IN2014CN02440A - - Google Patents
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- Publication number
- IN2014CN02440A IN2014CN02440A IN2440CHN2014A IN2014CN02440A IN 2014CN02440 A IN2014CN02440 A IN 2014CN02440A IN 2440CHN2014 A IN2440CHN2014 A IN 2440CHN2014A IN 2014CN02440 A IN2014CN02440 A IN 2014CN02440A
- Authority
- IN
- India
- Prior art keywords
- freeze
- spray chamber
- particles
- production
- liquid droplets
- Prior art date
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
- F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Drying Of Solid Materials (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11008057.9A EP2578974A1 (en) | 2011-10-05 | 2011-10-05 | Process line for the production of freeze-dried particles |
| PCT/EP2012/004168 WO2013050162A1 (en) | 2011-10-05 | 2012-10-04 | Process line for the production of freeze-dried particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN02440A true IN2014CN02440A (ja) | 2015-06-19 |
Family
ID=46980888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2407CHN2014 IN2014CN02407A (ja) | 2011-10-05 | 2012-10-04 | |
| IN2440CHN2014 IN2014CN02440A (ja) | 2011-10-05 | 2012-10-04 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2407CHN2014 IN2014CN02407A (ja) | 2011-10-05 | 2012-10-04 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9920989B2 (ja) |
| EP (4) | EP2578974A1 (ja) |
| JP (2) | JP5728135B2 (ja) |
| KR (2) | KR101512608B1 (ja) |
| CN (2) | CN103917841B (ja) |
| AU (2) | AU2012320848B8 (ja) |
| BR (2) | BR112014008001B1 (ja) |
| CA (2) | CA2849799C (ja) |
| CO (2) | CO6930351A2 (ja) |
| CR (2) | CR20140159A (ja) |
| DK (2) | DK2764309T3 (ja) |
| EA (2) | EA027602B1 (ja) |
| ES (2) | ES2608478T3 (ja) |
| HK (2) | HK1199656A1 (ja) |
| HU (2) | HUE029973T2 (ja) |
| IL (2) | IL231853A0 (ja) |
| IN (2) | IN2014CN02407A (ja) |
| MX (2) | MX359904B (ja) |
| MY (2) | MY152319A (ja) |
| PE (2) | PE20142141A1 (ja) |
| PL (2) | PL2764309T3 (ja) |
| SG (2) | SG11201400640VA (ja) |
| UA (2) | UA111858C2 (ja) |
| WO (2) | WO2013050156A1 (ja) |
| ZA (1) | ZA201401930B (ja) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
| EP2578975A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum freeze-dryer |
| EP2578974A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Process line for the production of freeze-dried particles |
| UA111631C2 (uk) | 2011-10-06 | 2016-05-25 | Санофі Пастер Са | Нагрівальний пристрій для роторної барабанної ліофільної сушарки |
| EP2578976A1 (en) | 2011-10-06 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum for use in a vacuum freeze-dryer |
| JP6173495B2 (ja) | 2013-05-29 | 2017-08-02 | ゲア・プロセス・エンジニアリング・アクティーゼルスカブ | トロリに収容されたトレイ内の製品の直列滅菌凍結乾燥を実現する方法、方法を実施するためのシステム、および方法の使用 |
| AU2015293983B2 (en) * | 2014-07-21 | 2017-02-09 | Sanofi Pasteur Sa | Liquid feeding device for the generation of droplets |
| US9561184B2 (en) | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
| DE102015105375B4 (de) * | 2015-01-07 | 2016-11-03 | Richard Süverkrüp | Vorrichtung und Verfahren zur Erzeugung monodisperser gefrorener Tropfen |
| US9739532B2 (en) * | 2015-02-04 | 2017-08-22 | Steven F. Baugh | Botanical freeze drying system and method |
