JP2005510505A5 - - Google Patents
Info
- Publication number
- JP2005510505A5 JP2005510505A5 JP2003539722A JP2003539722A JP2005510505A5 JP 2005510505 A5 JP2005510505 A5 JP 2005510505A5 JP 2003539722 A JP2003539722 A JP 2003539722A JP 2003539722 A JP2003539722 A JP 2003539722A JP 2005510505 A5 JP2005510505 A5 JP 2005510505A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- peroxide
- amount
- vaginal
- source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 58
- 150000002978 peroxides Chemical class 0.000 claims 23
- 238000009472 formulation Methods 0.000 claims 8
- 239000000227 bioadhesive Substances 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 230000002459 sustained Effects 0.000 claims 7
- AQLJVWUFPCUVLO-UHFFFAOYSA-N Hydrogen peroxide - urea Chemical group OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims 6
- 229940078916 carbamide peroxide Drugs 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 210000001215 Vagina Anatomy 0.000 claims 5
- 230000002195 synergetic Effects 0.000 claims 5
- 229950005134 Polycarbophil Drugs 0.000 claims 4
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 230000001954 sterilising Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Claims (35)
- ペルオキサイドのソース及び生体接着性持続的放出性処方物を含む薬学的膣組成物であって、患者へ局所投与したときに膣における酸素濃度を高めるのに十分な量で少なくとも１２時間の間ペルオキサイドを放出し且つ膣のｐＨを治療的に低下させ、膣の滅菌又は正常に望ましい局所的な膣フローラの有意な殺傷を起こさないように処方される、組成物。
- 前記相乗作用ミックスが少なくとも２４時間の間ペルオキサイドを放出する、請求項１に記載の組成物。
- 前記持続的放出性処方物が、生体接着性で水膨潤性で水不溶性の架橋されたポリカルボキシリックポリマー（ｐｏｌｙｃａｒｂｏｘｙｌｉｃ ｐｏｌｙｍｅｒ）を含む請求項２に記載の組成物。
- 前記ポリマーがポリカルボフィル（ｐｏｌｙｃａｒｂｏｐｈｉｌ）である、請求項３に記載の組成物。
- ペルオキサイドソースが約０．０１ｍｇ〜約５００ｍｇの量で存在する、請求項２に記載の組成物。
- ペルオキサイドソースが約０．１ｍｇ〜約７５ｍｇの量で存在する、請求項４に記載の組成物。
- ペルオキサイドソースがカルバミドペルオキサイド（ｃａｒｂａｍｉｄｅ ｐｅｒｏｘｉｄｅ）である、請求項２に記載の組成物。
- カルバミドペルオキサイドが、約０．０１重量％〜約１５重量％の量で存在する、請求項７に記載の組成物。
- ポリマーがポリカルボフィルである、請求項８に記載の組成物。
- カルバミドペルオキサイドが、約０．１％〜約０．２５％の量である、請求項９に記載の組成物。
- 組成物が１用量当たり約１ｇ〜約２ｇの量で投与されるように処方される、単一投薬形態における、請求項１０に記載の組成物。
- 相乗作用ミックスが少なくとも４８時間の間ペルオキサイドを放出する、請求項２に記載の組成物。
- 相乗作用ミックスが少なくとも７２時間の間ペルオキサイドを放出する、請求項３に記載の組成物。
- 組成物中のペルオキサイド量が０．００３５ｍｇ〜３５０ｍｇである、請求項２に記載の組成物。
- ペルオキサイド量が０．０１ｍｇ〜１００ｍｇである、請求項１４に記載の組成物。
- ペルオキサイドのソース及び生体接着性持続的放出性処方物を含む薬学的膣組成物であって、該組成物は患者へ局所投与したときに１時間当たり０．１重量％より少ない量でペルオキサイドを放出し且つ膣のｐＨを治療的に低下させ、膣の滅菌又は正常に望ましい局所的な膣フローラの有意な殺傷を起こさないように処方される、組成物。
- 前記持続的放出性処方物が、生体接着性で水膨潤性で水不溶性の架橋されたポリカルボキシリックポリマーを含む請求項１６に記載の組成物。
- 前記ポリマーがポリカルボフィルである、請求項１７に記載の組成物。
- ペルオキサイドソースが約０．０１ｍｇ〜約５００ｍｇの量で存在する、請求項１８に記載の組成物。
- ペルオキサイドソースが約０．１ｍｇ〜約７５ｍｇの量で存在する、請求項１９に記載の組成物。
- 前記組成物が、１用量当たり約１ｇ〜約２．５ｇの量で投与されるように処方され且つ該組成物中のペルオキサイド量が約０．０１ｍｇ〜約１００ｍｇである、単一投薬形態における、請求項２０に記載の組成物。
