IL96346A - Method for the preparation and purification of a mixture of gangliosides free of slow viral infectivity and pharmaceutical compositions containing said gangliosides - Google Patents
Method for the preparation and purification of a mixture of gangliosides free of slow viral infectivity and pharmaceutical compositions containing said gangliosidesInfo
- Publication number
- IL96346A IL96346A IL96346A IL9634690A IL96346A IL 96346 A IL96346 A IL 96346A IL 96346 A IL96346 A IL 96346A IL 9634690 A IL9634690 A IL 9634690A IL 96346 A IL96346 A IL 96346A
- Authority
- IL
- Israel
- Prior art keywords
- raw material
- mixture
- subjecting
- solubilized
- produce
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 150000002270 gangliosides Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000002994 raw material Substances 0.000 abstract 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 6
- 239000000126 substance Substances 0.000 abstract 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- 230000003381 solubilizing effect Effects 0.000 abstract 3
- 238000000638 solvent extraction Methods 0.000 abstract 3
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 239000007791 liquid phase Substances 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- 239000011877 solvent mixture Substances 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4174789A IT1236594B (it) | 1989-11-17 | 1989-11-17 | Metodo per la preparazione e purificazione di una miscela di glicosfingolipidi |
| IT04171690A IT1243295B (it) | 1990-10-18 | 1990-10-18 | Metodo per la preparazione e purificazione di una miscela di glicosfingolipidi priva di contaminanti da virus non convenzionali |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL96346A0 IL96346A0 (en) | 1991-08-16 |
| IL96346A true IL96346A (en) | 1997-06-10 |
Family
ID=26329145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL96346A IL96346A (en) | 1989-11-17 | 1990-11-14 | Method for the preparation and purification of a mixture of gangliosides free of slow viral infectivity and pharmaceutical compositions containing said gangliosides |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5521164A (fr) |
| EP (1) | EP0454818B1 (fr) |
| JP (1) | JP3140458B2 (fr) |
| KR (1) | KR0177820B1 (fr) |
| CN (1) | CN1027895C (fr) |
| AT (1) | ATE169926T1 (fr) |
| AU (1) | AU649635B2 (fr) |
| CA (1) | CA2045142C (fr) |
| DE (1) | DE69032578T2 (fr) |
| ES (1) | ES2119747T3 (fr) |
| FI (1) | FI97138C (fr) |
| HK (1) | HK1013294A1 (fr) |
| HU (2) | HU210145B (fr) |
| IE (1) | IE904135A1 (fr) |
| IL (1) | IL96346A (fr) |
| IN (1) | IN171530B (fr) |
| NO (1) | NO175311C (fr) |
| NZ (1) | NZ236059A (fr) |
| PE (1) | PE25491A1 (fr) |
| PT (1) | PT95917B (fr) |
| WO (1) | WO1991007417A1 (fr) |
| YU (1) | YU218790A (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1235161B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisogangliosidi |
| DE69132362T2 (de) * | 1991-05-16 | 2001-04-05 | Fidia Spa | Verfahren zur herstellung und reinigung von einer glykosphingolipidmischung frei von verunreinigungen durch ungewöhnliche viren |
| IT1260149B (it) * | 1992-04-17 | 1996-03-28 | Fidia Spa | Metodo per la preparazione e purificazione di miscele di fosfolipidi prive di contaminanti da virus non convenzionali |
| US6458761B2 (en) | 1999-11-24 | 2002-10-01 | Lore Maria Klett-Loch | Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect |
| JP4444543B2 (ja) * | 2000-02-24 | 2010-03-31 | 株式会社メニコン | プリオンを不活性化する方法およびそれに用いる処理溶液 |
