HUP0002012A2 - Dezferriexochelin alkalmazása ateroszklerózis és érfalkárosodás kezelésére szolgáló gyógyszerkészítmények előállítására - Google Patents
Dezferriexochelin alkalmazása ateroszklerózis és érfalkárosodás kezelésére szolgáló gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0002012A2 HUP0002012A2 HU0002012A HUP0002012A HUP0002012A2 HU P0002012 A2 HUP0002012 A2 HU P0002012A2 HU 0002012 A HU0002012 A HU 0002012A HU P0002012 A HUP0002012 A HU P0002012A HU P0002012 A2 HUP0002012 A2 HU P0002012A2
- Authority
- HU
- Hungary
- Prior art keywords
- desferriexochelin
- exochelins
- atherosclerosis
- smooth muscle
- preparation
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title abstract 3
- 208000024248 Vascular System injury Diseases 0.000 title 1
- 208000012339 Vascular injury Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108010013932 exochelins Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 208000037803 restenosis Diseases 0.000 abstract 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 208000031481 Pathologic Constriction Diseases 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000009931 harmful effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 208000037804 stenosis Diseases 0.000 abstract 1
- 230000036262 stenosis Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000003966 vascular damage Effects 0.000 abstract 1
- 238000007631 vascular surgery Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgya eljárás (módszer) ateroszklerózis és vaszkuláriskárosodás kezelésére exochelinek - különösen a Mycobacteriumtuberculosisból származó exochelinek - alkalmazásával, amelyek avaszkuláris simaizom-sejtek szaporodását gátolják. Egy élőszervezetben az érplasztikát és érsebészi műveletet követő resztenózis(ismételt szűkület) megakadályozható, ha a sebészi művelet helyéreorálisan, intravénásan vagy közvetlen úton dezferriexochelinek hatásosmennyiségét adagolják, mivel a dezferriexochelin megakadályozza vagylassítja a resztenózist előidéző simaizomsejt-szaporodást. Ennekalapján módszer alakítható ki ateroszklerózis, szisztémás magasvérnyomás, az érfalra kifejtett káros sugárhatás, valamint bypassvezetékek sztenózisának vagy elzáródásának a megakadályozására. Azexochelinek előnyös hatásának fő oka abban áll, hogy a jelenlegalkalmazott szerekkel ellentétben lipidekben oldhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/796,791 US5786326A (en) | 1995-02-03 | 1997-02-06 | Method for the treatment of atherosclerosis and vascular injury by prevention of vascular smooth muscle cell proliferation |
| PCT/US1998/002553 WO1998034619A1 (en) | 1997-02-06 | 1998-02-06 | Method for the treatment of atherosclerosis and vascular injury by prevention of vascular smooth muscle cell proliferation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002012A2 true HUP0002012A2 (hu) | 2000-11-28 |
| HUP0002012A3 HUP0002012A3 (en) | 2002-09-30 |
Family
ID=25169069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002012A HUP0002012A3 (en) | 1997-02-06 | 1998-02-06 | Use of desferriexochelin for the preparation of pharmaceutical compositions treating atherosclerosis and vascular injury |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5786326A (hu) |
| EP (1) | EP1021189B1 (hu) |
| JP (1) | JP2001512444A (hu) |
| KR (1) | KR20000070462A (hu) |
| CN (1) | CN1246796A (hu) |
| AT (1) | ATE216888T1 (hu) |
| AU (1) | AU719986B2 (hu) |
| CA (1) | CA2277022A1 (hu) |
| DE (1) | DE69805199T2 (hu) |
| EA (1) | EA001870B1 (hu) |
| HU (1) | HUP0002012A3 (hu) |
| PL (1) | PL335046A1 (hu) |
| WO (1) | WO1998034619A1 (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6511477B2 (en) * | 1997-03-13 | 2003-01-28 | Biocardia, Inc. | Method of drug delivery to interstitial regions of the myocardium |
| US6423751B1 (en) * | 1998-07-14 | 2002-07-23 | The Brigham And Women's Hospital, Inc. | Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
| US5952492A (en) * | 1998-08-14 | 1999-09-14 | Keystone Biomedical, Inc. | Chemical synthesis of exochelins |
| US6063919A (en) * | 1998-08-14 | 2000-05-16 | Keystone Biomedical, Inc. | Process for the synthesis of exochelins |
| WO2000027386A1 (en) * | 1998-11-11 | 2000-05-18 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of propionylcarnitine for the manufacture of a medicament for inhibiting smooth muscle cell proliferation |
| WO2000027387A1 (en) * | 1998-11-11 | 2000-05-18 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of propionyl l-carnitine for the preparation of a medicament capable of inducing apoptosis |
| US20020127263A1 (en) * | 2001-02-27 | 2002-09-12 | Wenda Carlyle | Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device |
| US6783541B2 (en) | 2001-11-21 | 2004-08-31 | Miravant Medical Technologies, Inc. | Methods for inhibiting or suppressing stenosis of arteriovenous access fistulas and grafts |
| US7798815B2 (en) * | 2002-04-03 | 2010-09-21 | University Of The West Indies | Computer-controlled tissue-based simulator for training in cardiac surgical techniques |
| US7553326B2 (en) | 2003-11-24 | 2009-06-30 | Sweet Richard M | Method and apparatus for preventing dialysis graft intimal hyperplasia |
| GB0526033D0 (en) * | 2005-12-21 | 2006-02-01 | Bioeos Ltd | Method |
| EP2413139B1 (en) * | 2010-07-30 | 2015-05-20 | Universität Leipzig | Method and compositions for the identification of agents that have a potential effect against chronic inflammatory diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2711990B1 (fr) * | 1993-11-05 | 1995-12-08 | Exsymol Sa | Produit pseudodipeptide possédant un groupement imidazole, et applications thérapeutiques, cosmétologiques et agroalimentaires. |
| US5721209A (en) * | 1995-02-03 | 1998-02-24 | The Regents Of The University Of California | Iron chelator and inhibitor of iron-mediated oxidant injury |
-
1997
- 1997-02-06 US US08/796,791 patent/US5786326A/en not_active Expired - Fee Related
-
1998
- 1998-02-06 AU AU63228/98A patent/AU719986B2/en not_active Ceased
- 1998-02-06 WO PCT/US1998/002553 patent/WO1998034619A1/en not_active Application Discontinuation
- 1998-02-06 CN CN98802338A patent/CN1246796A/zh active Pending
- 1998-02-06 PL PL98335046A patent/PL335046A1/xx unknown
- 1998-02-06 JP JP53501098A patent/JP2001512444A/ja active Pending
- 1998-02-06 HU HU0002012A patent/HUP0002012A3/hu unknown
- 1998-02-06 EP EP98907415A patent/EP1021189B1/en not_active Expired - Lifetime
- 1998-02-06 KR KR1019997006700A patent/KR20000070462A/ko not_active Application Discontinuation
- 1998-02-06 EA EA199900724A patent/EA001870B1/ru not_active IP Right Cessation
- 1998-02-06 DE DE69805199T patent/DE69805199T2/de not_active Expired - Fee Related
- 1998-02-06 AT AT98907415T patent/ATE216888T1/de not_active IP Right Cessation
- 1998-02-06 CA CA002277022A patent/CA2277022A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA001870B1 (ru) | 2001-10-22 |
| JP2001512444A (ja) | 2001-08-21 |
| PL335046A1 (en) | 2000-03-27 |
| EP1021189A1 (en) | 2000-07-26 |
| DE69805199D1 (de) | 2002-06-06 |
| DE69805199T2 (de) | 2002-12-12 |
| WO1998034619A1 (en) | 1998-08-13 |
| US5786326A (en) | 1998-07-28 |
| EA199900724A1 (ru) | 2000-02-28 |
| ATE216888T1 (de) | 2002-05-15 |
| HUP0002012A3 (en) | 2002-09-30 |
| CN1246796A (zh) | 2000-03-08 |
| AU6322898A (en) | 1998-08-26 |
| CA2277022A1 (en) | 1998-08-13 |
| KR20000070462A (ko) | 2000-11-25 |
| EP1021189B1 (en) | 2002-05-02 |
| AU719986B2 (en) | 2000-05-18 |
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