RU2004126705A - Композиции и способы лечения или предупреждения воспалительных заболеваний - Google Patents
Композиции и способы лечения или предупреждения воспалительных заболеваний Download PDFInfo
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- RU2004126705A RU2004126705A RU2004126705/14A RU2004126705A RU2004126705A RU 2004126705 A RU2004126705 A RU 2004126705A RU 2004126705/14 A RU2004126705/14 A RU 2004126705/14A RU 2004126705 A RU2004126705 A RU 2004126705A RU 2004126705 A RU2004126705 A RU 2004126705A
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- agent
- antimicrotubule agent
- antimicrotubule
- treating
- discodermolide
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- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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Claims (34)
1. Способ лечения или предупреждения рассеянного склероза, включающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что рассеянный склероз лечится или предупреждается.
2. Способ по п.1, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из эпотилона А или В, дискодермолида, оксида дейтерия (D2O), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
3. Способ по п.1, в котором вышеуказанный антимикротрубочковый агент является паклитакселом или его аналогом или производным.
4. Способ лечения или предупреждения псориаза, включающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что псориаз лечится или предупреждается.
5. Способ по п.4, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из эпотилона А или В, дискодермолида, оксида дейтерия (D2О), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
6. Способ по п.5, в котором вышеуказанный антимикротрубочковый агент вводят локально.
7. Способ лечения или предупреждения артрита, включающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что артрит лечится или предупреждается, при условии, что вышеуказанный антимикротрубочковый агент не является паклитакселом или его аналогом или производным.
8. Способ по п.7, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из эпотилона А или В, дискодермолида, оксида дейтерия (D2О), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
9. Способ по п.7, в котором вышеуказанный антимикротрубочковый агент вводят системно или внутрисуставно.
10. Способ лечения стеноза, включающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что стеноз лечится или предупреждается, при условии, что вышеуказанный антимикротрубочковый агент не является паклитакселом или его аналогом или производным.
11. Способ по п.10, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из эпотилона А или В, дискодермолида, оксида дейтерия (D2O), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
12. Способ по п.10, в котором вышеуказанный антимикротрубочковый агент вводят системно или периваскулярно.
13. Способ по п.10, в котором вышеуказанный антимикротрубочковый агент вводят в виде покрытия на медицинском устройстве.
14. Способ по п.13, в котором вышеуказанное медицинское устройство представляет собой стент, стент-трансплантат, сосудистый трансплантат или постоянный катетер.
15. Способ по п.10, в котором вышеуказанный антимикротрубочковый агент вводят через эндолюминальное устройство.
16. Способ лечения отторжения трансплантата, включающий введение пациенту антимикротрубочкового агента.
17. Способ по п.16, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из паклитаксела, эпотилона А или В, дискодермолида, оксида дейтерия (D2О), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
18. Способ лечения или предупреждения хирургических спаек, предусматривающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что хирургические спайки лечатся или предупреждаются, при условии, что вышеуказанный антимикротрубочковый агент не является паклитакселом или его аналогом или производным.
19. Способ по п.18, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из эпотилона А или В, дискодермолида, оксида дейтерия (D2О), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
20. Способ лечения или предупреждения воспалительного заболевания кишечника, включающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что воспалительное заболевание кишечника лечится или предупреждается.
21. Способ по п.20, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из паклитаксела, эпотилона А или В, дискодермолида, оксида дейтерия (D2O), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этилового эфира глицина, а также их аналогов или производных.
22. Способ лечения или предупреждения хронической воспалительной болезни легких, включающий введение пациенту терапевтически эффективного количества антимикротрубочкового агента таким образом, что назальные полипы лечатся или предупреждаются.
23. Способ по п.20, в котором вышеуказанный антимикротрубочковый агент выбран из группы, состоящей из паклитаксела, эпотилона А или В, дискодермолида, оксида дейтерия (D2O), гексиленгликоля, туберцидина, LY290181, фторида алюминия, бис(сукцинимидилсукцината)этиленгликоля, этиловогоэфира глицина, а также их аналогов или производных.
24. Способ по п.22, в котором вышеуказанный антимикротрубочковый агент вводят назально.
25. Способ по любому из пп.1, 4, 6, 8, 14 или 16, в котором вышеуказанный агент дополнительно содержит полимер.
26. Способ по п.25, в котором вышеуказанный полимер образован в виде микросфер, имеющих средний размер между 0,5 и 200 мкм.
27. Способ по п.25, в котором вышеуказанный полимер является сополимером молочной кислоты и гликолевой кислоты.
28. Способ по п.25, в котором вышеуказанный полимер содержит поли(капролактон).
29. Способ по п.25, в котором вышеуказанный полимер содержит поли(молочную кислоту).
30. Способ по п.25, в котором вышеуказанный полимер представляет собой сополимер поли(молочной кислоты) и поли(капролактона ).
31. Способ по п.25, в котором вышеуказанный полимер содержит этиленвинилацетат.
32. Способ по п.25, в котором вышеуказанный полимер содержит изопропилмиристат.
33. Способ по п.25, в котором вышеуказанный полимер содержит Транскутол®.
34. Способ по п.25, в котором вышеуказанный полимер является диблок- или триблок-сополимером.
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RU99114020/14A RU2242974C2 (ru) | 1996-12-02 | 1997-12-02 | Композиции и способы лечения или предупреждения воспалительных заболеваний |
RU2004126705/14A RU2004126705A (ru) | 1996-12-02 | 2004-09-03 | Композиции и способы лечения или предупреждения воспалительных заболеваний |
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RU99114020/14A RU2242974C2 (ru) | 1996-12-02 | 1997-12-02 | Композиции и способы лечения или предупреждения воспалительных заболеваний |
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US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
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