JP2001503736A - 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 - Google Patents

疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法

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Publication number
JP2001503736A
JP2001503736A JP51097398A JP51097398A JP2001503736A JP 2001503736 A JP2001503736 A JP 2001503736A JP 51097398 A JP51097398 A JP 51097398A JP 51097398 A JP51097398 A JP 51097398A JP 2001503736 A JP2001503736 A JP 2001503736A
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alkyl
formula
ring
group
hydrogen
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Ceased
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JP51097398A
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English (en)
Japanese (ja)
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JP2001503736A5 (enExample
Inventor
タン，ペン・チョ
サン，リ
マクマホン，ジェラルド
ハース，クラウス・ピーター
ショーヴァー，ローラ・ケイ
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Sugen LLC
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Sugen LLC
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Publication of JP2001503736A publication Critical patent/JP2001503736A/ja
Publication of JP2001503736A5 publication Critical patent/JP2001503736A5/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP51097398A 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 Ceased JP2001503736A (ja)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US70223296A 1996-08-23 1996-08-23
US3158896P 1996-12-05 1996-12-05
US3158696P 1996-12-05 1996-12-05
US3158596P 1996-12-05 1996-12-05
US3254796P 1996-12-05 1996-12-05
US3254696P 1996-12-05 1996-12-05
US4684397P 1997-05-05 1997-05-05
US4571497P 1997-05-05 1997-05-05
US4571597P 1997-05-05 1997-05-05
US4556597P 1997-05-05 1997-05-05
US4556697P 1997-05-05 1997-05-05
US60/046,843 1997-05-05
US60/045,715 1997-05-05
US60/032,547 1997-05-05
US60/045,565 1997-05-05
US60/031,588 1997-05-05
US60/031,585 1997-05-05
US60/032,546 1997-05-05
US60/045,566 1997-05-05
US08/702,232 1997-05-05
US60/045,714 1997-05-05
US60/031,586 1997-05-05
PCT/US1997/014736 WO1998007695A1 (en) 1996-08-23 1997-08-20 Indolinone combinatorial libraries and related products and methods for the treatment of disease

Publications (2)

Publication Number Publication Date
JP2001503736A true JP2001503736A (ja) 2001-03-21
JP2001503736A5 JP2001503736A5 (enExample) 2005-04-07

Family

ID=27582490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51097398A Ceased JP2001503736A (ja) 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法

Country Status (8)

Country Link
EP (2) EP0929520B1 (enExample)
JP (1) JP2001503736A (enExample)
AT (1) ATE308520T1 (enExample)
AU (1) AU4155697A (enExample)
CA (1) CA2264220A1 (enExample)
DE (1) DE69734521T9 (enExample)
ES (1) ES2251741T3 (enExample)
WO (1) WO1998007695A1 (enExample)

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JP2003514851A (ja) * 1999-11-24 2003-04-22 スージェン・インコーポレーテッド 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方
JP2004536127A (ja) * 2001-07-13 2004-12-02 フォルシュングスツェントルム カールスルーエ ゲゼルシャフト ミット ベシュレンクテル ハフツング キナーゼ阻害剤及びその使用
WO2011136319A1 (ja) * 2010-04-30 2011-11-03 国立大学法人 東京大学 抗がん剤
JP2016522223A (ja) * 2013-06-20 2016-07-28 中国人民解放軍軍事医学科学院放射及び輻射医学研究所Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｒａｄｉａｔｉｏｎ Ｍｅｄｉｃｉｎｅ， Ａｃａｄｅｍｙ Ｏｆ Ｍｉｌｉｔａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅｓ， Ｐｅｏｐｌｅ’Ｓ Ｌｉｂｒａｔｉｏｎ Ａｒｍｙ Ｏｆ Ｃｈｉｎａ チロシンキナーゼ阻害活性を有する物質ならびにその調製方法および使用

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US6147106A (en) 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US6696448B2 (en) 1996-06-05 2004-02-24 Sugen, Inc. 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
WO1998024432A2 (en) * 1996-12-05 1998-06-11 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
EP0984930B1 (en) * 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US6987113B2 (en) 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
US6313158B1 (en) 1997-06-20 2001-11-06 Sugen, Inc. Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
US6051593A (en) 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
EP1066257A2 (en) * 1998-03-26 2001-01-10 Sugen, Inc. Heterocylic classes of compounds for the modulating tyrosine protein kinase
US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
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DK2020408T3 (da) 1998-05-29 2013-09-30 Sugen Inc Pyrrol-substitueret 2-indolinon som proteinkinaseinhibitor
US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
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WO2000042213A1 (en) * 1999-01-13 2000-07-20 The Research Foundation Of State University Of New York A novel method for designing protein kinase inhibitors
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
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US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
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US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
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PT1255752E (pt) 2000-02-15 2007-10-17 Pharmacia & Upjohn Co Llc Inibidores de proteína quinases: 2-indolinonas substituídas com pirrolo
DE60111358T2 (de) 2000-02-28 2006-05-11 Sugen, Inc., San Diego 3-(pyrolyllacton)-2-indolinon verbindungen zur verwendung als kinase-hemmstoffe
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
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CN103183665B (zh) * 2011-12-30 2015-10-14 中国人民解放军军事医学科学院放射与辐射医学研究所 具有酪氨酸激酶抑制活性的物质、其制备方法及用途
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CN105481751A (zh) * 2014-09-16 2016-04-13 中国科学院海洋研究所 一类2-吲哚酮衍生物及其制备和应用
CN104326964A (zh) * 2014-09-16 2015-02-04 中国科学院海洋研究所 一类氟代2-吲哚酮衍生物及其制备和应用
CN108047119A (zh) * 2017-11-28 2018-05-18 四川理工学院 3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用
CN107840818A (zh) * 2017-11-28 2018-03-27 四川理工学院 含氟二氧化吲哚化合物及其应用
CN115073353B (zh) * 2021-03-15 2024-05-14 中国医学科学院药物研究所 木脂素类衍生物及其制法和其药物组合物与用途
WO2024149340A1 (zh) * 2023-01-12 2024-07-18 深圳众格生物科技有限公司 具有irak4抑制活性的吲哚酮衍生物及其制备方法和应用

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JP2003514851A (ja) * 1999-11-24 2003-04-22 スージェン・インコーポレーテッド 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方
JP2004536127A (ja) * 2001-07-13 2004-12-02 フォルシュングスツェントルム カールスルーエ ゲゼルシャフト ミット ベシュレンクテル ハフツング キナーゼ阻害剤及びその使用
WO2011136319A1 (ja) * 2010-04-30 2011-11-03 国立大学法人 東京大学 抗がん剤
CN103391936A (zh) * 2010-04-30 2013-11-13 国立大学法人东京大学 抗癌剂
JP2015063540A (ja) * 2010-04-30 2015-04-09 国立大学法人 東京大学 抗がん剤
US9156827B2 (en) 2010-04-30 2015-10-13 The University Of Tokyo Anticancer agent
CN103391936B (zh) * 2010-04-30 2016-04-27 国立大学法人东京大学 抗癌剂
JP2016522223A (ja) * 2013-06-20 2016-07-28 中国人民解放軍軍事医学科学院放射及び輻射医学研究所Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｒａｄｉａｔｉｏｎ Ｍｅｄｉｃｉｎｅ， Ａｃａｄｅｍｙ Ｏｆ Ｍｉｌｉｔａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅｓ， Ｐｅｏｐｌｅ’Ｓ Ｌｉｂｒａｔｉｏｎ Ａｒｍｙ Ｏｆ Ｃｈｉｎａ チロシンキナーゼ阻害活性を有する物質ならびにその調製方法および使用

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CA2264220A1 (en) 1998-02-26
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DE69734521D1 (de) 2005-12-08
EP0929520A1 (en) 1999-07-21
AU4155697A (en) 1998-03-06
WO1998007695A1 (en) 1998-02-26
DE69734521T9 (de) 2006-12-07
DE69734521T2 (de) 2006-07-06
EP1247803A2 (en) 2002-10-09
ES2251741T3 (es) 2006-05-01
EP1247803A3 (en) 2002-10-16

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