JP2002226399A5 - - Google Patents
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- JP2002226399A5 JP2002226399A5 JP2001401899A JP2001401899A JP2002226399A5 JP 2002226399 A5 JP2002226399 A5 JP 2002226399A5 JP 2001401899 A JP2001401899 A JP 2001401899A JP 2001401899 A JP2001401899 A JP 2001401899A JP 2002226399 A5 JP2002226399 A5 JP 2002226399A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- polymer
- medicament
- paclitaxel
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 8
- 229940044684 anti-microtubule agent Drugs 0.000 claims 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 208000031737 Tissue Adhesions Diseases 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003961 penetration enhancing agent Substances 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical group C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 229920000428 triblock copolymer Polymers 0.000 claims 1
Claims (21)
- 外科的接着の処置または予防のための医薬の製造のための抗微小管剤の使用であって、ここで、該医薬は、該外科的接着が処置または予防されるような、治療有効量の該抗微小管剤を患者に投与するために適合される、使用。
- 前記抗微小管剤がタキサンである、請求項1に記載の使用。
- 前記抗微小管剤がパクリタキセル、またはそのアナログ、もしくは誘導体である、請求項2に記載の使用。
- 前記パクリタキセル、またはそのアナログ、もしくは誘導体が、パクリタキセルである、請求項1に記載の使用。
- 前記抗微小管剤がドセタキセルである、請求項2に記載の使用。
- 前記薬剤がさらにポリマーを含む、請求項1〜5のいずれか1項に記載の使用。
- 前記ポリマーが乳酸およびグリコール酸のコポリマーを含む、請求項6に記載の使用。
- 前記ポリマーがポリ(カプロラクトン)である、請求項6に記載の使用。
- 前記ポリマーがポリ(乳酸)である、請求項6に記載の使用。
- 前記ポリマーがポリ(乳酸)およびポリ(カプロラクトン)のコポリマーを含む、請求項6に記載の使用。
- 前記ポリマーがポリエチレングリコールである、請求項6に記載の使用。
- 前記ポリマーがエチレン酢酸ビニルである、請求項6に記載の使用。
- 前記薬剤が、透過増強剤とともに処方される、請求項1〜12のいずれか1項に記載の使用。
- 前記透過増強剤がイソプロピルミリステートである、請求項13に記載の使用。
- 前記薬剤がさらにグリコールを含む、請求項1〜14のいずれか1項に記載の使用。
- 前記グリコールがエトキシジグリコールである、請求項15に記載の使用。
- 前記ポリマーがジブロックコポリマーまたはトリブロックコポリマーである、請求項6に記載の使用。
- 前記パクリタキセル、またはそのアナログ、もしくは誘導体が、0.5重量%〜20重量%のそのような組成物を含む、請求項6に記載の使用。
- 前記薬剤または組成物が、ペースト、フィルム、またはパッケージとして送達される、請求項1〜18のいずれか1項に記載の使用。
- 前記薬剤または組成物が、スプレーとして送達される、請求項1〜19のいずれか1項に記載の使用。
- 前記薬剤または組成物が、外科インプラントの表面に適用される、請求項1〜20のいずれか1項に記載の使用。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3221596P | 1996-12-02 | 1996-12-02 | |
US60/032,215 | 1996-12-02 | ||
US6308797P | 1997-10-24 | 1997-10-24 | |
US60/063,087 | 1997-10-24 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52499798A Division JP3287852B2 (ja) | 1996-12-02 | 1997-12-02 | 炎症性疾患を処置または予防するための組成物および方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009057154A Division JP2009161555A (ja) | 1996-12-02 | 2009-03-10 | 炎症性疾患を処置または予防するための組成物および方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002226399A JP2002226399A (ja) | 2002-08-14 |
JP2002226399A5 true JP2002226399A5 (ja) | 2005-10-13 |
Family
ID=26708132
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52499798A Expired - Fee Related JP3287852B2 (ja) | 1996-12-02 | 1997-12-02 | 炎症性疾患を処置または予防するための組成物および方法 |
JP2001401899A Withdrawn JP2002226399A (ja) | 1996-12-02 | 2001-12-28 | 炎症性疾患を処置または予防するための組成物および方法 |
JP2009057154A Pending JP2009161555A (ja) | 1996-12-02 | 2009-03-10 | 炎症性疾患を処置または予防するための組成物および方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52499798A Expired - Fee Related JP3287852B2 (ja) | 1996-12-02 | 1997-12-02 | 炎症性疾患を処置または予防するための組成物および方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009057154A Pending JP2009161555A (ja) | 1996-12-02 | 2009-03-10 | 炎症性疾患を処置または予防するための組成物および方法 |
Country Status (21)
Country | Link |
---|---|
US (1) | US6515016B2 (ja) |
EP (5) | EP1070502B1 (ja) |
JP (3) | JP3287852B2 (ja) |
KR (2) | KR100809304B1 (ja) |
CN (4) | CN1679937A (ja) |
AR (1) | AR013878A1 (ja) |
AT (4) | ATE241977T1 (ja) |
AU (1) | AU735655B2 (ja) |
BR (1) | BR9713673A (ja) |
CA (2) | CA2273240C (ja) |
DE (4) | DE69704877T2 (ja) |
DK (1) | DK0941089T3 (ja) |
ES (2) | ES2157601T3 (ja) |
GR (1) | GR3036364T3 (ja) |
HK (3) | HK1022270A1 (ja) |
NO (2) | NO322610B1 (ja) |
NZ (5) | NZ538260A (ja) |
PT (1) | PT941089E (ja) |
RU (2) | RU2242974C2 (ja) |
TW (1) | TW562674B (ja) |
WO (1) | WO1998024427A2 (ja) |
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1997
