AR041913A1 - Formulaciones de deposito de liberacion controlada - Google Patents
Formulaciones de deposito de liberacion controladaInfo
- Publication number
- AR041913A1 AR041913A1 ARP030104083A ARP030104083A AR041913A1 AR 041913 A1 AR041913 A1 AR 041913A1 AR P030104083 A ARP030104083 A AR P030104083A AR P030104083 A ARP030104083 A AR P030104083A AR 041913 A1 AR041913 A1 AR 041913A1
- Authority
- AR
- Argentina
- Prior art keywords
- beneficial agent
- gel
- polymer
- time
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
Abstract
Métodos, composiciones y kit para administrar en forma sistémica o local un agente beneficioso a un sujeto, e incluyen, por ejemplo, composiciones de depósito en gel que pueden inyectarse en una ubicación deseada y que pueden proveer la liberación controlada de un agente beneficioso durante un período prolongado de tiempo. Las composiciones incluyen un polímero biocompatible, un solvente biocompatible que tiene baja miscibilidad en agua que forma un gel viscoso con el polímero y limita la captación de agua por el implante, y un agente beneficioso. Reivindicación 1: Una composición de depósito inyectable para la aplicación prolongada de un agente beneficioso a un sujeto en un modo controlado durante un período predeterminado de tiempo luego de la administración que comprende: (a) una formulación viscosa en gel que comprende: (1) un polímero bioerosionable, biocompatible; y (2) un solvente que tiene una miscibilidad en agua de menos que o igual al 7% en peso a 25°C, en una cantidad efectiva para plastificar el polímero y formar un gel con éste; y (b) un agente beneficioso disuelto o disperso en el gel; en la cual dicha duración de tiempo es desde aproximadamente dos semanas hasta aproximadamente doce meses luego de la administración.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42442802P | 2002-11-06 | 2002-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR041913A1 true AR041913A1 (es) | 2005-06-01 |
Family
ID=32312806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104083A AR041913A1 (es) | 2002-11-06 | 2003-11-06 | Formulaciones de deposito de liberacion controlada |
Country Status (26)
Country | Link |
---|---|
US (1) | US7368126B2 (es) |
EP (1) | EP1581181B1 (es) |
JP (1) | JP2006508127A (es) |
KR (1) | KR20050088288A (es) |
CN (1) | CN1713890A (es) |
AR (1) | AR041913A1 (es) |
AT (1) | ATE418323T1 (es) |
AU (1) | AU2003295409B2 (es) |
BR (1) | BR0315304A (es) |
CA (1) | CA2504608C (es) |
CL (1) | CL2003002277A1 (es) |
DE (1) | DE60325511D1 (es) |
EC (2) | ECSP055838A (es) |
HK (1) | HK1085387A1 (es) |
MA (1) | MA27523A1 (es) |
MX (1) | MXPA05004927A (es) |
MY (1) | MY140155A (es) |
NO (1) | NO20052635L (es) |
NZ (1) | NZ539810A (es) |
PE (1) | PE20040675A1 (es) |
PL (1) | PL377333A1 (es) |
RU (1) | RU2355385C2 (es) |
TW (1) | TW200503774A (es) |
UY (1) | UY28067A1 (es) |
WO (1) | WO2004043432A2 (es) |
ZA (1) | ZA200504529B (es) |
Families Citing this family (142)
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2003
- 2003-11-04 JP JP2004551819A patent/JP2006508127A/ja active Pending
- 2003-11-04 CA CA2504608A patent/CA2504608C/en not_active Expired - Fee Related
- 2003-11-04 WO PCT/US2003/035416 patent/WO2004043432A2/en active Application Filing
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- 2003-11-04 EP EP03786595A patent/EP1581181B1/en not_active Expired - Lifetime
- 2003-11-04 BR BR0315304-5A patent/BR0315304A/pt not_active IP Right Cessation
- 2003-11-04 CN CNA2003801039719A patent/CN1713890A/zh active Pending
- 2003-11-04 PL PL377333A patent/PL377333A1/pl not_active Application Discontinuation
- 2003-11-04 MX MXPA05004927A patent/MXPA05004927A/es unknown
- 2003-11-04 RU RU2005117164/15A patent/RU2355385C2/ru active
- 2003-11-04 DE DE60325511T patent/DE60325511D1/de not_active Expired - Lifetime
- 2003-11-04 KR KR1020057008166A patent/KR20050088288A/ko not_active Application Discontinuation
- 2003-11-04 AU AU2003295409A patent/AU2003295409B2/en not_active Ceased
- 2003-11-04 AT AT03786595T patent/ATE418323T1/de not_active IP Right Cessation
- 2003-11-04 US US10/701,939 patent/US7368126B2/en not_active Expired - Fee Related
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- 2003-11-06 PE PE2003001127A patent/PE20040675A1/es not_active Application Discontinuation
- 2003-11-06 CL CL200302277A patent/CL2003002277A1/es unknown
- 2003-11-06 TW TW092131019A patent/TW200503774A/zh unknown
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- 2005-06-02 ZA ZA200504529A patent/ZA200504529B/en unknown
- 2005-06-06 EC EC2005005838A patent/ECSP055838A/es unknown
- 2005-12-22 EC EC2005006249A patent/ECSP056249A/es unknown
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PE20040675A1 (es) | 2004-09-25 |
CL2003002277A1 (es) | 2005-05-06 |
MY140155A (en) | 2009-11-30 |
ZA200504529B (en) | 2006-08-30 |
WO2004043432A2 (en) | 2004-05-27 |
NZ539810A (en) | 2008-03-28 |
JP2006508127A (ja) | 2006-03-09 |
TW200503774A (en) | 2005-02-01 |
ATE418323T1 (de) | 2009-01-15 |
ECSP055838A (es) | 2005-09-20 |
RU2355385C2 (ru) | 2009-05-20 |
UY28067A1 (es) | 2003-12-31 |
DE60325511D1 (de) | 2009-02-05 |
PL377333A1 (pl) | 2006-01-23 |
NO20052635L (no) | 2005-07-20 |
CA2504608C (en) | 2013-01-08 |
AU2003295409A1 (en) | 2004-06-03 |
AU2003295409B2 (en) | 2010-02-11 |
ECSP056249A (es) | 2006-10-17 |
BR0315304A (pt) | 2005-08-16 |
KR20050088288A (ko) | 2005-09-05 |
MA27523A1 (fr) | 2005-09-01 |
US7368126B2 (en) | 2008-05-06 |
US20040151753A1 (en) | 2004-08-05 |
NO20052635D0 (no) | 2005-06-01 |
EP1581181A2 (en) | 2005-10-05 |
EP1581181B1 (en) | 2008-12-24 |
WO2004043432A3 (en) | 2004-07-08 |
RU2005117164A (ru) | 2006-01-20 |
HK1085387A1 (en) | 2006-08-25 |
CN1713890A (zh) | 2005-12-28 |
MXPA05004927A (es) | 2005-09-08 |
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