CR20140159A - Línea de proceso para la producción de partículas criodesecadas - Google Patents
Línea de proceso para la producción de partículas criodesecadasInfo
- Publication number
- CR20140159A CR20140159A CR20140159A CR20140159A CR20140159A CR 20140159 A CR20140159 A CR 20140159A CR 20140159 A CR20140159 A CR 20140159A CR 20140159 A CR20140159 A CR 20140159A CR 20140159 A CR20140159 A CR 20140159A
- Authority
- CR
- Costa Rica
- Prior art keywords
- particles
- process line
- cryo
- production
- criodesecated
- Prior art date
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
- F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se proporciona una línea de proceso (300) para la producción de partículas criodesecadas bajo condiciones cerradas, la línea de proceso comprende al menos los siguientes dispositivos separados: uan cámara de aspersión (302) para la generación de gotitas y la criocongelación de las gotitas de líquido para formar partículas, y un criodesecador a granel (304) para la criodesecación de las partículas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11008057.9A EP2578974A1 (en) | 2011-10-05 | 2011-10-05 | Process line for the production of freeze-dried particles |
PCT/EP2012/004168 WO2013050162A1 (en) | 2011-10-05 | 2012-10-04 | Process line for the production of freeze-dried particles |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20140159A true CR20140159A (es) | 2014-10-30 |
Family
ID=46980888
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20140159A CR20140159A (es) | 2011-10-05 | 2014-04-04 | Línea de proceso para la producción de partículas criodesecadas |
CR20140158A CR20140158A (es) | 2011-10-05 | 2014-04-04 | Línea de proceso para la producción de partículas criodesecadas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20140158A CR20140158A (es) | 2011-10-05 | 2014-04-04 | Línea de proceso para la producción de partículas criodesecadas |
Country Status (25)
Country | Link |
---|---|
US (2) | US10006706B2 (es) |
EP (4) | EP2578974A1 (es) |
JP (2) | JP5728135B2 (es) |
KR (2) | KR101552804B1 (es) |
CN (2) | CN103917842B (es) |
AU (2) | AU2012320854B2 (es) |
BR (2) | BR112014008001B1 (es) |
CA (2) | CA2849802C (es) |
CO (2) | CO6930306A2 (es) |
CR (2) | CR20140159A (es) |
DK (2) | DK2764309T3 (es) |
EA (2) | EA027602B1 (es) |
ES (2) | ES2608478T3 (es) |
HK (2) | HK1199656A1 (es) |
HU (2) | HUE029973T2 (es) |
IL (2) | IL231853A0 (es) |
IN (2) | IN2014CN02440A (es) |
MX (2) | MX359904B (es) |
MY (2) | MY152319A (es) |
PE (2) | PE20142141A1 (es) |
PL (2) | PL2766682T3 (es) |
SG (2) | SG11201400640VA (es) |
UA (2) | UA111859C2 (es) |
WO (2) | WO2013050156A1 (es) |
ZA (1) | ZA201401930B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
EP2578975A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum freeze-dryer |
EP2578974A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Process line for the production of freeze-dried particles |
EP2578976A1 (en) | 2011-10-06 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum for use in a vacuum freeze-dryer |
UA111631C2 (uk) | 2011-10-06 | 2016-05-25 | Санофі Пастер Са | Нагрівальний пристрій для роторної барабанної ліофільної сушарки |
