ATE267589T1 - Zusammensetzung mit kontrollierter wirkstoff- freisetzung - Google Patents
Zusammensetzung mit kontrollierter wirkstoff- freisetzungInfo
- Publication number
- ATE267589T1 ATE267589T1 AT99911627T AT99911627T ATE267589T1 AT E267589 T1 ATE267589 T1 AT E267589T1 AT 99911627 T AT99911627 T AT 99911627T AT 99911627 T AT99911627 T AT 99911627T AT E267589 T1 ATE267589 T1 AT E267589T1
- Authority
- AT
- Austria
- Prior art keywords
- composition
- matrix
- water
- aqueous medium
- erosion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98610009 | 1998-04-03 | ||
PCT/DK1999/000174 WO1999051208A1 (en) | 1998-04-03 | 1999-03-25 | Controlled release composition |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE267589T1 true ATE267589T1 (de) | 2004-06-15 |
Family
ID=8235847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99911627T ATE267589T1 (de) | 1998-04-03 | 1999-03-25 | Zusammensetzung mit kontrollierter wirkstoff- freisetzung |
Country Status (10)
Country | Link |
---|---|
US (1) | US7883722B2 (de) |
EP (1) | EP1067910B1 (de) |
JP (1) | JP4533531B2 (de) |
AT (1) | ATE267589T1 (de) |
AU (1) | AU3024399A (de) |
CA (1) | CA2327685C (de) |
DE (1) | DE69917618T2 (de) |
DK (1) | DK1067910T3 (de) |
ES (1) | ES2221370T3 (de) |
WO (1) | WO1999051208A1 (de) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2327685C (en) | 1998-04-03 | 2008-11-18 | Bm Research A/S | Controlled release composition |
EP1429739A1 (de) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer-freigabe-system |
US20050019399A1 (en) | 2001-09-21 | 2005-01-27 | Gina Fischer | Controlled release solid dispersions |
US20040253310A1 (en) | 2001-09-21 | 2004-12-16 | Gina Fischer | Morphine polymer release system |
GB0203296D0 (en) | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
GB0222612D0 (en) * | 2002-09-30 | 2002-11-06 | Univ Gent | Controlled delivery system for bioactive substances |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
WO2004041252A1 (en) | 2002-11-08 | 2004-05-21 | Egalet A/S | Controlled release carvedilol compositions |
EP1610767B1 (de) | 2003-03-26 | 2011-01-19 | Egalet A/S | Morphin-system mit kontrollierter freisetzung |
ATE399538T1 (de) * | 2003-03-26 | 2008-07-15 | Egalet As | Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen |
ATE512659T1 (de) | 2003-04-24 | 2011-07-15 | Jagotec Ag | Tablette mit verzögerter wirkstofffreigabe und bestimmter formgeometrie |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
GB0318824D0 (en) * | 2003-08-11 | 2003-09-10 | Glaxo Group Ltd | Novel composition |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US20060078622A1 (en) * | 2004-08-13 | 2006-04-13 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
DE102004043863A1 (de) | 2004-09-10 | 2006-03-16 | Nitec Pharma Ag | Tabletten mit orts- und zeitgesteuerter Wirkstofffreisetzung im Gastrointestinum |
PT2801355E (pt) * | 2004-10-08 | 2015-09-18 | Forward Pharma As | Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico |
AU2005320547B2 (en) * | 2004-12-27 | 2009-02-05 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
US20060246003A1 (en) * | 2004-12-27 | 2006-11-02 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
US20060280789A1 (en) * | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
AU2006254554B2 (en) * | 2005-06-03 | 2011-11-24 | Egalet Ltd | A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids |
DK2049123T4 (en) | 2006-08-03 | 2016-11-28 | Horizon Pharma Ag | LATE discharge-glucocorticoid treatment of rheumatoid ILLNESS |
