JP2006508127A5 - - Google Patents
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- JP2006508127A5 JP2006508127A5 JP2004551819A JP2004551819A JP2006508127A5 JP 2006508127 A5 JP2006508127 A5 JP 2006508127A5 JP 2004551819 A JP2004551819 A JP 2004551819A JP 2004551819 A JP2004551819 A JP 2004551819A JP 2006508127 A5 JP2006508127 A5 JP 2006508127A5
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- 239000000203 mixture Substances 0.000 claims 48
- 239000003795 chemical substances by application Substances 0.000 claims 31
- 229920000642 polymer Polymers 0.000 claims 25
- 239000002904 solvent Substances 0.000 claims 16
- 238000006065 biodegradation reaction Methods 0.000 claims 9
- -1 polyesteramides Polymers 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- 229920000249 biocompatible polymer Polymers 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 5
- 239000003607 modifier Substances 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 4
- 230000002459 sustained Effects 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical group OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 3
- 239000004310 lactic acid Substances 0.000 claims 3
- 235000014655 lactic acid Nutrition 0.000 claims 3
- 229920000747 poly(lactic acid) polymer Polymers 0.000 claims 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N 2-Pyrrolidone Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N Benzyl benzoate Chemical group C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N Caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N Methyl acetate Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 239000001069 triethyl citrate Substances 0.000 claims 2
- 235000013769 triethyl citrate Nutrition 0.000 claims 2
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-caprolactone Chemical group O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 2
- GUSTUIJJPMXTTI-UHFFFAOYSA-N 1-dodecylazepane Chemical compound CCCCCCCCCCCCN1CCCCCC1 GUSTUIJJPMXTTI-UHFFFAOYSA-N 0.000 claims 1
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- DJHJJVWPFGHIPH-OODMECLYSA-N Chitin Chemical compound O[C@@H]1C(NC(=O)C)[C@H](O)OC(CO)[C@H]1COC[C@H]1C(NC(C)=O)[C@@H](O)[C@H](COC[C@H]2C([C@@H](O)[C@H](O)C(CO)O2)NC(C)=O)C(CO)O1 DJHJJVWPFGHIPH-OODMECLYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- FLKPEMZONWLCSK-UHFFFAOYSA-N Diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 1
- YSAVZVORKRDODB-WDSKDSINSA-N Diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 claims 1
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N Ethyl benzoate Chemical group CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims 1
- LZCLXQDLBQLTDK-UHFFFAOYSA-N Ethyl lactate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims 1
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims 1
- 239000004348 Glyceryl diacetate Substances 0.000 claims 1
- UYXTWWCETRIEDR-UHFFFAOYSA-N Glyceryl tributyrate Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N Malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920001083 Polybutene Polymers 0.000 claims 1
