BR0313539A - Composições depósito de polìmero multimodais injetáveis e seus usos - Google Patents

Composições depósito de polìmero multimodais injetáveis e seus usos

Info

Publication number
BR0313539A
BR0313539A BR0313539-0A BR0313539A BR0313539A BR 0313539 A BR0313539 A BR 0313539A BR 0313539 A BR0313539 A BR 0313539A BR 0313539 A BR0313539 A BR 0313539A
Authority
BR
Brazil
Prior art keywords
compositions
injectable
polymer
polymers
multimodal polymer
Prior art date
Application number
BR0313539-0A
Other languages
English (en)
Inventor
Guohua Chen
Paul Houston
Lothar Kleiner
Jeremy Wright
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BR0313539A publication Critical patent/BR0313539A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçõES DEPóSITO DE POLìMERO MULTIMODAIS INJETáVEIS E SEUS USOS". São providas composições depósito injetáveis que incluem uma matriz de polímero tendo uma pluralidade de polímeros bioerodíveis, biocompatíveis, em que cada polímero da pluralidade de polímeros tem um peso molecular médio especificado; e a matriz de polímero tem uma distribuição de peso molecular ampla da pluralidade de polímeros; um solvente tendo uma miscibilidade em água inferior ou igual a 7% em peso a 25<198>C, em uma quantidade eficaz para plastificar o polímero e formar um gel com o mesmo; e um agente benéfico. As composições têm comportamento melhorado de afinamento com cisalhamento e força de injeção reduzida, o que torna as composições prontamente implantadas debaixo da superfície do corpo de um paciente por injeção.
BR0313539-0A 2002-07-31 2003-07-28 Composições depósito de polìmero multimodais injetáveis e seus usos BR0313539A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39983202P 2002-07-31 2002-07-31
PCT/US2003/023439 WO2004011054A2 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof

Publications (1)

Publication Number Publication Date
BR0313539A true BR0313539A (pt) 2005-06-21

Family

ID=31188625

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313539-0A BR0313539A (pt) 2002-07-31 2003-07-28 Composições depósito de polìmero multimodais injetáveis e seus usos

Country Status (20)

Country Link
US (2) US8501215B2 (pt)
EP (2) EP1539101B1 (pt)
JP (1) JP4639400B2 (pt)
KR (1) KR20050083605A (pt)
CN (2) CN101057824A (pt)
AR (1) AR040753A1 (pt)
AT (1) ATE419831T1 (pt)
AU (2) AU2003256849A1 (pt)
BR (1) BR0313539A (pt)
CA (1) CA2494400A1 (pt)
DE (1) DE60325742D1 (pt)
DK (1) DK1539101T3 (pt)
ES (1) ES2321505T3 (pt)
HK (1) HK1079443A1 (pt)
IL (1) IL166463A0 (pt)
MX (1) MXPA05001244A (pt)
NO (1) NO20051025L (pt)
NZ (1) NZ537953A (pt)
WO (1) WO2004011054A2 (pt)
ZA (1) ZA200501645B (pt)

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DE60325742D1 (de) 2009-02-26
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HK1079443A1 (en) 2006-04-07
EP1539101B1 (en) 2009-01-07
MXPA05001244A (es) 2005-06-08
EP1539101A2 (en) 2005-06-15
JP4639400B2 (ja) 2011-02-23
AR040753A1 (es) 2005-04-20
CN101057824A (zh) 2007-10-24
AU2003256849A1 (en) 2004-02-16
CA2494400A1 (en) 2004-02-05
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US20040022859A1 (en) 2004-02-05
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IL166463A0 (en) 2006-01-15
AU2010200348A1 (en) 2010-02-18
ATE419831T1 (de) 2009-01-15
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