US5354844A
(en)
*
|
1989-03-16 |
1994-10-11 |
Boehringer Ingelheim International Gmbh |
Protein-polycation conjugates
|
US6830923B1
(en)
*
|
1989-03-16 |
2004-12-14 |
Boehringer Inglheim International Gmbh |
Genetics units for inhibiting the function of RNA
|
EP0800830A3
(en)
*
|
1989-11-03 |
1999-03-17 |
Vanderbilt University |
Method of in vivo delivery of functioning foreign genes
|
US5747641A
(en)
*
|
1989-12-21 |
1998-05-05 |
Biogen Inc |
Tat-derived transport polypeptide conjugates
|
US6316003B1
(en)
|
1989-12-21 |
2001-11-13 |
Whitehead Institute For Biomedical Research |
Tat-derived transport polypeptides
|
US5804604A
(en)
*
|
1989-12-21 |
1998-09-08 |
Biogen, Inc. |
Tat-derived transport polypeptides and fusion proteins
|
AU658818B2
(en)
*
|
1989-12-21 |
1995-05-04 |
Johns Hopkins University School Of Medicine, The |
Method of delivering molecules into eukaryotic cells using tat protein conjugate
|
ATE131042T1
(de)
*
|
1990-04-25 |
1995-12-15 |
Hoechst Ag |
Pharmakologische zubereitung, enthaltend polyelektrolytkomplexe in mikropartikulärer form und mindestens einen wirkstoff.
|
DE4110410C2
(de)
*
|
1991-03-29 |
1999-05-27 |
Boehringer Ingelheim Int |
Neue Protein-Polykation-Konjugate
|
DE59106279D1
(de)
*
|
1990-05-18 |
1995-09-21 |
Genentech Inc |
Neue protein-polykation-konjugate.
|
DE4104186A1
(de)
*
|
1991-02-12 |
1992-08-13 |
Genentech Inc |
Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
|
DE4110409C2
(de)
*
|
1991-03-29 |
1999-05-27 |
Boehringer Ingelheim Int |
Neue Protein-Polykation-Konjugate
|
DE4115038A1
(de)
*
|
1991-05-08 |
1992-11-12 |
Genentech Inc |
Neue konjugate, bestehend aus einem glykoprotein und einer nukleinsaeure-bindenden substanz
|
US6030954A
(en)
*
|
1991-09-05 |
2000-02-29 |
University Of Connecticut |
Targeted delivery of poly- or oligonucleotides to cells
|
RU2138553C1
(ru)
*
|
1991-09-30 |
1999-09-27 |
Берингер Ингельгейм Интернациональ ГмбХ |
Трансфекционная композиция для высших эукариотных клеток, комплекс нуклеиновой кислоты, пригодный в качестве компонента трансфекционной композиции, конъюгат, пригодный в качестве компонента трансфекционной композиции, эндосомолитический пептид, пригодный в качестве компонента трансфекционной композиции
|
IL103059A0
(en)
*
|
1991-09-30 |
1993-02-21 |
Boehringer Ingelheim Int |
Conjugates for introducing nucleic acid into higher eucaryotic cells
|
US5981273A
(en)
*
|
1991-09-30 |
1999-11-09 |
Boehringer Ingelheim Int'l. Gmbh |
Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells
|
US5521291A
(en)
*
|
1991-09-30 |
1996-05-28 |
Boehringer Ingelheim International, Gmbh |
Conjugates for introducing nucleic acid into higher eucaryotic cells
|
NZ244306A
(en)
*
|
1991-09-30 |
1995-07-26 |
Boehringer Ingelheim Int |
Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
|
DE4139001A1
(de)
*
|
1991-11-27 |
1993-06-03 |
Boehringer Mannheim Gmbh |
Verfahren zur einschleusung von nukleinsaeuren in zellen
|
CA2117293A1
(en)
*
|
1991-12-23 |
1993-07-08 |
Wilfried Ellmeier |
Neuroblastoma-associated regulator gene
|
US5922859A
(en)
*
|
1992-02-01 |
1999-07-13 |
Boehringer Ingelheim International Gmbh |
Complexes containing nucleic acid which can be taken-up by endocytosis into higher eukaryotic cells
|
PT636028E
(pt)
*
|
1992-04-03 |
2004-07-30 |
Univ California |
Sistema de fornecimento de polinucleotidos auto-organizado
|
US5656609A
(en)
*
|
1992-09-24 |
1997-08-12 |
University Of Connecticut |
Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine
|
DE4311651A1
(de)
*
|
1993-04-08 |
1994-10-13 |
Boehringer Ingelheim Int |
Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen
|
EP0693939A1
(de)
*
|
1993-04-14 |
1996-01-31 |
Roche Diagnostics GmbH |
Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen
|
US6106824A
(en)
*
|
1993-08-13 |
2000-08-22 |
The Rockefeller University |
Expression of growth associated protein B-50/GAP-43 in vitro and in vivo
|
RU2025487C1
(ru)
*
|
1993-10-18 |
1994-12-30 |
Товарищество с ограниченной ответственностью "БиоПрогресс" |
Способ направленной генетической трансформации молочной железы животного и устройство для введения генетического материала в молочный проток молочной железы животного
|
US20030036056A1
(en)
*
|
1994-01-24 |
2003-02-20 |
John J. Rossi |
Inhibitors and target molecule co-localization
|
FR2715847B1
(fr)
*
|
1994-02-08 |
1996-04-12 |
Rhone Poulenc Rorer Sa |
Composition contenant des acides nucléiques, préparation et utilisations.
|
WO1995022618A1
(en)
*
|
1994-02-22 |
1995-08-24 |
Dana-Farber Cancer Institute |
Nucleic acid delivery system, method of synthesis and uses thereof
|
US6037329A
(en)
*
|
1994-03-15 |
2000-03-14 |
Selective Genetics, Inc. |
Compositions containing nucleic acids and ligands for therapeutic treatment
|
US6551618B2
(en)
|
1994-03-15 |
2003-04-22 |
University Of Birmingham |
Compositions and methods for delivery of agents for neuronal regeneration and survival
|
US5972901A
(en)
|
1994-03-23 |
1999-10-26 |
Case Western Reserve University |
Serpin enzyme complex receptor--mediated gene transfer
|
AU696455C
(en)
*
|
1994-03-23 |
2006-03-02 |
Case Western Reserve University |
Compacted nucleic acids and their delivery to cells
|
US6077835A
(en)
*
|
1994-03-23 |
2000-06-20 |
Case Western Reserve University |
Delivery of compacted nucleic acid to cells
|
US5844107A
(en)
*
|
1994-03-23 |
1998-12-01 |
Case Western Reserve University |
Compacted nucleic acids and their delivery to cells
|
US5670347A
(en)
*
|
1994-05-11 |
1997-09-23 |
Amba Biosciences Llc |
Peptide-mediated gene transfer
|
CA2190963A1
(en)
|
1994-05-30 |
1995-12-07 |
Matthew Cotten |
Method for introducing foreign matter into higher eukaryotic cells
|
DE4418965A1
(de)
*
|
1994-05-31 |
1995-12-07 |
Boehringer Ingelheim Int |
Verfahren zum Einbringen von Nukleinsäure in höhere eukaryotische Zellen
|
CA2193954A1
(en)
*
|
1994-06-27 |
1996-01-04 |
Vu L. Truong |
Targeted gene delivery system
|
US5728399A
(en)
*
|
1994-06-29 |
1998-03-17 |
University Of Conn. |
Use of a bacterial component to enhance targeted delivery of polynucleotides to cells
|
US6350730B1
(en)
|
1994-08-17 |
2002-02-26 |
The Rockefeller University |
OB polypeptides and modified forms as modulators of body weight
|
US6124448A
(en)
*
|
1994-08-17 |
2000-09-26 |
The Rockfeller University |
Nucleic acid primers and probes for the mammalian OB gene
|
US6124439A
(en)
*
|
1994-08-17 |
2000-09-26 |
The Rockefeller University |
OB polypeptide antibodies and method of making
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
US6471956B1
(en)
|
1994-08-17 |
2002-10-29 |
The Rockefeller University |
Ob polypeptides, modified forms and compositions thereto
|
US6048837A
(en)
*
|
1994-08-17 |
2000-04-11 |
The Rockefeller University |
OB polypeptides as modulators of body weight
|
US6001968A
(en)
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
US6962686B2
(en)
|
1994-10-12 |
2005-11-08 |
California Institute Of Technology |
Cell-specific gene delivery vehicles
|
US6232295B1
(en)
|
1994-10-12 |
2001-05-15 |
Jon Faiz Kayyem |
Cell-specific contrast agent and gene delivery vehicles
|
GB9422495D0
(en)
*
|
1994-11-08 |
1995-01-04 |
Medical Res Council |
DNA transfer method
|
US6221959B1
(en)
|
1994-11-18 |
2001-04-24 |
Supratek Pharma, Inc. |
Polynucleotide compositions
|
WO1996021036A2
(en)
*
|
1994-12-30 |
1996-07-11 |
Chiron Viagene, Inc. |
Nucleic acid condensing agents with reduced immunogenicity
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
CA2212682A1
(en)
|
1995-02-10 |
1996-08-15 |
Worcester Foundation For Experimental Biology, Inc. |
Delivery of exogenous compounds
|
FR2730637B1
(fr)
|
1995-02-17 |
1997-03-28 |
Rhone Poulenc Rorer Sa |
Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
US20030069173A1
(en)
*
|
1998-03-16 |
2003-04-10 |
Life Technologies, Inc. |
Peptide-enhanced transfections
|
US5646034A
(en)
*
|
1995-06-07 |
1997-07-08 |
Mamounas; Michael |
Increasing rAAV titer
|
US6051429A
(en)
*
|
1995-06-07 |
2000-04-18 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
WO1996040961A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
US6127116A
(en)
*
|
1995-08-29 |
2000-10-03 |
Washington University |
Functional DNA clone for hepatitis C virus (HCV) and uses thereof
|
US5744326A
(en)
*
|
1996-03-11 |
1998-04-28 |
The Immune Response Corporation |
Use of viral CIS-acting post-transcriptional regulatory sequences to increase expression of intronless genes containing near-consensus splice sites
|
JP2000506865A
(ja)
*
|
1996-03-14 |
2000-06-06 |
ジ イミューン リスポンス コーポレイション |
インターフェロンをコードする遺伝子の標的を定めた送達
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US5679559A
(en)
*
|
1996-07-03 |
1997-10-21 |
University Of Utah Research Foundation |
Cationic polymer and lipoprotein-containing system for gene delivery
|
CN1181422A
(zh)
*
|
1996-10-31 |
1998-05-13 |
上海市肿瘤研究所 |
与生长因子受体结合的多肽所构建的基因转移载体
|
US6387700B1
(en)
*
|
1996-11-04 |
2002-05-14 |
The Reagents Of The University Of Michigan |
Cationic peptides, Cys-Trp-(LYS)n, for gene delivery
|
US5965441A
(en)
*
|
1996-11-13 |
1999-10-12 |
The General Hospital Coporation |
HSV/AAV hybrid amplicon vectors
|
FR2755976B1
(fr)
*
|
1996-11-15 |
1999-01-15 |
Idm Immuno Designed Molecules |
Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
|
US7008776B1
(en)
|
1996-12-06 |
2006-03-07 |
Aventis Pharmaceuticals Inc. |
Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
|
AU5729898A
(en)
*
|
1996-12-18 |
1998-07-15 |
Emory University |
Polycationic oligomers
|
US5969102A
(en)
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
US7338759B1
(en)
|
1997-03-04 |
2008-03-04 |
Washington University |
HCV variants
|
US7049428B1
(en)
|
1998-03-04 |
2006-05-23 |
Washington University |
HCV variants
|
IL132323A0
(en)
|
1997-04-28 |
2001-03-19 |
Rhone Poulenc Rorer Sa |
Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors
|
AU734827B2
(en)
|
1997-05-21 |
2001-06-21 |
Board Of Trustees Of The Leland Stanford Junior University |
Composition and method for enhancing transport across biological membranes
|
US6958148B1
(en)
*
|
1998-01-20 |
2005-10-25 |
Pericor Science, Inc. |
Linkage of agents to body tissue using microparticles and transglutaminase
|
US6919076B1
(en)
|
1998-01-20 |
2005-07-19 |
Pericor Science, Inc. |
Conjugates of agents and transglutaminase substrate linking molecules
|
WO1999040771A2
(en)
*
|
1998-02-13 |
1999-08-19 |
Selective Genetics, Inc. |
Concurrent flow mixing for preparing compositions comprising gene therapy vectors
|
US7101575B2
(en)
|
1998-03-19 |
2006-09-05 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
|
WO1999053961A1
(en)
*
|
1998-04-23 |
1999-10-28 |
The Regents Of The University Of Michigan |
Peptides for efficient gene transfer
|
US6169078B1
(en)
*
|
1998-05-12 |
2001-01-02 |
University Of Florida |
Materials and methods for the intracellular delivery of substances
|
US6171855B1
(en)
|
1998-05-28 |
2001-01-09 |
The Regents Of The University Of Michigan |
Vectors
|
US6927278B1
(en)
*
|
1998-09-01 |
2005-08-09 |
Trustees Of The University Of Pennsylvania |
Peptide scaffolds for transfer of molecules into eukaryotic cells
|
US6696089B2
(en)
|
1998-09-03 |
2004-02-24 |
Board Of Regents Of The University Of Nebraska |
Nanogel networks including polyion polymer fragments and biological agent compositions thereof
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
EP1829856A3
(en)
|
1998-11-12 |
2009-02-25 |
Invitrogen Corporation |
Transfection reagents
|
US6773911B1
(en)
|
1998-11-23 |
2004-08-10 |
Amgen Canada Inc. |
Apoptosis-inducing factor
|
US6395029B1
(en)
*
|
1999-01-19 |
2002-05-28 |
The Children's Hospital Of Philadelphia |
Sustained delivery of polyionic bioactive agents
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
US6281005B1
(en)
*
|
1999-05-14 |
2001-08-28 |
Copernicus Therapeutics, Inc. |
Automated nucleic acid compaction device
|
US7674951B1
(en)
|
1999-05-21 |
2010-03-09 |
Michigan Technological University |
Isolated cellulose synthase promoter regions
|
US7049481B1
(en)
|
1999-05-21 |
2006-05-23 |
Board Of Control Of Michigan Technological University |
Cellulose synthase encoding polynucleotides and uses thereof
|
DE19929104A1
(de)
*
|
1999-06-24 |
2000-12-28 |
Aventis Pharma Gmbh |
Neue Vektorkomplexe und deren Verwendung für die Gentherapie
|
US6770740B1
(en)
|
1999-07-13 |
2004-08-03 |
The Regents Of The University Of Michigan |
Crosslinked DNA condensate compositions and gene delivery methods
|
DE19933506A1
(de)
*
|
1999-07-16 |
2001-01-25 |
Deutsches Krebsforsch |
Zelluläre Aufnahme von DNA
|
EP1209971A4
(en)
*
|
1999-08-20 |
2004-04-14 |
Mirus Corp |
POLYION COMPLEX LOAD INVERSION
|
US7229961B2
(en)
*
|
1999-08-24 |
2007-06-12 |
Cellgate, Inc. |
Compositions and methods for enhancing drug delivery across and into ocular tissues
|
US6730293B1
(en)
|
1999-08-24 |
2004-05-04 |
Cellgate, Inc. |
Compositions and methods for treating inflammatory diseases of the skin
|
US6669951B2
(en)
|
1999-08-24 |
2003-12-30 |
Cellgate, Inc. |
Compositions and methods for enhancing drug delivery across and into epithelial tissues
|
EP1210121A2
(en)
|
1999-08-24 |
2002-06-05 |
Cellgate Inc. |
Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
|
EP1108743B1
(en)
*
|
1999-12-08 |
2006-11-15 |
JSR Corporation |
Separation of viruses and detection of viruses
|
US7070807B2
(en)
*
|
1999-12-29 |
2006-07-04 |
Mixson A James |
Branched histidine copolymers and methods for using same
|
CA2394758A1
(en)
*
|
1999-12-29 |
2001-07-05 |
A. James Mixson |
Histidine-containing copolymers enhance pharmaceutical agent delivery
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
US20030134420A1
(en)
*
|
2000-02-18 |
2003-07-17 |
Lollo Charles Peter |
Methods and compositions for gene delivery
|
EP1276500B1
(en)
|
2000-03-13 |
2011-06-08 |
Cornell Research Foundation, Inc. |
Blocking leukocyte emigration and inflammation by interfering with cd99/hec2
|
GB0018307D0
(en)
|
2000-07-26 |
2000-09-13 |
Aventis Pharm Prod Inc |
Polypeptides
|
EP1272526A4
(en)
|
2000-04-13 |
2004-10-13 |
Univ Rockefeller |
REINFORCING ANTIBODY-IMMUNE RESPONSE
|
AU2001257613A1
(en)
*
|
2000-04-23 |
2001-11-12 |
Arizeke Pharmaceuticals, Inc. |
Compositions comprising carriers and transportable complexes
|
ES2376725T3
(es)
|
2000-05-10 |
2012-03-16 |
Mayo Foundation For Medical Education And Research |
Anticuerpos IgM humanos con la capacidad de inducir remielinización y usos diagnósticos y terapéuticos de los mismos, particularmente en el sistema nervioso central
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
US7355019B2
(en)
|
2000-06-06 |
2008-04-08 |
Sibtech, Inc. |
Cysteine-containing peptide tag for site-specific conjugation of proteins
|
DE60128115T2
(de)
|
2000-08-08 |
2008-03-06 |
St. Jude Children's Research Hospital, Memphis |
Gruppe-b streptococcus polypeptide, nukleinsäure, therapeutische zusammensetzungen und impfstoffe davon
|
WO2002024232A2
(en)
*
|
2000-09-25 |
2002-03-28 |
Board Of Regents, The University Of Texas System |
Pei: dna vector formulations for in vitro and in vivo gene delivery
|
US20030161809A1
(en)
*
|
2000-10-02 |
2003-08-28 |
Houston L. L. |
Compositions and methods for the transport of biologically active agents across cellular barriers
|
US20030166160A1
(en)
*
|
2001-09-06 |
2003-09-04 |
Hawley Stephen B. |
Compounds and molecular complexes comprising multiple binding regions directed to transcytotic ligands
|
US8105825B2
(en)
|
2000-10-03 |
2012-01-31 |
Intrexon Corporation |
Multiple inducible gene regulation system
|
DE10049010A1
(de)
*
|
2000-10-04 |
2002-04-18 |
Boehringer Ingelheim Int |
Transferrin-Polykation/DNS-Komplexe für die systemische Therapie von Tumorerkrankungen mit zytotoxischen Proteinen
|
EP2402359A1
(en)
|
2000-12-28 |
2012-01-04 |
Wyeth LLC |
Recombinant protective protein from streptococcus pneumoniae
|
US8715959B2
(en)
|
2001-02-20 |
2014-05-06 |
Intrexon Corporation |
Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
JP4955905B2
(ja)
|
2001-02-20 |
2012-06-20 |
イントレキソン コーポレーション |
キメラレチノイドx受容体および新規エクジソン受容体−ベースの誘導性遺伝子発現システムにおけるそれらの使用
|
CA2441476A1
(en)
|
2001-03-02 |
2002-09-12 |
The Rockefeller University |
Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
|
IL157993A0
(en)
*
|
2001-03-23 |
2004-03-28 |
Napro Biotherapeutics Inc |
Molecular conjugates for use in cancer treatment and methods for the preparation thereof
|
US20030096748A1
(en)
*
|
2001-06-04 |
2003-05-22 |
The Regents Of The University Of Michigan |
Methods and compositions for the treatment of diseases associated with signal transduction aberrations
|
US7803915B2
(en)
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
EP1992643A3
(en)
|
2001-06-20 |
2008-12-10 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
CA2451643C
(en)
|
2001-06-21 |
2012-11-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
KR101008758B1
(ko)
|
2001-09-18 |
2011-01-14 |
제넨테크, 인크. |
종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
MX339524B
(es)
|
2001-10-11 |
2016-05-30 |
Wyeth Corp |
Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
|
EP2325193A3
(en)
|
2001-11-02 |
2012-05-02 |
Insert Therapeutics, Inc. |
Methods and compositions for therapeutic use of RNA interference
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
MXPA04006554A
(es)
|
2002-01-02 |
2005-03-31 |
Genentech Inc |
Composiciones y metodos para diagnostico y tratamiento de tumor.
