IN2012DN00605A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN00605A IN2012DN00605A IN605DEN2012A IN2012DN00605A IN 2012DN00605 A IN2012DN00605 A IN 2012DN00605A IN 605DEN2012 A IN605DEN2012 A IN 605DEN2012A IN 2012DN00605 A IN2012DN00605 A IN 2012DN00605A
- Authority
- IN
- India
- Prior art keywords
- 4alkyl
- hydrogen
- taken together
- dioxolane
- alkyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 101100173726 Arabidopsis thaliana OR23 gene Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/083—Syntheses without formation of a Si-C bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/0827—Syntheses with formation of a Si-C bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43254902P | 2002-12-11 | 2002-12-11 | |
| PCT/US2003/039554 WO2004052310A2 (en) | 2002-12-11 | 2003-12-10 | Process and intermediates for synthesis entecavir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00605A true IN2012DN00605A (hu) | 2015-06-12 |
Family
ID=32507962
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN604DEN2012 IN2012DN00604A (hu) | 2002-12-11 | 2003-12-10 | |
| IN605DEN2012 IN2012DN00605A (hu) | 2002-12-11 | 2003-12-10 | |
| IN606DEN2012 IN2012DN00606A (hu) | 2002-12-11 | 2003-12-10 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN604DEN2012 IN2012DN00604A (hu) | 2002-12-11 | 2003-12-10 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN606DEN2012 IN2012DN00606A (hu) | 2002-12-11 | 2003-12-10 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7034152B2 (hu) |
| EP (2) | EP2433941A1 (hu) |
| JP (2) | JP4726491B2 (hu) |
| KR (2) | KR101096830B1 (hu) |
| CN (6) | CN101130543B (hu) |
| AU (1) | AU2003300884B2 (hu) |
| BR (2) | BRPI0317255B8 (hu) |
| CA (2) | CA2735485A1 (hu) |
| DK (1) | DK1644384T3 (hu) |
| ES (1) | ES2397104T3 (hu) |
| IL (1) | IL168691A (hu) |
| IN (3) | IN2012DN00604A (hu) |
| MX (1) | MXPA05005971A (hu) |
| PL (2) | PL397715A1 (hu) |
| PT (1) | PT1644384E (hu) |
| SI (1) | SI1644384T1 (hu) |
| TW (1) | TWI327568B (hu) |
| WO (1) | WO2004052310A2 (hu) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003279690A1 (en) * | 2002-06-27 | 2004-01-19 | F. Hoffmann-La Roche Ag | Synthesis of purine derivatives |
| CN101130543B (zh) * | 2002-12-11 | 2011-06-08 | 布里斯托尔-迈尔斯斯奎布公司 | 制备抗病毒药[1S-(1α,3α,4β)]-2-氨基-1,9-二氢-9-[4-羟基-3-(羟甲基)-2-亚甲环戊基]-6H-嘌呤-6-酮的方法 |
| US7511139B2 (en) * | 2004-06-04 | 2009-03-31 | Bristol-Myers Squibb Company | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation |
| TW200540175A (en) * | 2004-06-04 | 2005-12-16 | Bristol Myers Squibb Co | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation |
| CN100379736C (zh) * | 2005-05-13 | 2008-04-09 | 上海仲夏化学有限公司 | 恩替卡韦的制备方法 |
| CN1699366A (zh) * | 2005-06-03 | 2005-11-23 | 北京市典范科技有限责任公司 | 嘌呤衍生物 |
| US20070060599A1 (en) * | 2005-09-09 | 2007-03-15 | Dimarco John D | Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
| CN101863842B (zh) * | 2006-08-24 | 2012-02-01 | 江苏正大天晴药业股份有限公司 | 恩替卡韦中间体及合成方法 |
| CN101838207B (zh) * | 2006-08-24 | 2012-04-25 | 江苏正大天晴药业股份有限公司 | 恩替卡韦的中间体及合成方法 |
| CN101838270B (zh) * | 2006-08-24 | 2012-04-18 | 江苏正大天晴药业股份有限公司 | 恩替卡韦的中间体及制备 |
| CN101130542B (zh) * | 2006-08-24 | 2010-08-04 | 江苏正大天晴药业股份有限公司 | 抗病毒核苷类似物的合成方法 |
| EP2078054A1 (en) * | 2006-10-30 | 2009-07-15 | Pirelli Tyre S.p.A. | Tire for vehicle wheels comprising crosslinked elastomeric composition |
| CN101245068A (zh) * | 2007-02-14 | 2008-08-20 | 浙江医药股份有限公司新昌制药厂 | 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途 |
| CN101371841A (zh) * | 2007-08-23 | 2009-02-25 | 浙江医药股份有限公司新昌制药厂 | 结晶型恩替卡韦制剂及其制备方法和应用 |
| CN101284799B (zh) | 2007-03-23 | 2013-04-03 | 浙江医药股份有限公司新昌制药厂 | 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途 |
| CN101074217B (zh) * | 2007-04-04 | 2010-11-24 | 北京精华耀邦医药科技有限公司 | 通过制备色谱分离得到高纯度恩替卡韦关键中间体的方法 |
| CN101397333A (zh) | 2007-09-27 | 2009-04-01 | 浙江医药股份有限公司新昌制药厂 | 去羟基万古霉素及其制备方法、和其药物组合物及其用途 |
| CN101723945B (zh) * | 2008-10-17 | 2011-11-02 | 上海清松制药有限公司 | 一种制备抗病毒药物恩替卡韦中间体的方法 |
| KR101150254B1 (ko) | 2008-12-26 | 2012-06-12 | 한미사이언스 주식회사 | 신규 중간체 및 이를 활용한 엔테카비르 제조방법 |
| CN101828693B (zh) | 2009-03-09 | 2013-01-02 | 浙江医药股份有限公司新昌制药厂 | 制备低粘度高流动性类胡萝卜素油悬浮液的方法及其应用 |
| CN101531660B (zh) * | 2009-04-14 | 2012-07-04 | 安徽贝克联合制药有限公司 | 一种恩替卡韦一水合物的工业化生产工艺 |
| CN102596956B (zh) | 2009-10-12 | 2014-09-24 | 韩美科学株式会社 | 恩替卡韦的新制备方法及其中使用的中间体 |
| CN101693713B (zh) * | 2009-10-28 | 2011-11-09 | 福建广生堂药业有限公司 | 一种恩替卡韦的晶型及其制备方法和药物应用 |
| CN101781301B (zh) * | 2010-01-15 | 2013-04-10 | 复旦大学 | 一种制备恩替卡韦的方法 |
| US8481728B2 (en) | 2010-02-16 | 2013-07-09 | Scinopharm Taiwan, Ltd. | Process for preparing entecavir and its intermediates |
| CN101805339B (zh) * | 2010-04-12 | 2012-01-11 | 王明 | 一种制备恩替卡韦化合物的方法 |
| CA2705953C (en) * | 2010-05-31 | 2018-05-01 | Alphora Research Inc. | Carbanucleoside synthesis and intermediate compounds useful therein |
| CN101891741B (zh) * | 2010-07-06 | 2013-01-23 | 苏州汉德森医药科技有限公司 | 抗病毒药恩替卡韦的新合成工艺 |
| CN102336754B (zh) * | 2010-07-15 | 2017-04-12 | 浙江奥翔药业股份有限公司 | 恩替卡韦的合成方法及其中间体化合物 |
| TWI668220B (zh) * | 2010-08-30 | 2019-08-11 | 浙江奧翔藥業股份有限公司 | 恩替卡韋的合成方法及其中間體化合物 |
| EP2474548A1 (en) * | 2010-12-23 | 2012-07-11 | Esteve Química, S.A. | Preparation process of an antiviral drug and intermediates thereof |
| KR101269491B1 (ko) * | 2010-12-23 | 2013-05-31 | 주식회사 한서켐 | 엔테카비어 제조방법 |
| CN102225938A (zh) * | 2011-04-25 | 2011-10-26 | 海南卫康制药(潜山)有限公司 | 恩替卡韦一水合物新合成工艺 |
| CN102267875B (zh) * | 2011-06-17 | 2013-04-24 | 常州寅盛药业有限公司 | 一种恩替卡韦中间体的制备方法 |
| CN102952156A (zh) * | 2011-08-29 | 2013-03-06 | 南京工业大学 | 一种抗乙肝药物恩替卡韦中间体及其合成 |
| CN102952135B (zh) * | 2011-08-31 | 2015-04-08 | 南京工业大学 | 一种乙肝药物恩替卡韦的合成方法 |