- 229920001748 Polybutylene Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N Propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- URAYPUMNDPQOKB-UHFFFAOYSA-N Triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 Triacetin Drugs 0.000 claims 1
- DQWPFSLDHJDLRL-UHFFFAOYSA-N Triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 229960002903 benzyl benzoate Drugs 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 1
- 229940116333 ethyl lactate Drugs 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229940074076 glycerol formal Drugs 0.000 claims 1
- 235000019443 glyceryl diacetate Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 229940099690 malic acid Drugs 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 229920002866 paraformaldehyde Polymers 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920001707 polybutylene terephthalate Polymers 0.000 claims 1
- 229920005646 polycarboxylate Polymers 0.000 claims 1
- 239000000622 polydioxanone Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920001855 polyketal Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 1
- 150000003890 succinate salts Chemical class 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- 230000000699 topical Effects 0.000 claims 1
- QZCLKYGREBVARF-UHFFFAOYSA-N tributyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims 1
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N tributyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 1
- YEJRWHAVMIAJKC-UHFFFAOYSA-N γ-lactone 4-hydroxy-butyric acid Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims 1
Claims (48)
- 投与後のあらかじめ定められた持続時間にわたり制御された仕方で対象者へ有益薬剤を持続的送達するための注射可能なデポー組成物であって:
(a)(1)生体分解性で生体適合性のポリマー;および
(2)該ポリマーを可塑化してそれでゲルを形成するのに有効な量の溶剤であって、25℃で7重量%未満またはそれに等しい水混和性を有する溶剤;
を含む粘性ゲル配合物;および
(b)該ゲル中に溶解または分散された有益薬剤;
を含み:
前記持続時間は、投与後約2週間から約12ヵ月までである注射可能デポー組成物。 - 該ポリマーが乳酸およびグリコール酸の共重合体である、請求項1の組成物。
- 該ポリマーがポリラクチドである、請求項1の組成物。
- 該ポリマーがカプロラクトンベースのポリマーである、請求項1の組成物。
- 該ポリマーが乳酸ベースのポリマーである、請求項1の組成物。
- 該ポリマーが約50:50から約100:0のL/G比および約3,000から約120,000までの範囲の分子量をもつ、請求項2の組成物。
- 前記生体分解性で生体適合性のポリマーの約5重量%から約90重量%までを含む、請求項1の組成物。
- 前記生体分解性で生体適合性のポリマーの約25重量%から約80重量%までを含む、請求項7の組成物。
- 前記生体分解性で生体適合性のポリマーの約35重量%から約75重量%までを含む、請求項7の組成物。
- 前記持続時間が投与後3ヵ月に等しいかまたはそれより長い、請求項1の組成物。
- 前記持続時間が投与後約3ヵ月から約6ヵ月までの、請求項1の組成物。
- 前記持続時間が投与後約3ヵ月から約9ヵ月までの、請求項1の組成物。
- 前記持続時間が投与後約6ヵ月から約9ヵ月までの、請求項1の組成物。
- 該粘性ゲルが、ポリラクチド類、ポリグリコリド類、カプラクトンベースの重合体類、ポリ(カプロラクトン)、ポリ無水物類、ポリアミン類、ポリエステルアミド類、ポリオルトエステル類、ポリジオキサノン類、ポリアセタール類、ポリケタール類、ポリカルボン酸塩類、ポリホスホエステル類、ポリエステル類、ポリブチレンテレフタル酸塩、ポリオルトカルボン酸塩類、ポリホスファゼン類、コハク酸塩類、ポリ(リンゴ酸)、ポリ(アミノ酸類)、ポリビニルピロリドン、ポリエチレングリコール、ポリヒドロキシセルロース、多糖類、キチン、キトサン、ヒアルロン酸、および共重合体類、三元共重合体類、およびそれらの混合物類、およびカプラクトンベースの重合体類、ポリカプロラクトン類、およびポリブチレンテレフタル酸塩を含む共重合体類を含む、生分解性およびそれらの共重合体類からなる群から選択されるポリマーを、さらに含む、請求項1の組成物。
- 次のものの少なくとも1つ、細孔形成剤;有益薬剤用の溶解性調整剤;および浸透剤:をさらに含む、請求項1の組成物。
- 該溶剤が、トリアセチン、ジアセチン、トリブチリン、クエン酸トリエチル(トリエチルシトレートに同じ、以下同様)、トリブチルシトレート、アセチルトリエチルシトレート、アセチルトリブチルシトレート、トリエチルグリセリド類、トリエチルホスフェート、ジエチルフタレート、ジエチルタートレート、鉱油、ポリブテン、シリコーン油、グリセリン、エチレングリコール、ポリエチレングリコール、オクタノール、エチルラクテート、プロピレングリコール、プロピレンカーボネート、エチレンカーボネート、ブチロラクトン、エチレンオキシド、プロピレンオキシド、N・メチル・2・ピロリドン、2・ピロリドン、グリセロールホルマル、メチルアセテート、エチルアセテート、メチルエチルケトン、ジメチルホルムアミド、ジメチルスルフォキシド、テトラヒドロフラン、カプロラクタム、デシルメチルスルフォキシド、オレイン酸、および1・ドデシルアザシクロ・ヘプタン・2・オン、およびそれらの混合物、からなる群から選択される成分溶剤を含む、請求項1の組成物。
- 該溶剤が、芳香族アルコール、アリール酸類の低級アルキルおよびアラルキルエステル類;アリール、アラルキルおよび低級アルキルケトン類;およびクエン酸の低級アルキルエステル類から選択される、請求項1の組成物。
- 該溶剤がベンジルアルコールである、請求項1の組成物。
- 該溶剤がベンジルベンゾエートである、請求項1の組成物。
- 該溶剤がエチルベンゾエートである、請求項1の組成物。
- 該組成物が25℃で7重量%より大きい水との混和性をもつ溶剤を含まない、請求項1の組成物。
- 前記送達が全身的送達である、請求項1の組成物。
- 前記送達が局所的送達である、請求項1の組成物。
- 前記送達が或る期間後に反復される、請求項1の組成物。
- 前記送達が複数の部位で提供される、請求項1の組成物。
- 該有益薬剤が投与後約2週間から約12ヵ月までの持続時間にわたって制御された仕方で全身的に送達される、請求項22の注射可能デポー組成物。
- 該有益薬剤が投与後約2週間から約12ヵ月までの持続時間にわたって制御された仕方で局所的に送達される、請求項23の注射可能デポー組成物。
- 投与後のあらかじめ定められた持続時間にわたって、制御された仕方で、対象者に有益薬剤を投与する方法であって:
(i)対象者へ、
(a)(1)生体分解性で生体適合性のポリマー;および
(2)該ポリマーを可塑化してそれでゲルを形成するのに有効な量の、25℃で7重量%未満またはそれに等しい水への混和性を有する溶剤;
を含む粘性ゲル配合物;
を投与すること:
(b)該ゲル中に溶解または分散された有益薬剤;および
(ii)投与後約2週間から約12ヵ月までの持続時間にわたって、対象者に該有益薬剤を送達すること:
を含む前記方法。 - 制御された仕方で対象者に有益薬剤を全身的に送達することをさらに含む、請求項28の方法。
- 或る期間後に送達工程(ii)を反復することをさらに含む、請求項28の方法。
- 或る期間後に送達工程(ii)を反復することをさらに含む、請求項29の方法。
- 制御された仕方で対象者に有益薬剤を局所的に送達することをさらに含む、請求項28の方法。
- 或る期間後に送達工程(ii)を反復することをさらに含む、請求項32の方法。
- 複数の部位で送達工程(ii)を行うことをさらに含む、請求項32の方法。
- 投与後のあらかじめ定められた持続時間にわたって、制御された仕方で、対象者に有益薬剤の持続的送達のための投与のためのキットであって:
(a)生体分解性で生体適合性のポリマー;
(b)該ポリマーを可塑化しそれでゲルを形成するのに有効な量の、25℃で7重量%未満またはそれに等しい水との混和性をもつ溶剤;
(c)該ゲル中に溶解または分散された有益薬剤;および、場合により次のものの1つ以上:
(d)乳化剤;
(e)細孔形成剤;
(f)場合により有益薬剤に結合する該有益薬剤用の溶解性調整剤;および
(g)浸透剤;
を含み、
ここで、少なくとも、場合により該溶解性調整剤に結合する該有益薬剤は、対象者への有益薬剤の投与のときまで、該溶剤から分離されて維持される、前記キット。 - 投与後のあらかじめ定められた持続時間にわたって、制御された仕方で、対象者に有益薬剤を持続的に送達するための、注射可能デポー組成物であって:
(a)(1)ポリマー類の生体分解性で生体適合性の混合物;および
(2)該ポリマーを可塑化しそれでゲルを形成するのに有効な量で、25℃で7重量%未満またはそれに等しい水との混和性をもつ溶剤;
を含む粘性ゲル配合物;および
(b)該ゲル中に溶解または分散された有益薬剤;
を含み:
ここで、前記持続時間が投与後約2週間から約12ヵ月までである、前記注射可能デポー組成物。 - 前記ポリマー類の混合物が乳酸およびグリコール酸の共重合体を含む、請求項36の組成物。
- 前記ポリマー類の混合物がポリラクチドを含む、請求項36の組成物。
- 前記ポリマー類の混合物がカプロラクトンベースのポリマーを含む、請求項36の組成物。
- 前記ポリマー類の混合物が約50:50から約100:0のL/G比および約3,000から約120,000までの範囲の分子量をもつポリマーを含む、請求項36の組成物
- 投与後のあらかじめ定められた持続時間にわたって、制御された仕方で、対象者に有益薬剤を投与する方法であって:
(i)対象者へ、
(a)(1)ポリマー類の生体分解性で生体適合性の混合物;および
(2)該ポリマーを可塑化しそれでゲルを形成するのに有効な量の、25℃で7重量%未満またはそれに等しい水との混和性をもつ溶剤;
を含む粘性ゲル配合物;および
(b)該ゲル中に溶解または分散された有益薬剤;
を投与すること:および
(ii)投与後約2週間から約12ヵ月までの持続時間にわたって、対象者に該有益薬剤を送達すること:
を含む前記方法。 - 制御された仕方で対象者に有益薬剤を全身的に送達することをさらに含む、請求項41の方法。
- 或る期間後に送達工程(ii)を反復することをさらに含む、請求項41の方法。
- 或る期間後に送達工程(ii)を反復することをさらに含む、請求項42の方法。
- 制御された仕方で対象者に有益薬剤を局所的に送達することをさらに含む、請求項41の方法。
- 或る期間後に送達工程(ii)を反復することをさらに含む、請求項45の方法。
- 複数の部位で送達工程(ii)を行うことをさらに含む、請求項45の方法。
- 投与後のあらかじめ定められた持続時間にわたって、制御された仕方で、対象者に有益薬剤の持続的送達のための投与のためのキットであって:
(a)ポリマー類の生体分解性で生体適合性の混合物;
(b)該ポリマー類を可塑化しそれでゲルを形成するのに有効な量の、25℃で7重量%未満またはそれに等しい水との混和性をもつ溶剤;
(c)該ゲル中に溶解または分散された有益薬剤;および、場合により次のものの1つ以上:
(d)乳化剤;
(e)細孔形成剤;
(f)場合により有益薬剤と結合する該有益薬剤用の溶解性調整剤;および
(g)浸透剤;
を含み、
ここで、場合により該溶解性調整剤に結合する少なくとも該有益薬剤は、対象者への有益薬剤の投与のときまで、該溶剤から分離されて維持される、前記キット。
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