| JP2005527467A (ja) | 2001-08-29 | 2005-09-15 | ネオーズ テクノロジーズ， インコーポレイテッド | 新規な合成ガングリオシド誘導体およびその組成物 |
| MXPA05009480A (es) | 2003-03-06 | 2006-02-22 | Neose Technologies Inc | Metodos y composiciones para la sintesis enzimatica de gangliosidos. |
| US7066261B2 (en) * | 2004-01-08 | 2006-06-27 | Halliburton Energy Services, Inc. | Perforating system and method |
| WO2010062197A1 (fr) * | 2008-11-25 | 2010-06-03 | Eduard Nekrasov | Produit laitier et procédé |
| EP3175857A1 (fr) | 2009-03-25 | 2017-06-07 | Seneb Biosciences Inc. | Glycolipides en tant que traitement de maladies |
| CN101838295B (zh) * | 2010-04-14 | 2015-02-25 | 李桂凤 | 一种利用具有特异识别功能色谱介质快速分离纯化神经节苷脂的工业化生产工艺 |
| US8710385B2 (en) | 2012-05-07 | 2014-04-29 | Robert Butch Sickels | Reliability fire pressure switch |
| CN105111253B (zh) * | 2015-09-18 | 2018-01-12 | 重庆寰瑞生物技术有限公司 | 一种提取分离神经节苷脂的方法 |
| CN109320566B (zh) * | 2018-08-14 | 2022-03-15 | 四川兴杰象药业有限公司 | 一种从猪脑髓中提取神经节苷脂的分离纯化制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3346413A (en) * | 1964-10-12 | 1967-10-10 | Hooker Chemical Corp | Method and apparatus for coating wire and solvent recovery |
| ES8506323A1 (es) * | 1984-01-04 | 1985-07-01 | Bioiberica | Procedimiento para la obtencion de un complejo glicoesfingolipidico |
| JPS60181019A (ja) * | 1984-02-28 | 1985-09-14 | Mitsui Toatsu Chem Inc | ガングリオシドの抽出方法 |
| IT1177863B (it) * | 1984-07-03 | 1987-08-26 | Fidia Farmaceutici | Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche |
| JPS61180719A (ja) * | 1985-02-06 | 1986-08-13 | Mitsui Toatsu Chem Inc | ガングリオシドの取得方法 |
| US4710490A (en) * | 1985-10-01 | 1987-12-01 | Angio Medical Corporation | Compositions containing ganglioside molecules with enhanced angiogenic activity |
| IT1223408B (it) * | 1987-12-09 | 1990-09-19 | Crinos Industria Farmaco | Procedimento per la preparazione di monosialoganglioside |
-
1990
- 1990-11-13 IN IN952/CAL/90A patent/IN171530B/en unknown
- 1990-11-13 NZ NZ236059A patent/NZ236059A/xx unknown
- 1990-11-14 IL IL96346A patent/IL96346A/xx active IP Right Grant
- 1990-11-15 PE PE1990177644A patent/PE25491A1/es not_active Application Discontinuation
- 1990-11-16 AT AT90916737T patent/ATE169926T1/de not_active IP Right Cessation
- 1990-11-16 WO PCT/EP1990/001960 patent/WO1991007417A1/fr active IP Right Grant
- 1990-11-16 KR KR1019910700744A patent/KR0177820B1/ko not_active IP Right Cessation
- 1990-11-16 CA CA002045142A patent/CA2045142C/fr not_active Expired - Fee Related
- 1990-11-16 DE DE69032578T patent/DE69032578T2/de not_active Expired - Fee Related
- 1990-11-16 PT PT95917A patent/PT95917B/pt not_active IP Right Cessation
- 1990-11-16 ES ES90916737T patent/ES2119747T3/es not_active Expired - Lifetime
- 1990-11-16 HU HU912391A patent/HU210145B/hu not_active IP Right Cessation
- 1990-11-16 EP EP90916737A patent/EP0454818B1/fr not_active Expired - Lifetime
- 1990-11-16 JP JP02515353A patent/JP3140458B2/ja not_active Expired - Fee Related
- 1990-11-16 YU YU218790A patent/YU218790A/sh unknown
- 1990-11-16 HU HU912391A patent/HUT58754A/hu unknown
- 1990-11-16 IE IE413590A patent/IE904135A1/en not_active IP Right Cessation
- 1990-11-16 AU AU67275/90A patent/AU649635B2/en not_active Ceased
- 1990-11-17 CN CN90109855A patent/CN1027895C/zh not_active Expired - Fee Related
-
1991
- 1991-07-16 NO NO912780A patent/NO175311C/no not_active IP Right Cessation
- 1991-07-17 FI FI913454A patent/FI97138C/fi active
-
1993
- 1993-09-03 US US08/116,268 patent/US5521164A/en not_active Expired - Fee Related
-
1998
- 1998-12-22 HK HK98114612A patent/HK1013294A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |