MX2016006544A - Witanolidos utiles para el tratamiento de enfermedades neurodegenerativas. - Google Patents

Witanolidos utiles para el tratamiento de enfermedades neurodegenerativas.

Info

Publication number
MX2016006544A
MX2016006544A MX2016006544A MX2016006544A MX2016006544A MX 2016006544 A MX2016006544 A MX 2016006544A MX 2016006544 A MX2016006544 A MX 2016006544A MX 2016006544 A MX2016006544 A MX 2016006544A MX 2016006544 A MX2016006544 A MX 2016006544A
Authority
MX
Mexico
Prior art keywords
neurodegenerative diseases
withanolides
useful
treatment
formula
Prior art date
Application number
MX2016006544A
Other languages
English (en)
Other versions
MX364528B (es
Inventor
A Shaw Anthony
H Chan Agnes
Pierre Julien Jean-
Original Assignee
Imstar Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imstar Therapeutics Inc filed Critical Imstar Therapeutics Inc
Publication of MX2016006544A publication Critical patent/MX2016006544A/es
Publication of MX364528B publication Critical patent/MX364528B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

La presente invención se relaciona con análogos sintéticos de los productos naturales de witanólido de la fórmula (I), en donde R1-R4 son como se definen en la presente, y sus usos farmacéuticos en el tratamiento de enfermedades neurodegenerativas.
MX2016006544A 2013-11-25 2014-11-25 Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas. MX364528B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361908455P 2013-11-25 2013-11-25
PCT/US2014/067436 WO2015077780A1 (en) 2013-11-25 2014-11-25 Withanolides useful for the treatment of neurodegenerative diseases

Publications (2)

Publication Number Publication Date
MX2016006544A true MX2016006544A (es) 2016-12-12
MX364528B MX364528B (es) 2019-04-30

Family

ID=52023694

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006544A MX364528B (es) 2013-11-25 2014-11-25 Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas.

Country Status (14)

Country Link
US (1) US10351590B2 (es)
EP (1) EP3074414B1 (es)
JP (1) JP6517833B2 (es)
KR (1) KR20160137945A (es)
CN (1) CN105940010B (es)
AU (1) AU2014352629B2 (es)
BR (1) BR112016012002A2 (es)
CA (1) CA2931064C (es)
ES (1) ES2728870T3 (es)
MX (1) MX364528B (es)
PL (1) PL3074414T3 (es)
TR (1) TR201905218T4 (es)
WO (1) WO2015077780A1 (es)
ZA (1) ZA201603117B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210087222A1 (en) * 2017-12-11 2021-03-25 Ethnodyne Compounds for treating neurodegenerative disorders
WO2019116071A1 (en) * 2017-12-11 2019-06-20 Ethnodyne Compounds for treating neurodegenerative disorders
EP3724170B1 (en) 2017-12-11 2022-04-27 Ethnodyne Compounds for treating neurodegenerative disorders
CN111377994A (zh) * 2018-12-28 2020-07-07 南开大学 七种来源于灯笼果的醉茄内酯类化合物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010030395A2 (en) * 2008-09-15 2010-03-18 Whitehead Institute For Biomedical Research Withaferin a analogs and uses thereof
WO2010053655A2 (en) * 2008-11-07 2010-05-14 University Of Kansas Therapeutic methods with withaferin a and analogs
US8598339B2 (en) * 2011-02-01 2013-12-03 University Of Kansas Withanolide isolated from Physalis longifolia and analogs and methods of use thereof
EP2723866B1 (en) 2011-06-22 2018-03-28 Universite Laval Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease

Also Published As

Publication number Publication date
AU2014352629B2 (en) 2019-03-28
CN105940010A (zh) 2016-09-14
KR20160137945A (ko) 2016-12-02
JP2016537432A (ja) 2016-12-01
US10351590B2 (en) 2019-07-16
CA2931064A1 (en) 2015-05-28
CA2931064C (en) 2022-10-18
WO2015077780A1 (en) 2015-05-28
ES2728870T3 (es) 2019-10-29
US20170022247A1 (en) 2017-01-26
BR112016012002A2 (pt) 2017-09-19
JP6517833B2 (ja) 2019-05-22
TR201905218T4 (tr) 2019-05-21
ZA201603117B (en) 2020-05-27
AU2014352629A1 (en) 2016-05-26
EP3074414A1 (en) 2016-10-05
PL3074414T3 (pl) 2019-12-31
CN105940010B (zh) 2018-03-30
MX364528B (es) 2019-04-30
EP3074414B1 (en) 2019-01-09

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Legal Events

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FG Grant or registration