| EP2597096A1 (en) | 2011-11-24 | 2013-05-29 | Esteve Química, S.A. | Process for preparing entecavir and intermediates thereof |
| CN103304375B (zh) * | 2012-03-12 | 2017-04-12 | 浙江奥翔药业股份有限公司 | 恩替卡韦的合成中间体及其制备方法 |
| RU2650112C2 (ru) | 2012-10-02 | 2018-04-09 | Кэлифорниа Инститьют Оф Текнолоджи | Восстановительное расщепление ароматических связей c-o, c-n и c-s активированными силанами без переходных металлов |
| WO2014055587A1 (en) | 2012-10-02 | 2014-04-10 | California Institute Of Techonolgy | Transition-metal-free silylation of aromatic compounds |
| CN104017012A (zh) * | 2013-02-28 | 2014-09-03 | 浙江星月药物科技股份有限公司 | 一类恩替卡韦的中间体的制备方法，以及中间体 |
| CN104017015B (zh) * | 2013-02-28 | 2017-04-05 | 浙江星月药物科技股份有限公司 | 一类恩替卡韦的中间体的制备方法，以及中间体 |
| CN104017014A (zh) * | 2013-02-28 | 2014-09-03 | 浙江星月药物科技股份有限公司 | 一类恩替卡韦的中间体的制备方法，以及中间体 |
| CN104016984A (zh) * | 2013-02-28 | 2014-09-03 | 浙江星月药物科技股份有限公司 | 一种恩替卡韦及其中间体的制备方法，以及中间体 |
| CN104017016B (zh) * | 2013-02-28 | 2017-04-05 | 浙江星月药物科技股份有限公司 | 一类恩替卡韦的中间体的制备方法，以及中间体 |
| CN104177397B (zh) * | 2013-05-23 | 2017-10-13 | 浙江星月药物科技股份有限公司 | 恩替卡韦中间体及其制备方法 |
| CN104177396A (zh) * | 2013-05-23 | 2014-12-03 | 浙江星月药物科技股份有限公司 | 恩替卡韦中间体及其制备方法 |
| CN104177394B (zh) * | 2013-05-23 | 2017-12-05 | 浙江星月药物科技股份有限公司 | 恩替卡韦中间体及其制备方法 |
| GB201313238D0 (en) | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| CN111253424B (zh) * | 2014-08-06 | 2023-06-20 | 加州理工学院 | 芳族杂环通过地球丰富的无过渡金属的催化剂的甲硅烷基化 |
| KR101640503B1 (ko) | 2015-04-15 | 2016-07-18 | 동방에프티엘(주) | 엔테카비르 일수화물의 개선된 제조방법 |
| KR101640504B1 (ko) | 2015-04-15 | 2016-07-18 | 동방에프티엘(주) | 엔테카비르 일수화물의 제조방법 |
| CN105037363B (zh) * | 2015-07-13 | 2016-08-24 | 山东罗欣药业集团股份有限公司 | 一种恩替卡韦化合物的新合成方法 |
| AU2017247103B2 (en) * | 2016-04-07 | 2021-05-06 | University Of Georgia Research Foundation, Inc. | Synthesis of 2'-fluoro-6'-methylene-carbocyclic adenosine (FMCA) and 2'-fluoro-6'-methylene-carbocyclic guanosine (FMCG) |
| CN107325122B (zh) * | 2017-01-06 | 2020-05-01 | 常州博海威医药科技股份有限公司 | 制备贝前列腺素的新中间体及其制备方法 |
| CN107163049B (zh) * | 2017-05-31 | 2019-06-18 | 湖北远大生命科学与技术有限责任公司 | 一种恩替卡韦的制备方法 |
| CN109705063B (zh) | 2017-10-26 | 2021-01-01 | 广州市朗启医药科技有限责任公司 | 恩替卡韦中间体及其合成方法以及恩替卡韦的合成方法 |
| WO2019080686A1 (zh) * | 2017-10-26 | 2019-05-02 | 广州市朗启医药科技有限责任公司 | 恩替卡韦中间体及其合成方法以及恩替卡韦的合成方法 |
| CN109232637B (zh) * | 2018-10-29 | 2020-11-24 | 常州博海威医药科技股份有限公司 | 一种恩替卡韦中间体的制备方法 |
| CN109593090A (zh) * | 2019-01-25 | 2019-04-09 | 连云港贵科药业有限公司 | 一种恩替卡韦的合成方法 |
| CN112625041A (zh) * | 2020-12-25 | 2021-04-09 | 常州博海威医药科技股份有限公司 | 恩替卡韦的新制备方法以及中间体 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4471130A (en) | 1980-08-06 | 1984-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for asymmetric epoxidation |
| US4594439A (en) | 1980-08-06 | 1986-06-10 | The Board Of Trustees Of The Leland Stanford Jr. University | Method for asymmetric epoxidation |
