JP2001502318A - 心臓血管系および中枢神経系の特定疾病を治療するための縮合（ヘタリール置換）１―ベンジル―３―ピラゾール誘導体の使用 - Google Patents
心臓血管系および中枢神経系の特定疾病を治療するための縮合（ヘタリール置換）１―ベンジル―３―ピラゾール誘導体の使用Info
- Publication number
- JP2001502318A JP2001502318A JP10517966A JP51796698A JP2001502318A JP 2001502318 A JP2001502318 A JP 2001502318A JP 10517966 A JP10517966 A JP 10517966A JP 51796698 A JP51796698 A JP 51796698A JP 2001502318 A JP2001502318 A JP 2001502318A
- Authority
- JP
- Japan
- Prior art keywords
- indazole
- hydroxymethylfuran
- fluorobenzyl
- benzyl
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
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- Vascular Medicine (AREA)
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- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642255.8 | 1996-10-14 | ||
| DE19642255A DE19642255A1 (de) | 1996-10-14 | 1996-10-14 | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
| PCT/EP1997/005381 WO1998016223A1 (de) | 1996-10-14 | 1997-10-01 | Verwendung von 1-benzyl-3-(substituiertes-hetaryl)-kondensierten pyrazol-derivaten zur belandlung von speziellen erkrankungen des herz-kreislaufsystems und des zentralnervensystems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2009042383A Division JP2009114205A (ja) | 1996-10-14 | 2009-02-25 | 心臓血管系および中枢神経系の特定疾病を治療するための縮合（ヘタリール置換）１−ベンジル−３−ピラゾール誘導体の使用 |
Publications (2)
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| JP2001502318A true JP2001502318A (ja) | 2001-02-20 |
| JP2001502318A5 JP2001502318A5 (enExample) | 2005-05-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP10517966A Pending JP2001502318A (ja) | 1996-10-14 | 1997-10-01 | 心臓血管系および中枢神経系の特定疾病を治療するための縮合（ヘタリール置換）１―ベンジル―３―ピラゾール誘導体の使用 |
| JP2009042383A Pending JP2009114205A (ja) | 1996-10-14 | 2009-02-25 | 心臓血管系および中枢神経系の特定疾病を治療するための縮合（ヘタリール置換）１−ベンジル−３−ピラゾール誘導体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2009042383A Pending JP2009114205A (ja) | 1996-10-14 | 2009-02-25 | 心臓血管系および中枢神経系の特定疾病を治療するための縮合（ヘタリール置換）１−ベンジル−３−ピラゾール誘導体の使用 |
Country Status (21)
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| US (1) | US6180656B1 (enExample) |
| EP (1) | EP0932403B1 (enExample) |
| JP (2) | JP2001502318A (enExample) |
| AT (1) | ATE311184T1 (enExample) |
| AU (1) | AU733967B2 (enExample) |
| BR (1) | BR9712304A (enExample) |
| CA (1) | CA2268314C (enExample) |
| CZ (1) | CZ129299A3 (enExample) |
| DE (2) | DE19642255A1 (enExample) |
| EE (1) | EE9900156A (enExample) |
| ES (1) | ES2252777T3 (enExample) |
| HU (1) | HUP9903885A3 (enExample) |
| ID (1) | ID22162A (enExample) |
| IL (1) | IL129318A (enExample) |
| NO (1) | NO991685D0 (enExample) |
| NZ (1) | NZ335091A (enExample) |
| PL (1) | PL332719A1 (enExample) |
| SK (1) | SK46599A3 (enExample) |
| TR (1) | TR199900782T2 (enExample) |
| TW (1) | TW442482B (enExample) |
| WO (1) | WO1998016223A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502722A (ja) * | 2001-09-14 | 2005-01-27 | カールスバッド テクノロジー，インコーポレイテッド | 学習及び記憶の亢進ならびに健忘症の治療 |
| JP2005075834A (ja) * | 2003-09-03 | 2005-03-24 | Carlsbad Technology Inc | 神経変性疾患の処置 |
| JP2005089457A (ja) * | 2003-09-03 | 2005-04-07 | Yung Shin Pharmaceutical Industry Co Ltd | 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物 |
| JP2013530150A (ja) * | 2010-05-26 | 2013-07-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換された５−フルオロ−１ｈ−ピラゾロピリジン及びそれらの使用 |
| JP2016500705A (ja) * | 2012-11-05 | 2016-01-14 | バイエル・ファルマ・アクティエンゲゼルシャフト | アミノ置換イミダゾ［１，２−ａ］ピリジンカルボキサミドおよびその使用 |
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| DE19744026A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
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| DE19853278A1 (de) | 1998-11-19 | 2000-05-25 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19904710A1 (de) | 1999-02-05 | 2000-08-10 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19943635A1 (de) * | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| GB0002666D0 (en) | 2000-02-04 | 2000-03-29 | Univ London | Blockade of voltage dependent sodium channels |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK181190D0 (da) | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
| JP2928079B2 (ja) * | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
-
1996
- 1996-10-14 DE DE19642255A patent/DE19642255A1/de not_active Withdrawn
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1997
- 1997-10-01 CZ CZ991292A patent/CZ129299A3/cs unknown
- 1997-10-01 AU AU50494/98A patent/AU733967B2/en not_active Ceased
- 1997-10-01 JP JP10517966A patent/JP2001502318A/ja active Pending
- 1997-10-01 ID IDW990187D patent/ID22162A/id unknown
- 1997-10-01 AT AT97913132T patent/ATE311184T1/de not_active IP Right Cessation
- 1997-10-01 NZ NZ335091A patent/NZ335091A/xx unknown
- 1997-10-01 US US09/284,032 patent/US6180656B1/en not_active Expired - Fee Related
- 1997-10-01 BR BR9712304-8A patent/BR9712304A/pt not_active Application Discontinuation
- 1997-10-01 WO PCT/EP1997/005381 patent/WO1998016223A1/de not_active Ceased
- 1997-10-01 CA CA002268314A patent/CA2268314C/en not_active Expired - Fee Related
- 1997-10-01 PL PL97332719A patent/PL332719A1/xx unknown
- 1997-10-01 HU HU9903885A patent/HUP9903885A3/hu unknown
- 1997-10-01 IL IL12931897A patent/IL129318A/en not_active IP Right Cessation
- 1997-10-01 EE EEP199900156A patent/EE9900156A/xx unknown
- 1997-10-01 EP EP97913132A patent/EP0932403B1/de not_active Expired - Lifetime
- 1997-10-01 TR TR1999/00782T patent/TR199900782T2/xx unknown
- 1997-10-01 ES ES97913132T patent/ES2252777T3/es not_active Expired - Lifetime
- 1997-10-01 SK SK465-99A patent/SK46599A3/sk unknown
- 1997-10-01 DE DE59712501T patent/DE59712501D1/de not_active Expired - Lifetime
- 1997-10-14 TW TW086115207A patent/TW442482B/zh not_active IP Right Cessation
-
1999
- 1999-04-09 NO NO991685A patent/NO991685D0/no not_active Application Discontinuation
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2009
- 2009-02-25 JP JP2009042383A patent/JP2009114205A/ja active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502722A (ja) * | 2001-09-14 | 2005-01-27 | カールスバッド テクノロジー，インコーポレイテッド | 学習及び記憶の亢進ならびに健忘症の治療 |
| JP2005075834A (ja) * | 2003-09-03 | 2005-03-24 | Carlsbad Technology Inc | 神経変性疾患の処置 |
| JP2005089457A (ja) * | 2003-09-03 | 2005-04-07 | Yung Shin Pharmaceutical Industry Co Ltd | 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物 |
| JP2013530150A (ja) * | 2010-05-26 | 2013-07-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換された５−フルオロ−１ｈ−ピラゾロピリジン及びそれらの使用 |
| JP2016500705A (ja) * | 2012-11-05 | 2016-01-14 | バイエル・ファルマ・アクティエンゲゼルシャフト | アミノ置換イミダゾ［１，２−ａ］ピリジンカルボキサミドおよびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0932403B1 (de) | 2005-11-30 |
| AU5049498A (en) | 1998-05-11 |
| NZ335091A (en) | 2000-09-29 |
| TW442482B (en) | 2001-06-23 |
| TR199900782T2 (xx) | 1999-07-21 |
| IL129318A0 (en) | 2000-02-17 |
| ATE311184T1 (de) | 2005-12-15 |
| EE9900156A (et) | 1999-12-15 |
| HUP9903885A3 (en) | 2000-12-28 |
| NO991685L (no) | 1999-04-09 |
| CA2268314A1 (en) | 1998-04-23 |
| JP2009114205A (ja) | 2009-05-28 |
| BR9712304A (pt) | 1999-08-31 |
| CA2268314C (en) | 2006-12-12 |
| PL332719A1 (en) | 1999-10-11 |
| ID22162A (id) | 1999-09-09 |
| DE59712501D1 (de) | 2006-01-05 |
| AU733967B2 (en) | 2001-05-31 |
| DE19642255A1 (de) | 1998-04-16 |
| ES2252777T3 (es) | 2006-05-16 |
| EP0932403A1 (de) | 1999-08-04 |
| US6180656B1 (en) | 2001-01-30 |
| IL129318A (en) | 2001-06-14 |
| WO1998016223A1 (de) | 1998-04-23 |
| NO991685D0 (no) | 1999-04-09 |
| HUP9903885A2 (hu) | 2000-11-28 |
| SK46599A3 (en) | 2000-02-14 |
| CZ129299A3 (cs) | 1999-07-14 |
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