- ペルオキサイド量が約０．１〜約７５ｍｇである、請求項２１に記載の組成物。
- ペルオキサイドソースがカルバミドペルオキサイドである、請求項１６に記載の組成物。
- カルバミドペルオキサイドが、約０．０１重量％〜約１５重量％の量で存在する、請求項２３に記載の組成物。
- 相乗作用ミックスが少なくとも２４時間の間ペルオキサイドを放出する、請求項１７に記載の組成物。
- 相乗作用ミックスが少なくとも４８時間の間ペルオキサイドを放出する、請求項１８に記載の組成物。
- ペルオキサイドのソース及び生体接着性持続的放出性処方物を含む薬学的膣組成物であって、該組成物は０．１重量％より少ないペルオキサイドを含み且つ患者へ局所投与したときに膣における酸素濃度を治療的に増大し且つ膣のｐＨを治療的に低下させ、膣の滅菌又は正常に望ましい局所的な膣フローラの有意な殺傷を起こさないように処方される、組成物。
- 前記持続的放出性処方物が、生体接着性で水膨潤性で水不溶性の架橋されたポリカルボキシリックポリマーを含む請求項２７に記載の組成物。
- 前記ポリマーがポリカルボフィルである、請求項２８に記載の組成物。
- ペルオキサイドソースがカルバミドペルオキサイドである、請求項２９に記載の組成物。
- ペルオキサイドが、約０．０３４重量％〜約０．０８５重量％の量である、請求項３０に記載の組成物。
- 前記組成物が、単一投薬当たり約１ｇ〜約２．５ｇの量で投与されるように処方される、投薬形態における、請求項２７に記載の組成物。
- 処方物におけるペルオキサイド量が、０．０１ｍｇ〜１００ｍｇである、請求項２７に記載の組成物。
- ペルオキサイドのソース及び生体接着性持続的放出性処方物が相乗作用有効量で存在する、請求項１、１６又は２７に記載の組成物。
- 請求項１〜３４のいずれか１項に記載の組成物を含む、膣感染の処置又は予防のための薬剤（agent）。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33068301P | 2001-10-29 | 2001-10-29 | |
| US60/330,683 | 2001-10-29 | ||
| US10/278,910 | 2002-10-24 | ||
| US10/278,910 US7709026B2 (en) | 2001-10-29 | 2002-10-24 | Low concentration of peroxide for treating or preventing vaginal infections |
| PCT/EP2002/012043 WO2003037382A1 (en) | 2001-10-29 | 2002-10-28 | Low concentration of peroxide for treating or preventing vaginal infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010152148A Division JP2010248232A (ja) | 2001-10-29 | 2010-07-02 | 膣感染を処置又は予防するための低濃度のペルオキサイド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005510505A JP2005510505A (ja) | 2005-04-21 |
| JP2005510505A5 true JP2005510505A5 (ja) | 2005-12-22 |
| JP5153049B2 JP5153049B2 (ja) | 2013-02-27 |
Family
ID=26959335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003539722A Expired - Fee Related JP5153049B2 (ja) | 2001-10-29 | 2002-10-28 | 膣感染を処置又は予防するための低濃度のペルオキサイド |
| JP2010152148A Pending JP2010248232A (ja) | 2001-10-29 | 2010-07-02 | 膣感染を処置又は予防するための低濃度のペルオキサイド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010152148A Pending JP2010248232A (ja) | 2001-10-29 | 2010-07-02 | 膣感染を処置又は予防するための低濃度のペルオキサイド |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7709026B2 (ja) |
| EP (1) | EP1441769B1 (ja) |
| JP (2) | JP5153049B2 (ja) |
| KR (1) | KR101009146B1 (ja) |
| CN (1) | CN1578676A (ja) |
| AR (1) | AR037047A1 (ja) |
| AT (1) | ATE297222T1 (ja) |
| AU (1) | AU2002346897B2 (ja) |
| BR (1) | BR0213584A (ja) |
| CA (1) | CA2465133C (ja) |
| DE (1) | DE60204584T2 (ja) |
| DK (1) | DK1441769T3 (ja) |
| ES (1) | ES2243772T3 (ja) |
| HK (1) | HK1063290A1 (ja) |
| HR (1) | HRP20040480B1 (ja) |
| HU (1) | HU229487B1 (ja) |
| IL (2) | IL161512A0 (ja) |
| MA (1) | MA26289A1 (ja) |
| ME (1) | MEP34608A (ja) |
| MX (1) | MXPA04003977A (ja) |
| MY (1) | MY137791A (ja) |
| NO (1) | NO20042199L (ja) |
| NZ (1) | NZ532294A (ja) |
| PE (1) | PE20030492A1 (ja) |
| PL (2) | PL216746B1 (ja) |
| PT (1) | PT1441769E (ja) |
| RS (1) | RS51154B (ja) |
| RU (1) | RU2329829C2 (ja) |
| SI (1) | SI1441769T1 (ja) |
| WO (1) | WO2003037382A1 (ja) |
| ZA (1) | ZA200402943B (ja) |
Families Citing this family (16)
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| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| CH697081A5 (de) * | 2002-01-22 | 2008-04-30 | Andreas F Dr Schaub | Zusammensetzung für die Unterstützung der Geburt eines menschlichen Föten. |
| US20040126369A1 (en) * | 2002-12-30 | 2004-07-01 | Richard Payne | Delivery of peroxide-generating enzymes to the vaginal tract |
| DE10328942A1 (de) * | 2003-06-27 | 2005-01-27 | Lts Lohmann Therapie-Systeme Ag | Transmukosale Darreichungsformen mit verminderter Schleimhautirritation |
| ES2237298B1 (es) * | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
| US20050276865A1 (en) * | 2004-05-20 | 2005-12-15 | Servet Buyuktimkin | Peroxide compounds for the prevention and treatment of sexual dysfunction in humans |
| DE102004054552A1 (de) * | 2004-11-11 | 2006-05-18 | Hcb Happy Child Birth Holding Ag | Neue Zusammensetzung zur Erleichterung der Humangeburt |
| ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
| US10383894B2 (en) * | 2010-03-17 | 2019-08-20 | Lutran Industries, Inc. | Human medicinal treatment using salt of peroxymonosulfuric acid |
| US20120074014A1 (en) * | 2010-09-27 | 2012-03-29 | Lutran Industries, Inc. | Product typically based on salt of peroxymonosulfuric acid and suitable for medicinal usage, and associated product fabrication |
| GB201108879D0 (en) * | 2011-05-25 | 2011-07-06 | Isis Innovation | Vector |
| US9895311B2 (en) | 2014-09-25 | 2018-02-20 | Pharmiva Ab | Foam-forming compositions and methods for delivering an active to a body cavity |
| US20180280340A1 (en) * | 2017-03-30 | 2018-10-04 | Konstantin Zubovskiy | Method of treating and preventing infections |
| JP7364556B2 (ja) | 2017-05-23 | 2023-10-18 | ファーミバ アーベー | 体腔に活性物質を送達するための泡形成性組成物 |
| CN113164384A (zh) * | 2018-10-26 | 2021-07-23 | 维拉莫有限公司 | 黏膜粘附性凝胶组合物 |
| US11850303B2 (en) * | 2020-10-27 | 2023-12-26 | Uqora, Inc. | Gel and a suppository and methods to provide the gel and suppository |
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-
2002
- 2002-10-24 US US10/278,910 patent/US7709026B2/en not_active Expired - Lifetime
