JP2000507578A5 - - Google Patents

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Publication number
JP2000507578A5
JP2000507578A5 JP1997535395A JP53539597A JP2000507578A5 JP 2000507578 A5 JP2000507578 A5 JP 2000507578A5 JP 1997535395 A JP1997535395 A JP 1997535395A JP 53539597 A JP53539597 A JP 53539597A JP 2000507578 A5 JP2000507578 A5 JP 2000507578A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997535395A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000507578A (ja
JP4759762B2 (ja
Filing date
Publication date
Priority claimed from US08/626,259 external-priority patent/US5717092A/en
Application filed filed Critical
Publication of JP2000507578A publication Critical patent/JP2000507578A/ja
Publication of JP2000507578A5 publication Critical patent/JP2000507578A5/ja
Application granted granted Critical
Publication of JP4759762B2 publication Critical patent/JP4759762B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP53539597A 1996-03-29 1997-03-24 改良された多剤耐性活性を有するｎ―（２―オキソアセチルまたはスルホニル）―ピロリジン／ピペリジン―２―カルボン酸誘導体 Expired - Fee Related JP4759762B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/626,259 1996-03-29
US08/626,259 US5717092A (en) 1996-03-29 1996-03-29 Compounds with improved multi-drug resistance activity
PCT/US1997/004916 WO1997036869A1 (en) 1996-03-29 1997-03-24 N-(2 oxoacetyl or sulphonyl)-pyrrolidine/piperidine-2-carboxylic acid derivatives with improved multi-drug resistance activity

Publications (3)

Publication Number Publication Date
JP2000507578A JP2000507578A (ja) 2000-06-20
JP2000507578A5 true JP2000507578A5 (enExample) 2004-12-02
JP4759762B2 JP4759762B2 (ja) 2011-08-31

Family

ID=24509627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53539597A Expired - Fee Related JP4759762B2 (ja) 1996-03-29 1997-03-24 改良された多剤耐性活性を有するｎ―（２―オキソアセチルまたはスルホニル）―ピロリジン／ピペリジン―２―カルボン酸誘導体

Country Status (11)

Country Link
US (2) US5717092A (enExample)
EP (1) EP0891331B1 (enExample)
JP (1) JP4759762B2 (enExample)
AT (1) ATE251140T1 (enExample)
AU (1) AU2346597A (enExample)
CA (1) CA2249369A1 (enExample)
DE (1) DE69725293T2 (enExample)
DK (1) DK0891331T3 (enExample)
ES (1) ES2208890T3 (enExample)
PT (1) PT891331E (enExample)
WO (1) WO1997036869A1 (enExample)

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US6150527A (en) * 1994-08-18 2000-11-21 Ariad Pharmaceuticals, Inc. Synthetic multimerizing agents
US20030036654A1 (en) * 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
US6133456A (en) * 1994-08-18 2000-10-17 Ariad Gene Therapeutics, Inc. Synthetic multimerizing agents
US5795877A (en) * 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US6121273A (en) * 1996-12-31 2000-09-19 Gpi Nil Holdings, Inc N-linked sulfonamides of heterocyclic thioesters
US5874449A (en) * 1996-12-31 1999-02-23 Gpi Nil Holdings, Inc. N-linked sulfonamides of heterocyclic thioesters
US5935989A (en) 1996-12-31 1999-08-10 Gpi Nil Holdings Inc. N-linked ureas and carbamates of heterocyclic thioesters
NZ336386A (en) * 1996-12-31 2001-09-28 Guilford Pharm Inc An urea or carbamate derivative of heterocyclic thioester useful for effecting neuronal activity
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US5846979A (en) * 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6852496B1 (en) * 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
KR20010042482A (ko) 1998-04-08 2001-05-25 피터 지. 스트링거 Ｍｒｐ1의 억제 방법
IL138389A0 (en) * 1998-04-08 2001-10-31 Lilly Co Eli Methods for inhibiting mrp1
US6410041B1 (en) 1998-04-28 2002-06-25 Trustees Of Tufts College Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine
US20020131972A1 (en) * 1998-05-21 2002-09-19 Daniel Sem Multi-partite ligands and methods of identifying and using same
AU743199B2 (en) * 1998-06-02 2002-01-24 Bristol-Myers Squibb Company Neurotrophic difluoroamide agents
EA200001247A1 (ru) 1998-06-03 2001-08-27 Джи Пи Ай Нил Холдингс, Инк. N-связанные сульфонамиды n-гетероциклических карбоновых кислот или изостеры карбоновых кислот
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
WO2000018725A1 (en) * 1998-09-30 2000-04-06 The Procter & Gamble Company 2-substituted ketoamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6228872B1 (en) 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
US6358531B1 (en) * 1999-02-01 2002-03-19 The Curators Of The University Of Missouri Method for preparing porous shells or gels from glass particles
AU6387500A (en) * 1999-08-05 2001-03-05 Procter & Gamble Company, The Multivalent exocyclic diketo compounds
DE60025744D1 (de) * 1999-10-07 2006-04-13 Lilly Co Eli Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
WO2001046195A1 (en) 1999-12-21 2001-06-28 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6593362B2 (en) 2001-05-21 2003-07-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
EP1404325A2 (en) * 2001-05-29 2004-04-07 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
US7653490B2 (en) * 2001-09-10 2010-01-26 Triad Liquidating Company LLC Nuclear magnetic resonance assembly of chemical entities
MXPA04004361A (es) * 2001-11-07 2005-03-31 Pharmacia Corp Metodos para promover la captacion y acumulacion nuclear de poliamidas en celulas eucarioticas.
US6635892B2 (en) * 2002-01-24 2003-10-21 Pei Electronics, Inc. Compact integrated infrared scene projector
US20030180797A1 (en) * 2002-03-20 2003-09-25 Lin Yu Identification of ligands for a receptor family and related methods
DE60331725D1 (de) * 2002-03-25 2010-04-29 Technologie Biolactis Inc Therapeutische mittel als antikrebs impfstoffadjuvantien und deren therapeutische verfahren
WO2005007162A1 (en) * 2003-07-10 2005-01-27 Vertex Pharmaceuticals Incorporated Compounds augmenting the activity of antibacterial agents
CN1281210C (zh) * 2003-11-29 2006-10-25 胡汛 五味子乙素在制备治疗肿瘤药物中的应用
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
EP1828202B1 (en) * 2004-12-20 2012-03-14 Wyeth LLC Rapamcyin analogues and the uses thereof in the treatment of neurological, proliferative and inflammatory disorders
EP1828203A2 (en) * 2004-12-20 2007-09-05 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
JP5767900B2 (ja) 2011-08-24 2015-08-26 株式会社東芝 水中溶接装置及び方法

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US4920218A (en) * 1988-10-12 1990-04-24 Merck & Co., Inc. Novel hydroxide mediated FK-506 rearrangement process
DE4015255A1 (de) * 1990-05-12 1991-11-14 Hoechst Ag Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
GB2247456A (en) * 1990-09-03 1992-03-04 Fujisawa Pharmaceutical Co Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same
US5620971A (en) * 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
HU217621B (hu) * 1991-05-09 2000-03-28 Vertex Pharmaceuticals Inc. Eljárás új glioxaloil-pipekolinsav-észterek, származékaik és az ezeket tartalmazó gyógyszerkészítmények előállítására
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
AU2152092A (en) * 1991-06-24 1993-01-25 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
WO1994006097A1 (en) * 1992-09-07 1994-03-17 Mikoh Technology Limited Diffraction surface data detector
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
JP4470226B2 (ja) * 1994-08-18 2010-06-02 アリアド・ファーマシューティカルズ・インコーポレイテッド 新規な多量体化剤
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity

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