MX364528B - Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas. - Google Patents
Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas.Info
- Publication number
- MX364528B MX364528B MX2016006544A MX2016006544A MX364528B MX 364528 B MX364528 B MX 364528B MX 2016006544 A MX2016006544 A MX 2016006544A MX 2016006544 A MX2016006544 A MX 2016006544A MX 364528 B MX364528 B MX 364528B
- Authority
- MX
- Mexico
- Prior art keywords
- neurodegenerative diseases
- withanolides
- useful
- treatment
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se relaciona con análogos sintéticos de los productos naturales de witanólido de la fórmula (I), en donde R1-R4 son como se definen en la presente, y sus usos farmacéuticos en el tratamiento de enfermedades neurodegenerativas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361908455P | 2013-11-25 | 2013-11-25 | |
PCT/US2014/067436 WO2015077780A1 (en) | 2013-11-25 | 2014-11-25 | Withanolides useful for the treatment of neurodegenerative diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016006544A MX2016006544A (es) | 2016-12-12 |
MX364528B true MX364528B (es) | 2019-04-30 |
Family
ID=52023694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016006544A MX364528B (es) | 2013-11-25 | 2014-11-25 | Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US10351590B2 (es) |
EP (1) | EP3074414B1 (es) |
JP (1) | JP6517833B2 (es) |
KR (1) | KR20160137945A (es) |
CN (1) | CN105940010B (es) |
AU (1) | AU2014352629B2 (es) |
BR (1) | BR112016012002A2 (es) |
CA (1) | CA2931064C (es) |
ES (1) | ES2728870T3 (es) |
MX (1) | MX364528B (es) |
PL (1) | PL3074414T3 (es) |
TR (1) | TR201905218T4 (es) |
WO (1) | WO2015077780A1 (es) |
ZA (1) | ZA201603117B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019116071A1 (en) * | 2017-12-11 | 2019-06-20 | Ethnodyne | Compounds for treating neurodegenerative disorders |
EP3724170B1 (en) * | 2017-12-11 | 2022-04-27 | Ethnodyne | Compounds for treating neurodegenerative disorders |
US20210087222A1 (en) * | 2017-12-11 | 2021-03-25 | Ethnodyne | Compounds for treating neurodegenerative disorders |
CN111377994A (zh) * | 2018-12-28 | 2020-07-07 | 南开大学 | 七种来源于灯笼果的醉茄内酯类化合物及其制备方法和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110230551A1 (en) * | 2008-09-15 | 2011-09-22 | Leslie Gunatilaka | Withaferin a analogs and uses thereof |
WO2010053655A2 (en) | 2008-11-07 | 2010-05-14 | University Of Kansas | Therapeutic methods with withaferin a and analogs |
US8598339B2 (en) * | 2011-02-01 | 2013-12-03 | University Of Kansas | Withanolide isolated from Physalis longifolia and analogs and methods of use thereof |
EP2723866B1 (en) * | 2011-06-22 | 2018-03-28 | Universite Laval | Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease |
-
2014
- 2014-11-25 US US15/038,927 patent/US10351590B2/en active Active
- 2014-11-25 TR TR2019/05218T patent/TR201905218T4/tr unknown
- 2014-11-25 JP JP2016554830A patent/JP6517833B2/ja active Active
- 2014-11-25 EP EP14812105.6A patent/EP3074414B1/en active Active
- 2014-11-25 KR KR1020167015115A patent/KR20160137945A/ko not_active Application Discontinuation
- 2014-11-25 MX MX2016006544A patent/MX364528B/es active IP Right Grant
- 2014-11-25 PL PL14812105T patent/PL3074414T3/pl unknown
- 2014-11-25 BR BR112016012002A patent/BR112016012002A2/pt not_active IP Right Cessation
- 2014-11-25 CA CA2931064A patent/CA2931064C/en active Active
- 2014-11-25 ES ES14812105T patent/ES2728870T3/es active Active
- 2014-11-25 AU AU2014352629A patent/AU2014352629B2/en active Active
- 2014-11-25 CN CN201480064227.0A patent/CN105940010B/zh active Active
- 2014-11-25 WO PCT/US2014/067436 patent/WO2015077780A1/en active Application Filing
-
2016
- 2016-05-10 ZA ZA2016/03117A patent/ZA201603117B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP6517833B2 (ja) | 2019-05-22 |
CN105940010A (zh) | 2016-09-14 |
US10351590B2 (en) | 2019-07-16 |
CN105940010B (zh) | 2018-03-30 |
TR201905218T4 (tr) | 2019-05-21 |
EP3074414A1 (en) | 2016-10-05 |
MX2016006544A (es) | 2016-12-12 |
KR20160137945A (ko) | 2016-12-02 |
WO2015077780A1 (en) | 2015-05-28 |
EP3074414B1 (en) | 2019-01-09 |
PL3074414T3 (pl) | 2019-12-31 |
CA2931064A1 (en) | 2015-05-28 |
CA2931064C (en) | 2022-10-18 |
ES2728870T3 (es) | 2019-10-29 |
AU2014352629B2 (en) | 2019-03-28 |
JP2016537432A (ja) | 2016-12-01 |
AU2014352629A1 (en) | 2016-05-26 |
ZA201603117B (en) | 2020-05-27 |
US20170022247A1 (en) | 2017-01-26 |
BR112016012002A2 (pt) | 2017-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA116648C2 (uk) | Фумарати як проліки та їх застосування при лікуванні різних захворювань | |
PH12016501139B1 (en) | Bicyclic heterocycle compounds and their uses in therapy | |
TN2015000278A1 (en) | Autotaxin inhibitors | |
PH12015501648A1 (en) | 2-aminopyrimidine derivatives for the treatment of viral infections | |
MX2020009780A (es) | Compuestos de inhibidor de autotaxina. | |
PH12015500274B1 (en) | Alkylpyrimidine derivatives for the treatment of viral infections and further diseases | |
MX2016016666A (es) | Derivados de acido boronico y usos terapeuticos de los mismos. | |
MX2016015093A (es) | Derivados de acido boronico y sus usos terapeuticos. | |
PH12014501738A1 (en) | Piperidino-pyrimidine derivatives for the treatment of viral infections | |
TW201613901A (en) | New compounds | |
PH12016500094A1 (en) | Autotaxin inhibitors | |
MX2015010125A (es) | Derivados de piridazinona-amidas. | |
GB201209613D0 (en) | New compounds | |
MX2014008705A (es) | Compuestos tricíclicos de sulfona y métodos para elaborarlos y utilizarlos. | |
PH12017500315A1 (en) | Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection | |
MX356755B (es) | Compuestos de tipo fumagilol y metodos para su elaboración y uso. | |
TR201910866T4 (tr) | Kanser tedavisi için birleşik preparasyonlar. | |
AU2018253600A1 (en) | Dosage forms and therapeutic uses of l-4-chlorokynurenine | |
MX2013013649A (es) | Compuestos de quinona para tratar enfermedades mediadas por ape1. | |
MX2016000294A (es) | Composicion farmaceutica para liberacion sostenida de lanreotida. | |
MX2015005732A (es) | Compuestos tricíclicos y métodos para hacer y utilizar los mismos. | |
MX364528B (es) | Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas. | |
MX2015013755A (es) | Formulacion farmaceutica para uso en el tratamiento y/o prevencion de restenosis. | |
MX2015005733A (es) | Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad. | |
MX2017009608A (es) | Compuestos anticancerigenos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |