JP2001503736A5 - - Google Patents

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Publication number
JP2001503736A5
JP2001503736A5 JP1998510973A JP51097398A JP2001503736A5 JP 2001503736 A5 JP2001503736 A5 JP 2001503736A5 JP 1998510973 A JP1998510973 A JP 1998510973A JP 51097398 A JP51097398 A JP 51097398A JP 2001503736 A5 JP2001503736 A5 JP 2001503736A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998510973A
Other languages
English (en)
Japanese (ja)
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JP2001503736A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/014736 external-priority patent/WO1998007695A1/en
Publication of JP2001503736A publication Critical patent/JP2001503736A/ja
Publication of JP2001503736A5 publication Critical patent/JP2001503736A5/ja
Ceased legal-status Critical Current

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JP51097398A 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 Ceased JP2001503736A (ja)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US70223296A 1996-08-23 1996-08-23
US08/702,232 1996-08-23
US3254796P 1996-12-05 1996-12-05
US3158696P 1996-12-05 1996-12-05
US3254696P 1996-12-05 1996-12-05
US3158896P 1996-12-05 1996-12-05
US3158596P 1996-12-05 1996-12-05
US60/031,585 1996-12-05
US60/031,586 1996-12-05
US60/032,547 1996-12-05
US60/032,546 1996-12-05
US60/031,588 1996-12-05
US4571597P 1997-05-05 1997-05-05
US4571497P 1997-05-05 1997-05-05
US4684397P 1997-05-05 1997-05-05
US4556597P 1997-05-05 1997-05-05
US4556697P 1997-05-05 1997-05-05
US60/045,714 1997-05-05
US60/045,565 1997-05-05
US60/045,715 1997-05-05
US60/045,566 1997-05-05
US60/046,843 1997-05-05
PCT/US1997/014736 WO1998007695A1 (en) 1996-08-23 1997-08-20 Indolinone combinatorial libraries and related products and methods for the treatment of disease

Publications (2)

Publication Number Publication Date
JP2001503736A JP2001503736A (ja) 2001-03-21
JP2001503736A5 true JP2001503736A5 (enExample) 2005-04-07

Family

ID=27582490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51097398A Ceased JP2001503736A (ja) 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法

Country Status (8)

Country Link
EP (2) EP0929520B1 (enExample)
JP (1) JP2001503736A (enExample)
AT (1) ATE308520T1 (enExample)
AU (1) AU4155697A (enExample)
CA (1) CA2264220A1 (enExample)
DE (1) DE69734521T9 (enExample)
ES (1) ES2251741T3 (enExample)
WO (1) WO1998007695A1 (enExample)

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US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US6696448B2 (en) 1996-06-05 2004-02-24 Sugen, Inc. 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
AU7622698A (en) * 1996-12-05 1998-06-29 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
WO1998050356A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US6987113B2 (en) 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
US6051593A (en) 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
US6313158B1 (en) 1997-06-20 2001-11-06 Sugen, Inc. Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
WO1999048868A2 (en) * 1998-03-26 1999-09-30 Sugen, Inc. Heterocyclic classes of compounds for the modulating tyrosine protein kinase
US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
IL139934A (en) * 1998-05-29 2007-10-31 Sugen Inc History 2 - Indulinone converted to pyrrole and pharmaceutical preparations containing them
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US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
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US6680335B2 (en) 1998-09-28 2004-01-20 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
DK1157019T3 (da) * 1998-12-17 2003-07-14 Hoffmann La Roche 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2
CA2354591A1 (en) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of jnk protein kinases
WO2000035921A1 (en) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4,5-pyrazinoxindoles as protein kinase inhibitors
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
TR200101747T2 (tr) * 1998-12-17 2001-11-21 F.Hoffmann-La Roche Ag 4- ve 5-alkinil oksindoller ve 4- ve 5-alkeniloksindoller.
AU760964B2 (en) * 1998-12-31 2003-05-22 Sugen, Inc. 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activityand for use in cancer chemotherapy
MXPA01007099A (es) * 1999-01-13 2002-03-27 Univ New York State Res Found Metodo novedoso para disenar inhibidores de la proteina cinasa.
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
WO2000056709A1 (en) * 1999-03-24 2000-09-28 Sugen, Inc. Indolinone compounds as kinase inhibitors
ES2367007T3 (es) * 1999-11-24 2011-10-27 Sugen, Inc. Derivados de indolinona ionizables y su uso como ligandos de ptk.
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
US20020010203A1 (en) 1999-12-22 2002-01-24 Ken Lipson Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
RS50444B (sr) 2000-02-15 2010-03-02 Sugen Inc. Inhibitori 2-indolinon protein kinaze supstituisani pirolom
JP2003525296A (ja) 2000-02-28 2003-08-26 スージェン・インコーポレーテッド キナーゼ阻害剤としての3−(ピロリルラクトン)−2−インドリノン化合物
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
CA2410509A1 (en) 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
WO2002002551A1 (en) 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
FR2821358B1 (fr) * 2001-02-27 2006-04-07 Aventis Pharma Sa Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique
DE10114138C2 (de) * 2001-03-16 2003-03-27 Schering Ag Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
DE10134196B4 (de) * 2001-07-13 2005-08-18 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
GB0302512D0 (en) * 2003-02-03 2003-03-05 Arrow Therapeutics Ltd Compounds
US7157577B2 (en) 2003-03-07 2007-01-02 Sugen Inc. 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
WO2005068424A1 (en) * 2004-01-20 2005-07-28 Cell Therapeutics Europe S.R.L. Indolinone derivatives as receptor tyrosine kinase ihibitors
SG176463A1 (en) 2005-02-22 2011-12-29 Univ Michigan Small molecule inhibitors of mdm2 and uses thereof
EP1883403A4 (en) * 2005-04-29 2011-02-16 Univ Ohio State Res Found KERATINOCYTE GROWTH FACTOR RECEPTOR TYROSINE-SPECIFIC INHIBITORS FOR THE PREVENTION OF CANCER METASTASE
JP2009529047A (ja) 2006-03-07 2009-08-13 アレイ バイオファーマ、インコーポレイテッド ヘテロ二環系ピラゾール化合物およびその使用
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
CA2736177A1 (en) * 2007-09-06 2009-03-12 Boston Biomedical, Inc. Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
CN101970426A (zh) * 2007-12-21 2011-02-09 大学健康网络 吲唑基、苯并咪唑基、苯并三唑基取代的二氢吲哚酮衍生物作为癌症治疗中有用的激酶抑制剂
EP2417127B1 (en) 2009-04-06 2014-02-26 University Health Network Kinase inhibitors and method of treating cancer with same
ES2639757T3 (es) 2010-04-06 2017-10-30 University Health Network Síntesis de 2-(1H-indazol-6-il)espiro[ciclopropan-1,3'-indolin]-2'-onas quirales
CN103391936B (zh) * 2010-04-30 2016-04-27 国立大学法人东京大学 抗癌剂
CN103183665B (zh) * 2011-12-30 2015-10-14 中国人民解放军军事医学科学院放射与辐射医学研究所 具有酪氨酸激酶抑制活性的物质、其制备方法及用途
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
EP3012248B1 (en) * 2013-06-20 2019-09-11 Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
MX357763B (es) 2013-10-18 2018-07-23 Univ Health Network Tratamiento para cancer pancreatico.
CN107002119A (zh) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联
CN104326964A (zh) * 2014-09-16 2015-02-04 中国科学院海洋研究所 一类氟代2-吲哚酮衍生物及其制备和应用
CN105481751A (zh) * 2014-09-16 2016-04-13 中国科学院海洋研究所 一类2-吲哚酮衍生物及其制备和应用
CN107840818A (zh) * 2017-11-28 2018-03-27 四川理工学院 含氟二氧化吲哚化合物及其应用
CN108047119A (zh) * 2017-11-28 2018-05-18 四川理工学院 3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用
CN115073353B (zh) * 2021-03-15 2024-05-14 中国医学科学院药物研究所 木脂素类衍生物及其制法和其药物组合物与用途
EP4650354A1 (en) * 2023-01-12 2025-11-19 Shenzhen Zhongge Biological Technology Co., Ltd. Indolone derivative having irak4 inhibitory activity, and preparation method therefor and use thereof

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