| US4900847A (en) | 1985-04-04 | 1990-02-13 | Massachusetts Institute Of Technology | Catalytic asymmetric epoxidation |
| JPH01207257A (ja) * | 1988-02-15 | 1989-08-21 | Nippon Oil & Fats Co Ltd | α−リノレン酸の分離法 |
| US5206244A (en) | 1990-10-18 | 1993-04-27 | E. R. Squibb & Sons, Inc. | Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines |
| EP0630897A3 (en) * | 1993-06-25 | 1995-03-01 | Bristol Myers Squibb Co | 3-hydroxy-4-hydroxymethyl-2-methylene-cyclopentyl purines and pyrimidines. |
| US5665890A (en) * | 1995-03-14 | 1997-09-09 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
| AU4090697A (en) * | 1996-09-03 | 1998-03-26 | Bristol-Myers Squibb Company | Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one |
| US6127159A (en) * | 1997-06-06 | 2000-10-03 | The Board Of Trustees Of The Leland Stanford Junior University | Mitofusin genes and their uses |
| RS51561B (sr) * | 2000-02-29 | 2011-08-31 | Bristol-Myers Squibb Co. | Formulacija male doze entekavira i upotreba |
| CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
| WO2001079246A2 (en) * | 2000-04-13 | 2001-10-25 | Pharmasset, Ltd. | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections |
| CN101130543B (zh) * | 2002-12-11 | 2011-06-08 | 布里斯托尔-迈尔斯斯奎布公司 | 制备抗病毒药[1S-(1α,3α,4β)]-2-氨基-1,9-二氢-9-[4-羟基-3-(羟甲基)-2-亚甲环戊基]-6H-嘌呤-6-酮的方法 |
| US7511139B2 (en) * | 2004-06-04 | 2009-03-31 | Bristol-Myers Squibb Company | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation |
| US20070060599A1 (en) * | 2005-09-09 | 2007-03-15 | Dimarco John D | Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
-
2003
- 2003-12-10 CN CN2007101499445A patent/CN101130543B/zh not_active Expired - Lifetime
- 2003-12-10 CN CN2010102360003A patent/CN101899063B/zh not_active Expired - Lifetime
- 2003-12-10 BR BRPI0317255A patent/BRPI0317255B8/pt active IP Right Grant
- 2003-12-10 EP EP11189882A patent/EP2433941A1/en not_active Withdrawn
- 2003-12-10 WO PCT/US2003/039554 patent/WO2004052310A2/en active Application Filing
- 2003-12-10 CN CN201510061020.4A patent/CN104788485B/zh not_active Expired - Lifetime
- 2003-12-10 MX MXPA05005971A patent/MXPA05005971A/es active IP Right Grant
- 2003-12-10 IN IN604DEN2012 patent/IN2012DN00604A/en unknown
- 2003-12-10 DK DK03812974.8T patent/DK1644384T3/da active
- 2003-12-10 AU AU2003300884A patent/AU2003300884B2/en not_active Expired
- 2003-12-10 IN IN605DEN2012 patent/IN2012DN00605A/en unknown
- 2003-12-10 SI SI200332236T patent/SI1644384T1/sl unknown
- 2003-12-10 KR KR1020097015624A patent/KR101096830B1/ko active IP Right Grant
- 2003-12-10 PL PL397715A patent/PL397715A1/pl unknown
- 2003-12-10 KR KR1020057010722A patent/KR100944063B1/ko active IP Right Grant
- 2003-12-10 PL PL377263A patent/PL212790B1/pl unknown
- 2003-12-10 CN CN201210089818.6A patent/CN102675355B/zh not_active Expired - Lifetime
