IL91850A - Preparations and methods for creating a seedling that stabilizes and breaks down within the body - Google Patents

Preparations and methods for creating a seedling that stabilizes and breaks down within the body

Info

Publication number
IL91850A
IL91850A IL9185089A IL9185089A IL91850A IL 91850 A IL91850 A IL 91850A IL 9185089 A IL9185089 A IL 9185089A IL 9185089 A IL9185089 A IL 9185089A IL 91850 A IL91850 A IL 91850A
Authority
IL
Israel
Prior art keywords
polymer
solvent
implant
liquid
biodegradable
Prior art date
Application number
IL9185089A
Other languages
English (en)
Hebrew (he)
Other versions
IL91850A0 (en
Original Assignee
Atrix Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrix Lab Inc filed Critical Atrix Lab Inc
Priority to IL10739389A priority Critical patent/IL107393A/en
Publication of IL91850A0 publication Critical patent/IL91850A0/xx
Priority to IL107393A priority patent/IL107393A0/xx
Publication of IL91850A publication Critical patent/IL91850A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0026—Sprayable compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0076—Sprayable compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A61F2002/30583—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with hardenable fluid, e.g. curable in-situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0085—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof hardenable in situ, e.g. epoxy resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
IL9185089A 1988-10-03 1989-09-29 Preparations and methods for creating a seedling that stabilizes and breaks down within the body IL91850A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL10739389A IL107393A (en) 1988-10-03 1989-09-29 Preparations and methods for creating a seedling that stabilizes and breaks down within the body
IL107393A IL107393A0 (en) 1988-10-03 1993-10-25 Compositions and methods for forming a biodegradable implant in-situ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07252645 US4938763B1 (en) 1988-10-03 1988-10-03 Biodegradable in-situ forming implants and method of producing the same

Publications (2)

Publication Number Publication Date
IL91850A0 IL91850A0 (en) 1990-06-10
IL91850A true IL91850A (en) 1995-03-30

Family

ID=22956926

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9185089A IL91850A (en) 1988-10-03 1989-09-29 Preparations and methods for creating a seedling that stabilizes and breaks down within the body

Country Status (17)

Country Link
US (7) US4938763B1 (de)
EP (2) EP0436667B1 (de)
JP (1) JP2992046B2 (de)
KR (1) KR0158669B1 (de)
AT (2) ATE151257T1 (de)
AU (1) AU666050B2 (de)
BR (1) BR8907686A (de)
CA (1) CA1340694C (de)
DE (3) DE68929441T2 (de)
DK (1) DK175906B1 (de)
HK (1) HK1005012A1 (de)
IL (1) IL91850A (de)
LU (1) LU91193I2 (de)
NL (1) NL300204I1 (de)
NO (2) NO304413B1 (de)
WO (1) WO1990003768A1 (de)
ZA (1) ZA897511B (de)