|
US20030186916A1
(en)
*
|
2002-03-12 |
2003-10-02 |
Lei Yu |
Vector for transfection of eukaryotic cells
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
NZ535925A
(en)
|
2002-04-16 |
2008-06-30 |
Genentech Inc |
An isolated antibody that binds to a particular polypeptide
|
AU2002307776A1
(en)
*
|
2002-04-16 |
2003-10-27 |
Kamada Ltd. |
Ultrapure transferrin for pharmaceutical compositions
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
US7074893B2
(en)
*
|
2002-06-03 |
2006-07-11 |
Regents Of The University Of Michigan |
Methods and compositions for the treatment of diseases associated with signal transduction aberrations
|
GB0215534D0
(en)
*
|
2002-07-04 |
2002-08-14 |
Ecole Polytech |
Selective photochemotherapy using oligonucleotide targeting agents
|
US7375093B2
(en)
|
2002-07-05 |
2008-05-20 |
Intrexon Corporation |
Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US7785608B2
(en)
|
2002-08-30 |
2010-08-31 |
Wyeth Holdings Corporation |
Immunogenic compositions for the prevention and treatment of meningococcal disease
|
EA008940B1
(ru)
|
2002-09-13 |
2007-10-26 |
Репликор, Инк. |
Антивирусные олигонуклеотиды, не связанные с комплементарностью последовательностей
|
EP2272958A1
(en)
|
2002-09-26 |
2011-01-12 |
ISIS Pharmaceuticals, Inc. |
Modulation of forkhead box O1A expression
|
CA2504929C
(en)
|
2002-11-05 |
2014-07-22 |
Charles Allerson |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
CA2504720C
(en)
|
2002-11-05 |
2013-12-24 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
PT2336318E
(pt)
|
2002-11-13 |
2013-06-12 |
Genzyme Corp |
Modulação anti-sentido da expressão de apolipoproteína b
|
AU2003294281B2
(en)
|
2002-11-13 |
2010-05-20 |
Kastle Therapeutics, Llc |
Antisense modulation of apolipoprotein B expression
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
US7465708B2
(en)
|
2002-11-25 |
2008-12-16 |
Mixson A James |
Branched cationic copolymers and methods for antimicrobial use
|
US7304161B2
(en)
|
2003-02-10 |
2007-12-04 |
Intrexon Corporation |
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
|
NZ541637A
(en)
|
2003-02-11 |
2008-07-31 |
Antisense Therapeutics Pty Ltd |
Modulation of insulin like growth factor I receptor
|
US7456315B2
(en)
|
2003-02-28 |
2008-11-25 |
Intrexon Corporation |
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
CA2522184A1
(en)
*
|
2003-04-17 |
2004-11-04 |
The Trustees Of Columbia University In The City Of New York |
Desmoglein 4 is a novel gene involved in hair growth
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
EP1633307A4
(en)
|
2003-06-03 |
2009-06-24 |
Isis Pharmaceuticals Inc |
MODULATION OF SURVIVIN EXPRESSION
|
WO2005007812A2
(en)
|
2003-07-03 |
2005-01-27 |
University Of Medicine And Dentistry Of New Jersey |
Genes as diagnostic tools for autism
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
NZ576775A
(en)
|
2003-09-18 |
2010-12-24 |
Isis Pharmaceuticals Inc |
Modulation of eIF4E expression
|
DK1678194T3
(da)
|
2003-10-10 |
2013-10-07 |
Alchemia Oncology Pty Ltd |
Modulering af syntese og degradering af hyaluronan i behandlingen af sygdom
|
US8133733B2
(en)
|
2003-10-24 |
2012-03-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides to target tissues
|
US8062891B2
(en)
|
2003-10-24 |
2011-11-22 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides to plants
|
AU2004297533B2
(en)
|
2003-10-24 |
2010-04-29 |
Gencia Corporation |
Methods and compositions for delivering polynucleotides
|
US20090123468A1
(en)
|
2003-10-24 |
2009-05-14 |
Gencia Corporation |
Transducible polypeptides for modifying metabolism
|
US8507277B2
(en)
|
2003-10-24 |
2013-08-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
EP2301568A1
(en)
|
2003-11-17 |
2011-03-30 |
Genentech, Inc. |
Antibody against IRTA2 for the treatment of tumour of hematopoietic origin
|
JP2007520222A
(ja)
|
2004-01-20 |
2007-07-26 |
アイシス ファーマシューティカルズ インコーポレイテッド |
グルココルチコイドレセプター発現の調節
|
US7468431B2
(en)
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
WO2005089268A2
(en)
|
2004-03-15 |
2005-09-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of rna by rnase h
|
DE102004013637A1
(de)
|
2004-03-19 |
2005-10-13 |
Capsulution Nanoscience Ag |
Verfahren zur Herstellung von CS-Partikeln und Mikrokapseln unter Verwendung poröser Template sowie CS-Partikel und Mikrokapseln
|
CA2561221C
(en)
*
|
2004-03-26 |
2016-09-20 |
Curis, Inc. |
Rna interference modulators of hedgehog signaling and uses thereof
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
ATE483981T1
(de)
|
2004-04-20 |
2010-10-15 |
Galapagos Nv |
Verfahren, zusammensetzungen und verbindungstests zur hemmung der amyloid-beta-proteinproduktion
|
EP2214018B1
(en)
|
2004-04-27 |
2013-06-26 |
Galapagos N.V. |
Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
|
US7935510B2
(en)
|
2004-04-30 |
2011-05-03 |
Intrexon Corporation |
Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
MXPA06014577A
(es)
|
2004-06-14 |
2007-03-23 |
Galapagos Nv |
Metodos para la identificacion y compuestos utiles para el tratamiento de enfermedades degenerativas e inflamatorias.
|
TW200613554A
(en)
|
2004-06-17 |
2006-05-01 |
Wyeth Corp |
Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
|
ES2427046T3
(es)
|
2004-06-21 |
2013-10-28 |
Galapagos N.V. |
Métodos y medios para el tratamiento de la osteoartritis
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006042112A2
(en)
|
2004-10-05 |
2006-04-20 |
California Institute Of Technology |
Aptamer regulated nucleic acids and uses thereof
|
US7485468B2
(en)
|
2004-10-15 |
2009-02-03 |
Galapagos Bv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
|
US8673268B2
(en)
|
2004-10-15 |
2014-03-18 |
Galapagos N.V. |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
|
US9034650B2
(en)
|
2005-02-02 |
2015-05-19 |
Intrexon Corporation |
Site-specific serine recombinases and methods of their use
|
EP1855694B1
(en)
|
2005-02-09 |
2020-12-02 |
Sarepta Therapeutics, Inc. |
Antisense composition for treating muscle atrophy
|
EP1869076A2
(en)
|
2005-03-10 |
2007-12-26 |
Genentech, Inc. |
Methods and compositions for modulating vascular integrity
|
EP1866414B9
(en)
|
2005-03-31 |
2012-10-03 |
Calando Pharmaceuticals, Inc. |
Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
|
US8088382B2
(en)
|
2005-07-05 |
2012-01-03 |
Cornell Research Foundation, Inc. |
Methods of inhibiting transendothelial migration of neutrophils and monocytes with anti-CD99L2 antibodies
|
US8129585B2
(en)
|
2005-08-03 |
2012-03-06 |
Michigan Technological University |
Methods for enhancing expression of secondary cell wall cellulose synthases in plants
|
AU2006318194B2
(en)
|
2005-11-21 |
2012-08-09 |
Isis Pharmaceuticals, Inc. |
Modulation of eiF4E-BP2 expression
|
US7951934B2
(en)
|
2006-01-26 |
2011-05-31 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to huntingtin
|
EP2614839A3
(en)
|
2006-04-05 |
2015-01-28 |
Genentech, Inc. |
Method for using BOC/CDO to modulate hedgehog signaling
|
MX2008014005A
(es)
|
2006-05-03 |
2009-01-27 |
Baltic Technology Dev Ltd |
Agentes antisentido que combinan un oligonucleotido modificado con base fuertemente unida y nucleasa artificial.
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
AU2007276793B2
(en)
|
2006-07-28 |
2014-01-16 |
Sanofi |
Composition and method for treatment of tumors
|
WO2008058291A2
(en)
|
2006-11-09 |
2008-05-15 |
California Institute Of Technology |
Modular aptamer-regulated ribozymes
|
CA2671850A1
(en)
*
|
2006-12-08 |
2008-06-19 |
Massachusetts Institute Of Technology |
Delivery of nanoparticles and/or agents to cells
|
AR064642A1
(es)
|
2006-12-22 |
2009-04-15 |
Wyeth Corp |
Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
|
WO2008086807A2
(en)
*
|
2007-01-19 |
2008-07-24 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
EP2114981B1
(en)
|
2007-01-29 |
2013-05-08 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
SI2140021T1
(sl)
|
2007-02-22 |
2012-04-30 |
Genentech Inc |
Postopki za detekcijo vnetne ÄŤrevesne bolezni
|
ATE517118T1
(de)
*
|
2007-04-05 |
2011-08-15 |
Symbiotec Gmbh |
Bis-met-histone
|
US8076517B2
(en)
|
2007-05-29 |
2011-12-13 |
Intrexon Corporation |
Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US8637257B2
(en)
|
2007-06-20 |
2014-01-28 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases
|
WO2009011855A2
(en)
*
|
2007-07-16 |
2009-01-22 |
California Institute Of Technology |
Selection of nucleic acid-based sensor domains within nucleic acid switch platform
|
EP2185730A4
(en)
|
2007-08-23 |
2010-10-27 |
Intrexon Corp |
METHOD AND COMPOSITIONS FOR SICKNESS DIAGNOSIS
|
US20120165387A1
(en)
|
2007-08-28 |
2012-06-28 |
Smolke Christina D |
General composition framework for ligand-controlled RNA regulatory systems
|
US8367815B2
(en)
*
|
2007-08-28 |
2013-02-05 |
California Institute Of Technology |
Modular polynucleotides for ligand-controlled regulatory systems
|
US8865667B2
(en)
*
|
2007-09-12 |
2014-10-21 |
California Institute Of Technology |
Higher-order cellular information processing devices
|
EP2183355B1
(en)
*
|
2007-09-17 |
2016-01-27 |
Rohm and Haas Company |
Compositions and methods for the modification of physiological responses in plants
|
JP5514727B2
(ja)
|
2007-09-26 |
2014-06-04 |
イントレキソン コーポレーション |
合成5’utr、発現ベクター、および導入遺伝子の発現を増加させる方法
|
AU2008307643B9
(en)
|
2007-09-28 |
2014-04-17 |
Intrexon Corporation |
Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
|
CA2700953A1
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
US7973019B1
(en)
*
|
2007-10-03 |
2011-07-05 |
Alcon Research, Ltd. |
Transferrin/transferrin receptor-mediated siRNA delivery
|
AU2008311292B9
(en)
|
2007-10-08 |
2014-10-09 |
Intrexon Corporation |
Engineered dendritic cells and uses for the treatment of cancer
|
DE102008023913A1
(de)
|
2008-05-16 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Beeinflussung des angeborenen Immunsystems
|
EP2212425A2
(de)
|
2007-11-22 |
2010-08-04 |
Biontex Laboratories Gmbh |
Verbesserung von transfektionsergebnissen nicht-viraler genliefersysteme durch beeinflussung des angeborenen immunsystems
|
DE102008016275A1
(de)
|
2008-03-28 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
DE102007056488A1
(de)
|
2007-11-22 |
2009-07-23 |
Biontex Laboratories Gmbh |
Steigerung von Transfektionseffizienzen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
US9029524B2
(en)
*
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
JP2011516065A
(ja)
|
2008-04-04 |
2011-05-26 |
カランド ファーマシューティカルズ, インコーポレイテッド |
Epas1阻害剤の組成物および使用
|
US8093043B2
(en)
|
2008-06-04 |
2012-01-10 |
New York University |
β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
|
WO2010008582A2
(en)
|
2008-07-18 |
2010-01-21 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell drug delivery system
|
CA2733262C
(en)
|
2008-08-25 |
2019-12-10 |
Excaliard Pharmaceuticals Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
US8765376B2
(en)
|
2008-09-11 |
2014-07-01 |
Galapagos Nv |
Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator
|
US8796443B2
