CR20140159A - Línea de proceso para la producción de partículas criodesecadas - Google Patents

Línea de proceso para la producción de partículas criodesecadas

Info

Publication number
CR20140159A
CR20140159A CR20140159A CR20140159A CR20140159A CR 20140159 A CR20140159 A CR 20140159A CR 20140159 A CR20140159 A CR 20140159A CR 20140159 A CR20140159 A CR 20140159A CR 20140159 A CR20140159 A CR 20140159A
Authority
CR
Costa Rica
Prior art keywords
particles
process line
cryo
production
criodesecated
Prior art date
Application number
CR20140159A
Other languages
English (en)
Inventor
Matthias Plitzko
Manfred Struschka
Bernhard Luy
Original Assignee
Sanofi Pasteur Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Sa filed Critical Sanofi Pasteur Sa
Publication of CR20140159A publication Critical patent/CR20140159A/es

Links

Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporciona una línea de proceso (300) para la producción de partículas criodesecadas bajo condiciones cerradas, la línea de proceso comprende al menos los siguientes dispositivos separados: uan cámara de aspersión (302) para la generación de gotitas y la criocongelación de las gotitas de líquido para formar partículas, y un criodesecador a granel (304) para la criodesecación de las partículas.
CR20140159A 2011-10-05 2014-04-04 Línea de proceso para la producción de partículas criodesecadas CR20140159A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11008057.9A EP2578974A1 (en) 2011-10-05 2011-10-05 Process line for the production of freeze-dried particles
PCT/EP2012/004168 WO2013050162A1 (en) 2011-10-05 2012-10-04 Process line for the production of freeze-dried particles

Publications (1)

Publication Number Publication Date
CR20140159A true CR20140159A (es) 2014-10-30

Family

ID=46980888

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20140159A CR20140159A (es) 2011-10-05 2014-04-04 Línea de proceso para la producción de partículas criodesecadas
CR20140158A CR20140158A (es) 2011-10-05 2014-04-04 Línea de proceso para la producción de partículas criodesecadas

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20140158A CR20140158A (es) 2011-10-05 2014-04-04 Línea de proceso para la producción de partículas criodesecadas

Country Status (25)