Families Citing this family (840)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
WO1990001969A1 (en) * 1988-08-24 1990-03-08 Slepian Marvin J Biodegradable polymeric endoluminal sealing
US5749915A (en) * 1988-08-24 1998-05-12 Focal, Inc. Polymeric endoluminal paving process
US5575815A (en) * 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5632727A (en) * 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5525348A (en) * 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
USRE37950E1 (en) 1990-04-24 2002-12-31 Atrix Laboratories Biogradable in-situ forming implants and methods of producing the same
NL9001428A (nl) * 1990-06-21 1992-01-16 Stichting Tech Wetenschapp Microporeuze buisvormige prothesen.
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
EP0489743A1 (de) * 1990-07-03 1992-06-17 Vipont Pharmaceutical, Inc. Intragingivale vorrichtung zur verabreichung von wirkstoffen zur behandlung paradontaler krankheiten
WO1992000747A1 (en) * 1990-07-12 1992-01-23 Sterilization Technical Services, Inc. Anti-thrombogenic and/or anti-microbial composition
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
WO1992019263A1 (en) 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
AU2605592A (en) 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5270047A (en) * 1991-11-21 1993-12-14 Kauffman Raymond F Local delivery of dipyridamole for the treatment of proliferative diseases
WO1993015787A1 (en) * 1992-02-12 1993-08-19 Chandler Jerry W Biodegradable stent
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
AU673160B2 (en) * 1992-02-28 1996-10-31 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
EP0560014A1 (de) * 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
US5370294A (en) * 1992-03-26 1994-12-06 Bauer; William Intranasal septal stapling device and method
US5540240A (en) * 1992-03-26 1996-07-30 Bauer; William Intranasal septal fastener driving method
FR2689400B1 (fr) * 1992-04-03 1995-06-23 Inoteb Materiau pour prothese osseuse contenant des particules de carbonate de calcium dispersees dans une matrice polymere bioresorbable.
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
NZ247712A (en) * 1992-06-19 1995-04-27 Colgate Palmolive Co Oral composition comprising an anti-bacterial compound, a water-insoluble biodegradable polymer, and an organic solvent
US5242910A (en) † 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5910520A (en) * 1993-01-15 1999-06-08 Mcneil-Ppc, Inc. Melt processable biodegradable compositions and articles made therefrom
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5800373A (en) * 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5749968A (en) * 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
WO1994021324A1 (en) * 1993-03-23 1994-09-29 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
US6004547A (en) 1997-09-29 1999-12-21 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
CA2123647C (en) * 1993-06-11 2007-04-17 Steven L. Bennett Bioabsorbable copolymer and coating composition containing same
US5925065A (en) * 1993-06-11 1999-07-20 United States Surgical Corporation Coated gut suture
US5425949A (en) * 1993-06-11 1995-06-20 United States Surgical Corporation Bioabsorbable copolymer and coating composition containing same
KR101222904B1 (ko) 1993-07-19 2013-01-17 안지오테크 파마슈티칼즈, 인코포레이티드 항맥관형성 조성물, 당해 조성물로 피복된 스텐트 및 당해 스텐트의 제조방법
JP3220331B2 (ja) * 1993-07-20 2001-10-22 エチコン・インコーポレーテツド 非経口投与用の吸収性液体コポリマー類
US6908910B2 (en) * 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
CA2128912A1 (en) * 1993-08-17 1995-02-18 Zygmunt Teodorczyk Modified phenol-aldehyde resin and binder system
US5468855A (en) * 1993-09-09 1995-11-21 Ciba-Geigy Corporation Bislactones
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5736160A (en) * 1993-10-28 1998-04-07 Thm Biomedical, Inc. Process and device for treating and healing a bone void
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
CA2140053C (en) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US6074840A (en) * 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US20020193338A1 (en) * 1994-02-18 2002-12-19 Goldstein Steven A. In vivo gene transfer methods for wound healing
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
ATE241394T1 (de) * 1994-04-08 2003-06-15 Atrix Lab Inc Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung
JP4259610B2 (ja) * 1994-04-08 2009-04-30 キューエルティー・ユーエスエイ・インコーポレーテッド 液体デリバリー組成物
US5556429A (en) * 1994-05-06 1996-09-17 Advanced Bio Surfaces, Inc. Joint resurfacing system
US20050043808A1 (en) * 1994-05-06 2005-02-24 Advanced Bio Surfaces, Inc. Knee joint prosthesis
US6140452A (en) * 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
DK63894A (da) * 1994-06-06 1996-01-08 Meadox Medicals Inc Kateter med stent samt fremgangsmåde til fremstilling af et sådant kateter med stent
US5665063A (en) * 1994-06-24 1997-09-09 Focal, Inc. Methods for application of intraluminal photopolymerized gels
US5531735A (en) * 1994-09-27 1996-07-02 Hercules Incorporated Medical devices containing triggerable disintegration agents
AU1287895A (en) * 1994-10-03 1996-04-26 Otogen Corporation Differentially biodegradable biomedical implants
US6335383B1 (en) 1994-10-18 2002-01-01 Ethicon, Inc. Microdispersions for coating surgical devices
US5599852A (en) 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
AU706434B2 (en) * 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
US5607686A (en) * 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US5550172A (en) * 1995-02-07 1996-08-27 Ethicon, Inc. Utilization of biocompatible adhesive/sealant materials for securing surgical devices
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
AU709527B2 (en) * 1995-03-23 1999-09-02 Board Of Regents, The University Of Texas System Redox and photoinitiator systems for priming for improved adherence of gels to substrates
EP0814774B1 (de) 1995-03-24 2005-10-19 Genzyme Corporation Verminderung von adhäsionen durch gesteuerte verabreichung von aktivsauerstoffinhibitoren
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6551610B2 (en) 1995-04-13 2003-04-22 Poly-Med, Inc. Multifaceted compositions for post-surgical adhesion prevention
US6413539B1 (en) 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
AU5069796A (en) * 1995-04-28 1996-11-07 Ethicon Inc. Solventless tipping of braided surgical ligature
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6413536B1 (en) * 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
ATE287673T1 (de) * 1995-06-07 2005-02-15 Southern Biosystems Inc Kontrolliertes zuführsystem mit einer flüssigkeit von hoher viskosität
US5722950A (en) * 1995-06-07 1998-03-03 Atrix Laboratories, Inc. Method for remote delivery of an aerosolized liquid
US5747058A (en) * 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5779673A (en) * 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
US5580568A (en) * 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
US5667767A (en) * 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
JPH11510837A (ja) 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
FR2741628B1 (fr) * 1995-11-29 1998-02-06 Centre Nat Rech Scient Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
US5997568A (en) * 1996-01-19 1999-12-07 United States Surgical Corporation Absorbable polymer blends and surgical articles fabricated therefrom
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US5702361A (en) 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
ES2180942T3 (es) * 1996-02-20 2003-02-16 Massachusetts Inst Technology Redes de polimeros biodegradables para su uso en aplicaciones ortopedicas y dentales.
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5921954A (en) * 1996-07-10 1999-07-13 Mohr, Jr.; Lawrence G. Treating aneurysms by applying hardening/softening agents to hardenable/softenable substances
US7022105B1 (en) * 1996-05-06 2006-04-04 Novasys Medical Inc. Treatment of tissue in sphincters, sinuses and orifices
IL118235A0 (en) * 1996-05-13 1996-09-12 Univ Ben Gurion Composition and method for forming biodegradable implants in situ and uses of these implants
DK0914102T3 (da) 1996-05-24 2006-01-09 Angiotech Pharm Inc Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler
US6103254A (en) * 1996-05-31 2000-08-15 Micro Therapeutics, Inc. Methods for sterilizing male mammals
WO1997045131A1 (en) 1996-05-31 1997-12-04 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US8353908B2 (en) 1996-09-20 2013-01-15 Novasys Medical, Inc. Treatment of tissue in sphincters, sinuses, and orifices
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
WO1998012274A1 (en) * 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5800412A (en) * 1996-10-10 1998-09-01 Sts Biopolymers, Inc. Hydrophilic coatings with hydrating agents
US6106473A (en) 1996-11-06 2000-08-22 Sts Biopolymers, Inc. Echogenic coatings
US7229413B2 (en) 1996-11-06 2007-06-12 Angiotech Biocoatings Corp. Echogenic coatings with overcoat
AU7178698A (en) * 1996-11-15 1998-06-03 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
ATE318580T1 (de) 1996-12-20 2006-03-15 Alza Corp Gelzusammensetzungen und verfahren
AU5522798A (en) 1996-12-31 1998-07-31 Kimberly-Clark Worldwide, Inc. Water-responsive polymer compositions and method of making the same
DE19701912C1 (de) * 1997-01-10 1998-05-14 Jenapharm Gmbh Injizierbares Implantat
US6338726B1 (en) 1997-02-06 2002-01-15 Vidacare, Inc. Treating urinary and other body strictures
US6630168B1 (en) * 1997-02-20 2003-10-07 Biomedicines, Inc. Gel delivery vehicles for anticellular proliferative agents
DE69832288T2 (de) * 1997-03-20 2006-07-13 Genzyme Corp., Cambridge Biologisch abbaubarer gewebespreizer
EP0975340B2 (de) 1997-03-31 2009-10-28 Boston Scientific Limited Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
KR20010020432A (ko) 1997-04-30 2001-03-15 토마스 씨. 서 폴리(고리지방족 포스포에스테르) 화합물로 이루어진 생분해성 조성물, 약품 및 그의 이용방법
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
AU8530498A (en) * 1997-06-05 1998-12-21 Roland Bodmeier Multiphase system
DE19724784A1 (de) * 1997-06-05 1998-12-10 Roland Prof Dr Bodmeier Verfahren zur in-situ Herstellung von Partikeln
WO1998055147A2 (en) 1997-06-06 1998-12-10 Battelle Memorial Institute Reversible geling co-polymer and method of making
US5962006A (en) * 1997-06-17 1999-10-05 Atrix Laboratories, Inc. Polymer formulation for prevention of surgical adhesions
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
WO1999006563A1 (en) 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
US5952433A (en) * 1997-07-31 1999-09-14 Kimberly-Clark Worldwide, Inc. Modified polyactide compositions and a reactive-extrusion process to make the same
US6552162B1 (en) 1997-07-31 2003-04-22 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable compositions and films and articles comprising a blend of polylactide and polyvinyl alcohol and methods for making the same
US6075118A (en) * 1997-07-31 2000-06-13 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable film compositions comprising polylactide and polyvinyl alcohol, and a method for making the films
US5945480A (en) * 1997-07-31 1999-08-31 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable fibers comprising polylactide modified polylactide and polyvinyl alcohol, and method for making the fibers
ZA987019B (en) * 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US9023031B2 (en) * 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
AUPO907697A0 (en) 1997-09-09 1997-10-02 Day, Robert Edward Chemical supplementation of bone
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US7637948B2 (en) * 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US6569417B2 (en) 1997-10-10 2003-05-27 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US6417247B1 (en) * 1997-10-14 2002-07-09 Beth L. Armstrong Polymer/ceramic composites
US6149931A (en) * 1997-10-27 2000-11-21 The Regents Of The University Of California Methods and pharmaceutical compositions for the closure of retinal breaks
US6193991B1 (en) 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
NZ330596A (en) 1998-06-05 2001-02-23 Dec Res Intravaginal devices allowing for increased uptake of active ingredients
CA2311311C (en) * 1997-11-21 2008-05-06 Interag Biodegradable intra vaginal devices
IL137388A (en) * 1998-01-29 2005-05-17 Poly Med Inc Absorbable microparticles
PL342135A1 (en) 1998-01-29 2001-05-21 Kinerton Ltd Method of obtaining absorbable microparticle
US20100114087A1 (en) * 1998-02-19 2010-05-06 Edwards Stuart D Methods and devices for treating urinary incontinence
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
US7128927B1 (en) 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
ATE281155T1 (de) * 1998-04-20 2004-11-15 Genzyme Corp Medikamentöse verabreichung von proteinen aus polymergemischen
US6177094B1 (en) 1998-04-30 2001-01-23 United States Surgical Corporation Bioabsorbable blends and coating composition containing same
US6350518B1 (en) 1998-06-01 2002-02-26 Kimberly-Clark Worldwide, Inc. Methods of making blend compositions of an unmodified poly vinyl alcohol and a thermoplastic elastomer
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
US6245345B1 (en) 1998-07-07 2001-06-12 Atrix Laboratories, Inc. Filamentous porous films and methods for producing the same
US6261583B1 (en) 1998-07-28 2001-07-17 Atrix Laboratories, Inc. Moldable solid delivery system
WO2000009199A1 (en) * 1998-08-14 2000-02-24 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6703047B2 (en) * 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
WO2000010568A1 (en) * 1998-08-24 2000-03-02 Draheim Susan E Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase a¿2?
US6419709B1 (en) * 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6565874B1 (en) 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US7767708B2 (en) * 1998-11-04 2010-08-03 Schering-Plough Animal Health Corp. Growth stimulant compositions
US6110484A (en) * 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
JP2002531217A (ja) * 1998-12-04 2002-09-24 チャンドラシェカー ピー． パサック， 生体適合性架橋ポリマー
US6200550B1 (en) 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
US6231613B1 (en) 1998-12-15 2001-05-15 Enteric Medical Technologies, Inc. Methods for soft tissue augmentation in mammals
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8498693B2 (en) * 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US20090030309A1 (en) * 2007-07-26 2009-01-29 Senorx, Inc. Deployment of polysaccharide markers
DE19908753C2 (de) * 1999-02-20 2003-10-02 Jenapharm Gmbh Bioabbaubare, injizierbare Oligomer-Polymer-Zusammensetzung
US6303100B1 (en) 1999-03-19 2001-10-16 Micro Therapeutics, Inc. Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms
US6203779B1 (en) 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
EP2305324B1 (de) * 1999-03-25 2014-09-17 Metabolix, Inc. Medizinische Geräte und Anwendungen aus Polyhydroxyalkanoat-Polymeren
US7341602B2 (en) * 1999-05-10 2008-03-11 Fell Barry M Proportioned surgically implantable knee prosthesis
US6206927B1 (en) 1999-04-02 2001-03-27 Barry M. Fell Surgically implantable knee prothesis
DE19916131A1 (de) * 1999-04-09 2000-10-26 S & C Polymer Silicon & Compos Adhesivsystem für Silicone
JP4558213B2 (ja) 1999-04-12 2010-10-06 コーネル・リサーチ・ファンデーション・インコーポレイテッド 疎水性および親水性の成分を有する水性ゲル形成システム
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
EP1173517A4 (de) * 1999-04-26 2006-06-28 California Inst Of Techn Hydrogele die sich in situ formen
US6858229B1 (en) 1999-04-26 2005-02-22 California Institute Of Technology In situ forming hydrogels
US6554851B1 (en) 1999-05-07 2003-04-29 Scimed Life Systems, Inc. Methods of sealing an injection site
US6866684B2 (en) 1999-05-10 2005-03-15 Barry M. Fell Surgically implantable knee prosthesis having different tibial and femoral surface profiles
US6966928B2 (en) 1999-05-10 2005-11-22 Fell Barry M Surgically implantable knee prosthesis having keels
US6923831B2 (en) * 1999-05-10 2005-08-02 Barry M. Fell Surgically implantable knee prosthesis having attachment apertures
US6855165B2 (en) * 1999-05-10 2005-02-15 Barry M. Fell Surgically implantable knee prosthesis having enlarged femoral surface
US6893463B2 (en) * 1999-05-10 2005-05-17 Barry M. Fell Surgically implantable knee prosthesis having two-piece keyed components
US6911044B2 (en) * 1999-05-10 2005-06-28 Barry M. Fell Surgically implantable knee prosthesis having medially shifted tibial surface
US6333020B1 (en) 1999-05-13 2001-12-25 Micro Therapeutics, Inc. Methods for treating AVM's using radio active compositions
US6241719B1 (en) 1999-05-13 2001-06-05 Micro Therapeutics, Inc. Method for forming a radioactive stent
US7018365B2 (en) 1999-05-21 2006-03-28 Micro Therapeutics, Inc. Threaded syringe with quick stop
US6645167B1 (en) 1999-05-21 2003-11-11 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an embolizing composition
EP1185223A1 (de) * 1999-05-21 2002-03-13 Micro Therapeutics, Inc. Verfahren zur in vivo verabreichung homogen dispergierter embolischer zusammensetzungen hoher viskosität
JP5148030B2 (ja) 1999-05-21 2013-02-20 タイコ ヘルスケア グループ リミテッド パートナーシップ 新規の高粘度塞栓形成組成物
EP1949890A3 (de) 1999-06-04 2011-05-18 ALZA Corporation Implantierbare Gelzusammensetzungen und Herstellungsverfahren dafür
EP1183010A2 (de) * 1999-06-04 2002-03-06 ALZA Corporation Implantierbare gel zusammensetzung und verfahren zur herstellung
DE60031114T2 (de) * 1999-06-11 2007-05-03 Cytyc Corp., Marlborough Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US6521431B1 (en) 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
US6541020B1 (en) * 1999-07-09 2003-04-01 Trimeris, Inc. Methods and compositions for administration of therapeutic reagents
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US7008635B1 (en) * 1999-09-10 2006-03-07 Genzyme Corporation Hydrogels for orthopedic repair
US7025980B1 (en) 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
US20020055708A1 (en) * 1999-09-24 2002-05-09 Peterson Kenneth R. Coupling syringe system and methods for obtaining a mixed composition
US8226598B2 (en) * 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US6420378B1 (en) 1999-10-15 2002-07-16 Supergen, Inc. Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
DK1229940T3 (da) * 1999-11-15 2014-08-18 Piramal Healthcare Canada Ltd Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6682754B2 (en) * 1999-11-24 2004-01-27 Willmar Poultry Company, Inc. Ovo delivery of an immunogen containing implant
WO2001041821A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
US20010037091A1 (en) * 1999-12-29 2001-11-01 Wironen John F. System for reconstituting pastes and methods of using same
PT1248596E (pt) * 2000-01-11 2007-06-21 Bertex Pharma Gmbh Kit para implantações contendo uma fase de veículo e um solvente
US7097855B1 (en) 2000-01-31 2006-08-29 Massachusetts Institute Of Technology Transdermal thermal polymerization
US6491672B2 (en) 2000-02-10 2002-12-10 Harmonia Medical Technologies, Inc. Transurethral volume reduction of the prostate (TUVOR)
FI20000317A (fi) * 2000-02-15 2001-08-16 Jvs Polymers Oy Biologisesti hajoava materiaali
AU4566001A (en) 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US6626945B2 (en) 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
US6632246B1 (en) 2000-03-14 2003-10-14 Chondrosite, Llc Cartilage repair plug
US7193007B2 (en) * 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
CA2427543A1 (en) * 2000-03-15 2004-11-02 Yu-Ling Cheng Thermally reversible implant and filler
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US6626870B1 (en) 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
US6566144B1 (en) 2000-03-27 2003-05-20 Atrix Laboratories Cover plate for use in lyophilization
EP1142596A1 (de) * 2000-04-03 2001-10-10 Universiteit Gent Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten
US6992065B2 (en) 2000-04-19 2006-01-31 Genentech, Inc. Sustained release formulations
US6550482B1 (en) * 2000-04-21 2003-04-22 Vascular Control Systems, Inc. Methods for non-permanent occlusion of a uterine artery
US6800671B1 (en) 2000-04-21 2004-10-05 Britesmile, Inc. Low peak exotherm curable compositions
US7018645B1 (en) * 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
WO2002000137A1 (en) * 2000-06-28 2002-01-03 Shukla Atul J Biodegradable vehicles and delivery systems of biologically active substances
BR0112109A (pt) * 2000-06-29 2007-05-29 Biosyntech Canada Inc composição e método para a correção e regeneração de cartilagem e outros tecidos
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
DE10037983B4 (de) * 2000-08-03 2006-04-13 Stefan Zikeli Polymerzusammensetzung und daraus hergestellter Formkörper mit einem Gehalt an Alkaloid
AU2001285488A1 (en) * 2000-08-28 2002-03-13 Advanced Bio Surfaces, Inc Method for mammalian joint resurfacing
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
DE10044545A1 (de) * 2000-09-05 2002-04-04 Roland Bodmeier Retardpartikeldispersion
ES2294026T3 (es) * 2000-09-06 2008-04-01 Ap Pharma, Inc. Polimeros degradables de poliacetal.
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
CA2423431A1 (en) * 2000-10-06 2002-04-11 Durect Corporation Devices and methods for management of inflammation
AU2001245283A1 (en) * 2000-10-11 2002-04-22 Micro Thereapeutics, Inc. Methods for treating aneurysms
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US6565601B2 (en) * 2000-11-15 2003-05-20 Micro Therapeutics, Inc. Methods for vascular reconstruction of diseased arteries
US6576226B1 (en) 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
WO2002041786A2 (en) * 2000-11-20 2002-05-30 Senorx, Inc. Tissue site markers for in vivo imaging
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US20020106406A1 (en) * 2000-12-08 2002-08-08 Mchugh Anthony J. Crystallizable/non-crystallizable polymer composites
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
CA2438047A1 (en) * 2001-02-14 2002-08-22 Hildegard M. Kramer Biocompatible fleece for hemostasis and tissue engineering
CA2439120C (en) * 2001-02-23 2011-07-05 Genentech, Inc. Erodible polymers for injection
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
AU2002256190A1 (en) * 2001-04-16 2002-10-28 Board Of Regents, The University Of Texas System Osteotropic biomaterials, methods of use thereof and implant systems incorporating the same
US7122523B2 (en) 2001-05-01 2006-10-17 University Of Southern California Methods for inhibiting tumor cell proliferation
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US7455657B2 (en) * 2001-06-19 2008-11-25 Boston Scientific Scimed, Inc Method and apparatus to modify a fluid using a selectively permeable membrane
ES2554106T3 (es) * 2001-06-21 2015-12-16 Genentech, Inc. Formulación de liberación sostenida
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
GB0116341D0 (en) * 2001-07-04 2001-08-29 Smith & Nephew Biodegradable polymer systems
US7342089B2 (en) * 2001-07-11 2008-03-11 Palatin Technologies, Inc. Cyclic peptides for treatment for cachexia
US7345144B2 (en) * 2001-07-11 2008-03-18 Palatin Technologies, Inc. Cyclic peptides for treatment of cachexia
US7105182B2 (en) 2001-07-25 2006-09-12 Szymaitis Dennis W Periodontal regeneration composition and method of using same
US20030026770A1 (en) * 2001-07-25 2003-02-06 Szymaitis Dennis W. Periodontal regeneration composition and method of using same
AU2002331064B2 (en) * 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US20030082235A1 (en) * 2001-08-13 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
US20080063620A1 (en) * 2001-08-13 2008-03-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
US20030060422A1 (en) 2001-08-31 2003-03-27 Balaji Venkataraman Tannate compositions and methods of treatment
US7081475B2 (en) 2001-09-14 2006-07-25 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same
US7309498B2 (en) * 2001-10-10 2007-12-18 Belenkaya Bronislava G Biodegradable absorbents and methods of preparation
WO2003037166A2 (en) * 2001-11-01 2003-05-08 Boyd Lawrence M Devices and methods for the restoration of a spinal disc
US7488320B2 (en) * 2001-11-01 2009-02-10 Renova Orthopedics, Llc Orthopaedic implant fixation using an in-situ formed anchor
US7799833B2 (en) * 2001-11-01 2010-09-21 Spine Wave, Inc. System and method for the pretreatment of the endplates of an intervertebral disc
WO2003041685A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Injectable depot composition
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
BR0206987A (pt) * 2001-11-14 2004-02-10 Alza Corp Composições de depósito injetáveis por cateter e usos destes
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
GB2399309A (en) * 2001-12-19 2004-09-15 Advanced Bio Surfaces Inc Bone smoothing method and system
CA2469734A1 (en) * 2002-01-14 2003-07-24 Micro Therapeutics, Inc. Methods for embolizing aneurysmal sites with a high viscosity embolizing composition
US20050058698A1 (en) * 2002-01-21 2005-03-17 Nolan Yvonne Mairead Pharmaceutically acceptable phosphate-glycerol carrying bodies and uses relating to Parkinson's Disease
US20040247641A1 (en) * 2002-01-22 2004-12-09 Felt Jeffrey C. Interpositional arthroplasty system & method
GB0202233D0 (en) * 2002-01-31 2002-03-20 Smith & Nephew Bioresorbable polymers
US8088388B2 (en) * 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
WO2003080629A2 (en) 2002-02-25 2003-10-02 Guilford Pharmaceuticals, Inc. Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
EP1478304A4 (de) * 2002-02-28 2006-02-15 Univ Wm Marsh Rice Vorgefertigter künstlich hergestellter gewebeplug
EP1344538A1 (de) * 2002-03-14 2003-09-17 Degradable Solutions AG Poröses und bioabbaubares Implantatmaterial und Verfahren zu seiner Herstellung
CA2479350A1 (en) * 2002-03-15 2003-09-25 Cypress Bioscience, Inc. Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes
WO2003080119A1 (en) * 2002-03-26 2003-10-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Responsive biomedical composites
US20030203000A1 (en) * 2002-04-24 2003-10-30 Schwarz Marlene C. Modulation of therapeutic agent release from a polymeric carrier using solvent-based techniques
US20030228365A1 (en) * 2002-06-07 2003-12-11 Fortuna Haviv Pharmaceutical formulation
US7432245B2 (en) * 2002-06-07 2008-10-07 Abbott Laboratories Inc. Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
US20030228366A1 (en) * 2002-06-11 2003-12-11 Chung Shih Reconstitutable compositions of biodegradable block copolymers
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20030232088A1 (en) * 2002-06-14 2003-12-18 Kimberly-Clark Worldwide, Inc. Materials with both bioadhesive and biodegradable components
US7037983B2 (en) * 2002-06-14 2006-05-02 Kimberly-Clark Worldwide, Inc. Methods of making functional biodegradable polymers
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AR039729A1 (es) 2002-06-25 2005-03-09 Alza Corp Formulaciones de deposito de corta duracion
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
DE60321683D1 (de) * 2002-07-11 2008-07-31 Advanced Bio Surfaces Inc Vorrichtung zur zwischenpositionierungs-arthroplastik