- 2002-10-28 PL PL369725A patent/PL216746B1/pl not_active IP Right Cessation
- 2002-10-28 NZ NZ532294A patent/NZ532294A/en not_active IP Right Cessation
- 2002-10-28 ES ES02783026T patent/ES2243772T3/es not_active Expired - Lifetime
- 2002-10-28 IL IL16151202A patent/IL161512A0/xx unknown
- 2002-10-28 EP EP02783026A patent/EP1441769B1/en not_active Expired - Lifetime
- 2002-10-28 AT AT02783026T patent/ATE297222T1/de active
- 2002-10-28 PE PE2002001057A patent/PE20030492A1/es not_active Application Discontinuation
- 2002-10-28 HU HU0401672A patent/HU229487B1/hu unknown
- 2002-10-28 CA CA2465133A patent/CA2465133C/en not_active Expired - Lifetime
- 2002-10-28 JP JP2003539722A patent/JP5153049B2/ja not_active Expired - Fee Related
- 2002-10-28 WO PCT/EP2002/012043 patent/WO2003037382A1/en active IP Right Grant
- 2002-10-28 PT PT02783026T patent/PT1441769E/pt unknown
- 2002-10-28 DE DE60204584T patent/DE60204584T2/de not_active Expired - Lifetime
- 2002-10-28 DK DK02783026T patent/DK1441769T3/da active
- 2002-10-28 BR BR0213584-1A patent/BR0213584A/pt not_active Application Discontinuation
- 2002-10-28 ME MEP-346/08A patent/MEP34608A/xx unknown
- 2002-10-28 RU RU2004116312/15A patent/RU2329829C2/ru not_active IP Right Cessation
- 2002-10-28 KR KR1020047006272A patent/KR101009146B1/ko not_active IP Right Cessation
- 2002-10-28 MX MXPA04003977A patent/MXPA04003977A/es active IP Right Grant
- 2002-10-28 AR ARP020104078A patent/AR037047A1/es not_active Application Discontinuation
- 2002-10-28 CN CNA028215664A patent/CN1578676A/zh active Pending
- 2002-10-28 SI SI200230172T patent/SI1441769T1/sl unknown
- 2002-10-28 RS YUP-366/04A patent/RS51154B/sr unknown
- 2002-10-28 AU AU2002346897A patent/AU2002346897B2/en not_active Ceased
- 2002-10-28 PL PL402550A patent/PL402550A1/pl not_active Application Discontinuation
- 2002-10-28 MY MYPI20024019A patent/MY137791A/en unknown
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2004
- 2004-04-19 IL IL161512A patent/IL161512A/en not_active IP Right Cessation
- 2004-04-19 ZA ZA2004/02943A patent/ZA200402943B/en unknown
- 2004-04-29 MA MA27664A patent/MA26289A1/fr unknown
- 2004-05-26 NO NO20042199A patent/NO20042199L/no not_active Application Discontinuation
- 2004-05-27 HR HR20040480A patent/HRP20040480B1/xx not_active IP Right Cessation
- 2004-08-12 HK HK04106057A patent/HK1063290A1/xx not_active IP Right Cessation
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2010
- 2010-07-02 JP JP2010152148A patent/JP2010248232A/ja active Pending
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