| BR112017025819B1 (pt) | 2015-06-01 | 2022-03-15 | Ima Life North America Inc | Sistema de liofilização para produto a granel, método para liofilizar um produto e método para liofilizar produto a granel contendo líquido |
| RU2615553C1 (ru) * | 2015-10-15 | 2017-04-05 | Акционерное общество "Военно-промышленная корпорация "Научно-производственное объединение машиностроения" | Способ и устройство непрерывной сублимационной сушки жидких продуктов |
| EP3167877A1 (en) | 2015-11-12 | 2017-05-17 | Bayer Pharma Aktiengesellschaft | Method for the production of freeze-dried pellets comprising factor viii |
| CN106705574A (zh) * | 2015-11-17 | 2017-05-24 | 上海东富龙科技股份有限公司 | 一种固体制剂制造设备和方法 |
| JP6666535B2 (ja) * | 2016-01-05 | 2020-03-18 | 株式会社あい・あいエナジーアソシエイツ | 液体の凍結乾燥装置及び凍結乾燥方法 |
| CN105674691B (zh) * | 2016-04-01 | 2017-11-21 | 苏州大学 | 用于收集喷雾冷冻冰球颗粒的双密封式设备及其收集方法 |
| US10507165B2 (en) | 2017-05-31 | 2019-12-17 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using same |
| US10369077B2 (en) * | 2017-05-31 | 2019-08-06 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using the same |
| DE102017119649A1 (de) | 2017-08-28 | 2019-02-28 | Richard Süverkrüp | Verfahren zur kontinuierlichen Herstellung gefriergetrockneter Tropfen in einem geschlossenen Gaskreislauf |
| ES2779023T3 (es) * | 2017-10-20 | 2020-08-13 | Martin Christ Gefriertrocknungsanlagen Gmbh | Procedimiento para la determinación a base de presión de un parámetro de producto en un liofilizador, liofilizador y producto de software |
| KR102450460B1 (ko) * | 2017-12-29 | 2022-09-30 | 아주대학교산학협력단 | 초음파 분무기를 이용한 미립구 약제의 양산 시스템 |
| WO2019175954A1 (ja) * | 2018-03-13 | 2019-09-19 | 株式会社プリス | 噴霧凍結造粒乾燥粉体製造装置及び噴霧凍結造粒乾燥粉体製造システム |
| CN111065874B (zh) * | 2018-06-08 | 2020-12-29 | 株式会社爱发科 | 真空冻结干燥装置和真空冻结干燥方法 |
| SG11202100028PA (en) * | 2018-07-05 | 2021-01-28 | Bayer Ag | METHOD FOR THE PRODUCTION OF FREEZE-DRIED PELLETS COMPRISING AN ANTI-COAGULATION FACTOR XIa (FXIa) ANTIBODY |
| WO2020161863A1 (ja) * | 2019-02-07 | 2020-08-13 | 株式会社アルバック | 真空凍結乾燥方法及び真空凍結乾燥装置 |
| US11243029B2 (en) * | 2019-04-26 | 2022-02-08 | Purdue Research Foundation | Process monitoring and control for lyophilization using a wireless sensor network |
| CN111207564B (zh) * | 2019-09-30 | 2022-01-04 | 中国科学院上海硅酸盐研究所 | 一种冷冻干燥系统及方法 |
| TW202202792A (zh) | 2020-05-18 | 2022-01-16 | 日商Ｍｉｉ股份有限公司 | 真空凍結乾燥裝置及真空凍結乾燥方法 |
| JP6777350B1 (ja) | 2020-05-18 | 2020-10-28 | 株式会社エムアイアイ | 真空凍結乾燥装置及び真空凍結乾燥方法 |
| US20230168034A1 (en) * | 2020-08-07 | 2023-06-01 | Ulvac, Inc. | Vacuum freeze-drying method, injection nozzle for a vacuum freeze-drying apparatus, and vacuum freeze-drying apparatus |
| JP6887050B1 (ja) * | 2020-08-07 | 2021-06-16 | 株式会社アルバック | 真空凍結乾燥方法および真空凍結乾燥装置 |
| US11874060B2 (en) | 2020-11-16 | 2024-01-16 | Sublime Stericeuticals Corporation | Continuous throughput lyophilizer-powder filler within a sterile boundary |
| JP7085088B1 (ja) | 2021-08-03 | 2022-06-16 | 株式会社エムアイアイ | 凍結乾燥物 |
| WO2023057444A1 (en) | 2021-10-05 | 2023-04-13 | Sanofi | METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME |
| US12085337B2 (en) * | 2021-10-20 | 2024-09-10 | DSM Sales & Manufacturing, Inc. | Freeze-drying systems and methods |
| TW202417038A (zh) | 2022-06-15 | 2024-05-01 | 法商賽諾菲公司 | 高度濃縮的抗體組成物 |
| US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
| US12083447B2 (en) | 2022-09-15 | 2024-09-10 | Velico Medical, Inc. | Alignment of a disposable for a spray drying plasma system |
| US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
| US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
| WO2024184721A1 (en) * | 2023-03-03 | 2024-09-12 | Pfizer Inc. | Systems and methods for pre-conditioning frozen bulk in dynamic bulk freeze drying |
| WO2024184725A1 (en) * | 2023-03-03 | 2024-09-12 | Pfizer Inc. | Systems and methods for reducing electrostatic force in dynamic freeze drying |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2388917A (en) * | 1941-10-13 | 1945-11-13 | Hormel & Co Geo A | Process for preservation of biological materials and products resulting therefrom |
| FR1378749A (fr) | 1964-01-07 | 1964-11-13 | Leybold Hochvakuum Anlagen | Procédé et dispositif de séchage par congélation |
| US3303578A (en) | 1964-07-29 | 1967-02-14 | William C Rockwell | Continuous freeze-drying apparatus |
| US3601901A (en) | 1969-09-12 | 1971-08-31 | Earl L Rader | Freeze drying apparatus with removable conveyor and heater structures |
| US3621587A (en) | 1970-08-06 | 1971-11-23 | Smitherm Industries | Freeze drying apparatus |
| US4033048A (en) | 1976-01-12 | 1977-07-05 | Clayton Van Ike | Freeze drying apparatus |
| JPS5844703Y2 (ja) | 1979-02-01 | 1983-10-11 | クラリオン株式会社 | スピ−カの取付構造 |
| JPS55112980A (en) * | 1979-02-26 | 1980-09-01 | Nippon Oxygen Co Ltd | Freezing drier |
| DE3105623A1 (de) * | 1981-02-16 | 1982-09-02 | Erhard Dipl.-Ing.agr. 8000 München Grolitsch | Verfahren zur schonenden gefriertrocknung und pulverisierung von empfindlichen trocknungsguetern wie wasserhaltigen lebensmitteln |
| AU650045B2 (en) | 1990-09-12 | 1994-06-09 | Lifecell Corporation | Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions |
| DE4113512C2 (de) * | 1991-04-25 | 1995-04-20 | Grolitsch Lisbeth | Verfahren und Vorrichtung zur Gefriertrocknung und Pulverisierung von Lebensmitteln |
| US5230162A (en) * | 1992-06-26 | 1993-07-27 | Oyler Jr James R | Systems and methods for the deliquification of liquid-containing substances by flash sublimation |
| GB9416582D0 (en) * | 1994-08-17 | 1994-10-19 | Ici Plc | Process for the production of exothermically reacting compositions |
| AU699042B2 (en) | 1995-03-09 | 1998-11-19 | Boc Group, Inc., The | Transfer port system |
| JPH0971536A (ja) | 1995-07-03 | 1997-03-18 | Nippon Telegr & Teleph Corp <Ntt> | 生物細胞含有液凍結乾燥装置 |
| DE19654134C2 (de) | 1996-04-25 | 2003-08-07 | Messer Griesheim Gmbh | Verfahren und Einrichtung zum Gefriertrocknen |
| JP3639783B2 (ja) * | 2000-10-30 | 2005-04-20 | 共和真空技術株式会社 | 食品・薬品等の凍結乾燥方法および凍結乾燥装置 |
| GB0103620D0 (en) * | 2001-02-14 | 2001-03-28 | Prometic Biosciences Ltd | Sterile composition and its preparation |
| US6543155B2 (en) | 2001-03-01 | 2003-04-08 | National Agricultural Research Organization | Freeze-dried product and process and apparatus for producing it |