DK1380263T3 (da) * 2002-07-12 2007-12-27 Mycrona Ges Fuer Innovative Me Fremgangsmåde og indretning til bestemmelse af et undersögelsesobjekts faktiske position
CN1668276A (zh) * 2002-07-31 2005-09-14 阿尔萨公司 可注射的储库组合物及其用途
DE60325742D1 (de) 2002-07-31 2009-02-26 Alza Corp Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen
US7041111B2 (en) 2002-08-02 2006-05-09 Boston Scientific Scimed, Inc. Placing sutures
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US20040121010A1 (en) * 2002-10-25 2004-06-24 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
MXPA05004927A (es) * 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US20060036158A1 (en) 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
CN101797221B (zh) 2002-12-13 2013-06-12 杜雷科特公司 包含高粘度液体载体材料的口服递药系统
JP2006515008A (ja) * 2003-01-28 2006-05-18 コレギウム ファーマシューティカル， インコーポレイテッド 経口投与のためのミルナシプランの多粒子状組成物
WO2004071356A2 (en) * 2003-02-10 2004-08-26 Smith & Nephew, Inc. Resorbable devices
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US20050025707A1 (en) * 2003-02-27 2005-02-03 Patterson William R. Fumed silica embolic compositions
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
JP2007525429A (ja) * 2003-03-11 2007-09-06 キューエルティー ユーエスエー，インコーポレイテッド． 細胞スケジュール依存性抗癌剤のための処方
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
US20060076295A1 (en) * 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
EP1622691B1 (de) 2003-03-14 2011-05-25 The Trustees of Columbia University in the City of New York Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid-austauschvorrichtung
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
DE10314082A1 (de) * 2003-03-28 2004-10-21 Mcs Micro Carrier Systems Gmbh Biodegradierbares injizierbares Implantat
US8404269B2 (en) * 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
US20040202694A1 (en) * 2003-04-11 2004-10-14 Vascular Control Systems, Inc. Embolic occlusion of uterine arteries
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US8034270B2 (en) 2003-05-08 2011-10-11 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
IL155866A0 (en) * 2003-05-12 2003-12-23 Yissum Res Dev Co Responsive polymeric system
US20040247672A1 (en) * 2003-05-16 2004-12-09 Alkermes Controlled Therapeutics, Inc. Injectable sustained release compositions
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
MXPA05013003A (es) * 2003-05-30 2006-03-17 Alza Corp Composiciones de deposito elastomerico implantables, usos de las mismas y metodo para elaboracion.
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20060188573A1 (en) * 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
JP5229768B2 (ja) 2003-06-26 2013-07-03 シヴィダ・ユーエス・インコーポレイテッド Ｉｎ−Ｓｉｔｕゲル化薬物輸送システム
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
EP1651273B1 (de) * 2003-07-08 2012-08-29 Tepha, Inc. Poly-4-hydroxybutyrat-matrizes zur kontinuierlichen arzneistoffzuführung
CA2819769C (en) 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
JP2007503221A (ja) * 2003-08-22 2007-02-22 テファ， インコーポレイテッド ポリヒドロキシアルカノエート神経再生デバイス
US7141354B2 (en) * 2003-09-30 2006-11-28 Dai Nippon Printing Co., Ltd. Photo radical generator, photo sensitive resin composition and article
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US20050273002A1 (en) * 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US20050107867A1 (en) * 2003-11-17 2005-05-19 Taheri Syde A. Temporary absorbable venous occlusive stent and superficial vein treatment method
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US8673021B2 (en) 2003-11-26 2014-03-18 Depuy Mitek, Llc Arthroscopic tissue scaffold delivery device
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US20060003008A1 (en) * 2003-12-30 2006-01-05 Gibson John W Polymeric devices for controlled release of active agents
BRPI0418304A (pt) * 2004-01-07 2007-05-02 Trimeris Inc peptìdeo sintético, uso do mesmo, composição farmacêutica, seqüência de nucleotìdeos, e, métodos para inibição da transmissão de hiv para uma célula, para inibição da fusão de hiv, e para tratamento de um indivìduo infectado com hiv
EP1703915A2 (de) * 2004-01-13 2006-09-27 Vasogenix Pharmaceuticals, Inc. Verfahren zur verwendung von cgrp für kardiovaskuläre und renale indikationen
JP2007517912A (ja) * 2004-01-13 2007-07-05 バソジェニックス ファーマシューティカルズ， インコーポレイテッド 心脈管および腎臓の適応症のための制御放出ｃｇｒｐ送達組成物
CA2552758A1 (en) * 2004-01-13 2005-08-04 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same
US20050165487A1 (en) 2004-01-28 2005-07-28 Muhanna Nabil L. Artificial intervertebral disc
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
JP2007526085A (ja) * 2004-03-02 2007-09-13 ナノセラピューティクス・インコーポレイテッド 骨を修復するための組成物ならびにそのような組成物を調製および使用するための方法
MY144221A (en) * 2004-03-03 2011-08-15 Polynovo Biomaterials Pty Ltd Biocompatible polymer compositions for dual or multistaged curing.
US20050228433A1 (en) * 2004-03-16 2005-10-13 Weenna Bucay-Couto In situ implant and method of forming same
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
CA2563923A1 (en) * 2004-04-15 2005-10-27 The University Of Utah Research Foundation Biodegradable and biocompatible peg-based poly(ester-urethanes)
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8657881B2 (en) 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8163030B2 (en) * 2004-05-06 2012-04-24 Degradable Solutions Ag Biocompatible bone implant compositions and methods for repairing a bone defect
US20050255045A1 (en) * 2004-05-13 2005-11-17 Woltering Eugene A Surgical marking composition and method
WO2005115489A2 (en) * 2004-05-24 2005-12-08 Genzyme Corporation Adherent polymeric compositions
US8142462B2 (en) 2004-05-28 2012-03-27 Cavitech, Llc Instruments and methods for reducing and stabilizing bone fractures
WO2005121250A2 (en) * 2004-06-03 2005-12-22 Cornell Research Foundation, Inc. Unsaturated poly(ester-amide) biomaterials
US20110015367A1 (en) * 2004-06-03 2011-01-20 Cornell University Unsaturated poly(ester-amide) and poly(ether ester amide) biomaterials
US8236292B2 (en) 2004-06-04 2012-08-07 Camurus Ab Liquid depot formulations
US20050271727A1 (en) * 2004-06-07 2005-12-08 Callisyn Pharmaceuticals, Inc. Biodegradable and biocompatible crosslinked polymer hydrogel prepared from PVA and/or PEG macromer mixtures
EP1604693A1 (de) 2004-06-09 2005-12-14 Scil Technology GmbH In-situ hergestelltes Gerüst, dessen Herstellungsverfahren und dessen Verwendung
US20080280973A1 (en) * 2004-06-28 2008-11-13 Wender Paul A Laulimalide Analogues as Therapeutic Agents
WO2006004887A2 (en) 2004-06-29 2006-01-12 Spine Wave, Inc. Methods for treating defects and injuries of an intervertebral disc
EP1773358A2 (de) * 2004-06-29 2007-04-18 BioCure, Inc. Biologisches material
JP5371426B2 (ja) 2004-07-09 2013-12-18 プロルックス ファーマシューティカルズ コープ． ワートマニン類似体及び化学療法薬と組み合わせた同一物を使用する方法
BRPI0513243B8 (pt) * 2004-07-12 2021-05-25 Allergan Inc composições oftálmicas e respectivos usos
ATE372772T1 (de) 2004-07-13 2007-09-15 Schering Oy Retardiertes freigabesystem mit kontrollierter initialabgabe
PT1778305E (pt) * 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
MX2007001760A (es) * 2004-08-12 2007-07-24 Quest Pharmaceutical Services Composiciones farmaceuticas para la distribucion de liberacion controlada de compuestos biologicamente activos.
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
EP1796693A2 (de) * 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantierbare gewebezusammensetzungen und verfahren
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
US20060052822A1 (en) * 2004-08-31 2006-03-09 Mirizzi Michael S Apparatus and material composition for permanent occlusion of a hollow anatomical structure
US20060045902A1 (en) * 2004-09-01 2006-03-02 Serbousek Jon C Polymeric wrap for in vivo delivery of osteoinductive formulations
US7754233B2 (en) * 2004-09-03 2010-07-13 Ethicon, Inc. Method of preventing post-operative surgical adhesion
US8440215B2 (en) 2004-09-03 2013-05-14 Ethicon, Inc. Absorbable polymer formulations
US20060057184A1 (en) * 2004-09-16 2006-03-16 Nycz Jeffrey H Process to treat avascular necrosis (AVN) with osteoinductive materials
SI2767292T1 (sl) 2004-09-17 2017-01-31 Durect Corporation Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem
US20060074422A1 (en) * 2004-09-27 2006-04-06 Story Brooks J Suture anchor and void filler combination
EP1804717A4 (de) 2004-09-28 2015-11-18 Atrium Medical Corp Arzneiabgabebeschichtung zur verwendung mit einem stent
EP1812022B1 (de) 2004-09-28 2014-01-15 Atrium Medical Corporation Alleinstehende folie und verfahren zu ihrer herstellung
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2006041942A2 (en) * 2004-10-04 2006-04-20 Qlt Usa, Inc. Ocular delivery of polymeric delivery formulations
US8313763B2 (en) * 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
BRPI0518383A2 (pt) 2004-10-25 2008-11-18 Polyzenix Gmbh partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
DK1824460T3 (en) 2004-11-10 2015-01-19 Tolmar Therapeutics Inc Stabilized polymeric delivery system
EP1827377B1 (de) * 2004-12-14 2008-03-19 Novartis AG In-situ-erzeugung eines implantats für tiere
TWI369218B (en) * 2004-12-14 2012-08-01 Novartis Ag In situ forming implant for animals
US20060282169A1 (en) * 2004-12-17 2006-12-14 Felt Jeffrey C System and method for upper extremity joint arthroplasty
US20060141040A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
CA2585417A1 (en) * 2005-01-08 2006-07-13 Alphaspine, Inc. Modular disc device
US7728097B2 (en) * 2005-01-10 2010-06-01 Ethicon, Inc. Method of making a diisocyanate terminated macromer
US20070167617A1 (en) * 2006-01-17 2007-07-19 Fitz Benjamin D Method of making a diisocyanate terminated macromer
US20060153796A1 (en) * 2005-01-10 2006-07-13 Fitz Benjamin D Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US7968668B2 (en) 2005-01-10 2011-06-28 Ethicon Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US8470954B2 (en) 2005-01-10 2013-06-25 Ethicon, Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US9649382B2 (en) 2005-01-14 2017-05-16 Camurus Ab Topical bioadhesive formulations
US8871712B2 (en) * 2005-01-14 2014-10-28 Camurus Ab Somatostatin analogue formulations
US8920782B2 (en) 2005-01-14 2014-12-30 Camurus Ab Topical bioadhesive formulations
CA2595385C (en) 2005-01-21 2011-01-25 Camurus Ab Pharmaceutical lipid compositions
US7972354B2 (en) 2005-01-25 2011-07-05 Tyco Healthcare Group Lp Method and apparatus for impeding migration of an implanted occlusive structure
DE602006016915D1 (de) * 2005-01-28 2010-10-28 Tepha Inc Embolisierung unter verwendung von poly-4-hydroxybutyrat-partikeln
US8137664B2 (en) * 2005-02-02 2012-03-20 Sdgi Holdings, Inc. Method and kit for repairing a defect in bone
US7611494B2 (en) * 2005-02-08 2009-11-03 Confluent Surgical, Inc. Spray for fluent materials
JP2008530305A (ja) * 2005-02-09 2008-08-07 タイコ ヘルスケア グループ エルピー 合成封止剤
EP1848489A2 (de) * 2005-02-16 2007-10-31 Cytori Therapeutics, Inc. Resorbierbare hohle vorrichtungen zur implantation und freisetzung therapeutischer mittel
CA2498623A1 (en) * 2005-02-18 2006-08-18 Qlt Inc. Treatment of onychomycosis
US20060189958A1 (en) * 2005-02-21 2006-08-24 Talton James D Inverted cannula for use in reconstituting dry material in syringes
US7851189B2 (en) * 2005-03-07 2010-12-14 Boston Scientific Scimed, Inc. Microencapsulated compositions for endoluminal tissue engineering
US7267690B2 (en) * 2005-03-09 2007-09-11 Vertebral Technologies, Inc. Interlocked modular disc nucleus prosthesis
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US10357328B2 (en) * 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US20060242562A1 (en) * 2005-04-22 2006-10-26 Microsoft Corporation Embedded method for embedded interaction code array
US9119901B2 (en) * 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
WO2006125074A1 (en) * 2005-05-17 2006-11-23 Brown University Research Foundation Drug delivery formulations for targeted delivery
JP5259392B2 (ja) * 2005-05-31 2013-08-07 ウォーソー・オーソペディック・インコーポレーテッド 疼痛を治療するための組成物および方法
WO2006131730A1 (en) * 2005-06-06 2006-12-14 Camurus Ab Glp-1 analogue formulations
US7727235B2 (en) * 2005-06-29 2010-06-01 Ethicon, Inc. Medical fixation devices with improved torsional drive head
WO2007009683A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1743638A1 (de) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmazeutische Formulierungen von substituierten Pyrazolinderivaten
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
AU2006278328A1 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
EP1919561A1 (de) 2005-08-08 2008-05-14 Cytyc Corporation Abstandsverfahren für anschwellende haut
AU2006281248A1 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc High strength devices and composites
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
GB0517674D0 (en) * 2005-08-31 2005-10-05 Astrazeneca Ab Formulation
GB0517673D0 (en) * 2005-08-31 2005-10-05 Astrazeneca Ab Formulation
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
US8574627B2 (en) 2006-11-06 2013-11-05 Atrium Medical Corporation Coated surgical mesh
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
US9278161B2 (en) * 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8052658B2 (en) 2005-10-07 2011-11-08 Bard Peripheral Vascular, Inc. Drug-eluting tissue marker
JP2009511190A (ja) 2005-10-13 2009-03-19 エンドルミナル セラピューティクス， インコーポレイテッド チャネルによる壁内治療
EA015860B1 (ru) 2005-10-13 2011-12-30 Хьюман Дженом Сайенсиз, Инк. Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа
CA2626030A1 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
US20070100449A1 (en) * 2005-10-31 2007-05-03 O'neil Michael Injectable soft tissue fixation technique
EP1948810A4 (de) * 2005-11-04 2010-06-30 Biosyntech Canada Inc Zusammensetzung und verfahren zur effizienten verabreichung von nukleinsäuren in zellen mithilfe von chitosan
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US7754826B1 (en) * 2005-11-15 2010-07-13 Clemson University Copolymers from lactide
EP1948271B1 (de) 2005-11-17 2013-10-02 Zogenix, Inc. Abgabe von viskosen formulierungen durch nadellose injektion
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
WO2007084460A2 (en) * 2006-01-18 2007-07-26 Qps, Llc Pharmaceutical compositions with enhanced stability
NZ570300A (en) 2006-02-02 2011-08-26 Trimeris Inc HIV fusion inhibitor peptides with improved biological properties
US8673398B2 (en) * 2006-02-23 2014-03-18 Meadwestvaco Corporation Method for treating a substrate
WO2007103276A2 (en) 2006-03-03 2007-09-13 Smith & Nephew, Inc. Systems and methods for delivering a medicament
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
WO2007115182A2 (en) * 2006-03-30 2007-10-11 Palatin Technologies, Inc. Linear natriuretic peptide constructs
US8580746B2 (en) 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
WO2007115175A2 (en) * 2006-03-30 2007-10-11 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
US9017361B2 (en) 2006-04-20 2015-04-28 Covidien Lp Occlusive implant and methods for hollow anatomical structure
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
WO2007137245A2 (en) 2006-05-22 2007-11-29 Columbia University Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
EP1872807A1 (de) * 2006-06-30 2008-01-02 Scil Technology GmbH Durch Polymere gegen Abbau stabilisiertes Biomaterial
WO2008008363A1 (en) * 2006-07-11 2008-01-17 Qps, Llc Pharmaceutical compositions for sustained release delivery of peptides
EP3061791B1 (de) 2006-07-20 2019-01-16 OrbusNeich Medical, Inc. Bioresorbierbare polymerzusammensetzung für eine medizinische vorrichtung
US20090171198A1 (en) * 2006-08-04 2009-07-02 Jones Michael L Powdered marker
US7945307B2 (en) * 2006-08-04 2011-05-17 Senorx, Inc. Marker delivery system with obturator
US8129445B2 (en) * 2006-08-09 2012-03-06 Ethicon, Inc. Moisture activated latent curing adhesive or sealant
US7947758B2 (en) * 2006-08-09 2011-05-24 Ethicon, Inc. Moisture activated latent curing adhesive or sealant
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
US20080058954A1 (en) * 2006-08-22 2008-03-06 Hai Trieu Methods of treating spinal injuries using injectable flowable compositions comprising organic materials
WO2008027557A2 (en) * 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
US8076448B2 (en) * 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
US8691321B2 (en) 2006-10-20 2014-04-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US8064987B2 (en) 2006-10-23 2011-11-22 C. R. Bard, Inc. Breast marker
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US20080102097A1 (en) * 2006-10-31 2008-05-01 Zanella John M Device and method for treating osteolysis using a drug depot to deliver an anti-inflammatory agent
ES2388355T3 (es) 2006-11-03 2012-10-11 Durect Corporation Sistemas de suministro transdémico que comprenden bupivacaína
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
JP5489719B2 (ja) 2006-11-17 2014-05-14 スパーナス ファーマシューティカルズ インコーポレイテッド トピラマートの徐放性配合物
US9737414B2 (en) 2006-11-21 2017-08-22 Vertebral Technologies, Inc. Methods and apparatus for minimally invasive modular interbody fusion devices
JP2010511751A (ja) 2006-11-30 2010-04-15 スミス アンド ネフュー インコーポレーテッド 繊維強化複合材料
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20080140106A1 (en) * 2006-12-12 2008-06-12 Kimberly-Clark Worldwide, Inc. Enhanced cuff sealing for endotracheal tubes
EP3542748B1 (de) 2006-12-12 2023-08-16 C. R. Bard, Inc. Gewebemarker mit mehreren bildgebungsmodi
ES2432572T3 (es) 2006-12-18 2013-12-04 C.R. Bard, Inc. Marcador de biopsia con propiedades de obtención de imágenes generadas in situ
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
FI3660073T3 (fi) 2007-02-15 2023-09-11 Tolmar International Ltd Matalan purskeen poly(laktidi-ko-glykolidi)
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
MX2009010689A (es) * 2007-04-03 2009-12-14 Trimeris Inc Formulaciones novedosas para el suministro de agentes terapeuticos de peptidos antivirales.
EP2142353A1 (de) * 2007-04-18 2010-01-13 Smith & Nephew PLC Expansionsformen von formgedächtnis-polymeren
WO2008130954A2 (en) * 2007-04-19 2008-10-30 Smith & Nephew, Inc. Graft fixation
WO2008131197A1 (en) 2007-04-19 2008-10-30 Smith & Nephew, Inc. Multi-modal shape memory polymers
AU2008255048B2 (en) 2007-05-15 2014-05-01 Barry M. Fell Surgically implantable knee prosthesis with captured keel
EP3115038A1 (de) 2007-05-18 2017-01-11 DURECT Corporation Verbesserte depot-formulierungen
EP2164405A2 (de) 2007-05-21 2010-03-24 AOI Medical Inc. Gelenkige kavitationsvorrichtung
CN101801415B (zh) 2007-05-25 2015-09-23 Rb医药品有限公司 利培酮化合物的持续递送制剂
CN201075472Y (zh) * 2007-05-28 2008-06-18 富士康(昆山)电脑接插件有限公司 电连接器
WO2008144881A1 (en) * 2007-05-28 2008-12-04 Genesis Group Inc. Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
GB0711656D0 (en) 2007-06-15 2007-07-25 Camurus Ab Formulations
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US20090149569A1 (en) * 2007-07-19 2009-06-11 Shastri V Prasad Surface engineering of tissue graft materials for enhanced porosity and cell adhesion
US7850453B2 (en) * 2007-08-08 2010-12-14 Coll Partners Ltd. Reshapable device for fixation at a dental site
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
GB0716385D0 (en) 2007-08-22 2007-10-03 Camurus Ab Formulations
CA2698580C (en) * 2007-09-07 2016-10-11 Qlt Plug Delivery, Inc. Lacrimal implant detection
JP2010540528A (ja) * 2007-09-25 2010-12-24 トリメリス，インコーポレーテッド 治療的抗ウイルス性ペプチドの新規合成方法
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8703119B2 (en) * 2007-10-05 2014-04-22 Polygene Ltd. Injectable biodegradable polymer compositions for soft tissue repair and augmentation
EP2052716B1 (de) 2007-10-24 2014-12-31 Camurus AB Formulierungen mit gesteuerter Freisetzung
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
EP2219620B1 (de) * 2007-11-13 2017-07-19 Surmodics, Inc. Viskose terpolymere als arzneiabgabe-plattform
AT506168B1 (de) * 2007-11-23 2012-02-15 Univ Wien Tech Verwendung von zusammensetzungen zur herstellung biologisch abbaubarer, bioverträglicher, vernetzter polymere auf basis von polyvinylalkohol
AU2008347158B8 (en) 2007-12-06 2013-08-22 Durect Corporation Oral pharmaceutical dosage forms
CA2710515A1 (en) * 2007-12-28 2009-07-09 Khashayar Kevin Neshat Controlled release local anesthetic for post dental surgery and method of use
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
SG10201906494PA (en) 2008-01-30 2019-09-27 Histogen Inc Extracellular matrix compositions
US8311610B2 (en) * 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
BRPI0907473A2 (pt) 2008-02-04 2019-09-24 Univ Columbia métodos, sistemas e dispositivos de separação de fluidos
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
US9107815B2 (en) 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
US8324292B2 (en) * 2008-02-29 2012-12-04 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
US8071663B2 (en) * 2008-02-29 2011-12-06 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
US8745133B2 (en) * 2008-03-28 2014-06-03 Yahoo! Inc. System and method for optimizing the storage of data
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
KR20130097813A (ko) 2008-04-21 2013-09-03 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
CN102014625A (zh) 2008-04-28 2011-04-13 佐吉尼克斯股份有限公司 用于治疗偏头痛的新制剂
EP2285312A4 (de) * 2008-05-01 2014-03-12 Columna Pty Ltd Systeme, verfahren und geräte zur bildung und einführung von gewebeprothesen
KR101534422B1 (ko) 2008-05-14 2015-07-09 오토노미, 인코포레이티드 귀 질환 치료를 위한 제어 방출형 코르티코스테로이드 조성물 및 방법
WO2009142741A1 (en) * 2008-05-21 2009-11-26 Theraject, Inc. Method of manufacturing solid solution peforator patches and uses thereof
US8877225B2 (en) * 2008-06-03 2014-11-04 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
EP2293784B1 (de) 2008-06-03 2016-04-13 Indivior UK Limited Fliessfähige zubereitungsform aus einem dehydrierten hydrogel und einem einschlusskomplex einer bioaktiven verbindung
RU2513142C2 (ru) 2008-06-12 2014-04-20 Медтроник Ксомед Инк. Способ лечения хронических ран
BRPI0916761A2 (pt) 2008-07-17 2018-02-14 Ap Pharma formulações analgésicas injetáveis de ação prolongada para animais
AU2009274229B2 (en) 2008-07-21 2013-08-22 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
BRPI0916557A2 (pt) 2008-07-30 2020-08-04 Mesynthes Limited arcabouços de tecido derivado da matriz extracelular do pré-estômago
US9271706B2 (en) * 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
CA2756573A1 (en) 2008-08-19 2010-02-25 Micro Therapeutics, Inc. Detachable tip microcatheter
GB0815435D0 (en) 2008-08-22 2008-10-01 Camurus Ab Formulations
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
EP2341923A2 (de) * 2008-09-26 2011-07-13 Saumya Sharma Pharmazeutische zusammensetzung mit coenzym q10
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9889230B2 (en) * 2008-10-17 2018-02-13 Covidien Lp Hemostatic implant
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
JP5611967B2 (ja) 2008-11-11 2014-10-22 シグナム バイオサイエンシーズ， インコーポレイテッド イソプレニル化合物およびその方法。
US8822546B2 (en) * 2008-12-01 2014-09-02 Medtronic, Inc. Flowable pharmaceutical depot
WO2010065801A1 (en) 2008-12-04 2010-06-10 Palatin Technologies, Inc. Amine substituted piperazine melanocortin receptor-specific compounds
WO2010065802A2 (en) 2008-12-04 2010-06-10 Palatin Technologies, Inc. Substituted pyrrolidine or imidazolidine melanocortin receptor-specific compounds
WO2010065799A2 (en) 2008-12-04 2010-06-10 Palatin Technologies, Inc. Amine substituted piperidine melanocortin receptor-specific compounds
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8951546B2 (en) 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US8670818B2 (en) * 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US8469779B1 (en) 2009-01-02 2013-06-25 Lifecell Corporation Method for debristling animal skin
WO2010079340A2 (en) 2009-01-08 2010-07-15 Eisai R & D Management Co., Ltd. Assay
EP2601934A1 (de) 2009-01-22 2013-06-12 Ludwig-Maximilians-Universität München Vesikuläre Phospholipid-Gele mit proteinösen Substanzen
US20100204570A1 (en) * 2009-02-06 2010-08-12 Paul Lubock Anchor markers
EP2396035A4 (de) 2009-02-12 2012-09-12 Human Genome Sciences Inc Verwendung von antagonisten des b-lymphozyten-stimulatorproteins zur förderung von transplantationstoleranz
EP2396070A4 (de) 2009-02-12 2012-09-19 Incept Llc Wirkstofffreisetzung mit hydrogel-plugs
WO2010094032A2 (en) 2009-02-16 2010-08-19 Aoi Medical Inc. Trauma nail accumulator
EP2223707B1 (de) * 2009-02-26 2014-04-09 New Dent AG Implantatsystem und Knochenimplantat
US8383140B2 (en) 2009-04-03 2013-02-26 Poly-Med, Inc. Absorbable crystalline copolyester-based bioactive hydroforming luminal liner compositions
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
AU2010246115A1 (en) * 2009-05-04 2011-12-08 Incept. Llc Biomaterials for track and puncture closure
CN102458436B (zh) 2009-06-08 2015-06-03 帕拉丁科技公司 黑皮质素受体特异性肽
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
US20110015672A1 (en) * 2009-07-17 2011-01-20 Tyco Healthcare Group Lp Method for Coating a Medical Device
US9200112B2 (en) 2009-08-10 2015-12-01 Ethicon, Inc. Semi-crystalline, fast absorbing polymer formulation
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
FR2949687B1 (fr) * 2009-09-04 2011-09-23 Sofradim Production Tissu avec picots revetus d'un materiau hydrosoluble
US8470355B2 (en) * 2009-10-01 2013-06-25 Covidien Lp Mesh implant
US8138236B2 (en) * 2009-10-29 2012-03-20 Ethicon, Inc. Solvent-free moisture activated latent curing surgical adhesive or sealant
US9044524B2 (en) * 2009-10-30 2015-06-02 Ethicon, Inc. Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants
AU2010314992B2 (en) 2009-11-09 2016-09-15 Spotlight Technology Partners Llc Polysaccharide based hydrogels
CA2780274C (en) 2009-11-09 2018-06-26 Spotlight Technology Partners Llc Fragmented hydrogels
JP5661117B2 (ja) 2009-11-12 2015-01-28 シグナム バイオサイエンシーズ， インコーポレイテッド 上皮関連の状態を処置するための抗菌剤の使用
EP2512540B1 (de) 2009-12-15 2019-08-07 Incept, LLC Implantate und biologisch abbaubare bezugsmarkierungen
GB0922438D0 (en) 2009-12-22 2010-02-03 Ucl Business Plc Agents having tissue generative activity
US20110218606A1 (en) * 2010-03-02 2011-09-08 Medtronic Vascular, Inc. Methods for Stabilizing Femoral Vessels
WO2011146614A1 (en) * 2010-05-19 2011-11-24 Transmed7, Llc Methods and apparatus for in situ formation of surgical implants
AU2011254206B2 (en) 2010-05-20 2015-06-25 Ecolab Usa Inc. Rheology modified low foaming liquid antimicrobial compositions and methods of use thereof
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
EP2394664B1 (de) 2010-05-31 2016-06-01 Laboratorios Farmaceuticos Rovi, S.A. Zusammensetzungen für injizierbare, in-situ biologisch abbaubare Implantate
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
PL2394663T3 (pl) 2010-05-31 2022-02-21 Laboratorios Farmaceuticos Rovi, S.A. Kompozycje do wstrzykiwania implantów biodegradowalnych in-situ
