MXPA01006742A - Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer. - Google Patents

Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer.

Info

Publication number
MXPA01006742A
MXPA01006742A MXPA01006742A MXPA01006742A MXPA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A
Authority
MX
Mexico
Prior art keywords
heteroarylidenyl
protein kinase
kinase activity
cancer chemotherapy
indolinone compounds
Prior art date
Application number
MXPA01006742A
Other languages
English (en)
Inventor
Peng Cho Tang
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of MXPA01006742A publication Critical patent/MXPA01006742A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invencion se refiere a los compuestos 3-heteroarilidenil-2-indolinona que modulan la actividad enzimatica de las quinasas de proteina y por lo tanto se espera que sean utiles en la prevencion y tratamiento de la quinasa de proteina relacionada a los desordenes celulares tal como el cancer. Ademas, se espera que estos compuestos mejoren la eficacia de otros agentes quimioterapeuticos, en particular, pirimidinas fluoradas, en el tratamiento del cancer.
MXPA01006742A 1998-12-31 1999-12-30 Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer. MXPA01006742A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11431398P 1998-12-31 1998-12-31
PCT/US1999/031232 WO2000038519A1 (en) 1998-12-31 1999-12-30 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy

Publications (1)

Publication Number Publication Date
MXPA01006742A true MXPA01006742A (es) 2004-04-21

Family

ID=22354480

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01006742A MXPA01006742A (es) 1998-12-31 1999-12-30 Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer.

Country Status (10)

Country Link
EP (1) EP1139754A4 (es)
JP (1) JP2002533360A (es)
KR (1) KR20010108063A (es)
CN (1) CN1356872A (es)
AU (1) AU760964B2 (es)
BR (1) BR9916735A (es)
CA (1) CA2357042A1 (es)
IL (1) IL143920A0 (es)
MX (1) MXPA01006742A (es)
WO (1) WO2000038519A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
ATE514676T1 (de) * 1999-11-24 2011-07-15 Sugen Inc Ionisierbare indolinon derivate und deren verwendung als ptk liganden
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
CA2401191C (en) * 2000-02-28 2006-05-02 Aventis Pharma S.A. A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
AU2001268154A1 (en) 2000-06-02 2001-12-17 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
EE05417B1 (et) 2001-03-14 2011-06-15 Bristol-Myers Squibb Company Epotilooni analoogide ja kemoterapeutikumide kombinatsiooni kasutamine teraapias
AU2002303892A1 (en) 2001-05-30 2002-12-09 Jingrong Cui 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
AR038957A1 (es) * 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
WO2003035619A1 (en) * 2001-10-25 2003-05-01 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2002348393A1 (en) * 2001-10-25 2003-05-06 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2003035616A2 (en) * 2001-10-25 2003-05-01 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003045307A2 (en) * 2001-11-21 2003-06-05 Sugen, Inc. Pharmaceutical formulations comprising indolinone derivatives
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
EP1458713B1 (en) 2001-12-27 2005-08-24 Theravance, Inc. Indolinone derivatives useful as protein kinase inhibitors
AU2003245637A1 (en) * 2002-06-25 2004-01-06 Wyeth Use of thio-oxindole derivatives in treatment of hormone-related conditions
KR20050012831A (ko) * 2002-06-25 2005-02-02 와이어쓰 피부 질환을 치료하는 데 있어서의 티오-옥스인돌유도체의 용도
CA2494695C (en) 2002-08-02 2011-04-05 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
CA2506085A1 (en) * 2002-11-15 2004-06-03 Ronald Lynn Merriman Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer
JP4971797B2 (ja) 2003-10-23 2012-07-11 アブ サイエンス チロシンキナーゼ阻害薬としての２−アミノアリールオキサゾール化合物
CN100432071C (zh) * 2004-11-05 2008-11-12 中国科学院上海药物研究所 取代1h－吲哚－2－酮类化合物及其制备方法和用途
JP5204643B2 (ja) 2005-04-04 2013-06-05 アブ サイエンス 置換オキサゾール誘導体、およびチロシンキナーゼ阻害薬としてのそれらの使用
US8246966B2 (en) 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
WO2008066755A2 (en) 2006-11-22 2008-06-05 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
PL2780011T3 (pl) * 2011-11-11 2018-08-31 Eli Lilly And Company Terapia skojarzona raka jajnika
ES2887474T3 (es) 2015-01-08 2021-12-22 Univ Leland Stanford Junior Factores y células que proporcionan inducción de hueso, médula ósea y cartílago
HUE053943T2 (hu) 2015-04-29 2021-08-30 Janssen Pharmaceutica Nv Azabenzimidazolok és ampa receptor modulátorokként való alkalmazásuk
CN105585558A (zh) * 2015-12-15 2016-05-18 贵州大学 双烷氧基嘧啶拼接3-烯键氧化吲哚衍生物及其制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
EP1247803A3 (en) * 1996-08-23 2002-10-16 Sugen, Inc. Indolinone compounds suitable for modulation of protein kinases

Also Published As

Publication number Publication date
AU2221500A (en) 2000-07-31
IL143920A0 (en) 2002-04-21
KR20010108063A (ko) 2001-12-07
CA2357042A1 (en) 2000-07-06
AU760964B2 (en) 2003-05-22
BR9916735A (pt) 2001-09-25
WO2000038519A1 (en) 2000-07-06
EP1139754A4 (en) 2002-12-18
CN1356872A (zh) 2002-07-03
JP2002533360A (ja) 2002-10-08
EP1139754A1 (en) 2001-10-10

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