IN2012DN00606A - - Google Patents

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Publication number
IN2012DN00606A
IN2012DN00606A IN606DEN2012A IN2012DN00606A IN 2012DN00606 A IN2012DN00606 A IN 2012DN00606A IN 606DEN2012 A IN606DEN2012 A IN 606DEN2012A IN 2012DN00606 A IN2012DN00606 A IN 2012DN00606A
Authority
IN
India
Prior art keywords
benzyl
alkyl
salt
hydrogen
compound
Prior art date
Application number
Inventor
R Pendri Yadagiri
H Chen Chung-Pin
S Patel Sunil
M Evans Jeffrey
Liang Jing
R Kronenthal David
L Powers Gerald
Josyula Prasad Siva
T Bien Jeffrey
Shi Zhongping
N Patel Ramesh
Banerjee Amit
Y Chan Yeung
K Rijhwani Sushil
K Singh Ambarish
Wang Shaopeng
Stojanovic Milan
J Kucera David
Polniaszek Richard
Lewis Charles
Thottathil John
Krishnamurty Dhileepkumar
X Zhou Maotang
Vemishetti Purushotham
Original Assignee
Bristol Mayers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Mayers Squibb Company filed Critical Bristol Mayers Squibb Company
Publication of IN2012DN00606A publication Critical patent/IN2012DN00606A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083—Syntheses without formation of a Si-C bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/0827—Syntheses with formation of a Si-C bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A compound of formula: wherein Rb is C1 to C6 alkyl; and R20 is hydrogen or benzyl, or a salt thereof.
IN606DEN2012 2002-12-11 2003-12-10 IN2012DN00606A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43254902P 2002-12-11 2002-12-11
PCT/US2003/039554 WO2004052310A2 (en) 2002-12-11 2003-12-10 Process and intermediates for synthesis entecavir

Publications (1)

Publication Number Publication Date
IN2012DN00606A true IN2012DN00606A (en) 2015-06-12

Family

ID=32507962

Family Applications (3)

Application Number Title Priority Date Filing Date
IN605DEN2012 IN2012DN00605A (en) 2002-12-11 2003-12-10
IN604DEN2012 IN2012DN00604A (en) 2002-12-11 2003-12-10
IN606DEN2012 IN2012DN00606A (en) 2002-12-11 2003-12-10

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IN605DEN2012 IN2012DN00605A (en) 2002-12-11 2003-12-10
IN604DEN2012 IN2012DN00604A (en) 2002-12-11 2003-12-10

Country Status (18)

Country Link
US (3) US7034152B2 (en)
EP (2) EP1644384B1 (en)
JP (2) JP4726491B2 (en)
KR (2) KR100944063B1 (en)
CN (6) CN100379746C (en)
AU (1) AU2003300884B2 (en)
BR (2) BRPI0317255B8 (en)
CA (2) CA2735485A1 (en)
DK (1) DK1644384T3 (en)
ES (1) ES2397104T3 (en)
IL (1) IL168691A (en)
IN (3) IN2012DN00605A (en)
MX (1) MXPA05005971A (en)
PL (2) PL212790B1 (en)
PT (1) PT1644384E (en)
SI (1) SI1644384T1 (en)
TW (1) TWI327568B (en)
WO (1) WO2004052310A2 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60313173T2 (en) * 2002-06-27 2008-01-03 F. Hoffmann-La Roche Ag SYNTHESIS OF PURIN DERIVATIVES
CN100379746C (en) * 2002-12-11 2008-04-09 布里斯托尔-迈尔斯斯奎布公司 Process for preparing the antiviral agent [1s-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6h-purin-6-one
US7511139B2 (en) 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
TW200540175A (en) * 2004-06-04 2005-12-16 Bristol Myers Squibb Co Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
CN100379736C (en) * 2005-05-13 2008-04-09 上海仲夏化学有限公司 Preparation process of entecavir
CN1699366A (en) * 2005-06-03 2005-11-23 北京市典范科技有限责任公司 Purine derivatives
US20070060599A1 (en) * 2005-09-09 2007-03-15 Dimarco John D Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
CN101838270B (en) * 2006-08-24 2012-04-18 江苏正大天晴药业股份有限公司 Intermediates of Entecavir and preparation thereof
CN101863842B (en) * 2006-08-24 2012-02-01 江苏正大天晴药业股份有限公司 Entecavir midbodies and synthesis method
CN101130542B (en) * 2006-08-24 2010-08-04 江苏正大天晴药业股份有限公司 Synthesis method of antiviral nucleoside analogue
CN101838207B (en) * 2006-08-24 2012-04-25 江苏正大天晴药业股份有限公司 Intermediates of Entecavir and synthesis method thereof
US8299152B2 (en) * 2006-10-30 2012-10-30 Pirelli Tyre S.P.A. Tire for vehicle wheels comprising crosslinked elastomeric composition
CN101245068A (en) * 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 Crystallization type entecavir, method of producing the same, pharmaceutical composition and uses thereof
CN101371841A (en) * 2007-08-23 2009-02-25 浙江医药股份有限公司新昌制药厂 Crystallization type Entecavir formulation as well as preparation method and use thereof
CN101284799B (en) 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 Nitrogen-contained derivates of caffeoylquinic acid, method for preparing same, pharmaceutical compositions thereof and uses
CN101074217B (en) * 2007-04-04 2010-11-24 北京精华耀邦医药科技有限公司 Method for obtaining endicawil critical intermediate by chromatogram separation
CN101397333A (en) 2007-09-27 2009-04-01 浙江医药股份有限公司新昌制药厂 De-hydroxyl vancomycin, preparation method thereof, medicament composition and use thereof
CN101723945B (en) * 2008-10-17 2011-11-02 上海清松制药有限公司 Method for preparing antiviral medicinal entecavir intermediate
KR101150254B1 (en) 2008-12-26 2012-06-12 한미사이언스 주식회사 Process for preparing entecavir and intermediates used therein
CN101828693B (en) 2009-03-09 2013-01-02 浙江医药股份有限公司新昌制药厂 Preparation method and application of low-viscosity high-fluidity carotenoid oil suspension
CN101531660B (en) * 2009-04-14 2012-07-04 安徽贝克联合制药有限公司 Industrialization production process of entecavir-monohydrate
CN102596956B (en) * 2009-10-12 2014-09-24 韩美科学株式会社 Novel method for preparing entecavir and intermediate used therein
CN101693713B (en) * 2009-10-28 2011-11-09 福建广生堂药业有限公司 New crystal system of entecavir, preparation process and medicament application thereof
CN101781301B (en) * 2010-01-15 2013-04-10 复旦大学 Method for preparing entecavir
US8481728B2 (en) 2010-02-16 2013-07-09 Scinopharm Taiwan, Ltd. Process for preparing entecavir and its intermediates
CN101805339B (en) * 2010-04-12 2012-01-11 王明 Entecavir compound preparation method
CA2705953C (en) 2010-05-31 2018-05-01 Alphora Research Inc. Carbanucleoside synthesis and intermediate compounds useful therein
CN101891741B (en) * 2010-07-06 2013-01-23 苏州汉德森医药科技有限公司 New synthesis process of antiviral drug entecavir
CN102336754B (en) * 2010-07-15 2017-04-12 浙江奥翔药业股份有限公司 Method for synthesizing entecavir and intermediate compound thereof
TWI668220B (en) * 2010-08-30 2019-08-11 浙江奧翔藥業股份有限公司 Synthetic method of entecavir and intermediate compounds thereof
EP2474548A1 (en) 2010-12-23 2012-07-11 Esteve Química, S.A. Preparation process of an antiviral drug and intermediates thereof
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CN102225938A (en) * 2011-04-25 2011-10-26 海南卫康制药(潜山)有限公司 Novel synthesis process of entecavir monohydrate
CN102267875B (en) * 2011-06-17 2013-04-24 常州寅盛药业有限公司 Preparation method of entecavir intermediate
CN102952156A (en) * 2011-08-29 2013-03-06 南京工业大学 Anti-hepatitis B drug entecavir intermediate and synthesis thereof
CN102952135B (en) * 2011-08-31 2015-04-08 南京工业大学 Method for synthesizing hepatitis B medicine entecavir
EP2597096A1 (en) 2011-11-24 2013-05-29 Esteve Química, S.A. Process for preparing entecavir and intermediates thereof
CN103304375B (en) * 2012-03-12 2017-04-12 浙江奥翔药业股份有限公司 Synthesis intermediate of Entecavir and preparation method thereof
RU2650112C2 (en) 2012-10-02 2018-04-09 Кэлифорниа Инститьют Оф Текнолоджи Transition-metal free reductive cleavage of aromatic c-o, c-n, and c-s bonds by activated silanes
CN107253967B (en) 2012-10-02 2021-03-30 加州理工学院 Transition metal-free silylation of aromatic compounds
CN104017014A (en) * 2013-02-28 2014-09-03 浙江星月药物科技股份有限公司 Entecavir intermediates and preparation method thereof
CN104017016B (en) * 2013-02-28 2017-04-05 浙江星月药物科技股份有限公司 The preparation method of the intermediate of one class Entecavir, and intermediate
CN104017015B (en) * 2013-02-28 2017-04-05 浙江星月药物科技股份有限公司 The preparation method of the intermediate of one class Entecavir, and intermediate
CN104016984A (en) * 2013-02-28 2014-09-03 浙江星月药物科技股份有限公司 Entecavir, intermediates thereof and preparation methods of Entecavir and intermediates thereof
CN104017012A (en) * 2013-02-28 2014-09-03 浙江星月药物科技股份有限公司 Entecavir intermediates and preparation method thereof
CN104177396A (en) * 2013-05-23 2014-12-03 浙江星月药物科技股份有限公司 Entecavir intermediates and preparation methods thereof
CN104177397B (en) * 2013-05-23 2017-10-13 浙江星月药物科技股份有限公司 Entecavir midbodies and preparation method thereof
CN104177394B (en) * 2013-05-23 2017-12-05 浙江星月药物科技股份有限公司 Entecavir midbodies and preparation method thereof
GB201313238D0 (en) 2013-07-24 2013-09-04 Avexxin As Process for the preparation of a polyunsaturated ketone compound
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KR101640503B1 (en) 2015-04-15 2016-07-18 동방에프티엘(주) Improved process for the preparation of entecavir Monohydrate
KR101640504B1 (en) 2015-04-15 2016-07-18 동방에프티엘(주) Novel process of Entecavir monohydrate
CN105037363B (en) * 2015-07-13 2016-08-24 山东罗欣药业集团股份有限公司 A kind of entecavir compound prepared novel synthesis
CN108884005B (en) * 2016-04-07 2021-11-12 佐治亚大学研究基金会 Synthesis of 2 '-fluoro-6' -methylene-carbocyclic adenosine (FMCA) and 2 '-fluoro-6' -methylene-carbocyclic guanosine (FMCG)
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CN107163049B (en) * 2017-05-31 2019-06-18 湖北远大生命科学与技术有限责任公司 A kind of preparation method of Entecavir
CN109705063B (en) 2017-10-26 2021-01-01 广州市朗启医药科技有限责任公司 Entecavir intermediate and synthetic method thereof, and synthetic method of entecavir
WO2019080686A1 (en) * 2017-10-26 2019-05-02 广州市朗启医药科技有限责任公司 Entecavir intermediate and synthesis method therefor, and method for synthesizing entecavir
CN109232637B (en) * 2018-10-29 2020-11-24 常州博海威医药科技股份有限公司 Preparation method of entecavir intermediate
CN109593090A (en) * 2019-01-25 2019-04-09 连云港贵科药业有限公司 A kind of synthetic method of Entecavir
CN113831341A (en) * 2020-06-08 2021-12-24 连云港润众制药有限公司 Preparation method of entecavir
CN112625041A (en) * 2020-12-25 2021-04-09 常州博海威医药科技股份有限公司 Novel preparation method and intermediate of entecavir