- 2003-12-10 CN CN2007101499407A patent/CN101130552B/zh not_active Expired - Lifetime
- 2003-12-10 PT PT38129748T patent/PT1644384E/pt unknown
- 2003-12-10 CA CA2735485A patent/CA2735485A1/en not_active Abandoned
- 2003-12-10 EP EP03812974A patent/EP1644384B1/en not_active Expired - Lifetime
- 2003-12-10 ES ES03812974T patent/ES2397104T3/es not_active Expired - Lifetime
- 2003-12-10 IN IN606DEN2012 patent/IN2012DN00606A/en unknown
- 2003-12-10 CA CA2508811A patent/CA2508811C/en not_active Expired - Fee Related
- 2003-12-10 CN CNB2003801056146A patent/CN100379746C/zh not_active Expired - Lifetime
- 2003-12-10 JP JP2004558730A patent/JP4726491B2/ja not_active Expired - Lifetime
- 2003-12-10 BR BR122019020833A patent/BR122019020833B8/pt active IP Right Grant
- 2003-12-11 US US10/734,012 patent/US7034152B2/en not_active Expired - Lifetime
- 2003-12-11 TW TW092135079A patent/TWI327568B/zh not_active IP Right Cessation
-
2005
- 2005-05-19 IL IL168691A patent/IL168691A/en active IP Right Grant
- 2005-12-19 US US11/311,598 patent/US7550619B2/en active Active
- 2005-12-19 US US11/311,194 patent/US7541460B2/en active Active
-
2010
- 2010-05-26 JP JP2010120589A patent/JP2010222365A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2012DN00605A (hu) | ||
| YU47600A (sh) | SUPSTITUISANI OKSOAZAHETEROCIKLIL INHIBITORI FAKTORA Xa | |
| CA2293247A1 (en) | 4-phenylpiperidine compounds | |
| IL148932A0 (en) | INHIBITORS OF αLβ2 MEDIATED CELL ADHESION | |
| BG106340A (en) | Substituted oxoazaheterocyclyl compounds | |
| TW200745034A (en) | New compounds | |
| DE69831868D1 (en) | Antithrombosemittel | |
| HK1068609A1 (en) | Sodium channel blockers | |
| DE69931393D1 (de) | Antithrombotische amide | |
| MY139235A (en) | One step process for the preparation of anticonvulsant derivatives | |
| TW200606137A (en) | Urea derivatives | |
| DK0443449T3 (da) | Fremgangsmåde til fremstilling af oxetanoner | |
| ATE273305T1 (de) | Thrombin-inhibitoren | |
| EP1048652A4 (en) | AROMATIC COMPOUNDS WITH A CYCLIC AMINO GROUP OR THEIR SALTS | |
| CA2418770A1 (en) | Acylacetonitrile compound, process for preparation thereof, and miticide containing the same | |
| CY1110539T1 (el) | Μεθοδος για παραγωγα φαινυλοξικου οξεος | |
| EA200300804A1 (ru) | Усовершенствованный способ получения карбапенема | |
| SG144736A1 (en) | Synthesis of temozolomide and analogs | |
| MY138051A (en) | Compounds and processes | |
| DK1706414T3 (da) | Fremgangsmåde til fluorcytidinderivater | |
| SG143062A1 (en) | Synthesis of temozolomide and analogs | |
| PL352493A1 (en) | Method of obtaining amlodipin benzenesulphonate | |
| EP1555261A4 (en) | VALEROLACTONE COMPOUNDS AND FRAGRANCE COMPOSITION | |
| GB0212410D0 (en) | Organic compounds | |
| PT1277750E (pt) | Hidratos e cristais de um composto de acido neuraminico |