BR9811956B1 - naftiridinonas e composição farmacêutica compreendendo as mesmas. - Google Patents
naftiridinonas e composição farmacêutica compreendendo as mesmas.Info
- Publication number
- BR9811956B1 BR9811956B1 BRPI9811956-7A BR9811956A BR9811956B1 BR 9811956 B1 BR9811956 B1 BR 9811956B1 BR 9811956 A BR9811956 A BR 9811956A BR 9811956 B1 BR9811956 B1 BR 9811956B1
- Authority
- BR
- Brazil
- Prior art keywords
- pct
- naphthyridinones
- pharmaceutical composition
- ptk
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5674697P | 1997-08-20 | 1997-08-20 | |
PCT/US1998/016848 WO1999009030A1 (en) | 1997-08-20 | 1998-08-13 | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9811956A BR9811956A (pt) | 2000-08-15 |
BR9811956B1 true BR9811956B1 (pt) | 2010-06-01 |
Family
ID=22006345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9811956-7A BR9811956B1 (pt) | 1997-08-20 | 1998-08-13 | naftiridinonas e composição farmacêutica compreendendo as mesmas. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6150359A (pt) |
EP (1) | EP1003745B1 (pt) |
JP (1) | JP4965021B2 (pt) |
KR (1) | KR20010023089A (pt) |
AT (1) | ATE286053T1 (pt) |
AU (1) | AU742999B2 (pt) |
BR (1) | BR9811956B1 (pt) |
CA (1) | CA2291222C (pt) |
DE (1) | DE69828408T2 (pt) |
ES (1) | ES2235353T3 (pt) |
NZ (1) | NZ502704A (pt) |
WO (1) | WO1999009030A1 (pt) |
ZA (1) | ZA987491B (pt) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1801112A1 (en) * | 1998-05-26 | 2007-06-27 | Warner-Lambert Company LLC | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
CN1138778C (zh) * | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
ATE320255T1 (de) | 2001-01-19 | 2006-04-15 | Smithkline Beecham Corp | Tie2 rezeptor-kinase-inhibitoren zur behandlung von angiogenen erkrankungen |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
CA2438294C (en) | 2001-02-26 | 2008-10-21 | Tanabe Seiyaku Co., Ltd. | Pyridopyrimidine or naphthyridine derivative |
US6822097B1 (en) | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
US20040005567A1 (en) * | 2002-07-02 | 2004-01-08 | Isis Pharmaceuticals Inc. | Antisense modulation of cyclin-dependent kinase 4 expression |
CA2483449A1 (en) | 2002-04-25 | 2003-11-06 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
CA2492112A1 (en) * | 2002-08-06 | 2004-02-19 | F. Hoffmann-La Roche Ag | 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors |
US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
BRPI0406809A (pt) * | 2003-01-17 | 2005-12-27 | Warner Lambert Co | Heterociclos substituìdos de 2-aminopiridina como inibidores da proliferação celular |
CN1863774B (zh) * | 2003-10-08 | 2010-12-15 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
JP2007513967A (ja) * | 2003-12-11 | 2007-05-31 | セラヴァンス, インコーポレーテッド | 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物 |
US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
EP1937681A1 (en) * | 2005-09-14 | 2008-07-02 | Janssen Pharmaceutica N.V. | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase |
US7642270B2 (en) | 2005-09-14 | 2010-01-05 | Janssen Pharmaceutica N.V. | 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase |
TW200800983A (en) | 2005-09-14 | 2008-01-01 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase |
JP2010509265A (ja) * | 2006-11-09 | 2010-03-25 | エフ.ホフマン−ラ ロシュ アーゲー | キナーゼ阻害剤としての置換6−フェニル−ピリド[2,3−d]ピリミジン−7−オン誘導体及びそれの使用方法 |
WO2008077064A2 (en) * | 2006-12-19 | 2008-06-26 | Board Of Regents, The University Of Texas System | Biomarker identifying the reactivation of stat3 after src inhibition |
WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
EP2252612B1 (en) | 2008-02-22 | 2012-03-28 | Irm Llc | Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors |
CN101684119B (zh) * | 2008-09-27 | 2012-11-28 | 中国科学院上海药物研究所 | 5,8-二取代-1,6-二氮杂萘-7-羰酰胺类化合物及其制备方法、组合物和用途 |
US9376664B2 (en) | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
EP3822273B1 (en) | 2012-06-13 | 2024-04-10 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
AU2013323736A1 (en) * | 2012-09-26 | 2015-04-09 | Mannkind Corporation | Multiple kinase pathway inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MX2017010673A (es) | 2015-02-20 | 2018-03-21 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr). |
WO2018108167A1 (zh) * | 2016-12-16 | 2018-06-21 | 基石药业 | Cdk4/6抑制剂 |