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594439A (en) 1980-08-06 1986-06-10 The Board Of Trustees Of The Leland Stanford Jr. University Method for asymmetric epoxidation
US4471130A (en) 1980-08-06 1984-09-11 The Board Of Trustees Of The Leland Stanford Junior University Method for asymmetric epoxidation
US4900847A (en) 1985-04-04 1990-02-13 Massachusetts Institute Of Technology Catalytic asymmetric epoxidation
JPH01207257A (en) * 1988-02-15 1989-08-21 Nippon Oil & Fats Co Ltd Method for separating alpha-linolenic acid
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
EP0630897A3 (en) * 1993-06-25 1995-03-01 Bristol Myers Squibb Co 3-Hydroxy-4-hydroxymethyl-2-methylene-cyclopentyl purines and pyrimidines.
US5665890A (en) * 1995-03-14 1997-09-09 President And Fellows Of Harvard College Stereoselective ring opening reactions
AU4090697A (en) * 1996-09-03 1998-03-26 Bristol-Myers Squibb Company Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one
US6127159A (en) * 1997-06-06 2000-10-03 The Board Of Trustees Of The Leland Stanford Junior University Mitofusin genes and their uses
MXPA02008359A (en) 2000-02-29 2003-02-12 Squibb Bristol Myers Co Low dose entecavir formulation and use.
CA2311734C (en) * 2000-04-12 2011-03-08 Bristol-Myers Squibb Company Flash-melt oral dosage formulation
JP2003532643A (en) * 2000-04-13 2003-11-05 フアーマセツト・リミテツド 3'- or 2'-hydroxymethyl-substituted nucleoside derivatives for treating hepatitis virus infection
CN100379746C (en) * 2002-12-11 2008-04-09 布里斯托尔-迈尔斯斯奎布公司 Process for preparing the antiviral agent [1s-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6h-purin-6-one
US7511139B2 (en) * 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
US20070060599A1 (en) * 2005-09-09 2007-03-15 Dimarco John D Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

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Publication number Publication date
IN2012DN00605A (en) 2015-06-12
PL397715A1 (en) 2012-03-26
ES2397104T3 (en) 2013-03-04
BRPI0317255B1 (en) 2019-12-24
EP2433941A1 (en) 2012-03-28
TWI327568B (en) 2010-07-21
CN104788485A (en) 2015-07-22
JP4726491B2 (en) 2011-07-20
SI1644384T1 (en) 2013-02-28
US7550619B2 (en) 2009-06-23
CN104788485B (en) 2017-10-03
CA2508811C (en) 2014-11-18
KR101096830B1 (en) 2011-12-22
WO2004052310A3 (en) 2005-03-03
CN100379746C (en) 2008-04-09
CA2735485A1 (en) 2004-06-24
JP2006509800A (en) 2006-03-23
TW200504065A (en) 2005-02-01
BR122019020833B1 (en) 2020-09-01
AU2003300884A1 (en) 2004-06-30
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