(en)
|
2008-09-22 |
2014-08-05 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
ES2648231T3
(es)
|
2008-11-05 |
2017-12-29 |
Wyeth Llc |
Composición inmunogénica de múltiples componentes para la prevención de la enfermedad por estreptococos beta hemolíticos (EBH)
|
KR101829469B1
(ko)
|
2008-12-04 |
2018-03-30 |
큐알엔에이, 인크. |
Epo에 대한 천연 안티센스 전사체의 억제에 의해 에리트로포에틴(epo) 관련된 질환의 치료
|
WO2010065787A2
(en)
|
2008-12-04 |
2010-06-10 |
Curna, Inc. |
Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
|
CN102307997B
(zh)
|
2008-12-04 |
2018-03-30 |
库尔纳公司 |
通过抑制针对沉默调节蛋白1的天然反义转录物来治疗沉默调节蛋白1(sirt1)相关的疾病
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
EP2216341A1
(en)
|
2009-02-10 |
2010-08-11 |
Novozymes Biopharma UK Limited |
Transferrin variants and conjugates
|
CN102387817B
(zh)
|
2009-02-12 |
2018-01-30 |
库尔纳公司 |
通过抑制针对脑衍生神经营养因子(bdnf)的天然反义转录物来治疗bdnf相关的疾病
|
WO2010093906A2
(en)
|
2009-02-12 |
2010-08-19 |
Curna, Inc. |
Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
|
US8329882B2
(en)
|
2009-02-18 |
2012-12-11 |
California Institute Of Technology |
Genetic control of mammalian cells with synthetic RNA regulatory systems
|
EP2398481A2
(en)
|
2009-02-19 |
2011-12-28 |
Galapagos N.V. |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
WO2010094732A1
(en)
|
2009-02-19 |
2010-08-26 |
Biofocus Dpi B.V. |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
EP2398479A2
(en)
|
2009-02-19 |
2011-12-28 |
Galapagos N.V. |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
EP2963116B1
(en)
|
2009-03-04 |
2020-11-11 |
CuRNA, Inc. |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt 1
|
WO2010107733A2
(en)
|
2009-03-16 |
2010-09-23 |
Curna, Inc. |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
|
US9708604B2
(en)
|
2009-03-17 |
2017-07-18 |
Curna, Inc. |
Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
WO2010115825A2
(en)
|
2009-03-31 |
2010-10-14 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
JP2012522977A
(ja)
|
2009-04-01 |
2012-09-27 |
ガラパゴス・ナムローゼ・フェンノートシャップ |
変形性関節症の治療のための方法及び手段
|
US9145555B2
(en)
|
2009-04-02 |
2015-09-29 |
California Institute Of Technology |
Integrated—ligand-responsive microRNAs
|
US8362218B2
(en)
|
2009-04-17 |
2013-01-29 |
New York University School Of Medicine |
Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof
|
EP3248618A1
(en)
|
2009-04-22 |
2017-11-29 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long rna molecules
|
US8318690B2
(en)
|
2009-05-01 |
2012-11-27 |
Curna, Inc. |
Treatment of hemoglobin (HBF/HBG) related diseases by inhibition of natural antisense transcript to HBF/HBG
|
US9155754B2
(en)
|
2009-05-06 |
2015-10-13 |
Curna, Inc. |
Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1
|
US20120046236A1
(en)
|
2009-05-06 |
2012-02-23 |
Opko Curna Llc |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
DK2432881T3
(en)
|
2009-05-18 |
2018-02-26 |
Curna Inc |
TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
|
CA2762987A1
(en)
|
2009-05-22 |
2010-11-25 |
Joseph Collard |
Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3
|
CN103221541B
(zh)
|
2009-05-28 |
2017-03-01 |
库尔纳公司 |
通过抑制抗病毒基因的天然反义转录物来治疗抗病毒基因相关疾病
|
WO2010148065A2
(en)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of paraoxonase 1 (pon1) related diseases by inhibition of natural antisense transcript to pon1
|
CA2765700C
(en)
|
2009-06-16 |
2021-01-05 |
Opko Curna, Llc |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
EP2446036B1
(en)
|
2009-06-24 |
2017-03-01 |
CuRNA, Inc. |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
US8921330B2
(en)
|
2009-06-26 |
2014-12-30 |
Curna, Inc. |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
JP6128848B2
(ja)
|
2009-08-05 |
2017-05-17 |
クルナ・インコーポレーテッド |
インスリン遺伝子(ins)に対する天然アンチセンス転写物の抑制によるインスリン遺伝子(ins)関連疾患の治療
|
US9023822B2
(en)
|
2009-08-25 |
2015-05-05 |
Curna, Inc. |
Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
|
EP2473522B1
(en)
|
2009-09-02 |
2016-08-17 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
WO2011046983A2
(en)
|
2009-10-12 |
2011-04-21 |
Smith Holdings, Llc |
Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
|
EP2490718B1
(en)
|
2009-10-22 |
2016-01-13 |
F.Hoffmann-La Roche Ag |
Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
|
US20120244169A1
(en)
|
2009-11-06 |
2012-09-27 |
Fibrogen, Inc. |
Treatment for Radiation-Induced Disorders
|
SG10201408598XA
(en)
|
2009-11-30 |
2015-02-27 |
Genentech Inc |
Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid2 )
|
CN104529945A
(zh)
|
2009-12-11 |
2015-04-22 |
基因密码公司 |
使用gdnf家族配体(gfl)模拟剂或ret信号传导通路活化剂促进神经细胞存活的方法
|
DK2513310T3
(en)
|
2009-12-16 |
2018-02-05 |
Curna Inc |
TREATMENT OF DISEASES CONNECTED WITH MEMBRANE-BONDED TRANSCRIPTION FACTOR Peptidase, site 1 (MBTPS1), BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTION TO MBTPS1
|
RU2619185C2
(ru)
|
2009-12-23 |
2017-05-12 |
Курна, Инк. |
Лечение заболеваний, связанных с разобщающим белком 2 (ucp2), путем ингибирования природного антисмыслового транскрипта к ucp2
|
DK2516648T3
(en)
|
2009-12-23 |
2018-02-12 |
Curna Inc |
TREATMENT OF HEPATOCYTE GROWTH FACTOR (HGF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT AGAINST HGF
|
US8962585B2
(en)
|
2009-12-29 |
2015-02-24 |
Curna, Inc. |
Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63
|
JP5993744B2
(ja)
|
2009-12-29 |
2016-09-14 |
カッパーアールエヌエー,インコーポレイテッド |
核呼吸因子1(nrf1)に対する天然アンチセンス転写物の阻害による核呼吸因子1関連疾患の治療
|
WO2011082409A2
(en)
|
2010-01-04 |
2011-07-07 |
Curna, Inc. |
Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8
|
EP2521785B1
(en)
|
2010-01-06 |
2022-03-09 |
CuRNA, Inc. |
Inhibition of natural antisense transcript to a pancreatic developmental gene for use in a treatment of pancreatic developmental gene related diseases
|
ES2664866T3
(es)
|
2010-01-11 |
2018-04-23 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la globulina fijadora de hormonas sexuales (shbg) mediante inhibición del transcrito antisentido natural a shbg
|
WO2011090971A2
(en)
|
2010-01-19 |
2011-07-28 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for male reproductive disorders
|
RU2611192C2
(ru)
|
2010-01-25 |
2017-02-21 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С РНКазой Н1, ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К РНКазе Н1
|
JP5976548B2
(ja)
|
2010-02-22 |
2016-08-23 |
カッパーアールエヌエー,インコーポレイテッド |
Pycr1に対する天然アンチセンス転写物の阻害によるピロリン−5−カルボン酸レダクターゼ1(pycr1)関連疾患の治療
|
CN102985113B
(zh)
|
2010-02-23 |
2015-05-20 |
霍夫曼-拉罗奇有限公司 |
用于肿瘤诊断和治疗的组合物和方法
|
WO2011119773A1
(en)
|
2010-03-23 |
2011-09-29 |
Roeth Jeremiah F |
Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
|
EP2550000A4
(en)
|
2010-03-24 |
2014-03-26 |
Advirna Inc |
RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING
|
US9044494B2
(en)
|
2010-04-09 |
2015-06-02 |
Curna, Inc. |
Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
|
JP5896175B2
(ja)
|
2010-04-29 |
2016-03-30 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
トランスサイレチン発現の調節
|
CN107090045A
(zh)
|
2010-05-03 |
2017-08-25 |
霍夫曼-拉罗奇有限公司 |
用于肿瘤诊断和治疗的组合物和方法
|
KR101915115B1
(ko)
|
2010-05-03 |
2018-11-05 |
큐알엔에이, 인크. |
시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
|
JP5866106B2
(ja)
|
2010-05-12 |
2016-02-17 |
コロンビア ユニヴァーシティ |
インスリンを産生し分泌する腸内分泌細胞の製造方法
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
ES2664572T3
(es)
|
2010-05-26 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el homólogo atonal 1 (ATOH1) mediante inhibición del transcrito antisentido natural a ATOH1
|
CA2805318A1
(en)
|
2010-07-14 |
2012-01-19 |
Curna, Inc. |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
CN103189071A
(zh)
|
2010-08-23 |
2013-07-03 |
惠氏有限责任公司 |
脑膜炎萘瑟氏菌rLP2086抗原的稳定制剂
|
EP3056212B1
(en)
|
2010-09-10 |
2019-04-03 |
Wyeth LLC |
Non-lipidated variants of neisseria meningitidis orf2086 antigens
|
US8481680B2
(en)
|
2010-10-05 |
2013-07-09 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
WO2012047956A2
(en)
|
2010-10-06 |
2012-04-12 |
Opko Curna Llc |
Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
|
CN103180445B
(zh)
|
2010-10-22 |
2018-02-16 |
库尔纳公司 |
通过抑制α‑L‑艾杜糖醛酸酶(IDUA)的天然反义转录物而治疗IDUA相关疾病
|
US20130210893A1
(en)
|
2010-10-27 |
2013-08-15 |
Curna, Inc. |
Treatment of interferon-related developmental regulator 1 (ifrd1) related diseases by inhibition of natural antisense transcript to ifrd1
|
WO2012061811A2
(en)
|
2010-11-05 |
2012-05-10 |
Fibrogen, Inc. |
Treatment method for lung remodeling diseases
|
CN103459599B
(zh)
|
2010-11-23 |
2017-06-16 |
库尔纳公司 |
通过抑制nanog的天然反义转录物而治疗nanog相关疾病
|
ES2729956T3
(es)
|
2011-02-02 |
2019-11-07 |
Excaliard Pharmaceuticals Inc |
Compuestos antisentido dirigidos al factor de crecimiento de tejido conectivo (ctgf) para su uso en un procedimiento de tratamiento de queloides o cicatrices hipertróficas
|
WO2012109495A1
(en)
|
2011-02-09 |
2012-08-16 |
Metabolic Solutions Development Company, Llc |
Cellular targets of thiazolidinediones
|
EP3450568A3
(en)
|
2011-03-04 |
2019-04-24 |
Intrexon Corporation |
Vectors conditionally expressing protein
|
CA2832972C
(en)
|
2011-04-13 |
2019-04-30 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of ptp1b expression
|
CA2838588C
(en)
|
2011-06-09 |
2021-09-14 |
Curna, Inc. |
Treatment of frataxin (fxn) related diseases by inhibition of natural antisense transcript to fxn
|
JP6043347B2
(ja)
|
2011-06-16 |
2016-12-14 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
線維芽細胞増殖因子受容体4の発現のアンチセンス調節
|
FR2979919B1
(fr)
|
2011-09-12 |
2015-12-11 |
Centre Nat Rech Scient |
Genomes lentiviraux chimeriques non-integratifs comme vaccins innovants contre vih-1
|
US9127040B2
(en)
|
2011-09-20 |
2015-09-08 |
The University Of North Carolina At Chapel Hill |
Regulation of sodium channels by PLUNC proteins
|
ES2796556T3
(es)
|
2011-09-20 |
2020-11-27 |
Ionis Pharmaceuticals Inc |
Modulación antisentido de la expresión de GCGR
|
FR2980801B1
(fr)
|
2011-09-29 |
2016-02-05 |
Centre Nat Rech Scient |
Utilisation de "polyketide synthases" de type iii (pks iii) recombinantes d'algues brunes marines
|
US20130085139A1
(en)
|
2011-10-04 |
2013-04-04 |
Royal Holloway And Bedford New College |
Oligomers
|
CA2853373A1
(en)
|
2011-10-25 |
2013-05-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of gccr expression
|
MX2018011291A
(es)
|
2012-03-09 |
2023-01-31 |
Pfizer |
Composiciones de neisseria meningitidis y metodos de las mismas.
|
SA115360586B1
(ar)
|
2012-03-09 |
2017-04-12 |
فايزر انك |
تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
|
HUE040179T2
(hu)
|
2012-03-15 |
2019-02-28 |
Curna Inc |
Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
|
US20160136159A1
(en)
|
2012-09-17 |
2016-05-19 |
Chemedest Ltd. |
Method for Treating Peripheral Neuropathy
|
CA2889181C
(en)
|
2012-10-22 |
2021-12-07 |
Fountain Biopharma Inc. |
Antibodies to interleukin-6 and uses thereof
|
BR112015010116A2
(pt)
|
2012-11-15 |
2017-08-22 |
Roche Innovation Ct Copenhagen As |
COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB
|
ES2685894T3
(es)
|
2013-03-08 |
2018-10-15 |
Pfizer Inc. |
Polipéptidos de fusión inmunogénicos
|
WO2014139885A2
(en)
|
2013-03-14 |
2014-09-18 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition
|
US20160054304A1
(en)
|
2013-03-14 |
2016-02-25 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases
|
WO2014139884A2
(en)
|
2013-03-14 |
2014-09-18 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrosis
|
WO2014152497A2
(en)
|
2013-03-15 |
2014-09-25 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for cognitive disorders
|
WO2014197938A1
(en)
|
2013-06-13 |
2014-12-18 |
Antisense Therapeutics Ltd |
Combination therapy
|
MX2016002934A
(es)
|
2013-09-05 |
2016-12-20 |
Sarepta Therapeutics Inc |
Inclusion del exon 2 inducida por antisentido en la alfa-glucosidasa ácida.
|
MX369534B
(es)
|
2013-09-08 |
2019-11-11 |
Pfizer |
Composiciones de neisseria meningitidis y sus metodos.