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481018B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
US9364518B2 (en) 2010-06-24 2016-06-14 Torrent Pharmaceuticals Limited Pharmaceutical composition containing goserelin for in-situ implant
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
EP2593141B1 (de) 2010-07-16 2018-07-04 Atrium Medical Corporation Zusammensetzung und verfahren zur veränderung der geschwindigkeit einer hydrolyse ausgehärteter materialien auf ölbasis
CA2809825A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Biodegradable terpolymers and terpolymer blends as pressure-sensitive adhesives
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
WO2015095745A1 (en) 2010-10-20 2015-06-25 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US20120101593A1 (en) * 2010-10-20 2012-04-26 BIOS2 Medical, Inc. Implantable polymer for bone and vascular lesions
US8740982B2 (en) * 2010-10-26 2014-06-03 Kyphon Sarl Devices containing a chemonucleolysis agent and methods for treating an intervertebral disc or spinal arachnoiditis
US9414930B2 (en) * 2010-10-26 2016-08-16 Kyphon SÀRL Activatable devices containing a chemonucleolysis agent
US9023897B2 (en) 2010-12-29 2015-05-05 Medincell Biodegradable drug delivery compositions
US9084602B2 (en) 2011-01-26 2015-07-21 Covidien Lp Buttress film with hemostatic action for surgical stapling apparatus
US9447187B2 (en) 2011-02-03 2016-09-20 Alexion Pharmaceuticals, Inc. Use of an anti-CD200 antibody for prolonging the survival of allografts
BR112013026200A2 (pt) 2011-04-14 2019-08-27 Lifecell Corp método para preparar uma composição de matriz de tecido, e matriz de tecido
US20130040923A1 (en) 2011-05-13 2013-02-14 Trimel Pharmaceuticals Corporation Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
AR082266A1 (es) 2011-05-13 2012-11-28 Univ Nac Del Litoral Microparticula inyectable de liberacion controlada
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
WO2012177759A1 (en) 2011-06-20 2012-12-27 Rdc Holdings, Llc System and method for repairing joints
US8998925B2 (en) 2011-06-20 2015-04-07 Rdc Holdings, Llc Fixation system for orthopedic devices
WO2013003157A1 (en) 2011-06-28 2013-01-03 Yale University Cell-free tissued engineered vascular grafts
US9089523B2 (en) 2011-07-28 2015-07-28 Lifecell Corporation Natural tissue scaffolds as tissue fillers
WO2013032784A1 (en) 2011-08-30 2013-03-07 Mayo Foundation For Medical Education And Research Natriuretic polypeptides
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
DE102011114986A1 (de) * 2011-09-28 2013-03-28 Ethris Gmbh Sprühsystem
US8586527B2 (en) 2011-10-20 2013-11-19 Jaipal Singh Cerivastatin to treat pulmonary disorders
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CA2856722C (en) 2011-11-30 2022-11-22 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
CA2858161C (en) 2011-12-05 2020-03-10 Incept, Llc Medical organogel processes and compositions
EP2787975B1 (de) 2011-12-05 2017-10-04 Camurus AB Robuste formulierungen mit gesteuerter freisetzung
US9115066B2 (en) 2011-12-14 2015-08-25 Indicator Systems International, Inc. Trisubstituted methyl alcohols and their polymerizable derivatives
US9532863B2 (en) 2011-12-20 2017-01-03 Lifecell Corporation Sheet tissue products
WO2013096252A1 (en) 2011-12-20 2013-06-27 Lifecell Corporation Flowable tissue products
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
CN104736158A (zh) 2012-01-23 2015-06-24 萨奇治疗股份有限公司 神经活性类固醇制剂和治疗中枢神经系统障碍的方法
EP3461508A1 (de) 2012-01-24 2019-04-03 LifeCell Corporation Längliche gewebematrizen
EP2819620A4 (de) 2012-02-29 2015-11-04 206 Ortho Inc Verfahren und vorrichtung zur behandlung von knochenbrüchen unter verwendung von zusammengesetzten implantaten
WO2013138340A1 (en) 2012-03-13 2013-09-19 Tensive Controls Inc. Melanocortin analogs having enhanced activity and transport
US9510953B2 (en) 2012-03-16 2016-12-06 Vertebral Technologies, Inc. Modular segmented disc nucleus implant
US8403927B1 (en) 2012-04-05 2013-03-26 William Bruce Shingleton Vasectomy devices and methods
US8753643B1 (en) 2012-04-11 2014-06-17 Life-Science Innovations, Llc Spray dried compositions and methods of use
AU2013251800B2 (en) 2012-04-24 2016-09-29 Lifecell Corporation Flowable tissue matrices
NL2008861C2 (en) * 2012-05-23 2013-11-26 Urogyn B V Composition for soft tissue treatment.
AU2013265210B2 (en) 2012-05-25 2016-09-15 Camurus Ab Somatostatin receptor agonist formulations
CA2875964C (en) 2012-06-07 2018-01-02 Georgia State University Research Foundation, Inc. Seca inhibitors and methods of making and using thereof
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
EP2872191B1 (de) 2012-07-13 2019-08-07 LifeCell Corporation Verfahren zur behandlung von adipösem gewebe
EP2877155B1 (de) 2012-07-26 2020-10-28 Camurus AB Opioid-formulierungen
RU2667010C2 (ru) 2012-08-21 2018-09-13 Сейдж Терапьютикс, Инк. Способы лечения эпилепсии или эпилептического статуса
CA2885327A1 (en) 2012-09-26 2014-04-03 Lifecell Corporation Processed adipose tissue
CN111529535A (zh) 2012-09-27 2020-08-14 儿童医学中心公司 用于治疗肥胖症的化合物和其使用方法
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
WO2014123703A1 (en) 2013-02-06 2014-08-14 Lifecell Corporation Methods for localized modification of tissue products
CN109602692B (zh) 2013-03-11 2022-11-04 度瑞公司 包含高粘度液体载体的可注射控制释放组合物
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
US10624865B2 (en) * 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event
WO2014144975A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
EP2981305B1 (de) 2013-04-04 2019-06-12 The Arizona Board of Regents on behalf of the University of Arizona Materialien, systeme, vorrichtungen und verfahren für endoluminale elektropolymere pflasterung und versiegelung
EP3795635A1 (de) 2013-05-23 2021-03-24 206 ORTHO, Inc. Vorrichtung zur behandlung von knochenbrüchen und/oder zur stärkung und/oder vermehrung von knochen einschliesslich der bereitstellung und verwendung zusammengesetzter implantate
CN105682742A (zh) 2013-08-27 2016-06-15 奥德纳米有限公司 小儿耳部病症的治疗
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby
US9668844B2 (en) 2013-11-06 2017-06-06 Colldent Y.A Ltd Device for fixation at a dental site
JP6672157B2 (ja) 2013-11-26 2020-03-25 ザ チルドレンズ メディカル センター コーポレーション 肥満を処置するための化合物およびその使用方法
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CA2935311C (en) * 2013-12-31 2018-11-27 Pb&B Sa Controlled release fatty acid compositions for use in body reconstruction and body-shaping
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
CN111620830A (zh) 2014-03-14 2020-09-04 北卡罗来纳大学教堂山分校 用于抑制雄性生育力的小分子
US20170209408A1 (en) 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
EP3157408A4 (de) 2014-06-17 2018-03-07 Ganiban, Gary Vorrichtungen und verfahren zur freihändigen depression der sklera bei augenärtzlichen verfahren
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
JP6297180B2 (ja) 2014-07-03 2018-03-20 オトノミ—，インク． シプロフロキサシン組成物の滅菌
EP3180040B1 (de) 2014-08-15 2020-05-13 Tepha, Inc. Selbsthaltendes chirurgisches nahtmaterial aus poly-4-hydroxybutyrat und copolymeren davon
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
WO2016044683A1 (en) 2014-09-19 2016-03-24 Tensive Controls, Inc. Anti-microbial peptides
EP3205189A4 (de) 2014-10-08 2018-06-13 The Arizona Board of Regents on behalf of the University of Arizona Fliessfähige elektronik
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
ES2808150T3 (es) 2014-11-07 2021-02-25 Indivior Uk Ltd Regímenes de dosificación de buprenorfina
US20160166504A1 (en) 2014-12-10 2016-06-16 Incept, Llc Hydrogel drug delivery implants
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP3230500A1 (de) 2014-12-11 2017-10-18 Tepha, Inc. Verfahren zur ausrichtung von multifilamentgarn und monofilamenten aus poly-4-hydroxybutyrat und copolymere davon
US11382731B2 (en) 2015-02-27 2022-07-12 Covidien Lp Medical devices with sealing properties
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
EP4279064A3 (de) 2015-05-12 2024-02-28 Incept, LLC Arzneimittelabgabe aus hydrogelen
CN107847432A (zh) 2015-05-29 2018-03-27 西德奈克西斯公司 D2o稳定化的药物制剂
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
BR112018001900A2 (pt) 2015-07-28 2018-09-18 Otonomy, Inc. composições agonistas de trkb ou trkc e métodos para o tratamento de condições óticas
US10786515B2 (en) 2015-08-03 2020-09-29 Tolmar International Limited Liquid polymer delivery system for extended administration of drugs
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
SG11201804037XA (en) 2015-11-16 2018-06-28 Evonik Roehm Gmbh Injection solution comprising a non-nucleoside reverse-transcriptase inhibitor and poly(lactide-co-glycolide)
JP2018536484A (ja) 2015-11-25 2018-12-13 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ 形状変化する薬物送達デバイス及び方法
WO2017100576A1 (en) 2015-12-11 2017-06-15 Otonomy, Inc. Ciprofloxacin otic composition and kits and method for using same
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
CA3025501A1 (en) 2016-06-03 2017-12-07 Lifecell Corporation Methods for localized modification of tissue products
US10925837B2 (en) 2016-08-26 2021-02-23 Akina, Inc. Biodegradable polymer formulations for extended efficacy of botulinum toxin
EP3512513A4 (de) 2016-09-16 2020-04-15 Otonomy, Inc. Gelformulierungen für das ohr zur behandlung von otitis externa
WO2018055615A1 (en) 2016-09-22 2018-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Injectable implants
JP7430529B2 (ja) 2016-09-23 2024-02-13 インセプト・リミテッド・ライアビリティ・カンパニー 前房内薬物送達デポ
EP3538131A4 (de) 2016-11-09 2020-07-01 Mayo Foundation for Medical Education and Research Manp-analoga
CA3050243A1 (en) * 2016-12-12 2018-06-21 Neuronoff, Inc. Electrode curable and moldable to contours of a target in bodily tissue and methods of manufacturing and placement and dispensers therefor
US11992482B2 (en) 2016-12-21 2024-05-28 Rilento Pharma, Llc Malleable controlled release local anesthetic with hemostatic composition
AU2017382173A1 (en) 2016-12-22 2019-06-06 Lifecell Corporation Devices and methods for tissue cryomilling
CA3052157A1 (en) 2017-01-31 2018-08-09 Veru Inc. Compositions and methods for long term release of ganadotropin-releasing hormone (gnrh) antagonists
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
US20200276209A1 (en) 2017-09-11 2020-09-03 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
EP3697460A1 (de) 2017-10-18 2020-08-26 LifeCell Corporation Fettgewebeprodukte und verfahren zur herstellung
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
CN111225690A (zh) 2017-10-19 2020-06-02 生命细胞公司 可流动无细胞组织基质产品以及产生方法
EP3700465A4 (de) * 2017-10-23 2021-08-18 Endologix LLC Endoluminale vorrichtung und polymer
WO2019104191A1 (en) 2017-11-21 2019-05-31 Sydnexis, Inc. Ophthalmic composition and delivery device thereof
CA3084339A1 (en) 2017-12-18 2019-06-27 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical compositions having a selected release duration
WO2019154895A1 (en) 2018-02-08 2019-08-15 Strekin Ag Gel formulation for preventing or treating hearing loss
EA202190224A1 (ru) 2018-07-09 2021-04-16 Ридженерон Фармасьютикалз, Инк. Регулирование кинетики высвобождения в гидрогелях
EP3856142A1 (de) 2018-09-25 2021-08-04 Tolmar International Limited Flüssigpolymerabgabesystem zur verlängerten verabreichung von arzneimitteln
EP3946547A4 (de) 2019-03-26 2023-01-18 Pocket Naloxone Corp. Vorrichtungen und verfahren zur abgabe von pharmazeutischen zusammensetzungen
EP3975990A1 (de) 2019-05-27 2022-04-06 Tolmar International Limited Leuprolidacetat-zusammensetzungen und verfahren zu deren verwendung zur behandlung von brustkrebs
JP2022534110A (ja) 2019-05-30 2022-07-27 ライフセル コーポレーション 生物学的乳房インプラント
GB2601922B (en) 2019-06-27 2024-04-24 Layerbio Inc Ocular device drub delivery systems
GB201910895D0 (en) * 2019-07-31 2019-09-11 Univ Birmingham Curable monomers and compositions
AU2020342591A1 (en) 2019-09-02 2022-03-03 Camurus Ab Formulations and treatment methods
FI4037660T3 (fi) 2019-09-30 2023-12-14 Tolmar International Ltd Nestemäiset polymeerikoostumukset ja järjestelmät peptidien pitkäaikaista luovutusta varten aktiivisina farmaseuttisina ainesosina
EP4041189A1 (de) 2019-10-07 2022-08-17 Oak Crest Institute of Science Oral implantierbare wirkstofffreisetzungsvorrichtung
EP4051238A1 (de) 2019-11-27 2022-09-07 Oak Crest Institute of Science Arzneimittelausgabevorrichtung mit verzögerter freisetzung
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
US11278709B1 (en) 2021-03-12 2022-03-22 Pocket Naloxone Corp. Drug delivery device and methods for using same
WO2023278695A1 (en) * 2021-06-30 2023-01-05 The University Of North Carolina At Chapel Hill Injectable, biodegradable and removable polymer based drug suspension for ultra-long-acting drug delivery
TW202313047A (zh) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 抗精神病可注射儲積型組合物
CN114404659B (zh) * 2021-12-06 2022-09-16 中国科学院长春应用化学研究所 一种管状材料、其制备方法及其应用
AU2023205140A1 (en) 2022-01-06 2024-08-01 Oak Crest Institute Of Science Subdermal implant for sustained drug delivery
WO2024003291A1 (en) 2022-06-30 2024-01-04 Virbac Deslorelin use in chemical castration of a non-human mammal related to pk/pd interaction
US20240139187A1 (en) 2022-10-12 2024-05-02 The Children's Medical Center Corporation Selective hypothalamus permeable hdac6 inhibitors for treatment of leptin-resistant obesity
WO2024168022A2 (en) 2023-02-10 2024-08-15 Tolmar, Inc. Degarelix polymeric formulations
WO2024168024A1 (en) 2023-02-10 2024-08-15 Tolmar, Inc. Degarelix organic solvent formulations

