MX341894B - Línea de proceso para la producción de partículas criodesecadas. - Google Patents
Línea de proceso para la producción de partículas criodesecadas.Info
- Publication number
- MX341894B MX341894B MX2014004000A MX2014004000A MX341894B MX 341894 B MX341894 B MX 341894B MX 2014004000 A MX2014004000 A MX 2014004000A MX 2014004000 A MX2014004000 A MX 2014004000A MX 341894 B MX341894 B MX 341894B
- Authority
- MX
- Mexico
- Prior art keywords
- freeze
- production
- particles
- dryer
- process line
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000007921 spray Substances 0.000 abstract 2
- 238000004108 freeze drying Methods 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
- F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Una línea de proceso (300) para la producción de partículas criodesecadas bajo condiciones cerradas que comprende al menos una cámara de aspersión (302) para la generación de gotitas y criocongelación de las gotitas de líquido para formar partículas y un criodesecador a granel (304) para criodesecar las partículas, el criodesecador (304), comprende un tambor giratorio para recibir las partículas. Además, una sección de transferencia (308) se proporciona para una transferencia de producto desde la cámara de aspersión (302) hasta el criodesecador (304). Para la producción de partículas bajo condiciones cerradas de extremo a extremo, cada uno de los dispositivos (302, 304) y la sección de transferencia (308) se adapta por separado para la operación de preservar esterilidad del producto que se criodesecará y/o tendrá contención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11008057.9A EP2578974A1 (en) | 2011-10-05 | 2011-10-05 | Process line for the production of freeze-dried particles |
| PCT/EP2012/004162 WO2013050156A1 (en) | 2011-10-05 | 2012-10-04 | Process line for the production of freeze-dried particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014004000A MX2014004000A (es) | 2014-07-22 |
| MX341894B true MX341894B (es) | 2016-09-07 |
Family
ID=46980888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014004041A MX359904B (es) | 2011-10-05 | 2012-10-04 | Línea de proceso para la producción de partículas criodesecadas. |
| MX2014004000A MX341894B (es) | 2011-10-05 | 2012-10-04 | Línea de proceso para la producción de partículas criodesecadas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014004041A MX359904B (es) | 2011-10-05 | 2012-10-04 | Línea de proceso para la producción de partículas criodesecadas. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10006706B2 (es) |
| EP (4) | EP2578974A1 (es) |
| JP (2) | JP5728135B2 (es) |
| KR (2) | KR101512608B1 (es) |
| CN (2) | CN103917841B (es) |
| AU (2) | AU2012320848B8 (es) |
| BR (2) | BR112014007862B1 (es) |
| CA (2) | CA2849799C (es) |
| CO (2) | CO6930306A2 (es) |
| CR (2) | CR20140158A (es) |
| DK (2) | DK2764309T3 (es) |
| EA (2) | EA027630B1 (es) |
| ES (2) | ES2608478T3 (es) |
| HU (2) | HUE030970T2 (es) |
| IL (2) | IL231849A0 (es) |
| IN (2) | IN2014CN02440A (es) |
| MX (2) | MX359904B (es) |
| MY (2) | MY152319A (es) |
| PE (2) | PE20142141A1 (es) |
| PH (2) | PH12014500621A1 (es) |
| PL (2) | PL2766682T3 (es) |
| SG (2) | SG11201400640VA (es) |
| UA (2) | UA111859C2 (es) |
| WO (2) | WO2013050162A1 (es) |
| ZA (1) | ZA201401930B (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1006722A2 (pt) | 2009-04-09 | 2017-10-10 | Entegrion Inc | "método de preparação de hemoderivados desidratado, hemoderivados desidratados, bandagem ou auxílio cirúrgico, método para a preparação de plaquetas sanguíneas fixas desidratadas, plaquetas sanguíneas fixas desidratadas, método para o tratamento de um paciente que sofre de um distúrbio sanguíneo e plaquetas de sangue fixas secas por atomização tendo geometria com cavidades esféricas" |
| US20110142885A1 (en) | 2009-09-16 | 2011-06-16 | Velico Medical, Inc. | Spray-dried human plasma |
| US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
| EP2578974A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Process line for the production of freeze-dried particles |
| EP2578975A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum freeze-dryer |
| EP2578976A1 (en) | 2011-10-06 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum for use in a vacuum freeze-dryer |
| UA111631C2 (uk) | 2011-10-06 | 2016-05-25 | Санофі Пастер Са | Нагрівальний пристрій для роторної барабанної ліофільної сушарки |
| WO2014190992A1 (en) | 2013-05-29 | 2014-12-04 | Gea Process Engineering A/S | Method of providing inline sterile freeze drying of a product in trays accommodated in a trolley, system for carrying out the method, and use of the method |
| EP3171954B1 (en) | 2014-07-21 | 2018-06-27 | Sanofi Pasteur SA | Liquid feeding device for the generation of droplets and its use for producing a vaccine composition |
| US9561184B2 (en) | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
| DE102015105375B4 (de) * | 2015-01-07 | 2016-11-03 | Richard Süverkrüp | Vorrichtung und Verfahren zur Erzeugung monodisperser gefrorener Tropfen |
| US9739532B2 (en) * | 2015-02-04 | 2017-08-22 | Steven F. Baugh | Botanical freeze drying system and method |
| EP3303958B1 (en) * | 2015-06-01 | 2019-10-09 | IMA Life North America Inc. | Bulk freeze drying using spray freezing and agitated drying with heating |
| RU2615553C1 (ru) * | 2015-10-15 | 2017-04-05 | Акционерное общество "Военно-промышленная корпорация "Научно-производственное объединение машиностроения" | Способ и устройство непрерывной сублимационной сушки жидких продуктов |
| EP3167877A1 (en) | 2015-11-12 | 2017-05-17 | Bayer Pharma Aktiengesellschaft | Method for the production of freeze-dried pellets comprising factor viii |
| CN106705574A (zh) * | 2015-11-17 | 2017-05-24 | 上海东富龙科技股份有限公司 | 一种固体制剂制造设备和方法 |
| JP6666535B2 (ja) * | 2016-01-05 | 2020-03-18 | 株式会社あい・あいエナジーアソシエイツ | 液体の凍結乾燥装置及び凍結乾燥方法 |
| CN105674691B (zh) * | 2016-04-01 | 2017-11-21 | 苏州大学 | 用于收集喷雾冷冻冰球颗粒的双密封式设备及其收集方法 |
| US10369077B2 (en) * | 2017-05-31 | 2019-08-06 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using the same |
| US10507165B2 (en) | 2017-05-31 | 2019-12-17 | Adienne Pharma & Biotech Sa | Multi chamber flexible bag and methods of using same |
| DE102017119649A1 (de) | 2017-08-28 | 2019-02-28 | Richard Süverkrüp | Verfahren zur kontinuierlichen Herstellung gefriergetrockneter Tropfen in einem geschlossenen Gaskreislauf |
| EP3473959B1 (de) * | 2017-10-20 | 2020-02-12 | Martin Christ Gefriertrocknungsanlagen GmbH | Verfahren zur druckbasierten ermittlung eines produktparameters in einem gefriertrockner, gefriertrockner und softwareprodukt |
| KR102450460B1 (ko) * | 2017-12-29 | 2022-09-30 | 아주대학교산학협력단 | 초음파 분무기를 이용한 미립구 약제의 양산 시스템 |
| WO2019175954A1 (ja) * | 2018-03-13 | 2019-09-19 | 株式会社プリス | 噴霧凍結造粒乾燥粉体製造装置及び噴霧凍結造粒乾燥粉体製造システム |
| CN111065874B (zh) * | 2018-06-08 | 2020-12-29 | 株式会社爱发科 | 真空冻结干燥装置和真空冻结干燥方法 |
| WO2020008022A1 (en) * | 2018-07-05 | 2020-01-09 | Bayer Aktiengesellschaft | METHOD FOR THE PRODUCTION OF FREEZE-DRIED PELLETS COMPRISING AN ANTI-COAGULATION FACTOR XIa (FXIa) ANTIBODY |
| ES2955971T3 (es) | 2018-10-11 | 2023-12-11 | Ima Life North America Inc | Sistema de liofilización a granel |
| WO2020161863A1 (ja) * | 2019-02-07 | 2020-08-13 | 株式会社アルバック | 真空凍結乾燥方法及び真空凍結乾燥装置 |
| US11243029B2 (en) * | 2019-04-26 | 2022-02-08 | Purdue Research Foundation | Process monitoring and control for lyophilization using a wireless sensor network |
| CN111207564B (zh) * | 2019-09-30 | 2022-01-04 | 中国科学院上海硅酸盐研究所 | 一种冷冻干燥系统及方法 |
| EP4072315B1 (en) * | 2019-12-09 | 2026-07-01 | Société des Produits Nestlé S.A. | PASTE FOR PREPARING A DRINK |
| JP6777350B1 (ja) | 2020-05-18 | 2020-10-28 | 株式会社エムアイアイ | 真空凍結乾燥装置及び真空凍結乾燥方法 |
| TWI860477B (zh) * | 2020-05-18 | 2024-11-01 | 日商Mii股份有限公司 | 真空凍結乾燥裝置及真空凍結乾燥方法 |
| JP6887050B1 (ja) * | 2020-08-07 | 2021-06-16 | 株式会社アルバック | 真空凍結乾燥方法および真空凍結乾燥装置 |
| WO2022030055A1 (ja) * | 2020-08-07 | 2022-02-10 | 株式会社アルバック | 真空凍結乾燥方法、真空凍結乾燥装置用の噴射ノズルおよび真空凍結乾燥装置 |
| CA3173146C (en) | 2020-11-16 | 2023-10-31 | Joel Peter LENNON-MEYER | Continuous throughput lyophilizer/powder filler within a sterile boundary |
| JP7793626B2 (ja) * | 2020-12-11 | 2026-01-05 | メルク・シャープ・アンド・ドーム・エルエルシー | 医薬品を隔離、処理、および包装するための小型封じ込めシステム |
| JP7085088B1 (ja) * | 2021-08-03 | 2022-06-16 | 株式会社エムアイアイ | 凍結乾燥物 |
| CN113701457A (zh) * | 2021-09-18 | 2021-11-26 | 楚天科技股份有限公司 | 一种冻干系统及冻干方法 |
| KR20240065326A (ko) | 2021-10-05 | 2024-05-14 | 사노피 | 지질 나노입자(lnp)를 냉동 및 냉동-건조하는 방법 및 이를 사용하여 수득된 lnp |
| US12085337B2 (en) | 2021-10-20 | 2024-09-10 | DSM Sales & Manufacturing, Inc. | Freeze-drying systems and methods |
| CN114192067A (zh) * | 2021-12-08 | 2022-03-18 | 南通东概念新材料有限公司 | 一种喷雾干燥、液氮速冻、真空冷冻干燥制备颗粒的方法 |
| US12454789B2 (en) | 2022-03-16 | 2025-10-28 | Haier Us Appliance Solutions, Inc. | Dryer appliance and method for cleaning operation |
| TW202417038A (zh) | 2022-06-15 | 2024-05-01 | 法商賽諾菲公司 | 高度濃縮的抗體組成物 |
| US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
| WO2024059770A1 (en) | 2022-09-15 | 2024-03-21 | Velico Medical, Inc. | Rapid spray drying system |
| US12246093B2 (en) | 2022-09-15 | 2025-03-11 | Velico Medical, Inc. | Methods for making spray dried plasma |
| US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
| US12246266B2 (en) | 2022-09-15 | 2025-03-11 | Velico Medical, Inc. | Disposable for a spray drying system |
| US12083447B2 (en) | 2022-09-15 | 2024-09-10 | Velico Medical, Inc. | Alignment of a disposable for a spray drying plasma system |
| US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
| US12539355B2 (en) | 2022-09-15 | 2026-02-03 | Velico Medical, Inc. | Dryer for a spray drying system |
| US12571587B2 (en) | 2022-09-15 | 2026-03-10 | Velico Medical, Inc. | Finishing apparatus for a spray drying system |
| WO2024184725A1 (en) * | 2023-03-03 | 2024-09-12 | Pfizer Inc. | Systems and methods for reducing electrostatic force in dynamic freeze drying |
| WO2024184721A1 (en) * | 2023-03-03 | 2024-09-12 | Pfizer Inc. | Systems and methods for pre-conditioning frozen bulk in dynamic bulk freeze drying |
| GB202402626D0 (en) * | 2024-02-23 | 2024-04-10 | Ttp Plc | Spray freeze drying formation of dry powder compositions |
| US20260049765A1 (en) * | 2024-08-14 | 2026-02-19 | Geb Impact Technology Company Limited | Apparatus and Method for Spray-Freeze Drying (SFD) of Microalgae |
| CN120926693B (zh) * | 2025-10-11 | 2026-01-02 | 天津凯莱英医药科技发展有限公司 | 喷雾冷冻干燥系统 |
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| US2388917A (en) * | 1941-10-13 | 1945-11-13 | Hormel & Co Geo A | Process for preservation of biological materials and products resulting therefrom |
| FR1378749A (fr) | 1964-01-07 | 1964-11-13 | Leybold Hochvakuum Anlagen | Procédé et dispositif de séchage par congélation |
| US3303578A (en) | 1964-07-29 | 1967-02-14 | William C Rockwell | Continuous freeze-drying apparatus |
| US3601901A (en) | 1969-09-12 | 1971-08-31 | Earl L Rader | Freeze drying apparatus with removable conveyor and heater structures |
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| US4033048A (en) * | 1976-01-12 | 1977-07-05 | Clayton Van Ike | Freeze drying apparatus |
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| JPS55112980A (en) * | 1979-02-26 | 1980-09-01 | Nippon Oxygen Co Ltd | Freezing drier |
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| DE202006018276U1 (de) | 2006-12-01 | 2007-02-08 | Püschner GmbH + Co. KG | Mikrowellen-Vakuumtrockungsanlage zur Trocknung von stückigem, pulverförmigem oder granulatförmigem Gut |
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| EP2101131A1 (en) * | 2007-12-31 | 2009-09-16 | Terruzzi Fercalx S.p.A. | Lyophilization method and system therefor |
| CN105944095B (zh) | 2008-03-05 | 2021-04-02 | 赛诺菲巴斯德有限公司 | 一种使含佐剂的疫苗组合物稳定的方法 |
| EP2578975A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum freeze-dryer |
| EP2578974A1 (en) | 2011-10-05 | 2013-04-10 | Sanofi Pasteur Sa | Process line for the production of freeze-dried particles |
| UA111631C2 (uk) | 2011-10-06 | 2016-05-25 | Санофі Пастер Са | Нагрівальний пристрій для роторної барабанної ліофільної сушарки |
| EP2578976A1 (en) | 2011-10-06 | 2013-04-10 | Sanofi Pasteur Sa | Rotary drum for use in a vacuum freeze-dryer |
-
2011
- 2011-10-05 EP EP11008057.9A patent/EP2578974A1/en not_active Withdrawn
-
2012
- 2012-04-10 UA UAA201404685A patent/UA111859C2/uk unknown
- 2012-04-10 UA UAA201404683A patent/UA111858C2/uk unknown
- 2012-10-04 MX MX2014004041A patent/MX359904B/es active IP Right Grant
- 2012-10-04 CA CA2849799A patent/CA2849799C/en not_active Expired - Fee Related
- 2012-10-04 ES ES12769026.1T patent/ES2608478T3/es active Active
- 2012-10-04 BR BR112014007862-9A patent/BR112014007862B1/pt active IP Right Grant
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