EP1247803A3 - Indolinone compounds suitable for modulation of protein kinases - Google Patents
Indolinone compounds suitable for modulation of protein kinases Download PDFInfo
- Publication number
- EP1247803A3 EP1247803A3 EP02077564A EP02077564A EP1247803A3 EP 1247803 A3 EP1247803 A3 EP 1247803A3 EP 02077564 A EP02077564 A EP 02077564A EP 02077564 A EP02077564 A EP 02077564A EP 1247803 A3 EP1247803 A3 EP 1247803A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- protein kinases
- modulation
- compounds suitable
- indolinone compounds
- indolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000001253 Protein Kinase Human genes 0.000 title abstract 3
- 108060006633 protein kinase Proteins 0.000 title abstract 3
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32546 | 1987-04-01 | ||
| US70223296A | 1996-08-23 | 1996-08-23 | |
| US702232 | 1996-08-23 | ||
| US3158696P | 1996-12-05 | 1996-12-05 | |
| US3158896P | 1996-12-05 | 1996-12-05 | |
| US3254796P | 1996-12-05 | 1996-12-05 | |
| US3254696P | 1996-12-05 | 1996-12-05 | |
| US3158596P | 1996-12-05 | 1996-12-05 | |
| US32547P | 1996-12-05 | ||
| US31585P | 1996-12-05 | ||
| US31586P | 1996-12-05 | ||
| US31588P | 1996-12-05 | ||
| US4556697P | 1997-05-05 | 1997-05-05 | |
| US4684397P | 1997-05-05 | 1997-05-05 | |
| US4571597P | 1997-05-05 | 1997-05-05 | |
| US4556597P | 1997-05-05 | 1997-05-05 | |
| US4571497P | 1997-05-05 | 1997-05-05 | |
| US45714P | 1997-05-05 | ||
| US45715P | 1997-05-05 | ||
| US45565P | 1997-05-05 | ||
| US46843P | 1997-05-05 | ||
| US45566P | 1997-05-05 | ||
| EP97939480A EP0929520B1 (en) | 1996-08-23 | 1997-08-20 | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97939480A Division EP0929520B1 (en) | 1996-08-23 | 1997-08-20 | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1247803A2 EP1247803A2 (en) | 2002-10-09 |
| EP1247803A3 true EP1247803A3 (en) | 2002-10-16 |
Family
ID=27582490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02077564A Withdrawn EP1247803A3 (en) | 1996-08-23 | 1997-08-20 | Indolinone compounds suitable for modulation of protein kinases |
| EP97939480A Expired - Lifetime EP0929520B1 (en) | 1996-08-23 | 1997-08-20 | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97939480A Expired - Lifetime EP0929520B1 (en) | 1996-08-23 | 1997-08-20 | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1247803A3 (enExample) |
| JP (1) | JP2001503736A (enExample) |
| AT (1) | ATE308520T1 (enExample) |
| AU (1) | AU4155697A (enExample) |
| CA (1) | CA2264220A1 (enExample) |
| DE (1) | DE69734521T9 (enExample) |
| ES (1) | ES2251741T3 (enExample) |
| WO (1) | WO1998007695A1 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| US6696448B2 (en) | 1996-06-05 | 2004-02-24 | Sugen, Inc. | 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| ATE292623T1 (de) * | 1997-05-07 | 2005-04-15 | Sugen Inc | 2-indolinonderivate als modulatoren der proteinkinase-ativität |
| US6987113B2 (en) | 1997-06-11 | 2006-01-17 | Sugen, Inc. | Tyrosine kinase inhibitors |
| US6051593A (en) | 1997-06-20 | 2000-04-18 | Sugen, Inc. | 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors |
| US6313158B1 (en) | 1997-06-20 | 2001-11-06 | Sugen, Inc. | Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| JP2002507598A (ja) * | 1998-03-26 | 2002-03-12 | スージェン・インコーポレーテッド | チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー |
| US6514981B1 (en) | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| DE69905712T2 (de) * | 1998-05-29 | 2004-01-29 | Gerhard Eisenbrand | Verwendung von indigoähnlichen bisindolen zur herstellung eines arzneimittels zur hemmung cyclin abhängiger kinasen |
| CO5031249A1 (es) | 1998-05-29 | 2001-04-27 | Sugen Inc | Pirrol substituido-2-indolinonas inhibidoras de proteinci-nasas |
| DE19824922A1 (de) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6319918B1 (en) | 1998-06-04 | 2001-11-20 | Boehringer Ingelheim Pharma Kg | Substituted indolinones with kinase inhibitory activity |
| US6680335B2 (en) | 1998-09-28 | 2004-01-20 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| KR20010087421A (ko) * | 1998-12-17 | 2001-09-15 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 4- 및 5-알키닐옥신돌과 4- 및 5-알케닐옥신돌 |
| BR9916223A (pt) | 1998-12-17 | 2001-09-04 | Hoffmann La Roche | 4-ariloxindóis como inibidores de cinases de proteìna jnk |
| AU767138B2 (en) * | 1998-12-17 | 2003-10-30 | F. Hoffmann-La Roche Ag | 4,5-pyrazinoxindoles as protein kinase inhibitors |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| ATE234830T1 (de) * | 1998-12-17 | 2003-04-15 | Hoffmann La Roche | 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2 |
| MXPA01006742A (es) * | 1998-12-31 | 2004-04-21 | Sugen Inc | Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer. |
| ATE494388T1 (de) * | 1999-01-13 | 2011-01-15 | Univ New York State Res Found | Neues verfahren zum erschaffen von proteinkinase- inhibitoren |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| JP2002540096A (ja) * | 1999-03-24 | 2002-11-26 | スージェン・インコーポレーテッド | キナーゼ阻害剤としてのインドリノン化合物 |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| PT1233943E (pt) * | 1999-11-24 | 2011-09-01 | Sugen Inc | Formulações para agentes farmacêuticos ionizáveis como ácidos livres ou bases livres |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| ES2267605T3 (es) * | 1999-12-22 | 2007-03-16 | Sugen, Inc. | Uso de compuestos de indolinona para la fabricacion de productos farmaceuticos destinados a modular la funcion de la c-kit-tirosina-proteina-quinasa. |
| ATE369359T1 (de) | 2000-02-15 | 2007-08-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
| AU2001241798A1 (en) | 2000-02-28 | 2001-09-12 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| JP2003535847A (ja) | 2000-06-02 | 2003-12-02 | スージェン・インコーポレーテッド | 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体 |
| JP2004502686A (ja) | 2000-06-30 | 2004-01-29 | スージェン・インコーポレーテッド | ４−ヘテロアリール−３−ヘテロアリーリデニル−２−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用 |
| GB0016454D0 (en) | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Thienopyrrolidinones |
| US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| FR2821358B1 (fr) * | 2001-02-27 | 2006-04-07 | Aventis Pharma Sa | Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique |
| DE10114138C2 (de) * | 2001-03-16 | 2003-03-27 | Schering Ag | Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit |
| DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| AR036042A1 (es) | 2001-05-30 | 2004-08-04 | Sugen Inc | Derivados aralquilsufonil-3-(pirrol-2-ilmetiliden)-2-indolinona, sus composiciones farmaceuticas y metodo para la modulacion de la actividad catalitica de una proteina quinasa |
| DE10134196B4 (de) * | 2001-07-13 | 2005-08-18 | Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt | Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| GB0302512D0 (en) * | 2003-02-03 | 2003-03-05 | Arrow Therapeutics Ltd | Compounds |
| US7157577B2 (en) | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
| WO2005068424A1 (en) * | 2004-01-20 | 2005-07-28 | Cell Therapeutics Europe S.R.L. | Indolinone derivatives as receptor tyrosine kinase ihibitors |
| US7759383B2 (en) | 2005-02-22 | 2010-07-20 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| EP1883403A4 (en) * | 2005-04-29 | 2011-02-16 | Univ Ohio State Res Found | KERATINOCYTE GROWTH FACTOR RECEPTOR TYROSINE-SPECIFIC INHIBITORS FOR THE PREVENTION OF CANCER METASTASE |
| JP2009529047A (ja) | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| US8299106B2 (en) * | 2007-09-06 | 2012-10-30 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
| US8765748B2 (en) * | 2007-12-21 | 2014-07-01 | University Health Network | Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer |
| WO2010115279A1 (en) | 2009-04-06 | 2010-10-14 | University Health Network | Kinase inhibitors and method of treating cancer with same |
| JP5442906B2 (ja) | 2010-04-06 | 2014-03-19 | ユニバーシティ・ヘルス・ネットワーク | キナーゼインヒビターおよびこれを用いた癌の治療方法 |
| JP5656233B2 (ja) * | 2010-04-30 | 2015-01-21 | 国立大学法人 東京大学 | 抗がん剤 |
| CN103183665B (zh) * | 2011-12-30 | 2015-10-14 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有酪氨酸激酶抑制活性的物质、其制备方法及用途 |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| EP3012248B1 (en) * | 2013-06-20 | 2019-09-11 | Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China | Substance having tyrosine kinase inhibitory activity and preparation method and use thereof |
| CA2927612C (en) | 2013-10-18 | 2022-08-30 | University Health Network | Treatment for pancreatic cancer |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| CN105481751A (zh) * | 2014-09-16 | 2016-04-13 | 中国科学院海洋研究所 | 一类2-吲哚酮衍生物及其制备和应用 |
| CN104326964A (zh) * | 2014-09-16 | 2015-02-04 | 中国科学院海洋研究所 | 一类氟代2-吲哚酮衍生物及其制备和应用 |
| CN108047119A (zh) * | 2017-11-28 | 2018-05-18 | 四川理工学院 | 3-氟烯基氧化吲哚-3-三氟甲基氧化吲哚化合物及其应用 |
| CN107840818A (zh) * | 2017-11-28 | 2018-03-27 | 四川理工学院 | 含氟二氧化吲哚化合物及其应用 |
| CN115073353B (zh) * | 2021-03-15 | 2024-05-14 | 中国医学科学院药物研究所 | 木脂素类衍生物及其制法和其药物组合物与用途 |
| EP4650354A1 (en) * | 2023-01-12 | 2025-11-19 | Shenzhen Zhongge Biological Technology Co., Ltd. | Indolone derivative having irak4 inhibitory activity, and preparation method therefor and use thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2968557A (en) * | 1955-12-23 | 1961-01-17 | Agfa Ag | Photographic filter layer |
| WO1991013055A2 (en) * | 1990-02-28 | 1991-09-05 | Farmitalia Carlo Erba S.R.L. | New aryl- and heteroarylethenylene derivatives and process for their preparation |
| EP0525472A2 (en) * | 1991-07-12 | 1993-02-03 | PHARMACIA S.p.A. | Methylen-oxindole derivatives and process for their preparation |
| EP0580502A1 (fr) * | 1992-07-21 | 1994-01-26 | Adir Et Compagnie | 3-(hydroxybenzylidényl)-indoline-2-ones, et les compositions pharmaceutiques qui les contiennent |
| WO1995001349A1 (en) * | 1993-07-01 | 1995-01-12 | Pharmacia S.P.A. | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors |
| WO1996000226A1 (en) * | 1994-06-24 | 1996-01-04 | Pharmacia S.P.A. | Substituted azaindolylidene compounds and process for their preparation |
| WO1996022976A1 (en) * | 1995-01-26 | 1996-08-01 | Pharmacia S.P.A. | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| WO1996032380A1 (en) * | 1995-04-07 | 1996-10-17 | Pharmacia & Upjohn S.P.A. | Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors |
| WO1996040116A1 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Indolinone compounds for the treatment of disease |
-
1997
- 1997-08-20 WO PCT/US1997/014736 patent/WO1998007695A1/en not_active Ceased
- 1997-08-20 EP EP02077564A patent/EP1247803A3/en not_active Withdrawn
- 1997-08-20 AU AU41556/97A patent/AU4155697A/en not_active Abandoned
- 1997-08-20 ES ES97939480T patent/ES2251741T3/es not_active Expired - Lifetime
- 1997-08-20 AT AT97939480T patent/ATE308520T1/de not_active IP Right Cessation
- 1997-08-20 CA CA002264220A patent/CA2264220A1/en not_active Abandoned
- 1997-08-20 EP EP97939480A patent/EP0929520B1/en not_active Expired - Lifetime
- 1997-08-20 DE DE69734521T patent/DE69734521T9/de active Active
- 1997-08-20 JP JP51097398A patent/JP2001503736A/ja not_active Ceased
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2968557A (en) * | 1955-12-23 | 1961-01-17 | Agfa Ag | Photographic filter layer |
| WO1991013055A2 (en) * | 1990-02-28 | 1991-09-05 | Farmitalia Carlo Erba S.R.L. | New aryl- and heteroarylethenylene derivatives and process for their preparation |
| EP0662473A1 (en) * | 1990-02-28 | 1995-07-12 | PHARMACIA S.p.A. | 2-Oxindole derivatives as tyrosine kinase inhibitors |
| EP0525472A2 (en) * | 1991-07-12 | 1993-02-03 | PHARMACIA S.p.A. | Methylen-oxindole derivatives and process for their preparation |
| EP0580502A1 (fr) * | 1992-07-21 | 1994-01-26 | Adir Et Compagnie | 3-(hydroxybenzylidényl)-indoline-2-ones, et les compositions pharmaceutiques qui les contiennent |
| WO1995001349A1 (en) * | 1993-07-01 | 1995-01-12 | Pharmacia S.P.A. | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors |
| WO1996000226A1 (en) * | 1994-06-24 | 1996-01-04 | Pharmacia S.P.A. | Substituted azaindolylidene compounds and process for their preparation |
| WO1996022976A1 (en) * | 1995-01-26 | 1996-08-01 | Pharmacia S.P.A. | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| WO1996032380A1 (en) * | 1995-04-07 | 1996-10-17 | Pharmacia & Upjohn S.P.A. | Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors |
| WO1996040116A1 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Indolinone compounds for the treatment of disease |
Non-Patent Citations (8)
| Title |
|---|
| ANDREANI, ALDO ET AL: "Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)- 1,3-dihydroindol-2-ones", ANTICANCER RES. (1996), 16(6B), 3585-3588 CODEN: ANTRD4;ISSN: 0250-7005, 1996, XP002049948 * |
| CODA ET AL., JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, vol. 4, 1984, LETCHWORTH GB, pages 615 - 620 * |
| DATABASE CROSSFIRE BEILSTEIN Beilstein; XP002049949 * |
| DATABASE CROSSFIRE BEILSTEIN Beilstein; XP002049950 * |
| DATABASE CROSSFIRE BEILSTEIN Beilstein; XP002049951 * |
| ELLIOT; RIVERS, JOURNAL OF ORGANIC CHEMISTRY, vol. 29, 1964, EASTON US, pages 2438 * |
| VON DOBENECK, HENNING ET AL: "Indole chemistry. VI..alpha.,.beta.'-Diindolylmethanes and.alpha.,.beta.'-diindolylmethenes", CHEM. BER. (1969), 102(4), 1347-56, XP002209981 * |
| WAHL; FAIVRET, ANN. CHIM., 1926, PARIS, pages 350 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998007695A1 (en) | 1998-02-26 |
| DE69734521T2 (de) | 2006-07-06 |
| EP1247803A2 (en) | 2002-10-09 |
| EP0929520A1 (en) | 1999-07-21 |
| JP2001503736A (ja) | 2001-03-21 |
| ES2251741T3 (es) | 2006-05-01 |
| EP0929520B1 (en) | 2005-11-02 |
| AU4155697A (en) | 1998-03-06 |
| DE69734521D1 (de) | 2005-12-08 |
| ATE308520T1 (de) | 2005-11-15 |
| CA2264220A1 (en) | 1998-02-26 |
| DE69734521T9 (de) | 2006-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1247803A3 (en) | Indolinone compounds suitable for modulation of protein kinases | |
| CA2192797A1 (en) | Indolinone compounds for the treatment of disease | |
| WO1999048868A3 (en) | Heterocyclic classes of compounds for the modulating tyrosine protein kinase | |
| WO1998024432A3 (en) | Use of indolinone compounds as modulators of protein kinases | |
| WO2000008202A3 (en) | 3-methylidenyl-2-indolinone modulators of protein kinase | |
| AU8071698A (en) | Novel heteroaryl compounds for the modulation of protein tyrosine enzyme relatedcellular signal transduction | |
| MX9606404A (es) | Composiciones farmaceuticas y metodos para formular trasnduccion de señales. | |
| BG104356A (en) | Compounds based on azabenzimidazole for the modulation of serin/treonin protein kinase function | |
| AU7398194A (en) | Oligonucleotide modulation of protein kinase c | |
| AU7289696A (en) | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | |
| BG102738A (en) | Inhibitors of farnesyl-protein transferase | |
| EP0984930A4 (en) | 2-INDOLINE DERIVATIVES AS MODULATORS OF THE PROTEIN KINASE ATIVITY | |
| WO2001045689A3 (en) | Indolinone derivatives for modulation of c-kit tyrosine protein kinase | |
| AU3693697A (en) | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | |
| AU3443997A (en) | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | |
| ZA988961B (en) | Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds. | |
| HUP9801826A3 (en) | Intracellular domain of the her-2/neu protein for prevention or treatment of malignancies | |
| AU2001241798A1 (en) | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors | |
| BG102872A (en) | 6-phenylpyridyl-3-amine derivatives | |
| CA2257010A1 (en) | Methods and compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia | |
| AU2396000A (en) | Treatment of hyperproliferative disorders using casein kinase | |
| AU2002228912A1 (en) | Short peptides from the "a-region" of protein kinases which selectively modulate protein kinase activity | |
| DE69729211D1 (en) | Tetrahydro-beta carbolinverbindungen | |
| WO2001042243A3 (en) | Protein kinase inhibitors | |
| CA2284142A1 (en) | Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| AC | Divisional application: reference to earlier application |
Ref document number: 929520 Country of ref document: EP |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHAWVER, LAURA KAY Inventor name: HIRTH, KLAUS PETER Inventor name: MCMAHON, GERALD Inventor name: SUN, LI Inventor name: TANG, PENG CHO |
|
| 17P | Request for examination filed |
Effective date: 20030213 |
|
| AKX | Designation fees paid |
Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| 17Q | First examination report despatched |
Effective date: 20040415 |
|
| 17Q | First examination report despatched |
Effective date: 20040415 |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SUGEN, INC. |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20090226 |