JP2002502226A - 三次元軟骨培養物 - Google Patents
三次元軟骨培養物Info
- Publication number
- JP2002502226A JP2002502226A JP50130896A JP50130896A JP2002502226A JP 2002502226 A JP2002502226 A JP 2002502226A JP 50130896 A JP50130896 A JP 50130896A JP 50130896 A JP50130896 A JP 50130896A JP 2002502226 A JP2002502226 A JP 2002502226A
- Authority
- JP
- Japan
- Prior art keywords
- cells
- stromal
- framework
- dimensional
- cartilage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.生きた間質組織をin vitroで調製する方法であって、三次元枠組み上に接種 した間質細胞を有効量の成長因子を含む培地で培養し、その結果として、間質 細胞および該間質細胞から天然に分泌された結合組織タンパク質が、間質細胞 により橋かけされた間隙を有する三次元構造体に形成された生物適合性の非生 存物質から構成された該枠組みに付着しかつそれを実質的におおうことにより 、三次元構築物に形作られることを含んでなる方法。 2.間質細胞が軟骨細胞である、請求項1に記載の方法。 3.間質細胞が繊維芽細胞または繊維芽細胞様の細胞である、請求項1に記載の 方法。 4.間質細胞が臍帯細胞または臍帯血由来の骨髄細胞である、請求項1に記載の 方法。 5.間質細胞が軟骨細胞、軟骨前駆細胞、および繊維芽細胞、繊維芽細胞様細胞 、内皮細胞、周皮細胞、マクロファージ、単球、白血球、形質細胞、マスト細 胞、脂肪細胞、臍帯細胞、および臍帯血由来の骨髄細胞の組合せである、請求 項1に記載の方法。 6.枠組みが生物分解性の物質から構成される、請求項1に記載の方法。 7.生物分解性の物質がポリグリコール酸、綿、ガット(腸線)縫合糸、セルロ ース、ゼラチン、コラーゲンまたはポリヒドロキシアルカノエートである、請 求項6に記載の方法。 8.ポリグリコール酸をエチレンオキシドで処理する、請求項7に記載の方法。 9.ポリグリコール酸を電子ビームで処理する、請求項7に記載の方法。 10.枠組みが非生物分解性の物質から構成される、請求項1に記載の方法。 11.非生物分解性の物質がポリアミド、ポリエステル、ポリスチレン、ポリプロ ピレン、ポリアクリレート、ポリビニル、ポリカーボネート、ポリテトラフル オロエチレン、またはニトロセルロース化合物である、請求項8に記載の方法 。 12.枠組みがメッシュである、請求項1に記載の方法。 13.生きた間質組織に接種した実質細胞を培養することをさらに含む、請求項1 に記載の方法。 14.実質細胞が軟骨細胞、軟骨前駆細胞、繊維芽細胞、繊維芽細胞様細胞、臍帯 細胞、または臍帯血由来の骨髄細胞を含む、請求項13に記載の方法。 15.培地が有効量のアスコルベートをさらに含む、請求項1に記載の方法。 16.培地が静止条件下に保持される、請求項1に記載の方法。 17.培地が対流による動的状態で周期的加圧下に保持される、請求項1に記載の 方法。 18.生きた軟骨組織構築物を移植または植え込む方法であって、 (a)三次元枠組み上に間質細胞を接種し、 (b)該間質細胞を培養して、それらをin vitroで増殖させ、そして (c)軟骨組織構築物を生体内に移植する、 ことを含んでなる方法。 19.三次元枠組みに接種した間質細胞および該間質細胞から天然に分泌された結 合組織タンパク質を含んでなり、該三次元枠組みに生細胞が住みついて、間質 細胞により橋かけされた間隙を有する三次元構造体を形成している、in vitro で調製された、生存間質細胞集落化三次元枠組み。 20.間質細胞が軟骨細胞である、請求項19に記載の生存間質細胞集落化三次元枠 組み。 21.間質細胞が繊維芽細胞または繊維芽細胞様の細胞である、請求項19に記載の 生存間質細胞集落化三次元枠組み。 22.間質細胞が臍帯細胞または臍帯血由来の骨髄細胞である、請求項19に記載の 生存間質細胞集落化三次元枠組み。 23.枠組みをエチレンオキシドで処理する、請求項19に記載の生存間質細胞集落 化三次元枠組み。 24.枠組みを電子ビームで処理する、請求項19に記載の生存間質細胞集落化三次 元枠組み。 25.枠組みが生物分解性の物質から構成される、請求項19に記載の生存間質細胞 集落化三次元枠組み。 26.生物分解性の物質がポリグリコール酸、綿、ガット(腸線)縫合糸、セルロ ース、ゼラチン、コラーゲンまたはポリヒドロキシアルカノエートである、請 求項19に記載の生存間質細胞集落化三次元枠組み。 27.枠組みが非生物分解性の物質から構成される、請求項19に記載の生存間質細 胞集落化三次元枠組み。 28.非生物分解性の物質がポリアミド、ポリエステル、ポリスチレン、ポリプロ ピレン、ポリアクリレート、ポリビニル、ポリカーボネート、ポリテトラフル オロエチレン、またはニトロセルロース化合物である、請求項19に記載の生存 間質細胞集落化三次元枠組み。 29.枠組みがメッシュである、請求項19に記載の生存間質細胞集落化三次元枠組 み。 30.間質細胞が軟骨前駆細胞、繊維芽細胞、繊維芽細胞様細胞、筋肉細胞、臍帯 細胞、または臍帯血由来の骨髄細胞を含む、請求項19に記載の生存間質細胞集 落化三次元枠組み。
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US25409694A | 1994-06-06 | 1994-06-06 | |
US08/463,566 US5902741A (en) | 1986-04-18 | 1995-06-05 | Three-dimensional cartilage cultures |
US08/463,566 | 1995-06-05 | ||
US08/254,096 | 1995-06-05 | ||
PCT/US1995/007296 WO1995033821A1 (en) | 1994-06-06 | 1995-06-06 | Three-dimensional cartilage cultures |
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JP2002502226A true JP2002502226A (ja) | 2002-01-22 |
JP3599341B2 JP3599341B2 (ja) | 2004-12-08 |
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JP50130896A Expired - Fee Related JP3599341B2 (ja) | 1994-06-06 | 1995-06-06 | 三次元軟骨培養物 |
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US (2) | US5902741A (ja) |
EP (1) | EP0812351A4 (ja) |
JP (1) | JP3599341B2 (ja) |
AU (1) | AU689605B2 (ja) |
CA (1) | CA2192064A1 (ja) |
IL (1) | IL114017A0 (ja) |
NZ (1) | NZ288467A (ja) |
WO (1) | WO1995033821A1 (ja) |
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JP2015524343A (ja) * | 2012-08-10 | 2015-08-24 | アドヴァンスド メディカル テクノロジーズ エルエルシーAdvanced Medical Technologies Llc | 線維芽細胞からのエクスビボ軟骨生成 |
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Also Published As
Publication number | Publication date |
---|---|
EP0812351A4 (en) | 1998-07-08 |
AU689605B2 (en) | 1998-04-02 |
US5902741A (en) | 1999-05-11 |
EP0812351A1 (en) | 1997-12-17 |
US5962325A (en) | 1999-10-05 |
WO1995033821A1 (en) | 1995-12-14 |
IL114017A0 (en) | 1995-11-27 |
CA2192064A1 (en) | 1995-12-14 |
JP3599341B2 (ja) | 2004-12-08 |
AU2769695A (en) | 1996-01-04 |
NZ288467A (en) | 1998-10-28 |
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