pfizer Inc Therapeutische polymernanopartikel mit vincaalkaloiden sowie verfahren zu ihrer herstellung und verwendung
US20110250274A1 (en) * 2008-09-19 2011-10-13 Shaked Ze Ev Estriol formulations
US8563041B2 (en) * 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
JP2012512175A (ja) * 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
EP2393487B1 (de) 2009-02-06 2016-11-02 Egalet Ltd. Gegen missbrauch resistente pharmazeutische zusammensetzungen
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
WO2010149169A2 (en) 2009-06-24 2010-12-29 Egalet A/S Controlled release formulations
ES2560210T3 (es) 2009-07-22 2016-02-17 Grünenthal GmbH Forma de dosificación resistente a la manipulación para opiádes sensibles a la oxidación
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
CA2775890C (en) 2009-09-30 2016-06-21 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
ES2721898T3 (es) 2009-12-11 2019-08-06 Pfizer Formulaciones estables para liofilizar partículas terapéuticas
EA201290499A1 (ru) 2009-12-15 2013-01-30 Байнд Байосайенсиз, Инк. Композиции терапевтических полимерных наночастиц с высокой температурой стеклования и высокомолекулярными сополимерами
JP2013522246A (ja) 2010-03-15 2013-06-13 フェロサン メディカル デバイシーズ エイ／エス 止血および／または創傷治癒を促進するための方法
WO2011153334A2 (en) 2010-06-04 2011-12-08 Trilogic Pharma Llc Bioadhesive compositions for epithelial drug delivery
TWI516286B (zh) 2010-09-02 2016-01-11 歌林達股份有限公司 含陰離子聚合物之抗破碎劑型
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
EP2629760A4 (de) * 2010-10-22 2014-04-02 Bind Therapeutics Inc Therapeutische nanopartikel mit copolymeren von hohem molekulargewicht
KR101775727B1 (ko) 2010-12-15 2017-09-19 가톨릭대학교 산학협력단 폴리알킬렌글리콜-링커-폴리에스터 공중합체, 그 제조방법 및 용도
CN103857386A (zh) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
TWI641396B (zh) 2011-09-23 2018-11-21 Bvw控股公司 醫療共聚物
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
WO2013127830A1 (en) * 2012-02-28 2013-09-06 Grünenthal GmbH Tamper-resistant pharmaceutical dosage form comprising nonionic surfactant
RU2657955C2 (ru) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Контейнер под давлением, содержащий гемостатическую пасту
CA2868142A1 (en) 2012-04-18 2013-10-24 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
KR101455901B1 (ko) * 2012-05-04 2014-11-03 성균관대학교산학협력단 세레콕시브 및 폴록사머를 포함하는 공융 혼합물
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ／エス 乾燥止血組成物
MX2014015880A (es) 2012-07-06 2015-08-05 Egalet Ltd Composiciones farmaceuticas disuasivas de abuso para liberacion controlada.
BR112015005940A2 (pt) 2012-09-17 2017-07-04 Bind Therapeutics Inc processo para a preparação de nanopartículas terapêuticas
MX366159B (es) 2012-11-30 2019-07-01 Acura Pharmaceuticals Inc Liberacion autorregulada de ingrediente farmaceutico activo.
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
WO2015044415A1 (en) * 2013-09-30 2015-04-02 Universiteit Gent Polyurethanes as oral drug delivery platform
US10350232B1 (en) 2013-11-04 2019-07-16 Peter D. Jaillet Medicinal drops
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
AU2014365038B2 (en) 2013-12-16 2019-09-12 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion
PL3116547T3 (pl) 2014-03-14 2019-11-29 Pfizer Terapeutyczne nanocząstki zawierające środek terapeutyczny i sposoby ich wytwarzania i zastosowania
CA2943728C (en) 2014-03-26 2020-03-24 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release biphasic matrix solid dosage form
EP3142646A1 (de) 2014-05-12 2017-03-22 Grünenthal GmbH Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
US10182993B2 (en) * 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
EP3281980B1 (de) * 2015-04-07 2021-03-03 Mitsubishi Chemical Corporation Harzzusammensetzung und mehrschichtige struktur damit sowie verfahren zur verbesserung der langfristigen stabilität
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
EP3302382A4 (de) * 2015-05-29 2019-02-20 Allergan, Inc. Implantat zur behandlung eines augenleidens
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
EP3135272A1 (de) * 2015-08-31 2017-03-01 Basf S.A. Zusammensetzungen für ein mundspülmittel in tablettenform
US11103581B2 (en) 2015-08-31 2021-08-31 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
EP3346991A1 (de) 2015-09-10 2018-07-18 Grünenthal GmbH Schutz vor oraler überdosierung mit missbrauchssicheren formulierungen mit sofortiger freisetzung
US20180362737A1 (en) * 2015-12-08 2018-12-20 Dow Global Technologies Llc Compositions comprising cellulose ethers and water-soluble esterified cellulose ethers
EP3184104B1 (de) * 2015-12-23 2018-09-12 Hexal AG Pharmazeutische zusammensetzung von vortioxetin-hydrobromid mit vortioxetinhydrobromid in einer polyethylenoxidmatrix
CN112368028A (zh) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 用于制备止血组合物的方法
TWI832871B (zh) 2018-06-29 2024-02-21 美商英塞特公司 Axl/mer 抑制劑之調配物
KR102538853B1 (ko) * 2019-10-30 2023-06-01 주식회사 에이디 할로이사이트 펠릿을 페로몬 흡수소재로 사용한 페로몬 방출기 및 그 제조방법
CN114796135B (zh) * 2022-03-29 2023-04-07 海南久常制药有限公司 一种硫糖铝口服制剂及其制备方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1430684A (en) 1972-06-26 1976-03-31 Lowey H Prolonged release lozenges
JPS5518694B2 (de) 1973-04-02 1980-05-21
US4330338A (en) 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3320583A1 (de) 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
AU591171B2 (en) 1983-11-02 1989-11-30 Alza Corporation Dispenser for delivering thermo-responsive composition
US4844984A (en) 1984-03-19 1989-07-04 Alza Corporation Dispensing system with means for increasing delivery of beneficial agent from the system
JPH0246008B2 (ja) 1984-06-01 1990-10-12 Takada Seiyaku Kk Nifuejipinjizokuseiseizainoseizohoho
US5082655A (en) * 1984-07-23 1992-01-21 Zetachron, Inc. Pharmaceutical composition for drugs subject to supercooling
GB2170104A (en) 1985-01-30 1986-07-30 Warner Lambert Co Coated pharmaceutical dosage forms
ES8801121A1 (es) 1985-02-19 1988-01-01 Key Pharma Procedimiento de fabricacion de una unidad de dosificacion para la administracion oral de cloruro potasico.
US4892742A (en) 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
US4824675A (en) * 1987-07-13 1989-04-25 Alza Corporation Dispenser with movable matrix comprising a plurality of tiny pills
EP0406315B1 (de) * 1988-03-24 1992-11-11 Bukh Meditec A/S Geregelte verabreichungszusammensetzung
FI101344B1 (fi) 1988-03-31 1998-06-15 Tanabe Seiyaku Co Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseuttisesti aktiivista ainetta
JPH04503058A (ja) 1989-01-30 1992-06-04 アルザ コーポレイション カルシウム拮抗体投与のための剤形
DK469989D0 (da) 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
IT1237904B (it) 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
US5102668A (en) 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
GB9025372D0 (en) 1990-11-22 1991-01-09 Nat Res Dev Pharmaceutical dosage forms
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5881926A (en) 1993-03-11 1999-03-16 Taro Pharmaceutical Industries, Ltd. Pharmaceutical compositions in semisolid form and a device for administration thereof
US5656291A (en) * 1994-03-16 1997-08-12 Pharmacia & Upjohn Aktiebolag Controlled release preparation
JPH07100191A (ja) 1993-10-06 1995-04-18 Daikyo Yakuhin Kogyo Kk 徐放性坐剤
US5419917A (en) 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
DK0746310T3 (da) 1994-02-23 1999-08-02 Bm Res As Præparat med styret afgivelse
IL139728A (en) 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
JP3161278B2 (ja) 1995-04-26 2001-04-25 株式会社村田製作所 誘電体磁器組成物
KR100459747B1 (ko) 1996-05-20 2005-01-27 오쓰까 세이야꾸 가부시키가이샤 로제시아치료제
WO1998006385A1 (de) 1996-08-15 1998-02-19 Losan Pharma Gmbh Gut schluckbare orale arzneiform
US20020054911A1 (en) 2000-05-11 2002-05-09 Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi Novel oral dosage form for carvedilol
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
DE69917618T2 (de) 1998-04-03 2005-06-23 Egalet A/S Zusammensetzung mit kontrollierter wirkstoff-freisetzung
IL138990A0 (en) * 1999-02-12 2001-11-25 Biostream Inc Matrices for drug delivery and methods for making and using the same
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6562375B1 (en) 1999-08-04 2003-05-13 Yamanouchi Pharmaceuticals, Co., Ltd. Stable pharmaceutical composition for oral use
US6534085B1 (en) * 1999-09-23 2003-03-18 Bioresponse L.L.C. Phytochemicals for promoting weight loss
JP4310010B2 (ja) * 1999-10-08 2009-08-05 パナソニック株式会社 単位電池
US6515010B1 (en) 1999-11-15 2003-02-04 Smithkline Beecham Corporation Carvedilol methanesulfonate
US6491949B2 (en) 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
US6352721B1 (en) 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
US6378165B1 (en) * 2000-02-17 2002-04-30 Emerson Electric Co. Pull handle with interlocking mounting mechanism for wet/dry vacuum appliance
US20010036959A1 (en) 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
CA2426811A1 (en) 2000-10-24 2002-08-29 Smithkline Beecham Corporation Novel formulations of carvedilol
IN191028B (de) 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
DE10131272B4 (de) * 2001-06-28 2006-03-30 Koenig & Bauer Ag Wendevorrichtung
WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
WO2003024429A1 (en) 2001-09-21 2003-03-27 Egalet A/S Polymer release system
WO2003024426A1 (en) 2001-09-21 2003-03-27 Egalet A/S Controlled release solid dispersions
US20040062804A1 (en) * 2001-09-28 2004-04-01 Der-Yang Lee Modified release dosage forms
WO2003077897A1 (en) * 2002-03-15 2003-09-25 Cypress Bioscience, Inc. Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes
US20040115262A1 (en) * 2002-07-29 2004-06-17 Frank Jao Formulations and dosage forms for controlled delivery of topiramate
WO2004041252A1 (en) 2002-11-08 2004-05-21 Egalet A/S Controlled release carvedilol compositions
DK1610768T3 (da) * 2003-03-26 2008-09-22 Egalet As Matrikskompositioner til styret afgivelse af lægemiddelsubstanser
EP2301526B1 (de) * 2003-03-26 2016-03-23 Egalet Ltd. System zur kontrollierten Freisetzung von Morphin
US20060177497A1 (en) 2003-07-21 2006-08-10 Bio Dar Ltd. Gellan gum based oral controlled release dosage forms-a novel platform technology for gastric retention
EP1670442A4 (de) 2003-09-19 2011-09-14 Penwest Pharmaceuticals Co Dosierformen mit verzögerter freisetzung
US20050163837A1 (en) 2003-12-31 2005-07-28 Garth Boehm Rosiglitazone formulations
AU2006254554B2 (en) 2005-06-03 2011-11-24 Egalet Ltd A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids

Also Published As

Publication number Publication date
US20070042044A1 (en) 2007-02-22
US20100166866A1 (en) 2010-07-01
JP4989217B2 (ja) 2012-08-01
CA2520312A1 (en) 2004-10-07
WO2004084869A1 (en) 2004-10-07
ATE454886T1 (de) 2010-01-15
CA2520312C (en) 2013-06-18
JP2006521301A (ja) 2006-09-21
EP2186510B1 (de) 2013-07-10
ES2307003T3 (es) 2008-11-16
EP1974726A2 (de) 2008-10-01
DE602004014747D1 (de) 2008-08-14
EP1610768A1 (de) 2006-01-04
EP2186510A3 (de) 2010-06-09
EP1974726B1 (de) 2010-01-13
EP2186510A2 (de) 2010-05-19
ATE399538T1 (de) 2008-07-15
EP1610768B1 (de) 2008-07-02
DK1610768T3 (da) 2008-09-22
US8298581B2 (en) 2012-10-30
EP1974726A3 (de) 2008-11-05

Similar Documents

Publication Publication Date Title
DE602004025159D1 (de) Matrixzubereitungen für die kontrollierte Darreichung von Arzneistoffen
US9511033B2 (en) Sublingual and buccal film compositions
EP2461795B2 (de) Sublinguale und orale filmzusammensetzungen
ATE495732T1 (de) Morphin-system mit kontrollierter freisetzung
US20190070100A1 (en) Sublingual and buccal film compositions
CN1929819A (zh) 递送活性剂的快速溶解膜
JPH04504515A (ja) 通気性バッキング
WO2007112436A3 (en) Use of polymeric materials with other substances for improved performance
EP1968558B1 (de) Ph-modulierte folien zur abgabe von wirkstoffen
US8298572B2 (en) Adhesive pharmaceutical preparation containing bisoprolol
CN1256627A (zh) 固体微粒形成用组合物
JP5749790B2 (ja) 多層溶融押出フィルム
CN102711834B (zh) 治疗hiv的可植入装置
CN101199494A (zh) 一种防治晕动病贴片及其制备方法
US20190046411A1 (en) Sublingual and buccal film compositions
CN1927189A (zh) 经皮吸收型药物制剂
WO2016123696A1 (en) Oral dosage film exhibiting enhanced mucosal penetration
Khokhlenkova Prospects of using biopolymeric films in medicine and pharmacy
JP3440284B2 (ja) 皮膚貼付薬用支持体
CN1250205C (zh) 口服颗粒制剂
JPH09255566A (ja) 経皮投与薬用支持体
TWI674900B (zh) 用於經皮輸送安非他命之組合物及方法
JPS61167615A (ja) 薬剤投与方法
TW200810795A (en) Drug delivery composition containing polymer and modifying agent
MXPA05012815A (es) Peliculas basadas en oxido de polietileno y sistemas para suministro de fármacos elaborados con ellas.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EGALET A/S, VAERLOESE, GB

R082 Change of representative

Ref document number: 1974726

Country of ref document: EP

Representative=s name: ZACCO DR. PETERS UND PARTNER, DE