Country Link
US (2) US10006706B2 (es)
EP (4) EP2578974A1 (es)
JP (2) JP5728135B2 (es)
KR (2) KR101552804B1 (es)
CN (2) CN103917842B (es)
AU (2) AU2012320854B2 (es)
BR (2) BR112014008001B1 (es)
CA (2) CA2849802C (es)
CO (2) CO6930306A2 (es)
CR (2) CR20140159A (es)
DK (2) DK2764309T3 (es)
EA (2) EA027602B1 (es)
ES (2) ES2608478T3 (es)
HK (2) HK1199656A1 (es)
HU (2) HUE029973T2 (es)
IL (2) IL231853A0 (es)
IN (2) IN2014CN02440A (es)
MX (2) MX359904B (es)
MY (2) MY152319A (es)
PE (2) PE20142141A1 (es)
PL (2) PL2766682T3 (es)
SG (2) SG11201400640VA (es)
UA (2) UA111859C2 (es)
WO (2) WO2013050156A1 (es)
ZA (1) ZA201401930B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140083628A1 (en) 2012-09-27 2014-03-27 Velico Medical, Inc. Spray drier assembly for automated spray drying
EP2578975A1 (en) 2011-10-05 2013-04-10 Sanofi Pasteur Sa Rotary drum freeze-dryer
EP2578974A1 (en) 2011-10-05 2013-04-10 Sanofi Pasteur Sa Process line for the production of freeze-dried particles
EP2578976A1 (en) 2011-10-06 2013-04-10 Sanofi Pasteur Sa Rotary drum for use in a vacuum freeze-dryer
UA111631C2 (uk) 2011-10-06 2016-05-25 Санофі Пастер Са Нагрівальний пристрій для роторної барабанної ліофільної сушарки
WO2014190992A1 (en) 2013-05-29 2014-12-04 Gea Process Engineering A/S Method of providing inline sterile freeze drying of a product in trays accommodated in a trolley, system for carrying out the method, and use of the method
BR112016031039B1 (pt) 2014-07-21 2022-02-15 Sanofi Pasteur Sa Dispositivo de alimentação de líquido para a geração de gotículas, linha de processo para a produção de partículas liofilizadas e processos para preparar uma composição de vacina compreendendo
US9561184B2 (en) * 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
DE102015105375B4 (de) 2015-01-07 2016-11-03 Richard Süverkrüp Vorrichtung und Verfahren zur Erzeugung monodisperser gefrorener Tropfen
US9739532B2 (en) * 2015-02-04 2017-08-22 Steven F. Baugh Botanical freeze drying system and method
ES2760075T3 (es) * 2015-06-01 2020-05-13 Ima Life North America Inc Liofilización a granel utilizando congelación por pulverización y secado en agitación con calentamiento
RU2615553C1 (ru) * 2015-10-15 2017-04-05 Акционерное общество "Военно-промышленная корпорация "Научно-производственное объединение машиностроения" Способ и устройство непрерывной сублимационной сушки жидких продуктов
EP3167877A1 (en) * 2015-11-12 2017-05-17 Bayer Pharma Aktiengesellschaft Method for the production of freeze-dried pellets comprising factor viii
CN106705574A (zh) * 2015-11-17 2017-05-24 上海东富龙科技股份有限公司 一种固体制剂制造设备和方法
JP6666535B2 (ja) * 2016-01-05 2020-03-18 株式会社あい・あいエナジーアソシエイツ 液体の凍結乾燥装置及び凍結乾燥方法
CN105674691B (zh) * 2016-04-01 2017-11-21 苏州大学 用于收集喷雾冷冻冰球颗粒的双密封式设备及其收集方法
US10369077B2 (en) * 2017-05-31 2019-08-06 Adienne Pharma & Biotech Sa Multi chamber flexible bag and methods of using the same
US10507165B2 (en) 2017-05-31 2019-12-17 Adienne Pharma & Biotech Sa Multi chamber flexible bag and methods of using same
DE102017119649A1 (de) 2017-08-28 2019-02-28 Richard Süverkrüp Verfahren zur kontinuierlichen Herstellung gefriergetrockneter Tropfen in einem geschlossenen Gaskreislauf
EP3473959B1 (de) * 2017-10-20 2020-02-12 Martin Christ Gefriertrocknungsanlagen GmbH Verfahren zur druckbasierten ermittlung eines produktparameters in einem gefriertrockner, gefriertrockner und softwareprodukt
KR102450460B1 (ko) * 2017-12-29 2022-09-30 아주대학교산학협력단 초음파 분무기를 이용한 미립구 약제의 양산 시스템
JP7038435B2 (ja) * 2018-03-13 2022-03-18 株式会社プリス 噴霧凍結造粒乾燥粉体製造装置及び噴霧凍結造粒乾燥粉体製造システム
WO2019235036A1 (ja) * 2018-06-08 2019-12-12 株式会社アルバック 凍結真空乾燥装置及び凍結真空乾燥方法
CA3105256A1 (en) 2018-07-05 2020-01-09 Bayer Aktiengesellschaft Novel stable high-concentration formulation for anti-fxia antibodies
WO2020161863A1 (ja) * 2019-02-07 2020-08-13 株式会社アルバック 真空凍結乾燥方法及び真空凍結乾燥装置
US11243029B2 (en) * 2019-04-26 2022-02-08 Purdue Research Foundation Process monitoring and control for lyophilization using a wireless sensor network
CN111207564B (zh) * 2019-09-30 2022-01-04 中国科学院上海硅酸盐研究所 一种冷冻干燥系统及方法
TW202202792A (zh) * 2020-05-18 2022-01-16 日商Mii股份有限公司 真空凍結乾燥裝置及真空凍結乾燥方法
JP6777350B1 (ja) 2020-05-18 2020-10-28 株式会社エムアイアイ 真空凍結乾燥装置及び真空凍結乾燥方法
JP6887050B1 (ja) * 2020-08-07 2021-06-16 株式会社アルバック 真空凍結乾燥方法および真空凍結乾燥装置
US20230168034A1 (en) * 2020-08-07 2023-06-01 Ulvac, Inc. Vacuum freeze-drying method, injection nozzle for a vacuum freeze-drying apparatus, and vacuum freeze-drying apparatus
US11874060B2 (en) 2020-11-16 2024-01-16 Sublime Stericeuticals Corporation Continuous throughput lyophilizer-powder filler within a sterile boundary
JP7085088B1 (ja) * 2021-08-03 2022-06-16 株式会社エムアイアイ 凍結乾燥物
KR20240065326A (ko) 2021-10-05 2024-05-14 사노피 지질 나노입자(lnp)를 냉동 및 냉동-건조하는 방법 및 이를 사용하여 수득된 lnp
US20230122361A1 (en) * 2021-10-20 2023-04-20 DSM Sales & Manufacturing, Inc. Freeze-drying systems and methods
WO2023242347A1 (en) 2022-06-15 2023-12-21 Sanofi Highly concentrated antibody compositions
US11975274B2 (en) 2022-09-15 2024-05-07 Velico Medical, Inc. Blood plasma product
US11998861B2 (en) 2022-09-15 2024-06-04 Velico Medical, Inc. Usability of a disposable for a spray drying plasma system
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2388917A (en) * 1941-10-13 1945-11-13 Hormel & Co Geo A Process for preservation of biological materials and products resulting therefrom
FR1378749A (fr) * 1964-01-07 1964-11-13 Leybold Hochvakuum Anlagen Procédé et dispositif de séchage par congélation
US3303578A (en) 1964-07-29 1967-02-14 William C Rockwell Continuous freeze-drying apparatus
US3601901A (en) 1969-09-12 1971-08-31 Earl L Rader Freeze drying apparatus with removable conveyor and heater structures
US3621587A (en) 1970-08-06 1971-11-23 Smitherm Industries Freeze drying apparatus
US4033048A (en) 1976-01-12 1977-07-05 Clayton Van Ike Freeze drying apparatus
JPS5844703Y2 (ja) 1979-02-01 1983-10-11 クラリオン株式会社 スピ−カの取付構造
JPS55112980A (en) * 1979-02-26 1980-09-01 Nippon Oxygen Co Ltd Freezing drier
DE3105623A1 (de) * 1981-02-16 1982-09-02 Erhard Dipl.-Ing.agr. 8000 München Grolitsch Verfahren zur schonenden gefriertrocknung und pulverisierung von empfindlichen trocknungsguetern wie wasserhaltigen lebensmitteln
AU650045B2 (en) 1990-09-12 1994-06-09 Lifecell Corporation Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions
DE4113512C2 (de) * 1991-04-25 1995-04-20 Grolitsch Lisbeth Verfahren und Vorrichtung zur Gefriertrocknung und Pulverisierung von Lebensmitteln
US5230162A (en) * 1992-06-26 1993-07-27 Oyler Jr James R Systems and methods for the deliquification of liquid-containing substances by flash sublimation
GB9416582D0 (en) * 1994-08-17 1994-10-19 Ici Plc Process for the production of exothermically reacting compositions
AU699042B2 (en) 1995-03-09 1998-11-19 Boc Group, Inc., The Transfer port system
JPH0971536A (ja) 1995-07-03 1997-03-18 Nippon Telegr & Teleph Corp <Ntt> 生物細胞含有液凍結乾燥装置
DE19654134C2 (de) 1996-04-25 2003-08-07 Messer Griesheim Gmbh Verfahren und Einrichtung zum Gefriertrocknen
JP3639783B2 (ja) 2000-10-30 2005-04-20 共和真空技術株式会社 食品・薬品等の凍結乾燥方法および凍結乾燥装置
GB0103620D0 (en) * 2001-02-14 2001-03-28 Prometic Biosciences Ltd Sterile composition and its preparation
US6543155B2 (en) 2001-03-01 2003-04-08 National Agricultural Research Organization Freeze-dried product and process and apparatus for producing it
JP3686594B2 (ja) 2001-06-14 2005-08-24 共和真空技術株式会社 食品・薬品類の凍結乾燥装置における液材料の分注装置
WO2003072016A2 (en) 2001-11-19 2003-09-04 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
JP3942093B2 (ja) 2003-01-28 2007-07-11 株式会社アルバック 噴霧式真空凍結乾燥装置
FR2862306B1 (fr) 2003-11-17 2008-05-30 Aventis Pasteur Composition vaccinale
DE102004005660A1 (de) 2004-02-04 2005-08-25 Rheinische Friedrich-Wilhelms-Universität Bonn Verfahren und Vorrichtung zur Herstellung eines lyophilisierten pharmazeutischen Materials
SE526792C2 (sv) * 2004-03-03 2005-11-08 Tetra Laval Holdings & Finance Anordning för evaporativ kylning av en vätskeformig produkt
BRPI0510529A (pt) 2004-05-01 2007-10-30 Agres Ltd processo e aparelho de secagem
JP4829229B2 (ja) 2004-07-23 2011-12-07 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 無菌凍結、乾燥、保存、分析及び充填方法(sfd−saf法)(非経口生物薬剤用のペレット凍結乾燥法)
US20060165717A1 (en) 2005-01-25 2006-07-27 Sanofi Pasteur DCchol in newborns
AR054822A1 (es) 2005-07-07 2007-07-18 Sanofi Pasteur Emulsion inmuno adyuvante
CN101494979A (zh) 2006-03-20 2009-07-29 沃泰克斯药物股份有限公司 药物组合物
KR101696727B1 (ko) 2006-07-17 2017-01-16 글락소스미스클라인 바이오로지칼즈 에스.에이. 인플루엔자 백신
DE102007055488B4 (de) * 2006-12-01 2015-01-22 Püschner GmbH + Co. KG Mikrowellen-Vakuumtrocknungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut
DE202006018276U1 (de) 2006-12-01 2007-02-08 Püschner GmbH + Co. KG Mikrowellen-Vakuumtrockungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut
CN101234257B (zh) 2007-02-01 2011-07-27 发泰(天津)科技有限公司 微波旋转薄膜浓缩器
DE102007012795B3 (de) * 2007-03-16 2008-04-10 Püschner GmbH + Co. KG Mikrowellen-Vakuumtrocknungsanlagen und Verfahren zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut mittels Mikrowellen
EP2101131A1 (en) * 2007-12-31 2009-09-16 Terruzzi Fercalx S.p.A. Lyophilization method and system therefor
KR101695800B1 (ko) 2008-03-05 2017-02-22 사노피 파스퇴르 항원보강제 함유 백신 조성물의 안정화 방법
EP2578975A1 (en) 2011-10-05 2013-04-10 Sanofi Pasteur Sa Rotary drum freeze-dryer
EP2578974A1 (en) 2011-10-05 2013-04-10 Sanofi Pasteur Sa Process line for the production of freeze-dried particles
EP2578976A1 (en) 2011-10-06 2013-04-10 Sanofi Pasteur Sa Rotary drum for use in a vacuum freeze-dryer
UA111631C2 (uk) 2011-10-06 2016-05-25 Санофі Пастер Са Нагрівальний пристрій для роторної барабанної ліофільної сушарки

