EA201490719A1 - Технологическая линия для производства лиофилизированных частиц - Google Patents

Технологическая линия для производства лиофилизированных частиц

Info

Publication number
EA201490719A1
EA201490719A1 EA201490719A EA201490719A EA201490719A1 EA 201490719 A1 EA201490719 A1 EA 201490719A1 EA 201490719 A EA201490719 A EA 201490719A EA 201490719 A EA201490719 A EA 201490719A EA 201490719 A1 EA201490719 A1 EA 201490719A1
Authority
EA
Eurasian Patent Office
Prior art keywords
particles
production
lyophilizer
lyophilized
conditions
Prior art date
Application number
EA201490719A
Other languages
English (en)
Other versions
EA027630B1 (ru
Inventor
Бернхард Луй
Маттиас Плитцко
Манфред Струшка
Original Assignee
Санофи Пастер Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи Пастер Са filed Critical Санофи Пастер Са
Publication of EA201490719A1 publication Critical patent/EA201490719A1/ru
Publication of EA027630B1 publication Critical patent/EA027630B1/ru

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Drying Of Solid Materials (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Предложена технологическая линия (300) для производства лиофилизированных частиц в закрытых условиях, содержащая, по меньшей мере, распылительную камеру (302) для образования капель, замораживания жидких капель и образования частиц, а также насыпной лиофилизатор (304) для лиофилизации частиц, причем лиофилизатор (304) включает вращающийся барабан для приема частиц. Кроме того, предложена переходная секция (308) для перемещения продукта из распылительной камеры (302) в лиофилизатор (304). Для производства частиц в полностью закрытых условиях каждое из устройств (302, 304) и переходная секция (308) отдельно приспособлены для работы в условиях защиты стерильности продукта, подлежащего лиофилизации, и/или герметичности.
EA201490719A 2011-10-05 2012-10-04 Технологическая линия для производства лиофилизированных частиц EA027630B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11008057.9A EP2578974A1 (en) 2011-10-05 2011-10-05 Process line for the production of freeze-dried particles
PCT/EP2012/004162 WO2013050156A1 (en) 2011-10-05 2012-10-04 Process line for the production of freeze-dried particles

Publications (2)

Publication Number Publication Date
EA201490719A1 true EA201490719A1 (ru) 2014-09-30
EA027630B1 EA027630B1 (ru) 2017-08-31

Family

ID=46980888

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201490723A EA027602B1 (ru) 2011-10-05 2012-10-04 Технологическая линия для производства лиофилизированных частиц
EA201490719A EA027630B1 (ru) 2011-10-05 2012-10-04 Технологическая линия для производства лиофилизированных частиц

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201490723A EA027602B1 (ru) 2011-10-05 2012-10-04 Технологическая линия для производства лиофилизированных частиц

Country Status (25)

Country Link
US (2) US10006706B2 (ru)
EP (4) EP2578974A1 (ru)
JP (2) JP5766361B2 (ru)
KR (2) KR101512608B1 (ru)
CN (2) CN103917841B (ru)
AU (2) AU2012320848B8 (ru)
BR (2) BR112014008001B1 (ru)
CA (2) CA2849799C (ru)
CO (2) CO6930306A2 (ru)
CR (2) CR20140159A (ru)
DK (2) DK2764309T3 (ru)
EA (2) EA027602B1 (ru)
ES (2) ES2608427T3 (ru)
HK (2) HK1199656A1 (ru)
HU (2) HUE029973T2 (ru)
IL (2) IL231853A0 (ru)
IN (2) IN2014CN02407A (ru)
MX (2) MX359904B (ru)
MY (2) MY151369A (ru)
PE (2) PE20142141A1 (ru)
PL (2) PL2764309T3 (ru)
SG (2) SG11201400640VA (ru)
UA (2) UA111858C2 (ru)
WO (2) WO2013050162A1 (ru)
ZA (1) ZA201401930B (ru)

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EP2578976A1 (en) 2011-10-06 2013-04-10 Sanofi Pasteur Sa Rotary drum for use in a vacuum freeze-dryer
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TW202034898A (zh) * 2018-07-05 2020-10-01 德商拜耳廠股份有限公司 抗－ＦＸＩａ抗體之新穎穩定高濃度調配物
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Also Published As

Publication number Publication date
EA027602B1 (ru) 2017-08-31
JP5728135B2 (ja) 2015-06-03
BR112014008001B1 (pt) 2021-01-19
KR20140088113A (ko) 2014-07-09
IN2014CN02407A (ru) 2015-06-19
EP2766682B1 (en) 2016-11-23
BR112014007862A2 (pt) 2017-04-18
JP2014530685A (ja) 2014-11-20
IL231853A0 (en) 2014-05-28
EP2766682A1 (en) 2014-08-20
WO2013050162A1 (en) 2013-04-11
EA201490723A1 (ru) 2014-08-29
AU2012320854B2 (en) 2015-02-19
CN103917841A (zh) 2014-07-09
ZA201401930B (en) 2015-02-25
EP2578974A1 (en) 2013-04-10
CR20140159A (es) 2014-10-30
EP2764309B1 (en) 2016-11-23
US10006706B2 (en) 2018-06-26
CO6930351A2 (es) 2014-04-28
CA2849802C (en) 2015-12-08
EP2764309A1 (en) 2014-08-13
MY152319A (en) 2014-09-08
PE20142141A1 (es) 2015-01-04
CN103917841B (zh) 2015-07-08
SG11201400640VA (en) 2014-06-27
UA111859C2 (uk) 2016-06-24
BR112014007862B1 (pt) 2021-01-19
AU2012320848B2 (en) 2015-02-26
MX359904B (es) 2018-10-16
AU2012320848B8 (en) 2015-03-05
CN103917842A (zh) 2014-07-09
CA2849799A1 (en) 2013-04-11
IL231849A0 (en) 2014-05-28
JP2014530061A (ja) 2014-11-17
HUE029973T2 (en) 2017-04-28
EP3211355A1 (en) 2017-08-30
ES2608427T3 (es) 2017-04-10
CA2849802A1 (en) 2013-04-11
MX2014004041A (es) 2014-08-01
PE20141979A1 (es) 2014-12-19
HUE030970T2 (en) 2017-06-28
SG11201400641QA (en) 2014-08-28
DK2766682T3 (en) 2017-01-09
HK1199656A1 (en) 2015-07-10
US9920989B2 (en) 2018-03-20
CA2849799C (en) 2015-12-08
HK1200207A1 (en) 2015-07-31
WO2013050156A1 (en) 2013-04-11
JP5766361B2 (ja) 2015-08-19
UA111858C2 (uk) 2016-06-24
CO6930306A2 (es) 2014-04-28
PL2766682T3 (pl) 2017-03-31
US20140230266A1 (en) 2014-08-21
KR20140088112A (ko) 2014-07-09
MY151369A (en) 2014-05-16
KR101552804B1 (ko) 2015-09-11
KR101512608B1 (ko) 2015-04-15
PL2764309T3 (pl) 2017-03-31
MX341894B (es) 2016-09-07
IN2014CN02440A (ru) 2015-06-19
ES2608478T3 (es) 2017-04-11
EA027630B1 (ru) 2017-08-31
CN103917842B (zh) 2015-08-05
US20140245629A1 (en) 2014-09-04
CR20140158A (es) 2014-10-30
BR112014008001A2 (pt) 2017-04-11
WO2013050156A8 (en) 2013-06-13
AU2012320854A1 (en) 2014-05-15
DK2764309T3 (en) 2017-01-09
MX2014004000A (es) 2014-07-22
AU2012320848A1 (en) 2014-05-15

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