EP1920767A1 (de) * | 2006-11-09 | 2008-05-14 | Abbott GmbH & Co. KG | Schmelzverarbeitete Darreichungsform mit Imatinib |
CA2930487A1 (en) * | 2007-01-16 | 2008-07-24 | Egalet Ltd. | Use of i) a polyglycol and ii) an active drug substance for the preparation of a pharmaceutical composition for i)mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse |
US8821928B2 (en) | 2007-06-04 | 2014-09-02 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
BRPI0906467C1 (pt) | 2008-01-25 | 2021-05-25 | Gruenenthal Gmbh | forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada |
EP2259803B2 (de) | 2008-02-29 | 2019-03-13 | Ferrosan Medical Devices A/S | Vorrichtung zur förderung von hämostase und/oder wundheilung |
KR101690094B1 (ko) | 2008-05-09 | 2016-12-27 | 그뤼넨탈 게엠베하 | 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법 |
WO2010017821A1 (en) * | 2008-08-14 | 2010-02-18 | Daniel Bar-Shalom | Coated tablets with a remaining degradation surface over the time8 |
WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
EP3184105A1 (de) | 2009-02-06 | 2017-06-28 | Egalet Ltd. | Missbrauchssichere pharmazeutische zusammensetzungen |
EP2429492B1 (de) * | 2009-05-13 | 2014-06-25 | Basf Se | Feste pharmazeutische Zubereitungen enthaltend Copolymere auf Basis von Polyethern in Kombination mit wasserschwerlöslichen Polymeren |
EP2445487A2 (de) | 2009-06-24 | 2012-05-02 | Egalet Ltd. | Retard-formulierungen |
PE20121067A1 (es) | 2009-07-22 | 2012-09-05 | Gruenenthal Chemie | Forma de dosificacion de liberacion controlada extruida por fusion en caliente |
WO2011009604A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
WO2011102505A1 (ja) * | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | 経口用徐放性固形製剤 |
CN102905732A (zh) | 2010-03-15 | 2013-01-30 | 弗罗桑医疗设备公司 | 用于促进止血和/或伤口愈合的方法 |
CN103037870B (zh) | 2010-05-12 | 2016-05-25 | 斯派克托姆制药公司 | 碱式碳酸镧、碳酸氧镧及其制造方法和用途 |
CA2808541C (en) | 2010-09-02 | 2019-01-08 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
WO2012028319A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
KR20140053158A (ko) | 2011-07-29 | 2014-05-07 | 그뤼넨탈 게엠베하 | 즉시 약물 방출을 제공하는 탬퍼-저항성 정제 |
AR087360A1 (es) | 2011-07-29 | 2014-03-19 | Gruenenthal Gmbh | Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato |
CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
CA2865349C (en) | 2012-03-06 | 2021-07-06 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
JP6282261B2 (ja) | 2012-04-18 | 2018-02-21 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 不正使用防止および過量放出防止医薬剤形 |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
CA2874290C (en) | 2012-06-12 | 2020-02-25 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
JP2015521988A (ja) | 2012-07-06 | 2015-08-03 | イガレット・リミテッド | 制御放出用乱用防止性医薬組成物 |
CA2913209A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
EP3003279A1 (de) | 2013-05-29 | 2016-04-13 | Grünenthal GmbH | Manipulationssichere darreichungsform mit einem oder mehreren partikeln |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
AU2014289187B2 (en) | 2013-07-12 | 2019-07-11 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
MX371372B (es) | 2013-11-26 | 2020-01-28 | Gruenenthal Gmbh | Preparacion de una composicion farmaceutica en polvo por medio de criomolienda. |
CA2928963C (en) | 2013-12-11 | 2020-10-27 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
WO2015091352A1 (en) | 2013-12-16 | 2015-06-25 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion |
WO2015122477A1 (ja) * | 2014-02-12 | 2015-08-20 | 沢井製薬株式会社 | フィルムコーティングされた口腔内崩壊錠 |
CA2947786A1 (en) | 2014-05-12 | 2015-11-19 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising tapentadol |
WO2015181059A1 (en) | 2014-05-26 | 2015-12-03 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
CN106999621B (zh) | 2014-10-13 | 2020-07-03 | 弗罗桑医疗设备公司 | 用于止血和伤口愈合的干组合物 |
US10653837B2 (en) | 2014-12-24 | 2020-05-19 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
JP2018517676A (ja) | 2015-04-24 | 2018-07-05 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時放出および溶媒抽出に対する耐性を有する改変防止製剤 |
EP3316930B1 (de) | 2015-07-03 | 2019-07-31 | Ferrosan Medical Devices A/S | Spritze zum mischen zweier komponenten und zum aufrechterhalten eines vakuums im lagerzustand |
WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
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CA1018456A (en) | 1972-06-26 | 1977-10-04 | Hans Lowey | Prolonged release lozenges |
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US6352721B1 (en) | 2000-01-14 | 2002-03-05 | Osmotica Corp. | Combined diffusion/osmotic pumping drug delivery system |
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US20040253310A1 (en) | 2001-09-21 | 2004-12-16 | Gina Fischer | Morphine polymer release system |
US20050019399A1 (en) | 2001-09-21 | 2005-01-27 | Gina Fischer | Controlled release solid dispersions |
EP1429739A1 (de) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer-freigabe-system |
CN1596101A (zh) | 2001-09-28 | 2005-03-16 | 麦克内尔-Ppc股份有限公司 | 含有糖果组分的剂型 |
WO2004041252A1 (en) | 2002-11-08 | 2004-05-21 | Egalet A/S | Controlled release carvedilol compositions |
ATE399538T1 (de) | 2003-03-26 | 2008-07-15 | Egalet As | Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen |
EP1610767B1 (de) | 2003-03-26 | 2011-01-19 | Egalet A/S | Morphin-system mit kontrollierter freisetzung |
CA2533165A1 (en) | 2003-07-21 | 2005-01-27 | Bio-Dar Ltd. | Gellan gum based oral controlled release dosage forms- a novel platform technology for gastric retention |
AP2006003585A0 (en) | 2003-09-19 | 2006-04-30 | Penwest Pharmaceuticals Co | Delayed release dosage forms. |
WO2005065654A2 (en) | 2003-12-31 | 2005-07-21 | Alpharma, Inc. | Rosiglitazone formulations |
AU2006254554B2 (en) | 2005-06-03 | 2011-11-24 | Egalet Ltd | A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids |
-
1999
- 1999-03-25 CA CA002327685A patent/CA2327685C/en not_active Expired - Fee Related
- 1999-03-25 EP EP99911627A patent/EP1067910B1/de not_active Expired - Lifetime
- 1999-03-25 JP JP2000541979A patent/JP4533531B2/ja not_active Expired - Fee Related
- 1999-03-25 AT AT99911627T patent/ATE267589T1/de active
- 1999-03-25 DK DK99911627T patent/DK1067910T3/da active
- 1999-03-25 AU AU30243/99A patent/AU3024399A/en not_active Abandoned
- 1999-03-25 ES ES99911627T patent/ES2221370T3/es not_active Expired - Lifetime
- 1999-03-25 DE DE69917618T patent/DE69917618T2/de not_active Expired - Lifetime
- 1999-03-25 WO PCT/DK1999/000174 patent/WO1999051208A1/en active IP Right Grant
-
2004
- 2004-05-14 US US10/845,522 patent/US7883722B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002510616A (ja) | 2002-04-09 |
US7883722B2 (en) | 2011-02-08 |
EP1067910B1 (de) | 2004-05-26 |
EP1067910A1 (de) | 2001-01-17 |
CA2327685A1 (en) | 1999-10-14 |
AU3024399A (en) | 1999-10-25 |
US20050089569A1 (en) | 2005-04-28 |
JP4533531B2 (ja) | 2010-09-01 |
CA2327685C (en) | 2008-11-18 |
WO1999051208A1 (en) | 1999-10-14 |
DK1067910T3 (da) | 2004-10-04 |
DE69917618T2 (de) | 2005-06-23 |
DE69917618D1 (de) | 2004-07-01 |
ES2221370T3 (es) | 2004-12-16 |
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