Also Published As

Publication number Publication date
MX341894B (es) 2016-09-07
CA2849802C (en) 2015-12-08
JP5766361B2 (ja) 2015-08-19
PE20142141A1 (es) 2015-01-04
WO2013050156A8 (en) 2013-06-13
CR20140158A (es) 2014-10-30
EA027602B1 (ru) 2017-08-31
EA201490719A1 (ru) 2014-09-30
JP2014530061A (ja) 2014-11-17
SG11201400641QA (en) 2014-08-28
AU2012320854A1 (en) 2014-05-15
EA201490723A1 (ru) 2014-08-29
EP3211355A1 (en) 2017-08-30
EP2578974A1 (en) 2013-04-10
US20140230266A1 (en) 2014-08-21
BR112014007862B1 (pt) 2021-01-19
CN103917841B (zh) 2015-07-08
HK1199656A1 (en) 2015-07-10
US10006706B2 (en) 2018-06-26
AU2012320848B2 (en) 2015-02-26
CA2849799C (en) 2015-12-08
AU2012320854B2 (en) 2015-02-19
PL2766682T3 (pl) 2017-03-31
WO2013050162A1 (en) 2013-04-11
EP2766682B1 (en) 2016-11-23
CN103917841A (zh) 2014-07-09
CO6930351A2 (es) 2014-04-28
MY152319A (en) 2014-09-08
PE20141979A1 (es) 2014-12-19
MX2014004041A (es) 2014-08-01
DK2764309T3 (en) 2017-01-09
IN2014CN02440A (es) 2015-06-19
ZA201401930B (en) 2015-02-25
UA111859C2 (uk) 2016-06-24
MY151369A (en) 2014-05-16
IL231853A0 (en) 2014-05-28
PL2764309T3 (pl) 2017-03-31
JP2014530685A (ja) 2014-11-20
KR20140088112A (ko) 2014-07-09
SG11201400640VA (en) 2014-06-27
EP2764309B1 (en) 2016-11-23
CN103917842B (zh) 2015-08-05
EA027630B1 (ru) 2017-08-31
AU2012320848B8 (en) 2015-03-05
ES2608478T3 (es) 2017-04-11
KR20140088113A (ko) 2014-07-09
KR101512608B1 (ko) 2015-04-15
HUE029973T2 (en) 2017-04-28
EP2764309A1 (en) 2014-08-13
AU2012320848A1 (en) 2014-05-15
ES2608427T3 (es) 2017-04-10
CA2849802A1 (en) 2013-04-11
HK1200207A1 (en) 2015-07-31
CO6930306A2 (es) 2014-04-28
DK2766682T3 (en) 2017-01-09
US9920989B2 (en) 2018-03-20
BR112014007862A2 (pt) 2017-04-18
EP2766682A1 (en) 2014-08-20
US20140245629A1 (en) 2014-09-04
WO2013050156A1 (en) 2013-04-11
HUE030970T2 (en) 2017-06-28
IL231849A0 (en) 2014-05-28
IN2014CN02407A (es) 2015-06-19
MX2014004000A (es) 2014-07-22
JP5728135B2 (ja) 2015-06-03
MX359904B (es) 2018-10-16
BR112014008001B1 (pt) 2021-01-19
BR112014008001A2 (pt) 2017-04-11
CA2849799A1 (en) 2013-04-11
UA111858C2 (uk) 2016-06-24
KR101552804B1 (ko) 2015-09-11
CN103917842A (zh) 2014-07-09

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