JP2001503736A5 - - Google Patents

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Publication number
JP2001503736A5
JP2001503736A5 JP1998510973A JP51097398A JP2001503736A5 JP 2001503736 A5 JP2001503736 A5 JP 2001503736A5 JP 1998510973 A JP1998510973 A JP 1998510973A JP 51097398 A JP51097398 A JP 51097398A JP 2001503736 A5 JP2001503736 A5 JP 2001503736A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998510973A
Other languages
English (en)
Japanese (ja)
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JP2001503736A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/014736 external-priority patent/WO1998007695A1/en
Publication of JP2001503736A publication Critical patent/JP2001503736A/ja
Publication of JP2001503736A5 publication Critical patent/JP2001503736A5/ja
Ceased legal-status Critical Current

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JP51097398A 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 Ceased JP2001503736A (ja)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US70223296A 1996-08-23 1996-08-23
US08/702,232 1996-08-23
US3158896P 1996-12-05 1996-12-05
US3254796P 1996-12-05 1996-12-05
US3158696P 1996-12-05 1996-12-05
US3254696P 1996-12-05 1996-12-05
US3158596P 1996-12-05 1996-12-05
US60/032,547 1996-12-05
US60/032,546 1996-12-05
US60/031,586 1996-12-05
US60/031,585 1996-12-05
US60/031,588 1996-12-05
US4571497P 1997-05-05 1997-05-05
US4556697P 1997-05-05 1997-05-05
US4571597P 1997-05-05 1997-05-05
US4556597P 1997-05-05 1997-05-05
US4684397P 1997-05-05 1997-05-05
US60/045,566 1997-05-05
US60/045,714 1997-05-05
US60/045,715 1997-05-05
US60/045,565 1997-05-05
US60/046,843 1997-05-05
PCT/US1997/014736 WO1998007695A1 (en) 1996-08-23 1997-08-20 Indolinone combinatorial libraries and related products and methods for the treatment of disease

Publications (2)

Publication Number Publication Date
JP2001503736A JP2001503736A (ja) 2001-03-21
JP2001503736A5 true JP2001503736A5 (enExample) 2005-04-07

Family

ID=27582490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51097398A Ceased JP2001503736A (ja) 1996-08-23 1997-08-20 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法

Country Status (8)

Country Link
EP (2) EP0929520B1 (enExample)
JP (1) JP2001503736A (enExample)
AT (1) ATE308520T1 (enExample)
AU (1) AU4155697A (enExample)
CA (1) CA2264220A1 (enExample)
DE (1) DE69734521T9 (enExample)
ES (1) ES2251741T3 (enExample)
WO (1) WO1998007695A1 (enExample)

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US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
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US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
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US6987113B2 (en) 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
US6313158B1 (en) 1997-06-20 2001-11-06 Sugen, Inc. Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
US6051593A (en) 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
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US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
WO1999048868A2 (en) * 1998-03-26 1999-09-30 Sugen, Inc. Heterocyclic classes of compounds for the modulating tyrosine protein kinase
US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
JP2002516851A (ja) * 1998-05-29 2002-06-11 ゲルハルト アイゼンブランド サイクリン依存性キナーゼを阻害する医薬製造のためのインジゴイドビスインドール誘導体の使用
KR100743287B1 (ko) 1998-05-29 2007-07-26 수젠, 인크. 피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
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US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
US6680335B2 (en) 1998-09-28 2004-01-20 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
DE69906152T2 (de) 1998-12-17 2004-02-12 F. Hoffmann-La Roche Ag 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2
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ES2301255T3 (es) * 1998-12-17 2008-06-16 F. Hoffmann-La Roche Ag 4,5-pirazinaxindoles como inhibidores de proteinoquinasas.
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
IL143920A0 (en) * 1998-12-31 2002-04-21 Sugen Inc 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same
EP1147214B1 (en) 1999-01-13 2011-01-05 The Research Foundation Of State University Of New York A novel method for designing protein kinase inhibitors
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
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AU3770000A (en) * 1999-03-24 2000-10-09 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
JP5336686B2 (ja) * 1999-11-24 2013-11-06 スージェン， インク． 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
CA2395461C (en) 1999-12-22 2010-05-25 Sugen, Inc. Methods of modulating c-kit tyrosine kinase function with indolinone compounds
HRP20020751B1 (hr) 2000-02-15 2011-01-31 Sugen Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
WO2001064681A2 (en) 2000-02-28 2001-09-07 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja) 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
WO2002002551A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
FR2821358B1 (fr) * 2001-02-27 2006-04-07 Aventis Pharma Sa Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique
DE10114138C2 (de) * 2001-03-16 2003-03-27 Schering Ag Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2002096361A2 (en) 2001-05-30 2002-12-05 Sugen, Inc. 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
DE10134196B4 (de) * 2001-07-13 2005-08-18 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
GB0302512D0 (en) * 2003-02-03 2003-03-05 Arrow Therapeutics Ltd Compounds
US7157577B2 (en) 2003-03-07 2007-01-02 Sugen Inc. 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
WO2005068424A1 (en) * 2004-01-20 2005-07-28 Cell Therapeutics Europe S.R.L. Indolinone derivatives as receptor tyrosine kinase ihibitors
US7759383B2 (en) 2005-02-22 2010-07-20 The Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof
WO2006119148A2 (en) * 2005-04-29 2006-11-09 The Ohio State University Research Foundation Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis
US7723330B2 (en) 2006-03-07 2010-05-25 Array Biopharma Inc. Heterobicyclic pyrazole compounds and methods of use
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
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EP2235004A4 (en) * 2007-12-21 2011-05-04 Univ Health Network INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT
WO2010115279A1 (en) 2009-04-06 2010-10-14 University Health Network Kinase inhibitors and method of treating cancer with same
TWI516262B (zh) 2010-04-06 2016-01-11 健康網路大學 激酶抑制劑及以其治療癌症的方法
CN103391936B (zh) * 2010-04-30 2016-04-27 国立大学法人东京大学 抗癌剂
CN103183665B (zh) * 2011-12-30 2015-10-14 中国人民解放军军事医学科学院放射与辐射医学研究所 具有酪氨酸激酶抑制活性的物质、其制备方法及用途
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
JP6239103B2 (ja) * 2013-06-20 2017-11-29 中国人民解放軍軍事医学科学院放射及び輻射医学研究所Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｒａｄｉａｔｉｏｎ Ｍｅｄｉｃｉｎｅ， Ａｃａｄｅｍｙ Ｏｆ Ｍｉｌｉｔａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅｓ， Ｐｅｏｐｌｅ’Ｓ Ｌｉｂｒａｔｉｏｎ Ａｒｍｙ Ｏｆ Ｃｈｉｎａ チロシンキナーゼ阻害活性を有する物質ならびにその調製方法および使用
EA030089B1 (ru) 2013-10-18 2018-06-29 Юниверсити Хелс Нетуорк Лечение рака поджелудочной железы
EP3122900A1 (en) 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
CN104326964A (zh) * 2014-09-16 2015-02-04 中国科学院海洋研究所 一类氟代2-吲哚酮衍生物及其制备和应用
CN105481751A (zh) * 2014-09-16 2016-04-13 中国科学院海洋研究所 一类2-吲哚酮衍生物及其制备和应用
CN108047119A (zh) * 2017-11-28 2018-05-18 四川理工学院 3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用
CN107840818A (zh) * 2017-11-28 2018-03-27 四川理工学院 含氟二氧化吲哚化合物及其应用
CN115073353B (zh) * 2021-03-15 2024-05-14 中国医学科学院药物研究所 木脂素类衍生物及其制法和其药物组合物与用途
US20260217704A1 (en) * 2023-01-12 2026-07-30 Dovetree Medicines Unus, Inc. Indolone derivative having irak4 inhibitory activity, and preparation method therefor and use thereof

Family Cites Families (9)

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BE553661A (enExample) * 1955-12-23
GB9004483D0 (en) * 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
GB9115160D0 (en) * 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
FR2694004B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9313638D0 (en) * 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9412719D0 (en) * 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease

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