WO2014190992A1 (en) | 2013-05-29 | 2014-12-04 | Gea Process Engineering A/S | Method of providing inline sterile freeze drying of a product in trays accommodated in a trolley, system for carrying out the method, and use of the method |
BR112016031039B1 (pt) | 2014-07-21 | 2022-02-15 | Sanofi Pasteur Sa | Dispositivo de alimentação de líquido para a geração de gotículas, linha de processo para a produção de partículas liofilizadas e processos para preparar uma composição de vacina compreendendo |
US9561184B2 (en) * | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
DE102015105375B4 (de) | 2015-01-07 | 2016-11-03 | Richard Süverkrüp | Vorrichtung und Verfahren zur Erzeugung monodisperser gefrorener Tropfen |
US9739532B2 (en) * | 2015-02-04 | 2017-08-22 | Steven F. Baugh | Botanical freeze drying system and method |
ES2760075T3 (es) * | 2015-06-01 | 2020-05-13 | Ima Life North America Inc | Liofilización a granel utilizando congelación por pulverización y secado en agitación con calentamiento |
RU2615553C1 (ru) * | 2015-10-15 | 2017-04-05 | Акционерное общество "Военно-промышленная корпорация "Научно-производственное объединение машиностроения" | Способ и устройство непрерывной сублимационной сушки жидких продуктов |
EP3167877A1 (en) * | 2015-11-12 | 2017-05-17 | Bayer Pharma Aktiengesellschaft | Method for the production of freeze-dried pellets comprising factor viii |
CN106705574A (zh) * | 2015-11-17 | 2017-05-24 | 上海东富龙科技股份有限公司 | 一种固体制剂制造设备和方法 |
JP6666535B2 (ja) * | 2016-01-05 | 2020-03-18 | 株式会社あい・あいエナジーアソシエイツ | 液体の凍結乾燥装置及び凍結乾燥方法 |
CN105674691B (zh) * | 2016-04-01 | 2017-11-21 | 苏州大学 | 用于收集喷雾冷冻冰球颗粒的双密封式设备及其收集方法 |
US10369077B2 (en) * | 2017-05-31 | 2019-08-06 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using the same |
US10507165B2 (en) | 2017-05-31 | 2019-12-17 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using same |
DE102017119649A1 (de) | 2017-08-28 | 2019-02-28 | Richard Süverkrüp | Verfahren zur kontinuierlichen Herstellung gefriergetrockneter Tropfen in einem geschlossenen Gaskreislauf |
EP3473959B1 (de) * | 2017-10-20 | 2020-02-12 | Martin Christ Gefriertrocknungsanlagen GmbH | Verfahren zur druckbasierten ermittlung eines produktparameters in einem gefriertrockner, gefriertrockner und softwareprodukt |
KR102450460B1 (ko) * | 2017-12-29 | 2022-09-30 | 아주대학교산학협력단 | 초음파 분무기를 이용한 미립구 약제의 양산 시스템 |
JP7038435B2 (ja) * | 2018-03-13 | 2022-03-18 | 株式会社プリス | 噴霧凍結造粒乾燥粉体製造装置及び噴霧凍結造粒乾燥粉体製造システム |
WO2019235036A1 (ja) * | 2018-06-08 | 2019-12-12 | 株式会社アルバック | 凍結真空乾燥装置及び凍結真空乾燥方法 |
CA3105256A1 (en) | 2018-07-05 | 2020-01-09 | Bayer Aktiengesellschaft | Novel stable high-concentration formulation for anti-fxia antibodies |
WO2020161863A1 (ja) * | 2019-02-07 | 2020-08-13 | 株式会社アルバック | 真空凍結乾燥方法及び真空凍結乾燥装置 |
US11243029B2 (en) * | 2019-04-26 | 2022-02-08 | Purdue Research Foundation | Process monitoring and control for lyophilization using a wireless sensor network |
CN111207564B (zh) * | 2019-09-30 | 2022-01-04 | 中国科学院上海硅酸盐研究所 | 一种冷冻干燥系统及方法 |
TW202202792A (zh) * | 2020-05-18 | 2022-01-16 | 日商Mii股份有限公司 | 真空凍結乾燥裝置及真空凍結乾燥方法 |