| JP3686594B2 (ja) | 2001-06-14 | 2005-08-24 | 共和真空技術株式会社 | 食品・薬品類の凍結乾燥装置における液材料の分注装置 |
| CN1607941A (zh) | 2001-11-19 | 2005-04-20 | 贝克顿迪肯森公司 | 粒状药物组合物 |
| JP3942093B2 (ja) | 2003-01-28 | 2007-07-11 | 株式会社アルバック | 噴霧式真空凍結乾燥装置 |
| FR2862306B1 (fr) | 2003-11-17 | 2008-05-30 | Aventis Pasteur | Composition vaccinale |
| DE102004005660A1 (de) * | 2004-02-04 | 2005-08-25 | Rheinische Friedrich-Wilhelms-Universität Bonn | Verfahren und Vorrichtung zur Herstellung eines lyophilisierten pharmazeutischen Materials |
| SE526792C2 (sv) | 2004-03-03 | 2005-11-08 | Tetra Laval Holdings & Finance | Anordning för evaporativ kylning av en vätskeformig produkt |
| MXPA06012614A (es) | 2004-05-01 | 2007-07-18 | Agres Ltd | Proceso y aparato de secado. |
| WO2006008006A1 (en) | 2004-07-23 | 2006-01-26 | Bayer Technology Services Gmbh | Sterile freezing, drying, storing, assaying and filling process (sfd-saf process) (pellet freeze-drying process for parenteral biopharmaceuticals) |
| US20060165717A1 (en) | 2005-01-25 | 2006-07-27 | Sanofi Pasteur | DCchol in newborns |
| AR054822A1 (es) | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
| EP2001498A4 (en) | 2006-03-20 | 2013-01-23 | Vertex Pharma | PHARMACEUTICAL COMPOSITIONS |
| KR101696727B1 (ko) | 2006-07-17 | 2017-01-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 인플루엔자 백신 |
| DE102007055488B4 (de) * | 2006-12-01 | 2015-01-22 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrocknungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut |
| DE202006018276U1 (de) * | 2006-12-01 | 2007-02-08 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrockungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut |
| CN101234257B (zh) | 2007-02-01 | 2011-07-27 | 发泰（天津）科技有限公司 | 微波旋转薄膜浓缩器 |
| DE102007012795B3 (de) * | 2007-03-16 | 2008-04-10 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrocknungsanlagen und Verfahren zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut mittels Mikrowellen |
| EP2101131A1 (en) * | 2007-12-31 | 2009-09-16 | Terruzzi Fercalx S.p.A. | Lyophilization method and system therefor |
| EP2589392B1 (en) | 2008-03-05 | 2016-11-30 | Sanofi Pasteur | Process for stabilizing an adjuvant containing vaccine composition |
| EP2578974A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Process line for the production of freeze-dried particles |
| EP2578975A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum freeze-dryer |
| EP2578976A1 (en) | 2011-10-06 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum for use in a vacuum freeze-dryer |
| UA111631C2 (uk) | 2011-10-06 | 2016-05-25 | Санофі Пастер Са | Нагрівальний пристрій для роторної барабанної ліофільної сушарки |
-
2011
- 2011-10-05 EP EP11008057.9A patent/EP2578974A1/en not_active Withdrawn
-
2012
- 2012-04-10 UA UAA201404683A patent/UA111858C2/uk unknown
- 2012-04-10 UA UAA201404685A patent/UA111859C2/uk unknown
- 2012-10-04 AU AU2012320848A patent/AU2012320848B8/en not_active Ceased
- 2012-10-04 KR KR1020147011244A patent/KR101512608B1/ko active IP Right Grant
- 2012-10-04 JP JP2014533796A patent/JP5728135B2/ja active Active
- 2012-10-04 EP EP12769026.1A patent/EP2766682B1/en active Active
