JP2001523231A - 膣ラクトバチルス薬 - Google Patents

膣ラクトバチルス薬

Info

Publication number
JP2001523231A
JP2001523231A JP54422298A JP54422298A JP2001523231A JP 2001523231 A JP2001523231 A JP 2001523231A JP 54422298 A JP54422298 A JP 54422298A JP 54422298 A JP54422298 A JP 54422298A JP 2001523231 A JP2001523231 A JP 2001523231A
Authority
JP
Japan
Prior art keywords
substrate
vaginal
strain
lactobacillus
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP54422298A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001523231A5 (https=
Inventor
エル． クリソープ、ジェラルド
Original Assignee
ジャイネロジックス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジャイネロジックス インコーポレイテッド filed Critical ジャイネロジックス インコーポレイテッド
Publication of JP2001523231A publication Critical patent/JP2001523231A/ja
Publication of JP2001523231A5 publication Critical patent/JP2001523231A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP54422298A 1997-04-11 1998-04-10 膣ラクトバチルス薬 Pending JP2001523231A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/834,649 1997-04-11
US08/834,649 US6093394A (en) 1997-04-11 1997-04-11 Vaginal lactobacillus medicant
PCT/US1998/007510 WO1998046261A1 (en) 1997-04-11 1998-04-10 Vaginal lactobacillus medicant

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009230743A Division JP2010031031A (ja) 1997-04-11 2009-10-02 膣ラクトバチルス薬

Publications (2)

Publication Number Publication Date
JP2001523231A true JP2001523231A (ja) 2001-11-20
JP2001523231A5 JP2001523231A5 (https=) 2005-11-24

Family

ID=25267456

Family Applications (2)

Application Number Title Priority Date Filing Date
JP54422298A Pending JP2001523231A (ja) 1997-04-11 1998-04-10 膣ラクトバチルス薬
JP2009230743A Pending JP2010031031A (ja) 1997-04-11 2009-10-02 膣ラクトバチルス薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009230743A Pending JP2010031031A (ja) 1997-04-11 2009-10-02 膣ラクトバチルス薬

Country Status (12)

Country Link
US (3) US6093394A (https=)
EP (1) EP1011721B1 (https=)
JP (2) JP2001523231A (https=)
KR (1) KR20010006273A (https=)
CN (1) CN1194758C (https=)
AT (1) ATE400281T1 (https=)
AU (1) AU732630B2 (https=)
BR (1) BR9808520A (https=)
CA (1) CA2285947C (https=)
DE (1) DE69839699D1 (https=)
NZ (2) NZ513835A (https=)
WO (1) WO1998046261A1 (https=)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005139176A (ja) * 2003-11-03 2005-06-02 Peter-Hansen Volkmann 膣ケア調合物
JP2008517015A (ja) * 2004-10-22 2008-05-22 メディノバ アクチェンゲゼルシャフト 胃腸病原菌に対して有用な乳酸菌、及び当該乳酸菌を含む組成物
JP2008517014A (ja) * 2004-10-22 2008-05-22 メディノヴァ・アクチェンゲゼルシャフト 泌尿生殖器の病原体に対して有用な乳酸菌株およびそれらを含む組成物
JP2010031031A (ja) * 1997-04-11 2010-02-12 Osel Inc 膣ラクトバチルス薬
JP2010511033A (ja) * 2006-11-28 2010-04-08 プロバイオティカル エス．ピー．エイ． 婦人科および直腸科分野における生物活性成分投与のための組成物とその使用方法
JP2015501635A (ja) * 2011-11-10 2015-01-19 ジェネラル ミルズ インコーポレーティッド 桿状菌の生存能力を高める手段及び方法
JP2017501741A (ja) * 2013-11-08 2017-01-19 スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド ラクトバチルス・クリスパタスおよびその応用
KR20180070485A (ko) * 2016-12-16 2018-06-26 (주)휴온스 안정성이 증진된 유산균 및 이의 제조방법
JP2019521134A (ja) * 2016-07-11 2019-07-25 ヘネピン・ライフ・サイエンシーズ・エルエルシーＨｅｎｎｅｐｉｎ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ，Ｌｌｃ 性感染症用組成物
JP2019531720A (ja) * 2016-09-16 2019-11-07 デュポン ニュートリション バイオサイエンシーズ エーピーエス 細菌
JP2020526583A (ja) * 2017-07-07 2020-08-31 オセル、インコーポレイテッド 高効力かつ安定な膣ラクトバチルス調製物
JP2024510109A (ja) * 2021-02-19 2024-03-06 インペリアル・カレッジ・イノベーションズ・リミテッド 妊娠中の対象に使用するためのラクトバチルス・クリスパタス組成物

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9916790D0 (en) * 1999-07-16 1999-09-22 Health Lab Service Board Storage of microorganisms,cells and tissue
SE521022C2 (sv) * 2001-09-20 2003-09-23 Ellen Ab Mjölksyraproducerande bakterier för användning som probiotiska organismer i vaginan hos människa
GB0124580D0 (en) * 2001-10-12 2001-12-05 Univ Reading New composition
US7709026B2 (en) * 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
AU2003276822A1 (en) * 2002-03-08 2004-02-02 Osel, Inc. Lactobacilli expressing biologically active polypeptides and uses thereof
DK1485463T3 (da) * 2002-03-21 2008-11-10 Bifodan As Lactobacillus stamme
KR100993562B1 (ko) 2002-03-21 2010-11-11 비포단 에이/에스 락토바실러스 균주
WO2003082306A1 (en) * 2002-03-28 2003-10-09 Gregor Reid Lactobacillus iners for the enhancement of urogenital health
JP2004067599A (ja) * 2002-08-07 2004-03-04 Kunihiko Tominaga 腟内洗浄剤
AT413334B (de) * 2002-12-23 2006-02-15 Belihart Josephine Feste darreichungsformen mit lebenden milchsäurebakterien
US20040126369A1 (en) * 2002-12-30 2004-07-01 Richard Payne Delivery of peroxide-generating enzymes to the vaginal tract
US20050095660A1 (en) * 2003-10-31 2005-05-05 Unibio, S.R.I. Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women
GB2408750B (en) * 2003-12-02 2008-12-10 Arthur A Codd Preservation of biological material
WO2005085287A1 (en) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
CA2572939C (en) * 2004-07-23 2011-04-26 Stephen M. Renzin Mini pad for reducing inflammation of the vulva and method of making the same
SE528382C2 (sv) * 2004-10-05 2006-10-31 Probi Ab Probiotiska lactobacillusstammar för förbättrad vaginal hälsa
US20060217446A1 (en) * 2005-03-28 2006-09-28 Kimberly-Clark Worldwide, Inc. Method for preventing and/or treating trichomonas vaginitis
US20060106117A1 (en) * 2004-11-12 2006-05-18 Kimberly-Clark Worldwide, Inc. Compound and method for prevention and/or treatment of vaginal infections
US7619008B2 (en) * 2004-11-12 2009-11-17 Kimberly-Clark Worldwide, Inc. Xylitol for treatment of vaginal infections
US20060223765A1 (en) * 2005-03-30 2006-10-05 Kimberly-Clark Worldwide, Inc. Method for inhibiting and/or treating vaginal infection
US7786176B2 (en) * 2005-07-29 2010-08-31 Kimberly-Clark Worldwide, Inc. Vaginal treatment composition containing xylitol
EP1919446A4 (en) * 2005-08-04 2009-01-14 Femaceuticals Llc METHOD OF TREATING SKIN IRRITATION SUCH AS ERITREA FESSIER OF INFANTS AND OTHERS
US20070082035A1 (en) * 2005-10-06 2007-04-12 New York Blood Center, Inc. Anti-infective hygiene products based on cellulose acetate phthalate
EP1965839B1 (en) 2005-12-22 2012-07-25 SCA Hygiene Products AB Absorbent article
US8399012B2 (en) 2006-04-17 2013-03-19 Kimberly-Clark Worldwide, Inc. Degradable therapeutic delivery device
CN101557838A (zh) * 2006-11-17 2009-10-14 Sca卫生用品公司 包含微生物抑制性组合物的卫生织物
WO2008060198A1 (en) 2006-11-17 2008-05-22 Sca Hygiene Products Ab Lactobacillus fermentum ess-1, dsm17851 and its use for the treatment and/or prevention of candidiasis and urinary tracrinfections
US9283297B2 (en) 2006-11-17 2016-03-15 Sca Hygiene Products Ab Sanitary article comprising a microbe-inhibiting composition
US20110066137A1 (en) * 2007-12-18 2011-03-17 Osel, Inc. Applicator for applying powder formulations and uses thereof
US8642029B2 (en) 2008-03-31 2014-02-04 Osel, Inc. Transiently buffered Lactobacillus preparations and use thereof
ITMI20080949A1 (it) * 2008-05-22 2009-11-23 Sinclair Pharma Srl Nuovo ceppo del genere lactobacillus e formulazioni farmaceutiche topiche che lo contengono
EP2206506A1 (en) 2008-12-18 2010-07-14 Bracco Imaging S.p.A Probiotic formulations
US8445226B2 (en) * 2010-02-01 2013-05-21 Microbios, Inc. Process and composition for the manufacture of a microbial-based product
US7888062B1 (en) 2010-02-01 2011-02-15 Microbios, Inc. Process and composition for the manufacture of a microbial-based product
IL208820A0 (en) 2010-10-19 2011-01-31 Rachel Teitelbaum Biologic female contraceptives
TWI401086B (zh) * 2010-07-20 2013-07-11 Univ China Medical 胚芽乳酸桿菌及其用途
US9034593B2 (en) 2010-11-22 2015-05-19 Kimberly-Clark Worldwide, Inc. Vaginal indicator to detect biomarkers of good health
CZ2010933A3 (cs) * 2010-12-15 2011-08-31 Valosun A.S. Probiotické kmeny Lactobacillus fermentum 16A/1 a Lactobacillus crispatus 13A a jejich využití k vaginální aplikaci
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9987222B2 (en) 2012-01-31 2018-06-05 Biosoma B.V. Method for administration of a probiotic
EA201590008A1 (ru) 2012-06-13 2015-05-29 Ивофем, Инк. Композиции и способы повышения эффективности бактерицидных средств контрацепции
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
CN102716325A (zh) * 2012-06-28 2012-10-10 刘倩 一种治疗慢性盆腔炎的中药制剂
FR2992973B1 (fr) 2012-07-09 2015-12-18 S P M D Nouvelle souche de lactobacillus crispatus
FR2992861B1 (fr) 2012-07-09 2014-10-17 Probionov Utilisation de thiosulfate pour potentialiser l'effet anti-pathogene des lactobacilles
CN103074270A (zh) * 2012-11-15 2013-05-01 上海交大昂立股份有限公司 一种卷曲乳杆菌及其应用
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN103911308A (zh) * 2013-01-05 2014-07-09 欣力菲生物医药技术（天津）有限公司 卷曲乳杆菌菌株及其用途
CN104178437B (zh) * 2013-11-08 2016-08-24 苏州欧赛微科生物医药科技有限公司 一种卷曲乳杆菌及其在妇科疾病中的应用
JP2017501227A (ja) 2013-12-19 2017-01-12 エヴォフェム，インク． アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
CN104293718B (zh) * 2014-10-11 2017-01-18 中国科学院微生物研究所 一株詹氏乳杆菌及其应用
KR101980252B1 (ko) 2015-05-26 2019-05-21 (주)투라인스 질증 치료용 조성물
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR102587444B1 (ko) 2015-09-29 2023-10-11 킴벌리-클라크 월드와이드, 인크. 미생물총의 건강한 균형을 유지하기 위한 상승 조성물
FR3048361B1 (fr) 2016-03-01 2020-12-18 Biose Compositions pour le traitement des candidoses
KR101957211B1 (ko) * 2016-03-21 2019-03-13 한국생명공학연구원 조산 및 질염 원인균에 대한 항균 활성, 성병 원인 바이러스에 대한 항바이러스 활성 및 질내 부착능이 우수한 락토바실러스 속 균주 및 이의 용도
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR101784847B1 (ko) * 2016-05-10 2017-10-13 주식회사 하우동천 질염 예방 및 치료용 유산균 함유 조성물 및 이의 용도
CN106176821A (zh) * 2016-08-31 2016-12-07 汪金小 一种微生态阴道菌剂及其制备方法和应用
US11419835B2 (en) 2016-10-04 2022-08-23 Evofem, Inc. Method of treatment and prevention of bacterial vaginosis
MX2019006193A (es) 2016-11-30 2019-08-21 Probioswiss Ag Formulacion para dispositivo medico urogenital a base de composiciones bioquimicas adecuadas para la estabilizacion de la acidez y el estado redox del fluido vaginal.
MX389431B (es) 2017-02-28 2025-03-20 Kimberly Clark Co Composicion sinergica para el mantenimiento del equilibrio saludable de la microflora.
WO2018183685A1 (en) 2017-03-29 2018-10-04 President And Fellows Of Harvard College Methods of regulating gene expression in a cell
DE102017113263A1 (de) 2017-06-16 2018-12-20 Lactopia GmbH Pharmazeutische Zusammensetzung enthaltend Bakterienstämme aus der Familie der Lactobacillaceae und Molke
CN107299065B (zh) * 2017-06-20 2020-02-14 广东强基药业有限公司 一种植物乳杆菌及其用于制备阴道抑菌药物的应用
EP3648779A4 (en) * 2017-07-07 2021-03-17 Osel, Inc. USING VAGINAL LACTOBACILLI TO IMPROVE THE SUCCESS RATE OF IN VITRO FERTILIZATION
KR20200077534A (ko) 2017-10-20 2020-06-30 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 이종 단백질 생성을 위한 인공 분비 펩티드
CN107815432B (zh) * 2017-12-07 2021-09-28 广州柏芳生物科技有限公司 一种人用灭活乳酸菌制剂及其用途
EP3843701B1 (en) * 2018-08-30 2024-02-21 Osel, Inc. Bacteriocins to improve vaginal colonization of hydrogen peroxide producing lactobacillus for female reproductive health
GB201816425D0 (en) * 2018-10-09 2018-11-28 Tervisetehnoloogiate Arenduskeskus As Probiotics
KR102053744B1 (ko) * 2018-11-27 2019-12-09 한국생명공학연구원 질염 원인균에 대한 항균 활성 및 질내 부착능이 우수한 락토바실러스 속 균주 및 이의 용도
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
TW202334391A (zh) * 2021-10-26 2023-09-01 南韓商日東製藥股份有限公司 多個捲曲乳桿菌菌株和含有該多個菌株的用於預防或治療陰道炎的組合物
KR102683248B1 (ko) 2021-11-10 2024-07-10 장효영 질염 예방 및 치료를 위한 주입형 질 유산균 조성물
CN115337256A (zh) * 2022-06-24 2022-11-15 郑州伊品医药科技有限公司 一种含有益生菌的阴道栓塞及胶囊的制备方法
CN116355805B (zh) * 2023-04-11 2025-07-25 吉林大学 一株猪源广谱抑菌的阴道乳杆菌及其应用
CN118308277B (zh) * 2024-06-12 2024-09-13 广州莱可福生物科技有限公司 一种卷曲乳杆菌及其应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953425A (ja) * 1982-09-22 1984-03-28 Meiji Milk Prod Co Ltd 「ちつ」
JPS60501160A (ja) * 1983-05-27 1985-07-25 シ−エイチア−ル　ハンセンズ　バイオ　システムズ　エ−／エス 膣用カプセル
JPS63198624A (ja) * 1986-12-16 1988-08-17 シェリング・コーポレーション 新規な膣坐剤
JPH01294632A (ja) * 1988-03-11 1989-11-28 Teikoku Seiyaku Kk 安定性のすぐれた生理活性ポリペプチド含有経膣剤
JPH02174675A (ja) * 1988-08-05 1990-07-06 Dr A Tosi Farmaceut Srl 特定のラクトバチラス菌よりなる製薬組成物
JPH0421633A (ja) * 1990-05-17 1992-01-24 Saikon Medics:Kk 生体下口腔内有用微生物叢の維持管理法および維持管理組成物
JPH04235920A (ja) * 1991-01-17 1992-08-25 Yakult Honsha Co Ltd 悪性腫瘍再発抑制剤
WO1995015157A1 (en) * 1993-12-03 1995-06-08 Lafor Laboratories Limited Viracidal, bactericidal and spermicidal vaginal suppository

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK127268A (https=) * 1970-01-12 1900-01-01
JPS52102419A (en) * 1976-02-23 1977-08-27 Seikenkai Lactic acid producing bacillus preparation
FI59925C (fi) * 1980-01-11 1981-11-10 Esko Viljo Nurmi Foerfarande foer framstaellning av ett bakteriepreparat anvaendbart foer foerhindrande av salmonellainfektion hos fjaederfae
US4592748A (en) * 1984-05-18 1986-06-03 Vortex Research Corp. Yoghurt based douche kit and assembly therefor
US4839281A (en) * 1985-04-17 1989-06-13 New England Medical Center Hospitals, Inc. Lactobacillus strains and methods of selection
US4956177A (en) * 1985-11-04 1990-09-11 Microlife Technics, Inc. Method for inhibiting fungi
US5804179A (en) * 1985-12-31 1998-09-08 Research Corporation Technologies, Inc. Lactobacillus compositions and methods for treating urinary tract infections
SU1364341A1 (ru) * 1986-09-18 1988-01-07 Центральный научно-исследовательский институт вакцин и сывороток им.И.И.Мечникова Способ получени бифидумбактерина
US4946791A (en) * 1986-10-02 1990-08-07 Bio Techniques Laboratories, Inc. Novel strain of Lactobacillus acidophilus
US4980164A (en) * 1986-10-02 1990-12-25 Bio Techniques Laboratories, Inc. Strains of lactobacillus for enhancing feed conversion efficiency
US5296221A (en) * 1990-01-31 1994-03-22 Sani-Ei Sucrochemical Co., Ltd. Lactobacillus johnsonii ferm bp-2680 lactic acid bacteria preparations using the same and a process of manufacturing the preparations
US5573765A (en) * 1991-02-19 1996-11-12 Mark S. Reinhard Composition and method for treatment of vaginal yeast infections
DE4109036C1 (https=) * 1991-03-15 1992-08-13 Eckhard Dr. 1000 Berlin De Lauer
US5256425A (en) * 1991-08-19 1993-10-26 Bio Techniques Laboratories, Inc. Antibiotic resistant strain of lactobacillus acidophilus
GB2261372A (en) * 1991-11-15 1993-05-19 Gregor Reid Lactobacillus and skim milk compositions for prevention of urogenital infection
UA39965C2 (uk) * 1993-12-03 2001-07-16 Лайфор Леборетріз Лтд Вірусоцидний, бактерицидний та руйнуючий сперматозоїди вагінальний засіб і вагінальний супозиторій ( варіанти )
FR2746109B1 (fr) * 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
EP0927023B1 (en) * 1996-09-13 2004-11-03 Clemson University Composition for treating acne
US6093394A (en) * 1997-04-11 2000-07-25 Gynelogix, Inc. Vaginal lactobacillus medicant
ATE207755T1 (de) 1998-04-30 2001-11-15 Vesely Renata Maria Cavaliere Pharmazeutische zusammensetzungen enthaltend lactobacillus brevis und lactobacillus salivarius zur behandlung von vaginainfektionen

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953425A (ja) * 1982-09-22 1984-03-28 Meiji Milk Prod Co Ltd 「ちつ」
JPS60501160A (ja) * 1983-05-27 1985-07-25 シ−エイチア−ル　ハンセンズ　バイオ　システムズ　エ−／エス 膣用カプセル
JPS63198624A (ja) * 1986-12-16 1988-08-17 シェリング・コーポレーション 新規な膣坐剤
JPH01294632A (ja) * 1988-03-11 1989-11-28 Teikoku Seiyaku Kk 安定性のすぐれた生理活性ポリペプチド含有経膣剤
JPH02174675A (ja) * 1988-08-05 1990-07-06 Dr A Tosi Farmaceut Srl 特定のラクトバチラス菌よりなる製薬組成物
JPH0421633A (ja) * 1990-05-17 1992-01-24 Saikon Medics:Kk 生体下口腔内有用微生物叢の維持管理法および維持管理組成物
JPH04235920A (ja) * 1991-01-17 1992-08-25 Yakult Honsha Co Ltd 悪性腫瘍再発抑制剤
WO1995015157A1 (en) * 1993-12-03 1995-06-08 Lafor Laboratories Limited Viracidal, bactericidal and spermicidal vaginal suppository

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010031031A (ja) * 1997-04-11 2010-02-12 Osel Inc 膣ラクトバチルス薬
KR101092731B1 (ko) 2003-11-03 2011-12-09 페테르 한센 볼크만 질 치료 조성물
JP2005139176A (ja) * 2003-11-03 2005-06-02 Peter-Hansen Volkmann 膣ケア調合物
JP2008517015A (ja) * 2004-10-22 2008-05-22 メディノバ アクチェンゲゼルシャフト 胃腸病原菌に対して有用な乳酸菌、及び当該乳酸菌を含む組成物
JP2008517014A (ja) * 2004-10-22 2008-05-22 メディノヴァ・アクチェンゲゼルシャフト 泌尿生殖器の病原体に対して有用な乳酸菌株およびそれらを含む組成物
JP2010511033A (ja) * 2006-11-28 2010-04-08 プロバイオティカル エス．ピー．エイ． 婦人科および直腸科分野における生物活性成分投与のための組成物とその使用方法
JP2015501635A (ja) * 2011-11-10 2015-01-19 ジェネラル ミルズ インコーポレーティッド 桿状菌の生存能力を高める手段及び方法
JP2017501741A (ja) * 2013-11-08 2017-01-19 スーヂョウ オーセル バイオ−ファーム カンパニー、リミテッド ラクトバチルス・クリスパタスおよびその応用
JP2019521134A (ja) * 2016-07-11 2019-07-25 ヘネピン・ライフ・サイエンシーズ・エルエルシーＨｅｎｎｅｐｉｎ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ，Ｌｌｃ 性感染症用組成物
JP7111699B2 (ja) 2016-09-16 2022-08-02 デュポン ニュートリション バイオサイエンシーズ エーピーエス 細菌
JP2019531720A (ja) * 2016-09-16 2019-11-07 デュポン ニュートリション バイオサイエンシーズ エーピーエス 細菌
KR20180070485A (ko) * 2016-12-16 2018-06-26 (주)휴온스 안정성이 증진된 유산균 및 이의 제조방법
KR102048690B1 (ko) 2016-12-16 2019-11-26 (주)휴온스 안정성이 증진된 유산균 및 이의 제조방법
JP2020526583A (ja) * 2017-07-07 2020-08-31 オセル、インコーポレイテッド 高効力かつ安定な膣ラクトバチルス調製物
JP7347760B2 (ja) 2017-07-07 2023-09-20 オセル、インコーポレイテッド 高効力かつ安定な膣ラクトバチルス調製物
JP2024510109A (ja) * 2021-02-19 2024-03-06 インペリアル・カレッジ・イノベーションズ・リミテッド 妊娠中の対象に使用するためのラクトバチルス・クリスパタス組成物

Also Published As

Publication number Publication date
DE69839699D1 (de) 2008-08-21
AU7359098A (en) 1998-11-11
BR9808520A (pt) 2002-01-15
KR20010006273A (ko) 2001-01-26
EP1011721A1 (en) 2000-06-28
NZ500788A (en) 2003-04-29
CN1259874A (zh) 2000-07-12
NZ513835A (en) 2001-09-28
US6093394A (en) 2000-07-25
US20020090365A1 (en) 2002-07-11
EP1011721A4 (en) 2003-09-24
AU732630B2 (en) 2001-04-26
ATE400281T1 (de) 2008-07-15
CA2285947C (en) 2012-02-28
US6468526B2 (en) 2002-10-22
JP2010031031A (ja) 2010-02-12
EP1011721B1 (en) 2008-07-09
CN1194758C (zh) 2005-03-30
US6372209B1 (en) 2002-04-16
WO1998046261A1 (en) 1998-10-22
CA2285947A1 (en) 1998-10-22

Similar Documents

Publication Publication Date Title
JP2001523231A (ja) 膣ラクトバチルス薬
KR101808972B1 (ko) 락토바실러스 크리스파투스 및 이의 사용
JP4267822B2 (ja) 新規な薬剤
CN117143783B (zh) 一种唾液联合乳杆菌vb330及其应用
CN116200306B (zh) 一种鼠李糖乳酪杆菌LRa16及其在制备治疗生殖道感染的药物方面的用途和产品
US12303538B2 (en) High potency stable formulations of vaginal lactobacillus
CN113604384A (zh) 一种鼠李糖乳杆菌及其应用
JP2024510109A (ja) 妊娠中の対象に使用するためのラクトバチルス・クリスパタス組成物
US20040022775A1 (en) Methods of treating viral infections in mammals
CN110831610A (zh) 阴道乳杆菌用于提高体外受精成功率的用途
CN117821307A (zh) 一株同时改善阴道黏膜损伤与抑制阴道炎症的约氏乳杆菌及其后生元
Ceddia et al. Prevalence of non-specific vaginitis and correlation with isolation of Gardnerella vaginalis in Italian outpatients
CN118562689B (zh) 一株抗幽门螺杆菌的凝结魏茨曼氏菌vb320及其应用与培养装置
CN118667688B (zh) 女性生殖道保护乳酸菌AUh01及其应用
US20010043933A1 (en) Methods and compositions for modulating the immune systems of animals
CN118291299A (zh) 一种发酵乳杆菌及其在缓解酒精性胃损伤制剂中的应用
CN119345191A (zh) 脂氧合酶Lipoxygenase在制备抗新型布尼亚病毒药物中的应用
CN120939064A (zh) 后生元mn45在制备缓解幽门螺杆菌感染产品中的应用
CN118542885A (zh) 一种乳酸菌二联活菌制剂、其制备方法及应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050408

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050408

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090406

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090602

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091002

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20090929

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20100114

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20100527

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110810

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110819

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20120112

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120628

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120709