NO20051025L - Injiserbare, multimodale polymerdepotpreparater og anvendelser derav - Google Patents

Injiserbare, multimodale polymerdepotpreparater og anvendelser derav

Info

Publication number
NO20051025L
NO20051025L NO20051025A NO20051025A NO20051025L NO 20051025 L NO20051025 L NO 20051025L NO 20051025 A NO20051025 A NO 20051025A NO 20051025 A NO20051025 A NO 20051025A NO 20051025 L NO20051025 L NO 20051025L
Authority
NO
Norway
Prior art keywords
polymer
polymers
compositions
injectable
applications
Prior art date
Application number
NO20051025A
Other languages
English (en)
Inventor
Jeremy Corwin Wright
Lothar W Kleiner
Guohua Chen
Paul Ricky Houston
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of NO20051025L publication Critical patent/NO20051025L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det er beskrevet injiserbare depotpreparater som omfatter en polymermatriks som har et flertall av bionedbiytbare, biokompatible polymerer hvor hver polymer av flertallet av polymerer har en spesifisert vektmidlere molekylvekt; og polymermafriksen har en bred molekylvektsfordeling av flertallet av polymerer; et oppløsningsmiddel som har en blandbarhet i vann på mindre enn eller lik 7 vekt-% ved 25°e, i en mengde effektiv for å mykne polymeren ved å danne en gel med denne og et fordelaktig middel. Preparatene har vesentlig forbedret skjærfortynningsoppførsel og redusert injeksjonskraft, hvilket gjør preparatene lett implanterbare under en pasients kroppsoverflate ved injeksjon.
NO20051025A 2002-07-31 2005-02-25 Injiserbare, multimodale polymerdepotpreparater og anvendelser derav NO20051025L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39983202P 2002-07-31 2002-07-31
PCT/US2003/023439 WO2004011054A2 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof

Publications (1)

Publication Number Publication Date
NO20051025L true NO20051025L (no) 2005-02-25

Family

ID=31188625

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051025A NO20051025L (no) 2002-07-31 2005-02-25 Injiserbare, multimodale polymerdepotpreparater og anvendelser derav

Country Status (20)

Country Link
US (2) US8501215B2 (no)
EP (2) EP2030611A1 (no)
JP (1) JP4639400B2 (no)
KR (1) KR20050083605A (no)
CN (2) CN101057824A (no)
AR (1) AR040753A1 (no)
AT (1) ATE419831T1 (no)
AU (2) AU2003256849A1 (no)
BR (1) BR0313539A (no)
CA (1) CA2494400A1 (no)
DE (1) DE60325742D1 (no)
DK (1) DK1539101T3 (no)
ES (1) ES2321505T3 (no)
HK (1) HK1079443A1 (no)
IL (1) IL166463A0 (no)
MX (1) MXPA05001244A (no)
NO (1) NO20051025L (no)
NZ (1) NZ537953A (no)
WO (1) WO2004011054A2 (no)
ZA (1) ZA200501645B (no)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1229940T3 (da) * 1999-11-15 2014-08-18 Piramal Healthcare Canada Ltd Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
WO2001041821A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
BR0112109A (pt) * 2000-06-29 2007-05-29 Biosyntech Canada Inc composição e método para a correção e regeneração de cartilagem e outros tecidos
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
MXPA05004927A (es) * 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
WO2006039336A2 (en) * 2004-10-01 2006-04-13 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US8541413B2 (en) 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US8313763B2 (en) * 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
WO2006041942A2 (en) * 2004-10-04 2006-04-20 Qlt Usa, Inc. Ocular delivery of polymeric delivery formulations
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2007020430A2 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc Multimodal high strength devices and composites
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
EP1948810A4 (en) * 2005-11-04 2010-06-30 Biosyntech Canada Inc COMPOSITION AND METHOD USING CHITOSAN FOR THE EFFICIENT ADMINISTRATION OF NUCLEIC ACIDS TO CELLS
US8236904B2 (en) 2005-12-28 2012-08-07 Ethicon, Inc. Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates
US20070149640A1 (en) * 2005-12-28 2007-06-28 Sasa Andjelic Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates
CN101453982B (zh) 2006-05-30 2011-05-04 精达制药公司 两件式内部通道渗透递送系统流动调节器
WO2008021133A2 (en) 2006-08-09 2008-02-21 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
US20100178346A1 (en) * 2007-02-01 2010-07-15 The Trustees Of The University Of Pennsylvania Disc augmentation with hyaluronic acid
US7867778B2 (en) * 2007-02-23 2011-01-11 Visiongate, Inc. Fluid focusing for positional control of a specimen for 3-D imaging
EP2142353A1 (en) 2007-04-18 2010-01-13 Smith & Nephew PLC Expansion moulding of shape memory polymers
WO2008130954A2 (en) 2007-04-19 2008-10-30 Smith & Nephew, Inc. Graft fixation
WO2008131197A1 (en) 2007-04-19 2008-10-30 Smith & Nephew, Inc. Multi-modal shape memory polymers
EP2157967B1 (en) 2007-04-23 2013-01-16 Intarcia Therapeutics, Inc Suspension formulations of insulinotropic peptides and uses thereof
EP3115038A1 (en) 2007-05-18 2017-01-11 DURECT Corporation Improved depot formulations
CN101801415B (zh) 2007-05-25 2015-09-23 Rb医药品有限公司 利培酮化合物的持续递送制剂
US8470360B2 (en) 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
US20110059140A1 (en) * 2007-12-21 2011-03-10 Gerhard Winter Extruded rod-shaped devices for controlled release of biological substances to humans and animals
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
KR101921800B1 (ko) * 2008-01-30 2018-11-23 노파르티스 아게 옥트레오티드 및 3종의 선형 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
US20090263456A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and Compositions for Reducing Preventing and Treating Adhesives
EP2293784B1 (en) * 2008-06-03 2016-04-13 Indivior UK Limited Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
US8802126B2 (en) * 2008-06-30 2014-08-12 Abbott Cardiovascular Systems Inc. Polyester implantable medical device with controlled in vivo biodegradability
JP2010232895A (ja) * 2009-03-26 2010-10-14 Fuji Xerox Co Ltd 通信制御装置及び情報処理装置
CN104323981B (zh) 2009-09-28 2019-03-12 精达制药公司 基本稳态药物递送的快速建立和/或终止
EP2308478A1 (en) 2009-10-06 2011-04-13 Abbott GmbH & Co. KG Delivery system for sustained release of a calcium-channel blocking agent
EP2394664B1 (en) * 2010-05-31 2016-06-01 Laboratorios Farmaceuticos Rovi, S.A. Antipsychotic injectable depot composition
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
DE102011114986A1 (de) 2011-09-28 2013-03-28 Ethris Gmbh Sprühsystem
US8735504B2 (en) * 2012-05-02 2014-05-27 Warsaw Orthopedic, Inc. Methods for preparing polymers having low residual monomer content
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN109602692B (zh) 2013-03-11 2022-11-04 度瑞公司 包含高粘度液体载体的可注射控制释放组合物
LT3046584T (lt) 2013-09-16 2017-10-10 Astrazeneca Ab Terapinės polimerinės nanodalelės ir jų gamybos būdai ir panaudojimas
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
WO2016196851A2 (en) 2015-06-03 2016-12-08 Intarcia Therapeutics, Inc. Implant placement and removal systems
MX2018014016A (es) 2016-05-16 2019-08-01 Intarcia Therapeutics Inc Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos.
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10668011B2 (en) 2016-06-30 2020-06-02 Durect Corporation Depot formulations
US10682340B2 (en) 2016-06-30 2020-06-16 Durect Corporation Depot formulations
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
DE102017106216A1 (de) 2017-03-22 2018-09-27 Amw Gmbh Extrudierte Depotform zur anhaltenden Wirkstofffreisetzung
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CN112816637A (zh) * 2020-06-17 2021-05-18 湖南慧泽生物医药科技有限公司 一种吗替麦考酚酯片的体外溶出方法
TW202313047A (zh) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 抗精神病可注射儲積型組合物

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US336307A (en) 1886-02-16 Feed-water regulator
US336254A (en) 1886-02-16 Eobeet t
US3797492A (en) 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3923939A (en) 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US3987790A (en) 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
LU83485A1 (fr) * 1981-07-09 1983-02-04 Metallurgie Hoboken Procede et installation pour couler une bande a oreilles en saillie laterale
US4443340A (en) 1981-10-09 1984-04-17 Betz Laboratories, Inc. Control of iron induced fouling in water systems
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4623588A (en) 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
US4568559A (en) 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4708861A (en) 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US4985404A (en) 1984-10-04 1991-01-15 Monsanto Company Prolonged release of biologically active polypeptides
US4668506A (en) 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
US4931279A (en) 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US4713244A (en) 1985-08-16 1987-12-15 Bausch & Lomb Incorporated Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4853218A (en) 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US4866050A (en) 1988-04-27 1989-09-12 Ben Amoz Daniel Ultrasonic transdermal application of steroid compositions
US5181914A (en) 1988-08-22 1993-01-26 Zook Gerald P Medicating device for nails and adjacent tissue
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5085866A (en) 1988-12-02 1992-02-04 Southern Research Institute Method of producing zero-order controlled-released devices
US5057318A (en) 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5112614A (en) 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5300295A (en) 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US5252318A (en) 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5151093A (en) 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
US5620700A (en) 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
AU8935591A (en) 1990-10-30 1992-05-26 Alza Corporation Drug delivery system and method
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
GB9027422D0 (en) 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
WO1992011843A1 (en) 1991-01-09 1992-07-23 Alza Corporation Bioerodible devices and compositions for diffusional release of agents
WO1992013567A1 (en) 1991-02-01 1992-08-20 Nova Pharmaceutical Corporation Biodegradable polymer blends for drug delivery
FR2673843B1 (fr) 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5288214A (en) 1991-09-30 1994-02-22 Toshio Fukuda Micropump
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
DE69207863T2 (de) 1991-11-13 1996-06-05 Glaxo Canada Vorrichtung zur kontrollierten Wirkstoffreigabe
EP0572675B1 (en) 1991-12-19 1999-09-22 Mitsui Chemicals, Inc. Polyhydroxy carboxylic acid and production thereof
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5209746A (en) 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
US5540912A (en) 1992-03-30 1996-07-30 Alza Corporation Viscous suspensions of controlled-release drug particles
ZA932273B (en) 1992-03-30 1993-11-26 Alza Corp Additives for bioerodible polymers to regulate degradation
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
ES2170074T3 (es) 1992-09-10 2002-08-01 Childrens Medical Center Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales.
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US5242910A (en) 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
DE69329295T2 (de) 1992-12-02 2001-03-15 Alkermes Controlled Therapeutics, Inc. Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
US5340614A (en) 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation
US5330452A (en) 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5447725A (en) 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5415866A (en) 1993-07-12 1995-05-16 Zook; Gerald P. Topical drug delivery system
US5849763A (en) 1993-10-13 1998-12-15 Darwin Discovery Limited Use of levobupivacaine as an anesthetic agent
PT727210E (pt) 1993-10-13 2002-06-28 Darwin Discovery Ltd Agente analgesico e sua utilizacao
GB9321061D0 (en) 1993-10-13 1993-12-01 Chiroscience Ltd Analgestic agent and its use
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5760077A (en) 1994-01-14 1998-06-02 Shahinian, Jr.; Lee Topical ophthalmic analgesic preparations for sustained and extended corneal analgesia
JPH09510961A (ja) 1994-01-14 1997-11-04 ジュニア シャヒニアン，リー 持続性および長期間の角膜鎮痛の方法
US5556905A (en) 1994-03-30 1996-09-17 Reilly Industries, Inc. Physically-modified degradable thermoplastic compositions
JP4259610B2 (ja) 1994-04-08 2009-04-30 キューエルティー・ユーエスエイ・インコーポレーテッド 液体デリバリー組成物
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5599534A (en) 1994-08-09 1997-02-04 University Of Nebraska Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
US5660817A (en) 1994-11-09 1997-08-26 Gillette Canada, Inc. Desensitizing teeth with degradable particles
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US6322548B1 (en) 1995-05-10 2001-11-27 Eclipse Surgical Technologies Delivery catheter system for heart chamber
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
CA2195119C (en) 1995-06-09 2001-09-11 Mark Chasin Formulations and methods for providing prolonged local anesthesia
US5897880A (en) 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
US5787175A (en) * 1995-10-23 1998-07-28 Novell, Inc. Method and apparatus for collaborative document control
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
WO1997044016A1 (en) 1996-05-23 1997-11-27 Samyang Corporation Locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof
DK0914102T3 (da) 1996-05-24 2006-01-09 Angiotech Pharm Inc Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler
CA2180601C (en) * 1996-07-05 2007-12-18 Chun Keung Mak Heated nozzle manifolds in a common plane interconnected through connector manifolds
BR9710289A (pt) 1996-07-11 1999-08-17 Farmarc Nederland Bv Composi-Æo farmac-utica contendo sal cido de adi-Æo de medicamento b sico
WO1998010387A2 (en) 1996-09-04 1998-03-12 Ht Medical Systems, Inc. Interventional radiology interface apparatus and method
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
ATE318580T1 (de) 1996-12-20 2006-03-15 Alza Corp Gelzusammensetzungen und verfahren
GB9704351D0 (en) 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
JPH10255221A (ja) * 1997-03-14 1998-09-25 Mitsubishi Electric Corp 複合型磁気ヘッド及び該複合型磁気ヘッドのヘッドコアの製造方法
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
US6197327B1 (en) 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6004295A (en) 1997-06-26 1999-12-21 An-Go-Gen Inc. Catheters
KR100367144B1 (ko) 1997-07-02 2003-01-14 유로-셀티크 소시에떼 아노뉨 관절과 체강(ｂｏｄｙ ｓｐａｃｅ)내에서 연장된 마취
US20010004644A1 (en) 1997-07-21 2001-06-21 Levin Bruce H. Compositions, kits, apparatus, and methods for inhibiting cephalic inflammation
US6432986B2 (en) 1997-07-21 2002-08-13 Bruce H. Levin Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches
EP0998287B1 (en) 1997-07-22 2003-05-07 Darwin Discovery Limited Use of levobupivacaine
US6306166B1 (en) 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US6183444B1 (en) 1998-05-16 2001-02-06 Microheart, Inc. Drug delivery module
US6193991B1 (en) 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
US6050986A (en) 1997-12-01 2000-04-18 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume liquid bolus
IT1298574B1 (it) 1998-02-06 2000-01-12 Vectorpharma Int Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
WO1999049908A1 (en) 1998-03-31 1999-10-07 University Of Cincinnati Temperature controlled solute delivery system
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6103266A (en) 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US6955819B2 (en) 1998-09-29 2005-10-18 Zars, Inc. Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6451346B1 (en) 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
EP1183010A2 (en) * 1999-06-04 2002-03-06 ALZA Corporation Implantable gel compositions and method of manufacture
US6423818B1 (en) 1999-07-30 2002-07-23 Takehisa Matsuda Coumarin endcapped absorbable polymers
US6352667B1 (en) 1999-08-24 2002-03-05 Absorbable Polymer Technologies, Inc. Method of making biodegradable polymeric implants
US6528086B2 (en) 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US6432415B1 (en) 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6899731B2 (en) 1999-12-30 2005-05-31 Boston Scientific Scimed, Inc. Controlled delivery of therapeutic agents by insertable medical devices
WO2001082863A2 (en) 2000-04-28 2001-11-08 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
WO2002000137A1 (en) * 2000-06-28 2002-01-03 Shukla Atul J Biodegradable vehicles and delivery systems of biologically active substances
AU2001280597A1 (en) 2000-07-17 2002-01-30 Guilford Pharmaceuticals Inc. Compositions for sustained release of analgesic agents, and methods of making and using the same
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
US6543081B1 (en) * 2000-08-15 2003-04-08 Sheldon C. Cohen Flip-up wringer sponge mop
US6823084B2 (en) * 2000-09-22 2004-11-23 Sri International Method and apparatus for portably recognizing text in an image sequence of scene imagery
WO2002038185A2 (en) * 2000-11-13 2002-05-16 Atrix Laboratories, Inc. Injectable sustained release delivery system with loperamide
KR100446101B1 (ko) * 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물
WO2002058670A1 (en) 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
US6375659B1 (en) 2001-02-20 2002-04-23 Vita Licensing, Inc. Method for delivery of biocompatible material
CA2439120C (en) 2001-02-23 2011-07-05 Genentech, Inc. Erodible polymers for injection
WO2002089849A1 (en) * 2001-05-07 2002-11-14 Corium International Compositions and delivery systems for administration of a local anesthetic agent
ATE507816T1 (de) 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
BR0206987A (pt) 2001-11-14 2004-02-10 Alza Corp Composições de depósito injetáveis por cateter e usos destes
WO2003041685A1 (en) 2001-11-14 2003-05-22 Alza Corporation Injectable depot composition
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
MXPA05004927A (es) 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
MXPA05013003A (es) 2003-05-30 2006-03-17 Alza Corp Composiciones de deposito elastomerico implantables, usos de las mismas y metodo para elaboracion.
US20070184084A1 (en) 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof

Also Published As

Publication number Publication date
AR040753A1 (es) 2005-04-20
HK1079443A1 (en) 2006-04-07
BR0313539A (pt) 2005-06-21
ES2321505T3 (es) 2009-06-08
WO2004011054A2 (en) 2004-02-05
DE60325742D1 (de) 2009-02-26
DK1539101T3 (da) 2009-04-27
EP1539101B1 (en) 2009-01-07
US20140051770A1 (en) 2014-02-20
NZ537953A (en) 2007-02-23
CN1684663A (zh) 2005-10-19
AU2003256849A1 (en) 2004-02-16
WO2004011054A3 (en) 2004-04-01
US20040022859A1 (en) 2004-02-05
IL166463A0 (en) 2006-01-15
ZA200501645B (en) 2006-05-31
EP2030611A1 (en) 2009-03-04
AU2010200348A1 (en) 2010-02-18
KR20050083605A (ko) 2005-08-26
CN101057824A (zh) 2007-10-24
US8501215B2 (en) 2013-08-06
EP1539101A2 (en) 2005-06-15
MXPA05001244A (es) 2005-06-08
CA2494400A1 (en) 2004-02-05
JP4639400B2 (ja) 2011-02-23
JP2005538107A (ja) 2005-12-15
ATE419831T1 (de) 2009-01-15

Similar Documents

Publication Publication Date Title
NO20051025L (no) Injiserbare, multimodale polymerdepotpreparater og anvendelser derav
Zhang et al. A tough and stiff hydrogel with tunable water content and mechanical properties based on the synergistic effect of hydrogen bonding and hydrophobic interaction
Wang et al. A physically cross-linked sodium alginate–gelatin hydrogel with high mechanical strength
Gao et al. Sea cucumber-inspired autolytic hydrogels exhibiting tunable high mechanical performances, repairability, and reusability
Yang et al. H-bonding supramolecular hydrogels with promising mechanical strength and shape memory properties for postoperative antiadhesion application
Matsuda et al. Yielding criteria of double network hydrogels
Reid et al. PEG hydrogel degradation and the role of the surrounding tissue environment
Chandrasekharan et al. In situ photocrosslinkable hyaluronic acid‐based surgical glue with tunable mechanical properties and high adhesive strength
Bruggeman et al. Biodegradable xylitol‐based polymers
WO2005012364A3 (fr) Matrice complexe a usage biomedical
Li et al. Click chemistry-based biopolymeric hydrogels for regenerative medicine
ES2173999T3 (es) Dispersante de cemento, metodo para la produccion del mismo y composicion de cemento que utiliza el dispersante.
Lowe et al. Oxidized dihydrocarvone as a renewable multifunctional monomer for the synthesis of shape memory polyesters
ATE502621T1 (de) Katheterinjizierbare depotzusammensetzungen und deren verwendung
BRPI0416032A (pt) excipientes em veìculos de distribuição de fármacos
BR0212389A (pt) Produção de materiais biopolìmeros como pelìcula, fibra, espuma ou adesivo a partir de derivados solúveis de queratina s-sulfonada
CN100455615C (zh) 树状热塑性弹性体及其产品
Costa et al. Highly robust hydrogels via a fast, simple and cytocompatible dual crosslinking-based process
Thankam et al. Biosynthetic hydrogels—Studies on chemical and physical characteristics on long‐term cellular response for tissue engineering
JP2017536458A (ja) ポリリン酸ヒドロゲル並びにその製造及び使用方法
BR0312520A (pt) Material para eletrólito de compósito molecular, método para fabricar o mesmo, bateria, e, eletrólito cerâmico polimérico sólido compósito
Chai et al. Bionic artificial penile Tunica albuginea
DE602004022996D1 (de) Kosmetische zusammensetzung mit einem ampholyt-copolymer
Qiu et al. Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury
ATE444739T1 (de) Polymerzusammensetzung sowie diese enthaltende darreichungsformen

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application