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2155658A (en) * 1936-01-08 1939-04-25 Chemische Forschungs Gmbh Surgical and medical preparations
BE565269A (de) * 1957-03-27
US3328246A (en) * 1957-08-20 1967-06-27 Bicrex Lab Ltd Dental compositions and methods of making same
US3218283A (en) * 1962-07-26 1965-11-16 Monsanto Co Novel solutions of poly-(acrylic anhydride) and poly-(methacrylic anhydride) polymers
US3219527A (en) * 1963-06-17 1965-11-23 Loyola University Peridontal pack or dressing composition
US3463158A (en) * 1963-10-31 1969-08-26 American Cyanamid Co Polyglycolic acid prosthetic devices
US3520949A (en) * 1966-07-26 1970-07-21 Nat Patent Dev Corp Hydrophilic polymers,articles and methods of making same
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3767784A (en) * 1970-12-01 1973-10-23 S Gluck Composition for the protection and treatment of injured body tissue and method of utilizing the same
US3760034A (en) * 1971-01-26 1973-09-18 Union Carbide Corp Graft copolymers of lactone polyesters
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3696811A (en) * 1971-06-17 1972-10-10 Squibb & Sons Inc Periodontal bandage and backing therefor
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US3939111A (en) * 1974-07-01 1976-02-17 The B. F. Goodrich Company Stable polyurethane solutions
US3935308A (en) * 1974-08-08 1976-01-27 The United States Of America As Represented By The Secretary Of The Navy Wound covering and method of application
US3931678A (en) * 1974-09-24 1976-01-13 Loctite (Ireland) Limited Dental filling method and composition formed thereby
CH625702A5 (de) * 1977-01-18 1981-10-15 Delalande Sa
US4148871A (en) * 1977-10-11 1979-04-10 Pitt Colin G Sustained subdermal delivery ofdrugs using poly(ε-caprolactone) and its copolymers
DE2917037C2 (de) * 1979-04-27 1980-12-11 Josef Dipl.-Chem. Dr. 8000 Muenchen Gaensheimer Parenteral arzneimittelhaltige partiell resorbierbare Mehrkomponentenmasse auf Basis von polymeren Stoffen
US4408023A (en) * 1980-11-12 1983-10-04 Tyndale Plains-Hunter, Ltd. Polyurethane diacrylate compositions useful for contact lenses and the like
JPS57110254A (en) * 1980-12-29 1982-07-09 Teijin Ltd Coating agent of injured membrane part of oral cavity
US4793336A (en) * 1981-03-25 1988-12-27 Wang Paul Y Wound coverings and processes for their preparation
US4447562A (en) * 1981-07-15 1984-05-08 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4570629A (en) * 1982-03-17 1986-02-18 University Of Illinois Foundation Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same
DE3377462D1 (en) * 1982-04-07 1988-09-01 Bernard Paul Philippe Feinmann Improved material and method for dentistry
CA1211266A (en) * 1982-11-12 1986-09-16 Alfred E. Lauchenauer Shaped semi-solid articles
US4439420A (en) * 1982-11-16 1984-03-27 Ethicon, Inc. Absorbable hemostatic composition
US4443430A (en) * 1982-11-16 1984-04-17 Ethicon, Inc. Synthetic absorbable hemostatic agent
US5286763A (en) * 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
EP0153407B1 (de) * 1983-08-31 1993-03-03 S.K.Y. Polymers Ltd. Einspritzbare physiologisch unbedenkliche polymerzusammensetzungen
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
GR80494B (en) * 1983-10-07 1985-02-04 Forsyth Dental Infirmary Intra-pocket drug delivery devices for treatment of periodontal diseases
EP0501523B1 (de) * 1983-11-14 1997-04-09 Columbia Laboratories, Inc. Bioadhäsive Mittel
JPS60226530A (ja) * 1984-04-02 1985-11-11 バテル　メモリアル　インステイチユート フイルム形成重合材
US4663077A (en) * 1984-06-11 1987-05-05 Morton Thiokol Inc. Microbiocidal compositions comprising an aryl alkanol and a microbiocidal compound dissolved therein
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
EP0169016B2 (de) * 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4595713A (en) * 1985-01-22 1986-06-17 Hexcel Corporation Medical putty for tissue augmentation
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4772470A (en) * 1985-04-27 1988-09-20 Nitto Electric Industrial Co., Ltd. Oral bandage and oral preparations
US4767627A (en) * 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4702917A (en) * 1985-11-18 1987-10-27 Research Triangle Institute Porous bioabsorbable polyesters
US4767861A (en) * 1986-01-28 1988-08-30 Vipont Laboratories Recovery of benzo-c-phenanthridine alkaloids
US4774227A (en) * 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US4857602A (en) * 1986-09-05 1989-08-15 American Cyanamid Company Bioabsorbable surgical suture coating
US4846165A (en) * 1986-11-26 1989-07-11 Dentsply Research & Development Corp. Wound dressing membrane
JPH0649735B2 (ja) * 1986-11-29 1994-06-29 住友化学工業株式会社 新規エチレン共重合体およびその製造方法
US4981696A (en) * 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
US4800219A (en) * 1986-12-22 1989-01-24 E. I. Du Pont De Nemours And Company Polylactide compositions
US4983689A (en) * 1987-05-07 1991-01-08 Yu Simon H Process for making macromolecular monomers of polylactones with terminal acryloyl unsaturation and block copolymers thereof
US5013553A (en) * 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US4804691A (en) * 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
US4920203A (en) * 1987-12-17 1990-04-24 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US5007940A (en) * 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
EP0560014A1 (de) * 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung
ATE241394T1 (de) * 1994-04-08 2003-06-15 Atrix Lab Inc Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung

Also Published As

Publication number Publication date
HK1005012A1 (en) 1998-12-18
AU666050B2 (en) 1996-01-25
ATE151257T1 (de) 1997-04-15
NL300204I1 (nl) 2005-10-03
NO911277L (no) 1991-05-31
US5278201A (en) 1994-01-11
US5278202A (en) 1994-01-11
AU5067793A (en) 1994-02-17
DK57291D0 (da) 1991-04-02
KR0158669B1 (ko) 1998-12-15
JPH04503163A (ja) 1992-06-11
DE68927956T2 (de) 1997-07-17
EP0773034B1 (de) 2002-12-04
EP0436667A1 (de) 1991-07-17
CA1340694C (en) 1999-08-03
US5340849A (en) 1994-08-23
NO304413B1 (no) 1998-12-14
EP0436667A4 (en) 1991-10-16
US5990194A (en) 1999-11-23
WO1990003768A1 (en) 1990-04-19
EP0773034A1 (de) 1997-05-14
EP0436667B1 (de) 1997-04-09
NO2005021I1 (no) 2005-10-03
DE68929441D1 (de) 2003-01-16
DK175906B1 (da) 2005-06-06
US5733950A (en) 1998-03-31
JP2992046B2 (ja) 1999-12-20
ATE228861T1 (de) 2002-12-15
US4938763B1 (en) 1995-07-04
NO911277D0 (no) 1991-04-02
DE122004000029I1 (de) 2004-11-18
KR920700017A (ko) 1992-02-19
LU91193I2 (fr) 2005-10-25
US5739176A (en) 1998-04-14
DE68927956D1 (de) 1997-05-15
IL91850A0 (en) 1990-06-10
ZA897511B (en) 1991-06-26
US4938763A (en) 1990-07-03
DK57291A (da) 1991-06-03
BR8907686A (pt) 1991-07-30
DE68929441T2 (de) 2003-09-25

Similar Documents

Publication Publication Date Title
US5278202A (en) Biodegradable in-situ forming implants and methods of producing the same
USRE37950E1 (en) Biogradable in-situ forming implants and methods of producing the same
EP0484387B1 (de) Biodegradierbares system zur regeneration des perodontiums
US5612052A (en) Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
CA2714757C (en) Low viscosity liquid polymeric delivery system
AU644581B2 (en) Biodegradable in-situ forming implants
IE900117A1 (en) Biodegradable in-situ forming implants and methods of¹producing the same
NZ232107A (en) Biodegradable implants formed in-situ; use as slow release carriers and prepolymer compositions
IL107393A (en) Preparations and methods for creating a seedling that stabilizes and breaks down within the body
KR0158670B1 (ko) 투입된 원위치에서 형성되는 생분해성 이식조직

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired