|
DE69633196D1
(de)
*
|
1995-10-16 |
2004-09-23 |
Fujisawa Pharmaceutical Co |
Heterocyclische verbindungen als h+-atpasen
|
|
GB9712761D0
(en)
*
|
1997-06-17 |
1997-08-20 |
Chiroscience Ltd |
Quinolines and their therapeutic use
|
|
US6262070B1
(en)
|
1998-11-04 |
2001-07-17 |
Darwin Discovery Ltd. |
Heterocyclic compounds and their therapeutic use
|
|
GB9824160D0
(en)
*
|
1998-11-04 |
1998-12-30 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
CZ302882B6
(cs)
*
|
1999-08-21 |
2012-01-04 |
Nycomed Gmbh |
Farmaceutický prostredek
|
|
WO2001032658A1
(en)
*
|
1999-11-02 |
2001-05-10 |
Ajinomoto Co., Inc. |
Polyazanaphthalene compound and medicinal use thereof
|
|
JP4603646B2
(ja)
*
|
1999-11-15 |
2010-12-22 |
富士フイルムファインケミカルズ株式会社 |
新規なジピリジル誘導体
|
|
US7217722B2
(en)
*
|
2000-02-01 |
2007-05-15 |
Kirin Beer Kabushiki Kaisha |
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
|
|
GB0003256D0
(en)
|
2000-02-11 |
2000-04-05 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
US6521618B2
(en)
|
2000-03-28 |
2003-02-18 |
Wyeth |
3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
|
|
DE10035928A1
(de)
*
|
2000-07-21 |
2002-03-07 |
Asta Medica Ag |
Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
|
|
US7112594B2
(en)
|
2000-08-09 |
2006-09-26 |
Mitsubishi Pharma Corporation |
Fused bicyclic amide compounds and medicinal use thereof
|
|
US6953774B2
(en)
|
2000-08-11 |
2005-10-11 |
Applied Research Systems Ars Holding N.V. |
Methods of inducing ovulation
|
|
JP2002300373A
(ja)
*
|
2001-03-30 |
2002-10-11 |
Minolta Co Ltd |
画像処理方法、画像処理装置、記録媒体及びプログラム
|
|
JP4510384B2
(ja)
|
2001-05-23 |
2010-07-21 |
田辺三菱製薬株式会社 |
骨折治癒促進用組成物
|
|
EP1389467B1
(en)
*
|
2001-05-23 |
2013-07-03 |
Mitsubishi Tanabe Pharma Corporation |
Therapeutic composition for the regenerative treatment of cartilage diseases
|
|
ATE341545T1
(de)
|
2001-07-16 |
2006-10-15 |
Astrazeneca Ab |
Quinolin-derivate und ihre verwendung als inhibitoren der tyrosine kinase
|
|
CN100506817C
(zh)
*
|
2001-08-15 |
2009-07-01 |
纳幕尔杜邦公司 |
用于防治无脊椎害虫的邻-杂环取代的芳基酰胺类化合物
|
|
DK1908463T3
(da)
|
2001-12-14 |
2011-11-28 |
Merck Serono Sa |
Fremgangsmåder til at inducere ægløsning ved anvendelse af en ikke polypeptid-CAMP-niveaumodulator
|
|
MY140561A
(en)
|
2002-02-20 |
2009-12-31 |
Nycomed Gmbh |
Dosage form containing pde 4 inhibitor as active ingredient
|
|
SE0200920D0
(sv)
*
|
2002-03-25 |
2002-03-25 |
Astrazeneca Ab |
Novel compounds
|
|
ES2195785B1
(es)
*
|
2002-05-16 |
2005-03-16 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
AU2002950217A0
(en)
|
2002-07-16 |
2002-09-12 |
Prana Biotechnology Limited |
8- Hydroxy Quinoline Derivatives
|
|
ES2211344B1
(es)
*
|
2002-12-26 |
2005-10-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
TWI324150B
(en)
*
|
2003-02-28 |
2010-05-01 |
Novartis Ag |
Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
|
|
US7153824B2
(en)
|
2003-04-01 |
2006-12-26 |
Applied Research Systems Ars Holding N.V. |
Inhibitors of phosphodiesterases in infertility
|
|
PE20100399A1
(es)
*
|
2003-04-02 |
2010-06-01 |
Novartis Ag |
Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
|
|
US20070010497A1
(en)
*
|
2003-05-29 |
2007-01-11 |
Nigel Boughton-Smith |
Pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine
|
|
US20070032465A1
(en)
*
|
2003-05-29 |
2007-02-08 |
Nigel Boughton-Smith |
Pharmaceutical composition comprising a p2x7-receptor antagonist and a tumour necrosis factor alpha
|
|
WO2004105796A1
(en)
*
|
2003-05-29 |
2004-12-09 |
Astrazeneca Ab |
A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate
|
|
GB0312609D0
(en)
*
|
2003-06-02 |
2003-07-09 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302139D0
(sv)
*
|
2003-07-28 |
2003-07-28 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302192D0
(sv)
*
|
2003-08-08 |
2003-08-08 |
Astrazeneca Ab |
Novel compounds
|
|
ES2286685T3
(es)
*
|
2003-09-15 |
2007-12-01 |
Schering Corporation |
Sintesis de quinolein 5-carboxamidas utles para la preparacion de inhibidores de pde iv.
|
|
SE0302488D0
(sv)
*
|
2003-09-18 |
2003-09-18 |
Astrazeneca Ab |
New combination
|
|
EP2284157A1
(en)
|
2003-12-12 |
2011-02-16 |
Wyeth |
Quinolines useful in treating cardiovascular disease
|
|
EP2666481B9
(en)
|
2003-12-26 |
2019-05-22 |
HAGIWARA, Masatoshi |
Method of regulating phosphorylation of sr protein and antiviral agents comprising sr protein activity regulator as the active ingredient
|
|
CA2555133A1
(en)
*
|
2004-02-04 |
2005-09-01 |
Pfizer Products Inc. |
Substituted quinoline compounds
|
|
RU2411043C2
(ru)
*
|
2004-04-01 |
2011-02-10 |
Юниверсите Де Льеж |
Фармацевтические композиции пиримидин-2,4,6-трионов
|
|
BRPI0511295A
(pt)
*
|
2004-05-18 |
2007-12-04 |
Schering Corp |
2-quinolil-oxazóis substituìdos úteis como inibidores de pde4
|
|
ES2251866B1
(es)
*
|
2004-06-18 |
2007-06-16 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
ES2251867B1
(es)
*
|
2004-06-21 |
2007-06-16 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridazin-3(2h)-ona.
|
|
GB0413960D0
(en)
*
|
2004-06-22 |
2004-07-28 |
Novartis Ag |
Organic compounds
|
|
MX341797B
(es)
*
|
2004-06-24 |
2016-09-02 |
Vertex Pharmaceuticals Incorporated * |
Moduladores de transportadores con casete de union con atp.
|
|
US8354427B2
(en)
*
|
2004-06-24 |
2013-01-15 |
Vertex Pharmaceutical Incorporated |
Modulators of ATP-binding cassette transporters
|
|
SA05260265A
(ar)
*
|
2004-08-30 |
2005-12-03 |
استرازينيكا ايه بي |
مركبات جديدة
|
|
MX2007004293A
(es)
*
|
2004-10-12 |
2007-06-18 |
Actelion Pharmaceuticals Ltd |
1[2-(4-bencil-4-hidroxi-piperidin-1-il)-etil]-3-(2-metil-quinolin -4-il)-urea como la sal de sulfato cristalina.
|
|
BRPI0518222A
(pt)
*
|
2004-10-19 |
2008-11-04 |
Hoffmann La Roche |
composto, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3 e utilização dos mesmos
|
|
SE0402925D0
(sv)
*
|
2004-11-30 |
2004-11-30 |
Astrazeneca Ab |
Novel Compounds
|
|
US8686002B2
(en)
|
2005-08-21 |
2014-04-01 |
AbbVie Deutschland GmbH & Co. KG |
Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
|
|
JP2009506069A
(ja)
|
2005-08-26 |
2009-02-12 |
ブレインセルス，インコーポレイティド |
ムスカリン性受容体調節による神経発生
|
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
|
JP2009512711A
(ja)
|
2005-10-21 |
2009-03-26 |
ブレインセルス，インコーポレイティド |
Ｐｄｅ阻害による神経新生の調節
|
|
EP2314289A1
(en)
|
2005-10-31 |
2011-04-27 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
EP1979367A2
(en)
*
|
2005-12-24 |
2008-10-15 |
Vertex Pharmaceuticals Incorporated |
Quinolin-4-one derivatives as modulators of abc transporters
|
|
LT1993360T
(lt)
*
|
2005-12-28 |
2017-06-12 |
Vertex Pharmaceuticals Incorporated |
N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
|
|
KR100821649B1
(ko)
*
|
2006-01-24 |
2008-04-11 |
서울시립대학교 산학협력단 |
클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
AU2007249399A1
(en)
|
2006-05-09 |
2007-11-22 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
|
KR20090026217A
(ko)
*
|
2006-07-11 |
2009-03-11 |
쉐링 코포레이션 |
치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염
|
|
CA2661850A1
(en)
|
2006-09-01 |
2008-03-06 |
Kyorin Pharmaceutical Co., Ltd. |
Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
CL2007003874A1
(es)
*
|
2007-01-03 |
2008-05-16 |
Boehringer Ingelheim Int |
Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio
|
|
ES2306595B1
(es)
*
|
2007-02-09 |
2009-09-11 |
Laboratorios Almirall S.A. |
Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
|
|
ES2320954B1
(es)
*
|
2007-03-02 |
2010-03-16 |
Laboratorio Almirall S.A. |
Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
|
|
PE20091225A1
(es)
*
|
2007-03-22 |
2009-09-16 |
Astrazeneca Ab |
Derivados de quinolina como antagonistas del receptor p2x7
|
|
US9321730B2
(en)
*
|
2007-08-21 |
2016-04-26 |
The Hong Kong Polytechnic University |
Method of making and administering quinoline derivatives as anti-cancer agents
|
|
US9493419B2
(en)
|
2007-08-21 |
2016-11-15 |
The Hong Kong Polytechnic University |
Quinoline derivatives as anti-cancer agents
|
|
PE20091036A1
(es)
|
2007-11-30 |
2009-08-15 |
Astrazeneca Ab |
Derivado de quinolina como antagonista del receptor p2x7
|
|
US12458635B2
(en)
|
2008-08-13 |
2025-11-04 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
MX384179B
(es)
|
2009-03-20 |
2025-03-14 |
Vertex Pharma |
Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística.
|
|
JP2011042643A
(ja)
*
|
2009-07-24 |
2011-03-03 |
Bayer Cropscience Ag |
殺虫性カルボキサミド類
|
|
JP5807058B2
(ja)
|
2010-05-10 |
2015-11-10 |
ギリアード サイエンシーズ， インコーポレイテッド |
二機能キノリン誘導体
|
|
UY33373A
(es)
|
2010-05-10 |
2011-12-30 |
Gilead Sciences Inc |
?Compuestos de pirazolopiridina bifuncionales, su uso en terapia y composiciones que los comprenden?.
|
|
EP2635280A4
(en)
*
|
2010-11-05 |
2014-05-28 |
Univ Minnesota |
CYTOSINDEAMINASE MODULATORS TO IMPROVE DNA TRANSFECTION
|
|
US8802700B2
(en)
|
2010-12-10 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
JP2015511583A
(ja)
|
2012-02-27 |
2015-04-20 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
薬学的組成物およびその投与
|
|
CN103285373A
(zh)
*
|
2013-05-30 |
2013-09-11 |
苏州普罗达生物科技有限公司 |
肿瘤坏死因子-α多肽抑制剂制备及其应用
|
|
CN103254291B
(zh)
*
|
2013-05-30 |
2014-06-25 |
常州亚当生物技术有限公司 |
肿瘤坏死因子-α多肽抑制剂及其应用
|
|
MY192489A
(en)
*
|
2013-10-14 |
2022-08-23 |
Eisai R&D Man Co Ltd |
Selectively substituted quinoline compounds
|
|
EP3204358B1
(en)
|
2014-10-07 |
2018-09-19 |
Vertex Pharmaceuticals Incorporated |
Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
|
|
RU2624906C2
(ru)
*
|
2015-12-22 |
2017-07-10 |
федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации |
Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность
|
|
CN111050558B
(zh)
|
2017-09-13 |
2022-05-27 |
先正达参股股份有限公司 |
杀微生物的喹啉(硫代)羧酰胺衍生物
|
|
CN107812006A
(zh)
*
|
2017-11-13 |
2018-03-20 |
全椒先奇医药科技有限公司 |
一种治疗急性肾衰药物组合物及其应用
|