|
WO2015042466A2
(en)
|
2013-09-19 |
2015-03-26 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Compositions and methods for inhibiting jc virus (jcv)
|
WO2015116902A1
(en)
|
2014-01-31 |
2015-08-06 |
Genentech, Inc. |
G-protein coupled receptors in hedgehog signaling
|
ES2694857T3
(es)
|
2014-02-04 |
2018-12-27 |
Genentech, Inc. |
Smoothened mutante y métodos de uso de la misma
|
KR101605421B1
(ko)
|
2014-03-05 |
2016-03-23 |
국립암센터 |
B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
|
WO2015171918A2
(en)
|
2014-05-07 |
2015-11-12 |
Louisiana State University And Agricultural And Mechanical College |
Compositions and uses for treatment thereof
|
GB2526867A
(en)
|
2014-06-05 |
2015-12-09 |
Oxitec Ltd |
Gene expression system
|
EP3160503B1
(en)
|
2014-06-26 |
2021-02-17 |
The Trustees of Columbia University in the City of New York |
Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
|
EP3169310A1
(en)
|
2014-07-15 |
2017-05-24 |
Life Technologies Corporation |
Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
WO2016081728A1
(en)
|
2014-11-19 |
2016-05-26 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for frailty associated with aging
|
CN107531774B
(zh)
|
2015-02-06 |
2021-12-14 |
北卡罗来纳大学查珀尔希尔分校 |
优化的人类凝血因子viii基因表达盒及其用途
|
KR20190049940A
(ko)
|
2015-02-19 |
2019-05-09 |
화이자 인코포레이티드 |
나이세리아 메닌지티디스 조성물 및 그의 방법
|
MA41795A
(fr)
|
2015-03-18 |
2018-01-23 |
Sarepta Therapeutics Inc |
Exclusion d'un exon induite par des composés antisens dans la myostatine
|
MA50829A
(fr)
|
2015-06-01 |
2018-04-11 |
Sarepta Therapeutics Inc |
Exclusion d'exon induite pat technologie antisens dans le collagène de type vii
|
WO2017058881A1
(en)
|
2015-09-28 |
2017-04-06 |
The Trustees Of Columbia University In The City Of New York |
Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
|
US20190177723A1
(en)
|
2015-10-09 |
2019-06-13 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
WO2017062953A1
(en)
|
2015-10-10 |
2017-04-13 |
Intrexon Corporation |
Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
|
WO2017075670A1
(en)
|
2015-11-05 |
2017-05-11 |
Children's Hospital Los Angeles |
"mobilizing leukemia cells"
|
CN106699889A
(zh)
|
2015-11-18 |
2017-05-24 |
礼进生物医药科技(上海)有限公司 |
抗pd-1抗体及其治疗用途
|
US11534451B2
(en)
|
2015-12-23 |
2022-12-27 |
Repluca Pty Ltd |
Nucleic acid oligomers and uses therefor
|
AU2017213826A1
(en)
|
2016-02-04 |
2018-08-23 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
AU2017222450A1
(en)
|
2016-02-22 |
2018-09-27 |
The University Of North Carolina At Chapel Hill |
Peptide inhibitors of calcium channels
|
EA201892366A1
(ru)
|
2016-04-18 |
2019-03-29 |
Сарепта Терапьютикс, Инк. |
Антисмысловые олигомеры и способы их применения для лечения заболеваний, связанных с геном кислой альфа-глюкозидазы
|
BR112019002771A2
(pt)
|
2016-08-12 |
2019-05-14 |
Oxitec Ltd |
polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna.
|
MX2019005235A
(es)
|
2016-11-09 |
2019-12-05 |
Intrexon Corp |
Constructos de expresion de frataxina.
|
SG10202111092UA
(en)
|
2017-01-31 |
2021-11-29 |
Pfizer |
Neisseria meningitidis compositions and methods thereof
|
US10994025B2
(en)
|
2017-05-12 |
2021-05-04 |
Massachusetts Institute Of Technology |
Argonaute protein-double stranded RNA complexes and uses related thereto
|
US11999953B2
(en)
|
2017-09-13 |
2024-06-04 |
The Children's Medical Center Corporation |
Compositions and methods for treating transposon associated diseases
|
US11555189B2
(en)
|
2017-10-18 |
2023-01-17 |
Sarepta Therapeutics, Inc. |
Antisense oligomer compounds
|
KR101915949B1
(ko)
|
2018-01-09 |
2018-11-07 |
주식회사 쎌바이오텍 |
유전자 발현 카세트 및 그를 포함하는 발현벡터
|
AR117409A1
(es)
|
2018-03-29 |
2021-08-04 |
Oxitec Ltd |
Noctuidas autolimitantes
|
EP3772928A4
(en)
|
2018-04-06 |
2021-12-29 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
WO2020032784A1
(ko)
|
2018-08-10 |
2020-02-13 |
주식회사 유틸렉스 |
Hla-dr에 결합하는 키메라 항원 수용체 및 car-t 세포
|
PE20210980A1
(es)
|
2018-08-14 |
2021-06-01 |
Oxitec Ltd |
Autoseleccion de artropodos machos esteriles
|
AU2019406452B2
(en)
|
2018-12-21 |
2021-09-16 |
Ose Immunotherapeutics |
Humanized anti-human-PD-1 antibody
|
WO2020127373A1
(en)
|
2018-12-21 |
2020-06-25 |
Ose Immunotherapeutics |
Bifunctional anti-pd-1/sirpa molecule
|
CA3123338A1
(en)
|
2018-12-21 |
2020-06-25 |
Ose Immunotherapeutics |
Bifunctional anti-pd-1/il-7 molecule
|
EP3897845A1
(en)
|
2018-12-21 |
2021-10-27 |
OSE Immunotherapeutics |
Bifunctional molecule directed against human pd-1
|
WO2020165374A1
(en)
|
2019-02-14 |
2020-08-20 |
Ose Immunotherapeutics |
Bifunctional molecule comprising il-15ra
|
US20220175781A1
(en)
|
2019-03-08 |
2022-06-09 |
Obsidian Therapeutics, Inc. |
Cd40l compositions and methods for tunable regulation
|
EP3835421A1
(en)
|
2019-12-11 |
2021-06-16 |
Consejo Superior de Investigaciones Científicas (CSIC) |
Vectors for tissue specific transcriptomics
|
AU2021205416A1
(en)
|
2020-01-08 |
2022-08-25 |
Obsidian Therapeutics, Inc. |
Compositions and methods for tunable regulation of transcription
|
JP2023516767A
(ja)
|
2020-03-06 |
2023-04-20 |
広州明訊生物科技有限公司 |
動物の製造方法
|
EP4240408A1
(en)
|
2020-11-05 |
2023-09-13 |
Neoimmunetech, Inc. |
Method of treating a tumor with a combination of an il-7 protein and a nucleotide vaccine
|
EP4019539A1
(en)
|
2020-12-22 |
2022-06-29 |
Consejo Superior de Investigaciones Científicas (CSIC) |
Recombinant bacterium and uses thereof
|
WO2022226291A1
(en)
|
2021-04-22 |
2022-10-27 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating cancer
|