- 2012-10-04 EP EP16199831.5A patent/EP3211355A1/en not_active Withdrawn
- 2012-10-04 SG SG11201400640VA patent/SG11201400640VA/en unknown
- 2012-10-04 KR KR1020147011243A patent/KR101552804B1/ko active IP Right Grant
- 2012-10-04 DK DK12769021.2T patent/DK2764309T3/en active
- 2012-10-04 MX MX2014004041A patent/MX359904B/es active IP Right Grant
- 2012-10-04 EA EA201490723A patent/EA027602B1/ru not_active IP Right Cessation
- 2012-10-04 JP JP2014533792A patent/JP5766361B2/ja active Active
- 2012-10-04 PE PE2014000480A patent/PE20142141A1/es not_active Application Discontinuation
- 2012-10-04 CN CN201280049533.8A patent/CN103917841B/zh active Active
- 2012-10-04 PE PE2014000479A patent/PE20141979A1/es not_active Application Discontinuation
- 2012-10-04 PL PL12769021T patent/PL2764309T3/pl unknown
- 2012-10-04 CA CA2849799A patent/CA2849799C/en not_active Expired - Fee Related
- 2012-10-04 WO PCT/EP2012/004162 patent/WO2013050156A1/en active Application Filing
- 2012-10-04 EP EP12769021.2A patent/EP2764309B1/en active Active
- 2012-10-04 MY MYPI2014000783 patent/MY152319A/en unknown
- 2012-10-04 MY MYPI2014000743 patent/MY151369A/en unknown
- 2012-10-04 SG SG11201400641QA patent/SG11201400641QA/en unknown
- 2012-10-04 IN IN2407CHN2014 patent/IN2014CN02407A/en unknown
- 2012-10-04 CA CA2849802A patent/CA2849802C/en not_active Expired - Fee Related
- 2012-10-04 MX MX2014004000A patent/MX341894B/es active IP Right Grant
- 2012-10-04 BR BR112014008001-1A patent/BR112014008001B1/pt active IP Right Grant
- 2012-10-04 BR BR112014007862-9A patent/BR112014007862B1/pt active IP Right Grant
- 2012-10-04 ES ES12769026.1T patent/ES2608478T3/es active Active
- 2012-10-04 HU HUE12769026A patent/HUE029973T2/en unknown
- 2012-10-04 EA EA201490719A patent/EA027630B1/ru not_active IP Right Cessation
- 2012-10-04 CN CN201280049534.2A patent/CN103917842B/zh active Active
- 2012-10-04 ES ES12769021.2T patent/ES2608427T3/es active Active
- 2012-10-04 AU AU2012320854A patent/AU2012320854B2/en active Active
- 2012-10-04 IN IN2440CHN2014 patent/IN2014CN02440A/en unknown
- 2012-10-04 PL PL12769026T patent/PL2766682T3/pl unknown
- 2012-10-04 HU HUE12769021A patent/HUE030970T2/en unknown
- 2012-10-04 DK DK12769026.1T patent/DK2766682T3/en active
- 2012-10-04 US US14/348,877 patent/US9920989B2/en active Active
- 2012-10-04 WO PCT/EP2012/004168 patent/WO2013050162A1/en active Application Filing
- 2012-10-04 US US14/348,869 patent/US10006706B2/en active Active
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2014
- 2014-03-17 ZA ZA2014/01930A patent/ZA201401930B/en unknown
- 2014-03-31 IL IL231853A patent/IL231853A0/en unknown
- 2014-03-31 IL IL231849A patent/IL231849A0/en unknown
- 2014-04-04 CR CR20140159A patent/CR20140159A/es unknown
- 2014-04-04 CR CR20140158A patent/CR20140158A/es unknown
- 2014-04-04 CO CO14073108A patent/CO6930351A2/es unknown
- 2014-04-04 CO CO14073110A patent/CO6930306A2/es unknown
-
2015
- 2015-01-06 HK HK15100076.0A patent/HK1199656A1/xx not_active IP Right Cessation
- 2015-01-20 HK HK15100624.7A patent/HK1200207A1/xx not_active IP Right Cessation
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