CN108264511B (zh) * | 2017-01-03 | 2021-04-13 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和其在医药上的用途 |
WO2018213219A1 (en) * | 2017-05-15 | 2018-11-22 | University Of Houston System | Pyrido[2,3-d]pyrimidin-7ones and related compounds as inhibitors of protein kinases |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
CN112867716A (zh) | 2018-05-04 | 2021-05-28 | 因赛特公司 | Fgfr抑制剂的固体形式和其制备方法 |
CN112566912A (zh) | 2018-05-04 | 2021-03-26 | 因赛特公司 | Fgfr抑制剂的盐 |
CN113473986A (zh) * | 2018-11-20 | 2021-10-01 | 恩福莱克逊治疗有限公司 | 用于治疗皮肤疾病萘啶酮苯胺化合物 |
CA3124574A1 (en) * | 2018-12-28 | 2020-07-02 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
JP2022533182A (ja) * | 2019-05-16 | 2022-07-21 | ユニバーシティー オブ ヒューストン システム | タンパク質キナーゼ阻害剤ならびに疾患および状態の治療のためのその使用 |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
MX2022003873A (es) * | 2019-10-01 | 2022-06-02 | Goldfinch Bio Inc | Inhibidores de 1,6-naftiridina sustituida de cdk5. |
AU2020366006A1 (en) | 2019-10-14 | 2022-04-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
AR122928A1 (es) * | 2020-07-10 | 2022-10-19 | Goldfinch Bio Inc | 1,6-naftiridinas sustituidas inhibidoras de cdk5 |
WO2022236319A1 (en) * | 2021-05-07 | 2022-11-10 | Enliven Therapeutics, Inc. | Naphthyridone compounds for inhibition of raf kinases and/or bcr-abl tyrosine kinases |
US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1171218A (en) * | 1967-11-09 | 1969-11-19 | Parke Davis & Co | New Heterocyclic Amine Compounds and Methods for their Production |
US3639401A (en) * | 1969-07-28 | 1972-02-01 | Parke Davis & Co | 6-aryl-2 7-bis((trialkylsilyl)amino)pyrido (2 3-d)pyrimidine compounds |
US4271164A (en) * | 1979-04-16 | 1981-06-02 | Warner-Lambert Company | 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives |
AU658646B2 (en) * | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
FR2706898B1 (pt) * | 1993-06-25 | 1995-09-08 | Union Pharma Scient Appl | |
DE69515898T2 (de) * | 1994-11-14 | 2000-08-17 | Warner Lambert Co | 6-ARYL-PYRIDO[2,3-d]PYRIMIDINE UND -NAPHTHYRIDINE ZUR HEMMUNG DER DURCH PROTEIN-TYROSIN-KINASE HERVORGERUFENEN ZELLVERMEHRUNG |
US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
-
1998
- 1998-08-13 US US09/463,553 patent/US6150359A/en not_active Expired - Lifetime
- 1998-08-13 AU AU88289/98A patent/AU742999B2/en not_active Ceased
- 1998-08-13 AT AT98939941T patent/ATE286053T1/de not_active IP Right Cessation
- 1998-08-13 ES ES98939941T patent/ES2235353T3/es not_active Expired - Lifetime
- 1998-08-13 JP JP2000509710A patent/JP4965021B2/ja not_active Expired - Fee Related
- 1998-08-13 NZ NZ502704A patent/NZ502704A/en unknown
- 1998-08-13 WO PCT/US1998/016848 patent/WO1999009030A1/en not_active Application Discontinuation
- 1998-08-13 KR KR1020007001710A patent/KR20010023089A/ko not_active Application Discontinuation
- 1998-08-13 DE DE69828408T patent/DE69828408T2/de not_active Expired - Lifetime
- 1998-08-13 CA CA002291222A patent/CA2291222C/en not_active Expired - Fee Related
- 1998-08-13 BR BRPI9811956-7A patent/BR9811956B1/pt not_active IP Right Cessation
- 1998-08-13 EP EP98939941A patent/EP1003745B1/en not_active Expired - Lifetime
- 1998-08-19 ZA ZA987491A patent/ZA987491B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69828408D1 (de) | 2005-02-03 |
KR20010023089A (ko) | 2001-03-26 |
US6150359A (en) | 2000-11-21 |
BR9811956A (pt) | 2000-08-15 |
DE69828408T2 (de) | 2005-12-08 |
ATE286053T1 (de) | 2005-01-15 |
AU742999B2 (en) | 2002-01-17 |
EP1003745A1 (en) | 2000-05-31 |
AU8828998A (en) | 1999-03-08 |
EP1003745B1 (en) | 2004-12-29 |
ZA987491B (en) | 1999-04-21 |
WO1999009030A1 (en) | 1999-02-25 |
ES2235353T3 (es) | 2005-07-01 |
JP4965021B2 (ja) | 2012-07-04 |
CA2291222A1 (en) | 1999-02-25 |
NZ502704A (en) | 2002-06-28 |
JP2001515078A (ja) | 2001-09-18 |
CA2291222C (en) | 2004-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: C07D 471/02, A61K 31/4375, A61K 31/498, A61K 31/4985, A61P 9/08, A61P 9/10, A61P 17/06, A61P 35/00, A61P 43/00 Ipc: C07D 471/02 (2008.01), A61K 31/4375 (2008.01), A61 |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/06/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 16A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2266 DE 10-06-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |