|
US6147106A
(en)
|
1997-08-20 |
2000-11-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
US6906093B2
(en)
|
1995-06-07 |
2005-06-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
|
US6316635B1
(en)
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
US6696448B2
(en)
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
|
AU7622698A
(en)
*
|
1996-12-05 |
1998-06-29 |
Sugen, Inc. |
Use of indolinone compounds as modulators of protein kinases
|
|
US6316429B1
(en)
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
|
US6486185B1
(en)
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
|
WO1998050356A1
(en)
*
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
US6987113B2
(en)
|
1997-06-11 |
2006-01-17 |
Sugen, Inc. |
Tyrosine kinase inhibitors
|
|
US6051593A
(en)
|
1997-06-20 |
2000-04-18 |
Sugen, Inc. |
3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
|
|
US6313158B1
(en)
|
1997-06-20 |
2001-11-06 |
Sugen, Inc. |
Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
|
|
GB9716557D0
(en)
*
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
GB9718913D0
(en)
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
|
US6531502B1
(en)
|
1998-01-21 |
2003-03-11 |
Sugen, Inc. |
3-Methylidenyl-2-indolinone modulators of protein kinase
|
|
WO1999048868A2
(en)
*
|
1998-03-26 |
1999-09-30 |
Sugen, Inc. |
Heterocyclic classes of compounds for the modulating tyrosine protein kinase
|
|
US6514981B1
(en)
|
1998-04-02 |
2003-02-04 |
Sugen, Inc. |
Methods of modulating tyrosine protein kinase function with indolinone compounds
|
|
US6569868B2
(en)
|
1998-04-16 |
2003-05-27 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
IL139934A
(en)
*
|
1998-05-29 |
2007-10-31 |
Sugen Inc |
History 2 - Indulinone converted to pyrrole and pharmaceutical preparations containing them
|
|
IL139914A0
(en)
*
|
1998-05-29 |
2002-02-10 |
Eisenbrand Gerhard |
Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases
|
|
US6319918B1
(en)
|
1998-06-04 |
2001-11-20 |
Boehringer Ingelheim Pharma Kg |
Substituted indolinones with kinase inhibitory activity
|
|
DE19824922A1
(de)
*
|
1998-06-04 |
1999-12-09 |
Boehringer Ingelheim Pharma |
Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6680335B2
(en)
|
1998-09-28 |
2004-01-20 |
Sugen, Inc. |
Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
|
|
DK1157019T3
(da)
*
|
1998-12-17 |
2003-07-14 |
Hoffmann La Roche |
4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2
|
|
CA2354591A1
(en)
|
1998-12-17 |
2000-06-22 |
F. Hoffmann-La Roche Ag |
4-aryloxindoles as inhibitors of jnk protein kinases
|
|
WO2000035921A1
(en)
|
1998-12-17 |
2000-06-22 |
F. Hoffmann-La Roche Ag |
4,5-pyrazinoxindoles as protein kinase inhibitors
|
|
US6153634A
(en)
|
1998-12-17 |
2000-11-28 |
Hoffmann-La Roche Inc. |
4,5-azolo-oxindoles
|
|
TR200101747T2
(tr)
*
|
1998-12-17 |
2001-11-21 |
F.Hoffmann-La Roche Ag |
4- ve 5-alkinil oksindoller ve 4- ve 5-alkeniloksindoller.
|
|
AU760964B2
(en)
*
|
1998-12-31 |
2003-05-22 |
Sugen, Inc. |
3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activityand for use in cancer chemotherapy
|
|
MXPA01007099A
(es)
*
|
1999-01-13 |
2002-03-27 |
Univ New York State Res Found |
Metodo novedoso para disenar inhibidores de la proteina cinasa.
|
|
US6624171B1
(en)
|
1999-03-04 |
2003-09-23 |
Smithkline Beecham Corporation |
Substituted aza-oxindole derivatives
|
|
US6492398B1
(en)
|
1999-03-04 |
2002-12-10 |
Smithkline Beechman Corporation |
Thiazoloindolinone compounds
|
|
GB9904933D0
(en)
|
1999-03-04 |
1999-04-28 |
Glaxo Group Ltd |
Compounds
|
|
US6689806B1
(en)
|
1999-03-24 |
2004-02-10 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
|
WO2000056709A1
(en)
*
|
1999-03-24 |
2000-09-28 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
|
ES2367007T3
(es)
*
|
1999-11-24 |
2011-10-27 |
Sugen, Inc. |
Derivados de indolinona ionizables y su uso como ligandos de ptk.
|
|
US6878733B1
(en)
|
1999-11-24 |
2005-04-12 |
Sugen, Inc. |
Formulations for pharmaceutical agents ionizable as free acids or free bases
|
|
US6313310B1
(en)
|
1999-12-15 |
2001-11-06 |
Hoffmann-La Roche Inc. |
4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
|
|
US20020010203A1
(en)
|
1999-12-22 |
2002-01-24 |
Ken Lipson |
Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
|
|
RS50444B
(sr)
|
2000-02-15 |
2010-03-02 |
Sugen Inc. |
Inhibitori 2-indolinon protein kinaze supstituisani pirolom
|
|
JP2003525296A
(ja)
|
2000-02-28 |
2003-08-26 |
スージェン・インコーポレーテッド |
キナーゼ阻害剤としての3−(ピロリルラクトン)−2−インドリノン化合物
|
|
US6620818B1
(en)
|
2000-03-01 |
2003-09-16 |
Smithkline Beecham Corporation |
Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
|
|
MY128449A
(en)
|
2000-05-24 |
2007-02-28 |
Sugen Inc |
Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
|
|
CA2410509A1
(en)
|
2000-06-02 |
2001-12-13 |
Sugen, Inc. |
Indolinone derivatives as protein kinase/phosphatase inhibitors
|
|
WO2002002551A1
(en)
|
2000-06-30 |
2002-01-10 |
Sugen, Inc. |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
|
|
GB0016454D0
(en)
|
2000-07-04 |
2000-08-23 |
Hoffmann La Roche |
Thienopyrrolidinones
|
|
US6504034B2
(en)
|
2001-01-23 |
2003-01-07 |
Hoffmann-La Roche Inc. |
Naphthostyrils
|
|
AR042586A1
(es)
|
2001-02-15 |
2005-06-29 |
Sugen Inc |
3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
|
|
FR2821358B1
(fr)
*
|
2001-02-27 |
2006-04-07 |
Aventis Pharma Sa |
Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique
|
|
DE10114138C2
(de)
*
|
2001-03-16 |
2003-03-27 |
Schering Ag |
Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
|
|
DE10117204A1
(de)
*
|
2001-04-06 |
2002-10-10 |
Boehringer Ingelheim Pharma |
In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6599902B2
(en)
|
2001-05-30 |
2003-07-29 |
Sugen, Inc. |
5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
|
|
DE10134196B4
(de)
*
|
2001-07-13 |
2005-08-18 |
Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt |
Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
|
|
US7005445B2
(en)
|
2001-10-22 |
2006-02-28 |
The Research Foundation Of State University Of New York |
Protein kinase and phosphatase inhibitors and methods for designing them
|
|
GB0302512D0
(en)
*
|
2003-02-03 |
2003-03-05 |
Arrow Therapeutics Ltd |
Compounds
|
|
US7157577B2
(en)
|
2003-03-07 |
2007-01-02 |
Sugen Inc. |
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
|
|
WO2005068424A1
(en)
*
|
2004-01-20 |
2005-07-28 |
Cell Therapeutics Europe S.R.L. |
Indolinone derivatives as receptor tyrosine kinase ihibitors
|
|
SG176463A1
(en)
|
2005-02-22 |
2011-12-29 |
Univ Michigan |
Small molecule inhibitors of mdm2 and uses thereof
|
|
EP1883403A4
(en)
*
|
2005-04-29 |
2011-02-16 |
Univ Ohio State Res Found |
KERATINOCYTE GROWTH FACTOR RECEPTOR TYROSINE-SPECIFIC INHIBITORS FOR THE PREVENTION OF CANCER METASTASE
|
|
JP2009529047A
(ja)
|
2006-03-07 |
2009-08-13 |
アレイ バイオファーマ、インコーポレイテッド |
ヘテロ二環系ピラゾール化合物およびその使用
|
|
US7838542B2
(en)
|
2006-06-29 |
2010-11-23 |
Kinex Pharmaceuticals, Llc |
Bicyclic compositions and methods for modulating a kinase cascade
|
|
CA2736177A1
(en)
*
|
2007-09-06 |
2009-03-12 |
Boston Biomedical, Inc. |
Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
|
|
CN101970426A
(zh)
*
|
2007-12-21 |
2011-02-09 |
大学健康网络 |
吲唑基、苯并咪唑基、苯并三唑基取代的二氢吲哚酮衍生物作为癌症治疗中有用的激酶抑制剂
|
|
EP2417127B1
(en)
|
2009-04-06 |
2014-02-26 |
University Health Network |
Kinase inhibitors and method of treating cancer with same
|
|
ES2639757T3
(es)
|
2010-04-06 |
2017-10-30 |
University Health Network |
Síntesis de 2-(1H-indazol-6-il)espiro[ciclopropan-1,3'-indolin]-2'-onas quirales
|
|
CN103391936B
(zh)
*
|
2010-04-30 |
2016-04-27 |
国立大学法人东京大学 |
抗癌剂
|
|
CN103183665B
(zh)
*
|
2011-12-30 |
2015-10-14 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有酪氨酸激酶抑制活性的物质、其制备方法及用途
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
EP3012248B1
(en)
*
|
2013-06-20 |
2019-09-11 |
Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China |
Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
|
|
MX357763B
(es)
|
2013-10-18 |
2018-07-23 |
Univ Health Network |
Tratamiento para cancer pancreatico.
|
|
CN107002119A
(zh)
|
2014-03-24 |
2017-08-01 |
豪夫迈·罗氏有限公司 |
使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联
|
|
CN104326964A
(zh)
*
|
2014-09-16 |
2015-02-04 |
中国科学院海洋研究所 |
一类氟代2-吲哚酮衍生物及其制备和应用
|
|
CN105481751A
(zh)
*
|
2014-09-16 |
2016-04-13 |
中国科学院海洋研究所 |
一类2-吲哚酮衍生物及其制备和应用
|
|
CN107840818A
(zh)
*
|
2017-11-28 |
2018-03-27 |
四川理工学院 |
含氟二氧化吲哚化合物及其应用
|
|
CN108047119A
(zh)
*
|
2017-11-28 |
2018-05-18 |
四川理工学院 |
3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用
|
|
CN115073353B
(zh)
*
|
2021-03-15 |
2024-05-14 |
中国医学科学院药物研究所 |
木脂素类衍生物及其制法和其药物组合物与用途
|
|
EP4650354A1
(en)
*
|
2023-01-12 |
2025-11-19 |
Shenzhen Zhongge Biological Technology Co., Ltd. |
Indolone derivative having irak4 inhibitory activity, and preparation method therefor and use thereof
|