- 1997-12-01 US US08/980,549 patent/US6515016B2/en not_active Expired - Fee Related
- 1997-12-02 CA CA002273240A patent/CA2273240C/en not_active Expired - Fee Related
- 1997-12-02 AT AT00123557T patent/ATE241977T1/de not_active IP Right Cessation
- 1997-12-02 ES ES97945697T patent/ES2157601T3/es not_active Expired - Lifetime
- 1997-12-02 RU RU99114020/14A patent/RU2242974C2/ru not_active IP Right Cessation
- 1997-12-02 EP EP00123557A patent/EP1070502B1/en not_active Expired - Lifetime
- 1997-12-02 PT PT97945697T patent/PT941089E/pt unknown
- 1997-12-02 EP EP97945697A patent/EP0941089B1/en not_active Expired - Lifetime
- 1997-12-02 WO PCT/CA1997/000910 patent/WO1998024427A2/en active IP Right Grant
- 1997-12-02 DE DE69704877T patent/DE69704877T2/de not_active Expired - Fee Related
- 1997-12-02 DE DE69724016T patent/DE69724016T2/de not_active Expired - Lifetime
- 1997-12-02 EP EP05011601A patent/EP1582210B1/en not_active Expired - Lifetime
- 1997-12-02 DK DK97945697T patent/DK0941089T3/da active
- 1997-12-02 BR BR9713673-5A patent/BR9713673A/pt not_active Application Discontinuation
- 1997-12-02 NZ NZ538260A patent/NZ538260A/en not_active IP Right Cessation
- 1997-12-02 JP JP52499798A patent/JP3287852B2/ja not_active Expired - Fee Related
- 1997-12-02 ES ES00123534T patent/ES2207451T3/es not_active Expired - Lifetime
- 1997-12-02 TW TW086118104A patent/TW562674B/zh not_active IP Right Cessation
- 1997-12-02 NZ NZ552215A patent/NZ552215A/en not_active IP Right Cessation
- 1997-12-02 KR KR1019997004880A patent/KR100809304B1/ko not_active IP Right Cessation
- 1997-12-02 AT AT00123534T patent/ATE246500T1/de not_active IP Right Cessation
- 1997-12-02 NZ NZ336094A patent/NZ336094A/en unknown
- 1997-12-02 CN CNA2005100547705A patent/CN1679937A/zh active Pending
- 1997-12-02 CN CNB97181581XA patent/CN1200706C/zh not_active Expired - Fee Related
- 1997-12-02 DE DE69722681T patent/DE69722681T2/de not_active Expired - Lifetime
- 1997-12-02 CN CN200610099927.0A patent/CN101011576B/zh not_active Expired - Fee Related
- 1997-12-02 CN CNA2006100998954A patent/CN101195028A/zh active Pending
- 1997-12-02 AU AU51132/98A patent/AU735655B2/en not_active Ceased
- 1997-12-02 EP EP00123534A patent/EP1092433B1/en not_active Expired - Lifetime
- 1997-12-02 DE DE69739761T patent/DE69739761D1/de not_active Expired - Lifetime
- 1997-12-02 AR ARP970105661A patent/AR013878A1/es not_active Application Discontinuation
- 1997-12-02 EP EP00123537A patent/EP1090637A3/en not_active Withdrawn
- 1997-12-02 AT AT97945697T patent/ATE201138T1/de not_active IP Right Cessation
- 1997-12-02 AT AT05011601T patent/ATE457170T1/de not_active IP Right Cessation
- 1997-12-02 NZ NZ547206A patent/NZ547206A/en not_active IP Right Cessation
- 1997-12-02 NZ NZ512097A patent/NZ512097A/en unknown
- 1997-12-02 KR KR1020057018245A patent/KR20050098031A/ko not_active Application Discontinuation
- 1997-12-02 CA CA002607067A patent/CA2607067A1/en not_active Abandoned
-
1999
- 1999-06-01 NO NO19992641A patent/NO322610B1/no not_active IP Right Cessation
-
2000
- 2000-02-28 HK HK00101207A patent/HK1022270A1/xx not_active IP Right Cessation
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2001
- 2001-06-12 HK HK01104005A patent/HK1033422A1/xx not_active IP Right Cessation
- 2001-08-10 GR GR20010401220T patent/GR3036364T3/el not_active IP Right Cessation
- 2001-10-18 HK HK01107305A patent/HK1037320A1/xx not_active IP Right Cessation
- 2001-12-28 JP JP2001401899A patent/JP2002226399A/ja not_active Withdrawn
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2004
- 2004-09-03 RU RU2004126705/14A patent/RU2004126705A/ru unknown
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2006
- 2006-08-15 NO NO20063667A patent/NO20063667L/no not_active Application Discontinuation
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2009
- 2009-03-10 JP JP2009057154A patent/JP2009161555A/ja active Pending
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