CN100379736C - 恩替卡韦的制备方法 - Google Patents
恩替卡韦的制备方法 Download PDFInfo
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- CN100379736C CN100379736C CNB2005100257929A CN200510025792A CN100379736C CN 100379736 C CN100379736 C CN 100379736C CN B2005100257929 A CNB2005100257929 A CN B2005100257929A CN 200510025792 A CN200510025792 A CN 200510025792A CN 100379736 C CN100379736 C CN 100379736C
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CNB2005100257929A CN100379736C (zh) | 2005-05-13 | 2005-05-13 | 恩替卡韦的制备方法 |
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CNB2005100257929A CN100379736C (zh) | 2005-05-13 | 2005-05-13 | 恩替卡韦的制备方法 |
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CN1861602A CN1861602A (zh) | 2006-11-15 |
CN100379736C true CN100379736C (zh) | 2008-04-09 |
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CNB2005100257929A Active CN100379736C (zh) | 2005-05-13 | 2005-05-13 | 恩替卡韦的制备方法 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2488522A2 (en) * | 2009-10-12 | 2012-08-22 | Hanmi Holdings Co., Ltd. | Novel method for preparing entecavir and intermediate used therein |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101245068A (zh) * | 2007-02-14 | 2008-08-20 | 浙江医药股份有限公司新昌制药厂 | 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途 |
CN101074217B (zh) * | 2007-04-04 | 2010-11-24 | 北京精华耀邦医药科技有限公司 | 通过制备色谱分离得到高纯度恩替卡韦关键中间体的方法 |
CN101693713B (zh) * | 2009-10-28 | 2011-11-09 | 福建广生堂药业有限公司 | 一种恩替卡韦的晶型及其制备方法和药物应用 |
CN106928227B (zh) | 2010-07-15 | 2020-06-30 | 浙江奥翔药业股份有限公司 | 恩替卡韦的合成方法及其中间体化合物 |
CN102417506B (zh) * | 2010-09-27 | 2016-04-06 | 杭州赛利药物研究所有限公司 | 一种抗病毒药物恩替卡韦的制备方法 |
EP2474548A1 (en) | 2010-12-23 | 2012-07-11 | Esteve Química, S.A. | Preparation process of an antiviral drug and intermediates thereof |
CN102229608B (zh) * | 2011-08-10 | 2013-02-27 | 上海清松制药有限公司 | 一种改进的制备恩替卡韦一水合物的方法 |
EP2597096A1 (en) | 2011-11-24 | 2013-05-29 | Esteve Química, S.A. | Process for preparing entecavir and intermediates thereof |
CN102924454B (zh) * | 2012-11-13 | 2015-07-22 | 苏州市玮琪生物科技有限公司 | 恩替卡韦的合成方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061972A (zh) * | 1990-10-18 | 1992-06-17 | E·R斯奎布父子公司 | 制备羟甲基(亚甲基环戊基)嘌呤和嘧啶的方法 |
WO1998009964A1 (en) * | 1996-09-03 | 1998-03-12 | Bristol-Myers Squibb Company | IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE |
WO2004052310A2 (en) * | 2002-12-11 | 2004-06-24 | Bristol-Myers Squibb Company | Process and intermediates for synthesis entecavir |
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2005
- 2005-05-13 CN CNB2005100257929A patent/CN100379736C/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061972A (zh) * | 1990-10-18 | 1992-06-17 | E·R斯奎布父子公司 | 制备羟甲基(亚甲基环戊基)嘌呤和嘧啶的方法 |
WO1998009964A1 (en) * | 1996-09-03 | 1998-03-12 | Bristol-Myers Squibb Company | IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE |
WO2004052310A2 (en) * | 2002-12-11 | 2004-06-24 | Bristol-Myers Squibb Company | Process and intermediates for synthesis entecavir |
Non-Patent Citations (1)
Title |
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恩替卡韦. 朱玫等.肝脏,第8卷第2期. 2003 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2488522A2 (en) * | 2009-10-12 | 2012-08-22 | Hanmi Holdings Co., Ltd. | Novel method for preparing entecavir and intermediate used therein |
JP2013507436A (ja) * | 2009-10-12 | 2013-03-04 | ハンミ・サイエンス・カンパニー・リミテッド | エンテカビルの新規な製造方法及びこれに使用される中間体 |
EP2488522A4 (en) * | 2009-10-12 | 2013-05-29 | Hanmi Science Co Ltd | A NEW PROCESS FOR THE PREPARATION OF ENTERTAINMENT AND INTERMEDIATE USED IN THIS METHOD |
US8569491B2 (en) | 2009-10-12 | 2013-10-29 | Hanmi Science Co., Ltd | Method for preparing entecavir and intermediate used therein |
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Publication number | Publication date |
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CN1861602A (zh) | 2006-11-15 |
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Owner name: SHANGHAI QINGSONG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANGHAI ZHONGXIA CHEMISTRY CO., LTD. Effective date: 20110817 |
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Denomination of invention: Method for preparing entecavir Effective date of registration: 20130508 Granted publication date: 20080409 Pledgee: China Minsheng Banking Corp Shanghai branch Pledgor: Shanghai Qingsong Pharmaceutical Co., Ltd. Registration number: 2013310000021 |
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Date of cancellation: 20141115 Granted publication date: 20080409 Pledgee: China Minsheng Banking Corp Shanghai branch Pledgor: Shanghai Qingsong Pharmaceutical Co., Ltd. Registration number: 2013310000021 |
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Denomination of invention: Method for preparing entecavir Effective date of registration: 20141126 Granted publication date: 20080409 Pledgee: China Merchants Bank, Limited by Share Ltd, Shanghai new railway station sub branch Pledgor: Shanghai Qingsong Pharmaceutical Co., Ltd. Registration number: 2014310000082 |
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Date of cancellation: 20160415 Granted publication date: 20080409 Pledgee: China Merchants Bank, Limited by Share Ltd, Shanghai new railway station sub branch Pledgor: Shanghai Qingsong Pharmaceutical Co., Ltd. Registration number: 2014310000082 |
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Denomination of invention: Method for preparing entecavir Effective date of registration: 20160512 Granted publication date: 20080409 Pledgee: China Minsheng Banking Corp Shanghai branch Pledgor: Shanghai Qingsong Pharmaceutical Co., Ltd. Registration number: 2015990000388 |
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