DE69917618D1 - Zusammensetzung mit kontrollierter wirkstoff-freisetzung - Google Patents

Zusammensetzung mit kontrollierter wirkstoff-freisetzung

Info

Publication number
DE69917618D1
DE69917618D1 DE69917618T DE69917618T DE69917618D1 DE 69917618 D1 DE69917618 D1 DE 69917618D1 DE 69917618 T DE69917618 T DE 69917618T DE 69917618 T DE69917618 T DE 69917618T DE 69917618 D1 DE69917618 D1 DE 69917618D1
Authority
DE
Germany
Prior art keywords
composition
matrix
water
active substance
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69917618T
Other languages
English (en)
Other versions
DE69917618T2 (de
Inventor
Daniel Bar-Shalom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egalet AS
Original Assignee
Egalet AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egalet AS filed Critical Egalet AS
Application granted granted Critical
Publication of DE69917618D1 publication Critical patent/DE69917618D1/de
Publication of DE69917618T2 publication Critical patent/DE69917618T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69917618T 1998-04-03 1999-03-25 Zusammensetzung mit kontrollierter wirkstoff-freisetzung Expired - Lifetime DE69917618T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98610009 1998-04-03
EP98610009 1998-04-03
PCT/DK1999/000174 WO1999051208A1 (en) 1998-04-03 1999-03-25 Controlled release composition

Publications (2)

Publication Number Publication Date
DE69917618D1 true DE69917618D1 (de) 2004-07-01
DE69917618T2 DE69917618T2 (de) 2005-06-23

Family

ID=8235847

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69917618T Expired - Lifetime DE69917618T2 (de) 1998-04-03 1999-03-25 Zusammensetzung mit kontrollierter wirkstoff-freisetzung

Country Status (10)

Country Link
US (1) US7883722B2 (de)
EP (1) EP1067910B1 (de)
JP (1) JP4533531B2 (de)
AT (1) ATE267589T1 (de)
AU (1) AU3024399A (de)
CA (1) CA2327685C (de)
DE (1) DE69917618T2 (de)
DK (1) DK1067910T3 (de)
ES (1) ES2221370T3 (de)
WO (1) WO1999051208A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1067910B1 (de) 1998-04-03 2004-05-26 Egalet A/S Zusammensetzung mit kontrollierter wirkstoff-freisetzung
ES2298401T3 (es) * 2001-09-21 2008-05-16 Egalet A/S Dispersiones solidas de liberacion controlada de carvedilol.
EP2957281A1 (de) 2001-09-21 2015-12-23 Egalet Ltd. Polymer-freigabe-system
WO2003024430A1 (en) * 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
GB0222612D0 (en) * 2002-09-30 2002-11-06 Univ Gent Controlled delivery system for bioactive substances
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
EP1610767B1 (de) 2003-03-26 2011-01-19 Egalet A/S Morphin-system mit kontrollierter freisetzung
US8298581B2 (en) 2003-03-26 2012-10-30 Egalet A/S Matrix compositions for controlled delivery of drug substances
CN102525993B (zh) 2003-04-24 2017-04-12 佳高泰克有限公司 具有限定内核几何形状的缓释片剂
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
GB0318824D0 (en) * 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
US20060078623A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
DE102004043863A1 (de) 2004-09-10 2006-03-16 Nitec Pharma Ag Tabletten mit orts- und zeitgesteuerter Wirkstofffreisetzung im Gastrointestinum
ES2582942T3 (es) * 2004-10-08 2016-09-16 Forward Pharma A/S Composiciones farmacéuticas de liberación controlada que comprenden un éster de ácido fumárico
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
EP1830886B1 (de) * 2004-12-27 2016-04-13 Eisai R&D Management Co., Ltd. Verfahren zur stabilisierung eines arzneimittels gegen demenz
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20090274759A1 (en) * 2005-06-03 2009-11-05 Egalet A/S Solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
SG10201503411QA (en) 2006-08-03 2015-06-29 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid disease
EP1920767A1 (de) * 2006-11-09 2008-05-14 Abbott GmbH & Co. KG Schmelzverarbeitete Darreichungsform mit Imatinib
EP2104493A2 (de) * 2007-01-16 2009-09-30 Egalet A/S Verwendung i) eines polyglycols und n) einer wirkstoffsubstanz zur herstellung einer pharmazeutischen zusammensetzung i) zur abschwächung des risikos alkoholbedingten dose-dumpings und/oder ii) zur reduzierung des risikos eines medikamentenmissbrauchs
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
CA2713128C (en) 2008-01-25 2016-04-05 Gruenenthal Gmbh Pharmaceutical dosage form
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
WO2010017821A1 (en) * 2008-08-14 2010-02-18 Daniel Bar-Shalom Coated tablets with a remaining degradation surface over the time8
NZ594208A (en) 2009-02-06 2012-10-26 Egalet Ltd Pharmaceutical compositions resistant to abuse
CA2751667C (en) 2009-02-06 2016-12-13 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
WO2010130728A2 (de) * 2009-05-13 2010-11-18 Basf Se Feste pharmazeutischen zubereitungen enthaltend copolymere auf basis von polyethern in kombination mit wasserschwerlöslichen polymeren
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
PE20120572A1 (es) 2009-07-22 2012-06-06 Gruenenthal Chemie Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion
EP2540317A4 (de) * 2010-02-22 2014-04-16 Daiichi Sankyo Co Ltd Feststoffpräparat mit verzögerter freisetzung zur oralen verabreichung
CN102905732A (zh) 2010-03-15 2013-01-30 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的方法
AU2011252983C1 (en) 2010-05-12 2015-02-19 Unicycive Therapeutics, Inc. Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
AU2011297892B2 (en) 2010-09-02 2014-05-29 Grunenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
MX2013002377A (es) 2010-09-02 2013-04-29 Gruenenthal Gmbh Forma de dosificacion resistente a manipulacion que comprende una sal inorganica.
MX348054B (es) 2011-07-29 2017-05-25 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco.
NO2736495T3 (de) 2011-07-29 2018-01-20
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
US11109849B2 (en) 2012-03-06 2021-09-07 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
PT2838512T (pt) 2012-04-18 2018-11-09 Gruenenthal Gmbh Forma farmacêutica resistente à adulteração e resistente à libertação inesperada de alta quantidade (dose-dumping)
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112014030962A2 (pt) 2012-06-12 2017-06-27 Ferrosan Medical Devices As métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático
MX2014015880A (es) 2012-07-06 2015-08-05 Egalet Ltd Composiciones farmaceuticas disuasivas de abuso para liberacion controlada.
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形
WO2014191397A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
EP3010419B1 (de) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vakuumerweiterte trockenzusammensetzung und spritze zum zurückhalten davon
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ/エス 押し出し増強因子を含んでいる乾燥組成物
US20150164807A1 (en) 2013-12-16 2015-06-18 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion
WO2015122477A1 (ja) * 2014-02-12 2015-08-20 沢井製薬株式会社 フィルムコーティングされた口腔内崩壊錠
CN106572980A (zh) 2014-05-12 2017-04-19 格吕伦塔尔有限公司 包含他喷他多的防篡改即释胶囊制剂
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
EP3206726B1 (de) 2014-10-13 2020-05-27 Ferrosan Medical Devices A/S Trockene zusammensetzung zur verwendung in der hämostase und wundheilung
CN107206165B (zh) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 用于保持并混合第一和第二物质的注射器
AU2016251854A1 (en) 2015-04-24 2017-10-19 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP6747651B2 (ja) 2015-07-03 2020-08-26 フェロサン メディカル デバイシーズ エイ/エス 保管状態で真空を保持するための、及び2種の成分を混合するためのシリンジ
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
WO2019215274A1 (en) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1018456A (en) 1972-06-26 1977-10-04 Hans Lowey Prolonged release lozenges
US4330338A (en) * 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3320583A1 (de) * 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
AU591171B2 (en) 1983-11-02 1989-11-30 Alza Corporation Dispenser for delivering thermo-responsive composition
US4844984A (en) * 1984-03-19 1989-07-04 Alza Corporation Dispensing system with means for increasing delivery of beneficial agent from the system
JPH0246008B2 (ja) * 1984-06-01 1990-10-12 Takada Seiyaku Kk Nifuejipinjizokuseiseizainoseizohoho
GB2170104A (en) 1985-01-30 1986-07-30 Warner Lambert Co Coated pharmaceutical dosage forms
IE59066B1 (en) 1985-02-19 1993-12-15 Key Pharma Controlled release potassium chloride
US4898733A (en) * 1985-11-04 1990-02-06 International Minerals & Chemical Corp. Layered, compression molded device for the sustained release of a beneficial agent
US4892742A (en) * 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
US4824675A (en) * 1987-07-13 1989-04-25 Alza Corporation Dispenser with movable matrix comprising a plurality of tiny pills
AU3432689A (en) * 1988-03-24 1989-10-16 Bukh Meditec A/S Controlled release composition
FI101344B (fi) * 1988-03-31 1998-06-15 Tanabe Seiyaku Co Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta
ES2054333T3 (es) 1989-01-30 1994-08-01 Alza Corp Forma de dosificacion para administrar un antagonista del calcio.
JP2727009B2 (ja) * 1989-03-10 1998-03-11 ダイト株式会社 持続性製剤
DK469989D0 (da) 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
IT1237904B (it) * 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
US5102668A (en) * 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
GB9025372D0 (en) 1990-11-22 1991-01-09 Nat Res Dev Pharmaceutical dosage forms
US5683719A (en) 1990-11-22 1997-11-04 British Technology Group Limited Controlled release compositions
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5881926A (en) 1993-03-11 1999-03-16 Taro Pharmaceutical Industries, Ltd. Pharmaceutical compositions in semisolid form and a device for administration thereof
JPH071001A (ja) * 1993-06-21 1995-01-06 Nippon Steel Corp 鏡面材用ステンレス鋼板およびその製造方法
US5419917A (en) * 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
EP0746310B1 (de) * 1994-02-23 1998-11-18 BM Research A/S Zusammensetzung mit gesteuerter freisetzung
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5686106A (en) * 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery
EP0908181B8 (de) 1996-05-20 2009-04-15 Otsuka Pharmaceutical Co., Ltd. Heilmittel fuer rosazea
AU3691297A (en) * 1996-08-15 1998-03-06 Losan Pharma Gmbh Easy to swallow oral medicament composition
GB9700624D0 (en) * 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
NZ513456A (en) * 1997-07-01 2003-02-28 Pfizer Sertraline acetate, L-lactate and L-aspartate, processes for their preparation and their uses in psychotic disorders
US20020054911A1 (en) * 2000-05-11 2002-05-09 Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi Novel oral dosage form for carvedilol
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
EP1067910B1 (de) 1998-04-03 2004-05-26 Egalet A/S Zusammensetzung mit kontrollierter wirkstoff-freisetzung
JP4812167B2 (ja) * 1999-02-12 2011-11-09 モレキュラー インサイト ファーマスーティカルズ インコーポレイテッド 薬物輸送用マトリックス、ならびにその作成方法および使用方法
US6562375B1 (en) * 1999-08-04 2003-05-13 Yamanouchi Pharmaceuticals, Co., Ltd. Stable pharmaceutical composition for oral use
US6534085B1 (en) * 1999-09-23 2003-03-18 Bioresponse L.L.C. Phytochemicals for promoting weight loss
WO2001035958A1 (en) 1999-11-15 2001-05-25 Smithkline Beecham Corporation Carvedilol methanesulfonate
US6491949B2 (en) 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
US6352721B1 (en) 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
US6488962B1 (en) * 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
AU2001297631A1 (en) 2000-10-24 2002-09-04 Smithkline Beecham Corporation Novel formulations of carvedilol
IN191028B (de) * 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
ES2298401T3 (es) * 2001-09-21 2008-05-16 Egalet A/S Dispersiones solidas de liberacion controlada de carvedilol.
EP2957281A1 (de) * 2001-09-21 2015-12-23 Egalet Ltd. Polymer-freigabe-system
WO2003024430A1 (en) * 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
NZ532097A (en) * 2001-09-28 2006-02-24 Mcneil Ppc Inc Dosage forms having an inner core and outer shell
US20040151772A1 (en) * 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
EP1610767B1 (de) * 2003-03-26 2011-01-19 Egalet A/S Morphin-system mit kontrollierter freisetzung
US8298581B2 (en) * 2003-03-26 2012-10-30 Egalet A/S Matrix compositions for controlled delivery of drug substances
CA2533165A1 (en) 2003-07-21 2005-01-27 Bio-Dar Ltd. Gellan gum based oral controlled release dosage forms- a novel platform technology for gastric retention
BRPI0414311A (pt) 2003-09-19 2008-03-04 Penwest Pharmaceutical Co formas de dosagem de liberação controlada
WO2005065654A2 (en) * 2003-12-31 2005-07-21 Alpharma, Inc. Rosiglitazone formulations
US20090274759A1 (en) * 2005-06-03 2009-11-05 Egalet A/S Solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids

Also Published As

Publication number Publication date
US7883722B2 (en) 2011-02-08
DK1067910T3 (da) 2004-10-04
ES2221370T3 (es) 2004-12-16
JP4533531B2 (ja) 2010-09-01
CA2327685A1 (en) 1999-10-14
DE69917618T2 (de) 2005-06-23
CA2327685C (en) 2008-11-18
US20050089569A1 (en) 2005-04-28
EP1067910A1 (de) 2001-01-17
JP2002510616A (ja) 2002-04-09
AU3024399A (en) 1999-10-25
EP1067910B1 (de) 2004-05-26
ATE267589T1 (de) 2004-06-15
WO1999051208A1 (en) 1999-10-14

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