JP6777350B1 (ja) | 2020-05-18 | 2020-10-28 | 株式会社エムアイアイ | 真空凍結乾燥装置及び真空凍結乾燥方法 |
JP6887050B1 (ja) * | 2020-08-07 | 2021-06-16 | 株式会社アルバック | 真空凍結乾燥方法および真空凍結乾燥装置 |
US20230168034A1 (en) * | 2020-08-07 | 2023-06-01 | Ulvac, Inc. | Vacuum freeze-drying method, injection nozzle for a vacuum freeze-drying apparatus, and vacuum freeze-drying apparatus |
US11874060B2 (en) | 2020-11-16 | 2024-01-16 | Sublime Stericeuticals Corporation | Continuous throughput lyophilizer-powder filler within a sterile boundary |
JP7085088B1 (ja) * | 2021-08-03 | 2022-06-16 | 株式会社エムアイアイ | 凍結乾燥物 |
KR20240065326A (ko) | 2021-10-05 | 2024-05-14 | 사노피 | 지질 나노입자(lnp)를 냉동 및 냉동-건조하는 방법 및 이를 사용하여 수득된 lnp |
US20230122361A1 (en) * | 2021-10-20 | 2023-04-20 | DSM Sales & Manufacturing, Inc. | Freeze-drying systems and methods |
WO2023242347A1 (en) | 2022-06-15 | 2023-12-21 | Sanofi | Highly concentrated antibody compositions |
US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2388917A (en) * | 1941-10-13 | 1945-11-13 | Hormel & Co Geo A | Process for preservation of biological materials and products resulting therefrom |
FR1378749A (fr) * | 1964-01-07 | 1964-11-13 | Leybold Hochvakuum Anlagen | Procédé et dispositif de séchage par congélation |
US3303578A (en) | 1964-07-29 | 1967-02-14 | William C Rockwell | Continuous freeze-drying apparatus |
US3601901A (en) | 1969-09-12 | 1971-08-31 | Earl L Rader | Freeze drying apparatus with removable conveyor and heater structures |
US3621587A (en) | 1970-08-06 | 1971-11-23 | Smitherm Industries | Freeze drying apparatus |
US4033048A (en) | 1976-01-12 | 1977-07-05 | Clayton Van Ike | Freeze drying apparatus |
JPS5844703Y2 (ja) | 1979-02-01 | 1983-10-11 | クラリオン株式会社 | スピ−カの取付構造 |
JPS55112980A (en) * | 1979-02-26 | 1980-09-01 | Nippon Oxygen Co Ltd | Freezing drier |
DE3105623A1 (de) * | 1981-02-16 | 1982-09-02 | Erhard Dipl.-Ing.agr. 8000 München Grolitsch | Verfahren zur schonenden gefriertrocknung und pulverisierung von empfindlichen trocknungsguetern wie wasserhaltigen lebensmitteln |
AU650045B2 (en) | 1990-09-12 | 1994-06-09 | Lifecell Corporation | Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions |
DE4113512C2 (de) * | 1991-04-25 | 1995-04-20 | Grolitsch Lisbeth | Verfahren und Vorrichtung zur Gefriertrocknung und Pulverisierung von Lebensmitteln |
US5230162A (en) * | 1992-06-26 | 1993-07-27 | Oyler Jr James R | Systems and methods for the deliquification of liquid-containing substances by flash sublimation |
GB9416582D0 (en) * | 1994-08-17 | 1994-10-19 | Ici Plc | Process for the production of exothermically reacting compositions |
AU699042B2 (en) | 1995-03-09 | 1998-11-19 | Boc Group, Inc., The | Transfer port system |
JPH0971536A (ja) | 1995-07-03 | 1997-03-18 | Nippon Telegr & Teleph Corp <Ntt> | 生物細胞含有液凍結乾燥装置 |
DE19654134C2 (de) | 1996-04-25 | 2003-08-07 | Messer Griesheim Gmbh | Verfahren und Einrichtung zum Gefriertrocknen |
JP3639783B2 (ja) | 2000-10-30 | 2005-04-20 | 共和真空技術株式会社 | 食品・薬品等の凍結乾燥方法および凍結乾燥装置 |
GB0103620D0 (en) * | 2001-02-14 | 2001-03-28 | Prometic Biosciences Ltd | Sterile composition and its preparation |
US6543155B2 (en) | 2001-03-01 | 2003-04-08 | National Agricultural Research Organization | Freeze-dried product and process and apparatus for producing it |
JP3686594B2 (ja) | 2001-06-14 | 2005-08-24 | 共和真空技術株式会社 | 食品・薬品類の凍結乾燥装置における液材料の分注装置 |
WO2003072016A2 (en) | 2001-11-19 | 2003-09-04 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
JP3942093B2 (ja) | 2003-01-28 | 2007-07-11 | 株式会社アルバック | 噴霧式真空凍結乾燥装置 |
FR2862306B1 (fr) | 2003-11-17 | 2008-05-30 | Aventis Pasteur | Composition vaccinale |
DE102004005660A1 (de) | 2004-02-04 | 2005-08-25 | Rheinische Friedrich-Wilhelms-Universität Bonn | Verfahren und Vorrichtung zur Herstellung eines lyophilisierten pharmazeutischen Materials |
SE526792C2 (sv) * | 2004-03-03 | 2005-11-08 | Tetra Laval Holdings & Finance | Anordning för evaporativ kylning av en vätskeformig produkt |
BRPI0510529A (pt) | 2004-05-01 | 2007-10-30 | Agres Ltd | processo e aparelho de secagem |
JP4829229B2 (ja) | 2004-07-23 | 2011-12-07 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 無菌凍結、乾燥、保存、分析及び充填方法(sfd−saf法)(非経口生物薬剤用のペレット凍結乾燥法) |
US20060165717A1 (en) | 2005-01-25 | 2006-07-27 | Sanofi Pasteur | DCchol in newborns |
AR054822A1 (es) | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
CN101494979A (zh) | 2006-03-20 | 2009-07-29 | 沃泰克斯药物股份有限公司 | 药物组合物 |
KR101696727B1 (ko) | 2006-07-17 | 2017-01-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 인플루엔자 백신 |
DE102007055488B4 (de) * | 2006-12-01 | 2015-01-22 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrocknungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut |
DE202006018276U1 (de) | 2006-12-01 | 2007-02-08 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrockungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut |
CN101234257B (zh) | 2007-02-01 | 2011-07-27 | 发泰(天津)科技有限公司 | 微波旋转薄膜浓缩器 |
DE102007012795B3 (de) * | 2007-03-16 | 2008-04-10 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrocknungsanlagen und Verfahren zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut mittels Mikrowellen |
EP2101131A1 (en) * | 2007-12-31 | 2009-09-16 | Terruzzi Fercalx S.p.A. | Lyophilization method and system therefor |
KR101695800B1 (ko) | 2008-03-05 | 2017-02-22 | 사노피 파스퇴르 | 항원보강제 함유 백신 조성물의 안정화 방법 |
EP2578975A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum freeze-dryer |
EP2578974A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Process line for the production of freeze-dried particles |
EP2578976A1 (en) | 2011-10-06 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum for use in a vacuum freeze-dryer |
UA111631C2 (uk) | 2011-10-06 | 2016-05-25 | Санофі Пастер Са | Нагрівальний пристрій для роторної барабанної ліофільної сушарки |
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2011
- 2011-10-05 EP EP11008057.9A patent/EP2578974A1/en not_active Withdrawn
-
2012
- 2012-04-10 UA UAA201404685A patent/UA111859C2/uk unknown
- 2012-04-10 UA UAA201404683A patent/UA111858C2/uk unknown
- 2012-10-04 CA CA2849802A patent/CA2849802C/en not_active Expired - Fee Related
- 2012-10-04 JP JP2014533796A patent/JP5728135B2/ja active Active
- 2012-10-04 SG SG11201400640VA patent/SG11201400640VA/en unknown
- 2012-10-04 EP EP16199831.5A patent/EP3211355A1/en not_active Withdrawn
- 2012-10-04 MX MX2014004041A patent/MX359904B/es active IP Right Grant
- 2012-10-04 KR KR1020147011243A patent/KR101552804B1/ko active IP Right Grant
- 2012-10-04 EA EA201490723A patent/EA027602B1/ru not_active IP Right Cessation
- 2012-10-04 AU AU2012320854A patent/AU2012320854B2/en active Active
- 2012-10-04 WO PCT/EP2012/004162 patent/WO2013050156A1/en active Application Filing
- 2012-10-04 ES ES12769026.1T patent/ES2608478T3/es active Active
- 2012-10-04 EA EA201490719A patent/EA027630B1/ru not_active IP Right Cessation
- 2012-10-04 BR BR112014008001-1A patent/BR112014008001B1/pt active IP Right Grant
- 2012-10-04 WO PCT/EP2012/004168 patent/WO2013050162A1/en active Application Filing
- 2012-10-04 HU HUE12769026A patent/HUE029973T2/en unknown
- 2012-10-04 PL PL12769026T patent/PL2766682T3/pl unknown
- 2012-10-04 EP EP12769021.2A patent/EP2764309B1/en active Active
- 2012-10-04 MY MYPI2014000783 patent/MY152319A/en unknown
- 2012-10-04 PL PL12769021T patent/PL2764309T3/pl unknown
- 2012-10-04 US US14/348,869 patent/US10006706B2/en active Active
- 2012-10-04 CA CA2849799A patent/CA2849799C/en not_active Expired - Fee Related
- 2012-10-04 DK DK12769021.2T patent/DK2764309T3/en active
- 2012-10-04 AU AU2012320848A patent/AU2012320848B8/en not_active Ceased
- 2012-10-04 IN IN2440CHN2014 patent/IN2014CN02440A/en unknown
- 2012-10-04 IN IN2407CHN2014 patent/IN2014CN02407A/en unknown
- 2012-10-04 SG SG11201400641QA patent/SG11201400641QA/en unknown
- 2012-10-04 MY MYPI2014000743 patent/MY151369A/en unknown
- 2012-10-04 ES ES12769021.2T patent/ES2608427T3/es active Active
- 2012-10-04 KR KR1020147011244A patent/KR101512608B1/ko active IP Right Grant
- 2012-10-04 DK DK12769026.1T patent/DK2766682T3/en active
- 2012-10-04 CN CN201280049534.2A patent/CN103917842B/zh active Active
- 2012-10-04 PE PE2014000480A patent/PE20142141A1/es not_active Application Discontinuation
- 2012-10-04 BR BR112014007862-9A patent/BR112014007862B1/pt active IP Right Grant
- 2012-10-04 EP EP12769026.1A patent/EP2766682B1/en active Active
- 2012-10-04 MX MX2014004000A patent/MX341894B/es active IP Right Grant
- 2012-10-04 HU HUE12769021A patent/HUE030970T2/en unknown
- 2012-10-04 PE PE2014000479A patent/PE20141979A1/es not_active Application Discontinuation
- 2012-10-04 CN CN201280049533.8A patent/CN103917841B/zh active Active
- 2012-10-04 JP JP2014533792A patent/JP5766361B2/ja active Active
- 2012-10-04 US US14/348,877 patent/US9920989B2/en active Active
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2014
- 2014-03-17 ZA ZA2014/01930A patent/ZA201401930B/en unknown
- 2014-03-31 IL IL231853A patent/IL231853A0/en unknown
- 2014-03-31 IL IL231849A patent/IL231849A0/en unknown
- 2014-04-04 CR CR20140159A patent/CR20140159A/es unknown
- 2014-04-04 CR CR20140158A patent/CR20140158A/es unknown
- 2014-04-04 CO CO14073110A patent/CO6930306A2/es unknown
- 2014-04-04 CO CO14073108A patent/CO6930351A2/es unknown
-
2015
- 2015-01-06 HK HK15100076.0A patent/HK1199656A1/xx not_active IP Right Cessation
- 2015-01-20 HK HK15100624.7A patent/HK1200207A1/xx not_active IP Right Cessation
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