GB2246954A - Pharmaceutical anti-infective composition containing metronidazole - Google Patents
Pharmaceutical anti-infective composition containing metronidazole Download PDFInfo
- Publication number
- GB2246954A GB2246954A GB9018039A GB9018039A GB2246954A GB 2246954 A GB2246954 A GB 2246954A GB 9018039 A GB9018039 A GB 9018039A GB 9018039 A GB9018039 A GB 9018039A GB 2246954 A GB2246954 A GB 2246954A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- metronidazole
- steroid
- oral
- skin infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical composition for treating oral and skin infections comprises an anti-inflammatory steroid and metronidazole. Dexamethasone sodium phosphate is the preferred steroid used in the composition. In use, the composition is applied directly onto the infected area in the form of a paste. The composition is particularly suitable for treating dry dental sockets (localised osteoitis), pericoronitis, and for use in peridontal packs.
Description
PHARMACEUTICAL COMPOSITION FOR ORAL AND SKIN INFECTIONS
The invention relates to a pharmaceutical composition which finds particular use in the treatment of oral and skin infections.
Oral infections may arise following dental surgery.
For example, after tooth extraction exposed bone may become infected resulting in dry sockets (localised osteoitis) . A patient with dry sockets would normally be given penicillin tablets to reduce infection. Oral infections may occur simply as a result of tooth decay when soft tissues surrounding an infected tooth become inflamed and painful. An object of the invention is to provide a pharmaceutical composition for treating such infections and skin infections from wounds simply and rapidly.
According to the invention, therefore, a pharmaceutical composition is provided comprising an anti-inflammatory steroid and an anti-bacterial agent, such as metronidazole. Preferably,the steroid is dexamethasone (its acetate or phosphate) and the steroid and metronidazole are present in the composition in weight proportions of 1:102 to 104, preferably 1:500 to 2000, respectively. As an example, 0.5 to 2.0 mg dexamethasone sodium phosphate and 1000 mg metronidazole is used. The ingredients are mixed together with other conventional ingredients, as required, to form a paste of a consistency suitable for direct application to the infected area.
The invention also relates to the use of the composition described above in the treatment of oral and skin infections. In particular, the use of the composition in the treatment of dry sockets, pericoronitis and periodontal packs.
Furthermore, the invention relates to a method of forming a composition for the treatment of oral and skin infections, comprising mixing an anti-inflammatory steroid and metronidazole to a consistency suitable for application onto the infected area.
In use, the composition is applied directly onto the infected area. Within a few minutes after application an improvement is felt by the patient as inflammation and pain are reduced. The combination of dexamethasone and metronidazole have been found to be particularly effective but it is possible that other corticosteroids or corticosteroid analogues with antiinflammatory activity and/or other anti-bacterial agents would also be effective. Moreover, instead of being applied to the infected area in the form of a paste, the composition could be applied in other forms such as a cream, lotion or spray, whichever is most appropriate for the area to be treated.
Claims (7)
1. A pharmaceutical composition for treating oral and skin infections, comprising an anti-inflammatory steroid and metronidazole.
2. A composition according to claim 1, wherein the steroid is dexamethasone.
3. A composition according to claim 1 or claim 2, wherein the steroid and metronidazole are present in weight proportions of 1:500 to 2000, respectively.
4. A composition according to any preceding claim, in the form of a paste for direct application to the infected area.
5. Use of a composition comprising an antiinflammatory steroid and metronidazole in the treatment of oral and skin infections.
6. Use according to claim 5 in the treatment of dry sockets (localised osteoitis), pericoronitis and periodontal packs.
7. A method of forming a composition for the treatment of oral and skin infections comprising mixing together an anti-inflammatory steroid and metronidazo le to a consistency suitable for direct application to the infected area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9018039A GB2246954B (en) | 1990-08-16 | 1990-08-16 | Pharmaceutical compositions comprising metrondiazole and an anti-inflammatory steroid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9018039A GB2246954B (en) | 1990-08-16 | 1990-08-16 | Pharmaceutical compositions comprising metrondiazole and an anti-inflammatory steroid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB9018039D0 GB9018039D0 (en) | 1990-10-03 |
| GB2246954A true GB2246954A (en) | 1992-02-19 |
| GB2246954B GB2246954B (en) | 1994-04-27 |
Family
ID=10680789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9018039A Expired - Fee Related GB2246954B (en) | 1990-08-16 | 1990-08-16 | Pharmaceutical compositions comprising metrondiazole and an anti-inflammatory steroid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2246954B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2446786C1 (en) * | 2011-04-15 | 2012-04-10 | Сергей Владимирович Сирак | Polycomponent tooth paste for deep caries and acute local pulpitis |
-
1990
- 1990-08-16 GB GB9018039A patent/GB2246954B/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2446786C1 (en) * | 2011-04-15 | 2012-04-10 | Сергей Владимирович Сирак | Polycomponent tooth paste for deep caries and acute local pulpitis |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2246954B (en) | 1994-04-27 |
| GB9018039D0 (en) | 1990-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20030816 |